CD99L2

Functionⁱ

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).By similarity

GO - Biological processⁱ

cell adhesion Source: UniProtKB-KW
diapedesis Source: Ensembl
positive regulation of neutrophil extravasation Source: Ensembl
positive regulation of T cell extravasation Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD99 antigen-like protein 2 Alternative name(s): MIC2-like protein 1 CD_antigen: CD99
Gene namesⁱ	Name:CD99L2 Synonyms:MIC2L1 ORF Names:UNQ1964/PRO4486
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000102181.20
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18237 CD99L2
MIMⁱ	300846 gene
neXtProtⁱ	NX_Q8TCZ2

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 185	ExtracellularSequence analysisAdd BLAST	160
Transmembraneⁱ	186 – 206	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	207 – 262	CytoplasmicSequence analysisAdd BLAST	56

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000102181
PharmGKBⁱ	PA30805

Polymorphism and mutation databases

BioMutaⁱ	CD99L2
DMDMⁱ	74730601

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Sequence analysisAdd BLAST		25
ChainⁱPRO_0000340092	26 – 262	CD99 antigen-like protein 2Add BLAST		237

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q8TCZ2
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TCZ2
PaxDbⁱ	Q8TCZ2
PeptideAtlas More...PeptideAtlasⁱ	Q8TCZ2
PRIDEⁱ	Q8TCZ2
ProteomicsDBⁱ	74199 74200 [Q8TCZ2-2] 74201 [Q8TCZ2-3] 74202 [Q8TCZ2-4] 74203 [Q8TCZ2-5]
TopDownProteomicsⁱ	Q8TCZ2-1 [Q8TCZ2-1]

PTM databases

iPTMnetⁱ	Q8TCZ2
PhosphoSitePlusⁱ	Q8TCZ2
SwissPalmⁱ	Q8TCZ2

Expressionⁱ

Tissue specificityⁱ

Expressed in many tissues, with low expression in thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000102181 Expressed in 192 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_CD99L2
ExpressionAtlasⁱ	Q8TCZ2 baseline and differential
Genevisibleⁱ	Q8TCZ2 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038782 HPA038783 HPA061400

HPAⁱ

HPA038782
HPA038783
HPA061400

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
SGTA	O43765	5	EBI-2824782,EBI-347996
SGTB	Q96EQ0	4	EBI-2824782,EBI-744081
UBQLN1	Q9UMX0	6	EBI-2824782,EBI-741480
UBQLN1	Q9UMX0-2	6	EBI-2824782,EBI-10173939

Protein-protein interaction databases

BioGridⁱ	123726, 18 interactors
IntActⁱ	Q8TCZ2, 20 interactors
STRINGⁱ	9606.ENSP00000359403

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TCZ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	49 – 54	Poly-Thr	6
Compositional biasⁱ	99 – 102	Poly-Thr	4
Compositional biasⁱ	141 – 144	Poly-Gly	4
Compositional biasⁱ	253 – 259	Poly-Pro	7

Sequence similaritiesⁱ

Belongs to the CD99 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J1MW Eukaryota ENOG410YNQK LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063944
HOGENOMⁱ	HOG000233665
HOVERGENⁱ	HBG067989
InParanoidⁱ	Q8TCZ2
OMAⁱ	RWDRVTT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YLT
PhylomeDBⁱ	Q8TCZ2
TreeFamⁱ	TF332323

Family and domain databases

InterProⁱ	View protein in InterPro IPR022078 CD99L2
PANTHERⁱ	PTHR15076 PTHR15076, 2 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12301 CD99L2, 2 hits

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TCZ2-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT 
        60         70         80         90        100
TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT 
       110        120        130        140        150
TTKRPVTTRA PANTLGNDFD LADALDDRND RDDGRRKPIA GGGGFSDKDL 
       160        170        180        190        200
EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM VAEPGTIAGV ASALAMALIG 
       210        220        230        240        250
AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ VKYSTLHTQS 
       260 
AEPPPPPEPA RI

Length:262

Mass (Da):27,986

Last modified:June 1, 2002 - v1

Checksum:ⁱ3A254961DD32C191

GO

Isoform 2 (identifier: Q8TCZ2-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
45-93: Missing.

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQRWNHVT 
        60         70         80         90        100
TTTKRPVTTR APANTLGNDF DLADALDDRN DRDDGRRKPI AGGGGFSDKD 
       110        120        130        140        150
LEDIVGGGEY KPDKGKGDGR YGSNDDPGSG MVAEPGTIAG VASALAMALI 
       160        170        180        190        200
GAVSSYISYQ QKKFCFSIQQ GLNADYVKGE NLEAVVCEEP QVKYSTLHTQ 
       210 
SAEPPPPPEP ARI

Show »

Length:213

Mass (Da):22,833

Checksum:ⁱF90595DAA99BA7D5

GO

Isoform 3 (identifier: Q8TCZ2-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
44-44: Q → R
45-116: Missing.

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKRNDFDLA 
        60         70         80         90        100
DALDDRNDRD DGRRKPIAGG GGFSDKDLED IVGGGEYKPD KGKGDGRYGS 
       110        120        130        140        150
NDDPGSGMVA EPGTIAGVAS ALAMALIGAV SSYISYQQKK FCFSIQQGLN 
       160        170        180        190
ADYVKGENLE AVVCEEPQVK YSTLHTQSAE PPPPPEPARI

Show »

Length:190

Mass (Da):20,300

Checksum:ⁱF21A43C7F6B319F6

GO

Isoform 4 (identifier: Q8TCZ2-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
44-145: QPWDHTTTTT...RKPIAGGGGF → PALGMYHKLD...GFKAHLDNPG
146-262: Missing.

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKPALGMYH 
        60         70         80         90        100
KLDGLKQQNF ILSLFWMLEV LYQGVGWATF SLKALGKNLS LTFPTSGGSR 
       110        120        130        140 
CSLVCGCITP ISASVVTWCS PFCVSLLSLT KMLVSGFKAH LDNPG

Note: No experimental confirmation available.

Show »

Length:145

Mass (Da):15,708

Checksum:ⁱ777A148801613231

GO

Isoform 5 (identifier: Q8TCZ2-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
68-68: G → GPTEG
218-219: QQ → QHAAAGQE

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT 
        60         70         80         90        100
TTTTNRPGTT RAPAKPPGPT EGSGLDLADA LDDQDDGRRK PGIGGRERWN 
       110        120        130        140        150
HVTTTTKRPV TTRAPANTLG NDFDLADALD DRNDRDDGRR KPIAGGGGFS 
       160        170        180        190        200
DKDLEDIVGG GEYKPDKGKG DGRYGSNDDP GSGMVAEPGT IAGVASALAM 
       210        220        230        240        250
ALIGAVSSYI SYQQKKFCFS IQHAAAGQEG LNADYVKGEN LEAVVCEEPQ 
       260        270 
VKYSTLHTQS AEPPPPPEPA RI

Note: No experimental confirmation available.

Show »

Length:272

Mass (Da):28,907

Checksum:ⁱ6A92D41FDA0C5FD4

GO

Isoform 6 (identifier: Q8TCZ2-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
93-165: Missing.

« Hide

        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT 
        60         70         80         90        100
TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRGDGRYGSN 
       110        120        130        140        150
DDPGSGMVAE PGTIAGVASA LAMALIGAVS SYISYQQKKF CFSIQQGLNA 
       160        170        180 
DYVKGENLEA VVCEEPQVKY STLHTQSAEP PPPPEPARI

Note: No experimental confirmation available.

Show »

Length:189

Mass (Da):20,032

Checksum:ⁱ9F21AFB2BA02904B

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0U1RQT8	A0A0U1RQT8_HUMAN	CD99 antigen-like protein 2 CD99 antigen-like protein 2	CD99L2	177	Annotation score:
H0Y4H3	H0Y4H3_HUMAN	CD99 antigen-like protein 2 CD99 antigen-like protein 2	CD99L2	157	Annotation score:

Sequence cautionⁱ

The sequence CAB66515 differs from that shown. Reason: Frameshift at position 156.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	109	R → I in BAF82889 (PubMed:14702039).Curated	1
Sequence conflictⁱ	128	R → Q in BAG54124 (PubMed:14702039).Curated	1
Sequence conflictⁱ	170	Y → H in BAF82889 (PubMed:14702039).Curated	1
Sequence conflictⁱ	176	P → R in BAF84064 (PubMed:14702039).Curated	1
Sequence conflictⁱ	229	E → G in BAG56778 (PubMed:14702039).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_034181	44 – 145	QPWDH…GGGGF → PALGMYHKLDGLKQQNFILS LFWMLEVLYQGVGWATFSLK ALGKNLSLTFPTSGGSRCSL VCGCITPISASVVTWCSPFC VSLLSLTKMLVSGFKAHLDN PG in isoform 4. 1 PublicationAdd BLAST	102
Alternative sequenceⁱVSP_034182	44	Q → R in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_034183	45 – 116	Missing in isoform 3. 1 PublicationAdd BLAST	72
Alternative sequenceⁱVSP_034184	45 – 93	Missing in isoform 2. 2 PublicationsAdd BLAST	49
Alternative sequenceⁱVSP_041815	68	G → GPTEG in isoform 5. 1 Publication	1
Alternative sequenceⁱVSP_044663	93 – 165	Missing in isoform 6. 1 PublicationAdd BLAST	73
Alternative sequenceⁱVSP_034185	146 – 262	Missing in isoform 4. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_041816	218 – 219	QQ → QHAAAGQE in isoform 5. 1 Publication	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY078165 mRNA Translation: AAL86617.1 AY078166 mRNA Translation: AAL86618.1 AY078167 mRNA Translation: AAL86619.1 AL136580 mRNA Translation: CAB66515.1 Frameshift. AY358837 mRNA Translation: AAQ89196.1 AK290200 mRNA Translation: BAF82889.1 AK291375 mRNA Translation: BAF84064.1 AK293244 mRNA Translation: BAG56778.1 AK125020 mRNA Translation: BAG54124.1 AF002223 Genomic DNA No translation available. AF274573 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99391.1 CH471169 Genomic DNA Translation: EAW99392.1 CH471169 Genomic DNA Translation: EAW99393.1 CH471169 Genomic DNA Translation: EAW99395.1 BC025729 mRNA Translation: AAH25729.1 BC030536 mRNA Translation: AAH30536.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14697.1 [Q8TCZ2-3] CCDS14698.1 [Q8TCZ2-2] CCDS35427.1 [Q8TCZ2-1] CCDS55527.1 [Q8TCZ2-6] CCDS76044.1 [Q8TCZ2-5]
NCBI Reference Sequences More...RefSeqⁱ	NP_001171737.1, NM_001184808.1 [Q8TCZ2-6] NP_001229543.1, NM_001242614.1 [Q8TCZ2-5] NP_113650.2, NM_031462.3 [Q8TCZ2-1] NP_604394.1, NM_134445.3 [Q8TCZ2-3] NP_604395.1, NM_134446.3 [Q8TCZ2-2] XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]
UniGeneⁱ	Hs.522805

Genome annotation databases

Ensemblⁱ	ENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4] ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3] ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1] ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6] ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2] ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]
GeneIDⁱ	83692
KEGGⁱ	hsa:83692
UCSC genome browser More...UCSCⁱ	uc004fek.4 human [Q8TCZ2-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Species	Length	Source
Q8TCZ2	CD99 antigen-like 2, isoform CRA_d	HUMAN	262	UniRef100_Q8TCZ2
Q8TCZ2-2	CD99 molecule like 2	GORGO	213	UniRef100_A0A2I2YBL0
Q8TCZ2-3	CD99 molecule like 2	GORGO	190	UniRef100_G3SEI7

Protein	Similar proteins		Species	Score	Length	Source
Q8TCZ2	CD99 antigen-like 2, isoform CRA_d		HUMAN		262	UniRef90_Q8TCZ2
CD99L2 isoform 4		PANTR		268
CD99 molecule like 2		GORGO		262
CD99 antigen-like protein 2		PONAB		261
Uncharacterized protein		NOMLE		258
+7
Q8TCZ2-2	CD99 antigen-like protein 2		PONAB		218	UniRef90_Q5RE35
Uncharacterized protein		MACMU		219
CD99 molecule-like 2		PANTR		213
CD99 antigen-like protein 2 isoform 2		CALJA		213
CD99 molecule like 2		SAIBB		213
+18
Q8TCZ2-3	Uncharacterized protein		PANPA		181	UniRef90_A0A2R8ZN80
CD99 molecule-like 2		PANTR		190
CD99 molecule like 2		GORGO		190
CD99 molecule like 2		SAIBB		189
Uncharacterized protein		MACMU		189
+13
Q8TCZ2-4	CD99L2 isoform 2		PONAB		145	UniRef90_Q8TCZ2-4
CD99L2 isoform 2		PANTR		145
Q8TCZ2-5	CD99L2 isoform 4		PONAB		271	UniRef90_Q8TCZ2-5
CD99 antigen-like protein 2 isoform 5		CALJA		268
Uncharacterized protein		CHLSB		267
Uncharacterized protein		MACMU		267
Uncharacterized protein		MACFA		267
+27
Q8TCZ2-6	CD99 molecule like 2		PANTR		189	UniRef90_Q8TCZ2-6
CD99 molecule like 2		GORGO		189
Uncharacterized protein		RHIBE		189
Uncharacterized protein		RHIRO		166
CD99 molecule like 2		SAIBB		188
+9

Protein	Similar proteins		Species	Score	Length	Source
Q8TCZ2	CD99 antigen-like 2, isoform CRA_d		HUMAN		262	UniRef50_Q8TCZ2
CD99L2 isoform 4		PANTR		268
CD99 molecule like 2		GORGO		262
CD99 antigen-like protein 2		PONAB		261
Uncharacterized protein		NOMLE		258
+13
Q8TCZ2-2	CD99 antigen-like protein 2		BOVIN		217	UniRef50_A1A4K1
CD99 antigen-like protein 2		PONAB		218
Uncharacterized protein		RHIRO		209
Uncharacterized protein		Cebus capucinus imitator		192
CD99 antigen-like protein 2 isoform X2		PHYCD		212
+73
Q8TCZ2-3	Isoform 2 of CD99 antigen-like protein 2		MOUSE		214	UniRef50_Q8BIF0-2
CD99 antigen-like protein 2		PTEAL		205
CD99 molecule-like 2		PANTR		190
CD99 molecule like 2		GORGO		190
Uncharacterized protein		MACMU		189
+38
Q8TCZ2-4	CD99L2 isoform 2		PONAB		145	UniRef50_Q8TCZ2-4
CD99L2 isoform 2		PANTR		145
Q8TCZ2-5	CD99L2 isoform 4		PONAB		271	UniRef50_Q8TCZ2-5
CD99 antigen-like protein 2 isoform 5		CALJA		268
Uncharacterized protein		MACMU		267
Uncharacterized protein		MACFA		267
Uncharacterized protein		CHLSB		267
+88
Q8TCZ2-6	CD99 molecule like 2		PANTR		189	UniRef50_Q8TCZ2-6
Uncharacterized protein		RHIBE		189
Uncharacterized protein		RHIRO		166
CD99 molecule like 2		GORGO		189
Uncharacterized protein		MACMU		188
+23

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY078165 mRNA Translation: AAL86617.1 AY078166 mRNA Translation: AAL86618.1 AY078167 mRNA Translation: AAL86619.1 AL136580 mRNA Translation: CAB66515.1 Frameshift. AY358837 mRNA Translation: AAQ89196.1 AK290200 mRNA Translation: BAF82889.1 AK291375 mRNA Translation: BAF84064.1 AK293244 mRNA Translation: BAG56778.1 AK125020 mRNA Translation: BAG54124.1 AF002223 Genomic DNA No translation available. AF274573 Genomic DNA No translation available. CH471169 Genomic DNA Translation: EAW99391.1 CH471169 Genomic DNA Translation: EAW99392.1 CH471169 Genomic DNA Translation: EAW99393.1 CH471169 Genomic DNA Translation: EAW99395.1 BC025729 mRNA Translation: AAH25729.1 BC030536 mRNA Translation: AAH30536.1
CCDSⁱ	CCDS14697.1 [Q8TCZ2-3] CCDS14698.1 [Q8TCZ2-2] CCDS35427.1 [Q8TCZ2-1] CCDS55527.1 [Q8TCZ2-6] CCDS76044.1 [Q8TCZ2-5]
RefSeqⁱ	NP_001171737.1, NM_001184808.1 [Q8TCZ2-6] NP_001229543.1, NM_001242614.1 [Q8TCZ2-5] NP_113650.2, NM_031462.3 [Q8TCZ2-1] NP_604394.1, NM_134445.3 [Q8TCZ2-3] NP_604395.1, NM_134446.3 [Q8TCZ2-2] XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]
UniGeneⁱ	Hs.522805

3D structure databases

ProteinModelPortalⁱ	Q8TCZ2
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123726, 18 interactors
IntActⁱ	Q8TCZ2, 20 interactors
STRINGⁱ	9606.ENSP00000359403

PTM databases

iPTMnetⁱ	Q8TCZ2
PhosphoSitePlusⁱ	Q8TCZ2
SwissPalmⁱ	Q8TCZ2

Polymorphism and mutation databases

BioMutaⁱ	CD99L2
DMDMⁱ	74730601

Proteomic databases

EPDⁱ	Q8TCZ2
MaxQBⁱ	Q8TCZ2
PaxDbⁱ	Q8TCZ2
PeptideAtlasⁱ	Q8TCZ2
PRIDEⁱ	Q8TCZ2
ProteomicsDBⁱ	74199 74200 [Q8TCZ2-2] 74201 [Q8TCZ2-3] 74202 [Q8TCZ2-4] 74203 [Q8TCZ2-5]
TopDownProteomicsⁱ	Q8TCZ2-1 [Q8TCZ2-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	83692
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4] ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3] ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1] ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6] ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2] ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]
GeneIDⁱ	83692
KEGGⁱ	hsa:83692
UCSCⁱ	uc004fek.4 human [Q8TCZ2-1]

Organism-specific databases

CTDⁱ	83692
EuPathDBⁱ	HostDB:ENSG00000102181.20
GeneCardsⁱ	CD99L2
HGNCⁱ	HGNC:18237 CD99L2
HPAⁱ	HPA038782 HPA038783 HPA061400
MIMⁱ	300846 gene
neXtProtⁱ	NX_Q8TCZ2
OpenTargetsⁱ	ENSG00000102181
PharmGKBⁱ	PA30805
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J1MW Eukaryota ENOG410YNQK LUCA
GeneTreeⁱ	ENSGT00530000063944
HOGENOMⁱ	HOG000233665
HOVERGENⁱ	HBG067989
InParanoidⁱ	Q8TCZ2
OMAⁱ	RWDRVTT
OrthoDBⁱ	EOG091G0YLT
PhylomeDBⁱ	Q8TCZ2
TreeFamⁱ	TF332323

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSⁱ	CD99L2 human
GeneWikiⁱ	CD99L2
GenomeRNAiⁱ	83692
Protein Ontology More...PROⁱ	PR:Q8TCZ2
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000102181 Expressed in 192 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_CD99L2
ExpressionAtlasⁱ	Q8TCZ2 baseline and differential
Genevisibleⁱ	Q8TCZ2 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR022078 CD99L2
PANTHERⁱ	PTHR15076 PTHR15076, 2 hits
Pfamⁱ	View protein in Pfam PF12301 CD99L2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	C99L2_HUMAN
Accessionⁱ	Q8TCZ2Primary (citable) accession number: Q8TCZ2 Secondary accession number(s): A8K2D5 Q9BQG9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TCZ2 (C99L2_HUMAN)

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CD99 antigen-like protein 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ