UniProtKB - Q8TCZ2 (C99L2_HUMAN)
Protein
CD99 antigen-like protein 2
Gene
CD99L2
Organism
Homo sapiens (Human)
Status
Functioni
Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).By similarity
GO - Biological processi
- cell adhesion Source: UniProtKB-KW
- diapedesis Source: Ensembl
- positive regulation of neutrophil extravasation Source: Ensembl
- positive regulation of T cell extravasation Source: Ensembl
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | Q8TCZ2 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
Names & Taxonomyi
Protein namesi | Recommended name: CD99 antigen-like protein 2Alternative name(s): MIC2-like protein 1 CD_antigen: CD99 |
Gene namesi | Name:CD99L2 Synonyms:MIC2L1 ORF Names:UNQ1964/PRO4486 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18237, CD99L2 |
MIMi | 300846, gene |
neXtProti | NX_Q8TCZ2 |
VEuPathDBi | HostDB:ENSG00000102181.20 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein By similarity; Extracellular side By similarity
Other locations
- Cell junction By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- adherens junction Source: Ensembl
- cell surface Source: Ensembl
- focal adhesion Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 185 | ExtracellularSequence analysisAdd BLAST | 160 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 207 – 262 | CytoplasmicSequence analysisAdd BLAST | 56 |
Keywords - Cellular componenti
Cell junction, Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 83692 |
OpenTargetsi | ENSG00000102181 |
PharmGKBi | PA30805 |
Miscellaneous databases
Pharosi | Q8TCZ2, Tbio |
Genetic variation databases
BioMutai | CD99L2 |
DMDMi | 74730601 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_0000340092 | 26 – 262 | CD99 antigen-like protein 2Add BLAST | 237 |
Post-translational modificationi
O-glycosylated.By similarity
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8TCZ2 |
jPOSTi | Q8TCZ2 |
MassIVEi | Q8TCZ2 |
MaxQBi | Q8TCZ2 |
PaxDbi | Q8TCZ2 |
PeptideAtlasi | Q8TCZ2 |
PRIDEi | Q8TCZ2 |
ProteomicsDBi | 19570 74199 [Q8TCZ2-1] 74200 [Q8TCZ2-2] 74201 [Q8TCZ2-3] 74202 [Q8TCZ2-4] 74203 [Q8TCZ2-5] |
TopDownProteomicsi | Q8TCZ2-1 [Q8TCZ2-1] |
PTM databases
GlyGeni | Q8TCZ2, 2 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q8TCZ2 |
PhosphoSitePlusi | Q8TCZ2 |
SwissPalmi | Q8TCZ2 |
Expressioni
Tissue specificityi
Expressed in many tissues, with low expression in thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000102181, Expressed in frontal cortex and 206 other tissues |
ExpressionAtlasi | Q8TCZ2, baseline and differential |
Genevisiblei | Q8TCZ2, HS |
Organism-specific databases
HPAi | ENSG00000102181, Tissue enhanced (skeletal) |
Interactioni
Binary interactionsi
Hide detailsQ8TCZ2
Protein-protein interaction databases
BioGRIDi | 123726, 29 interactors |
IntActi | Q8TCZ2, 26 interactors |
STRINGi | 9606.ENSP00000480322 |
Miscellaneous databases
RNActi | Q8TCZ2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 49 – 54 | Poly-Thr | 6 | |
Compositional biasi | 99 – 102 | Poly-Thr | 4 | |
Compositional biasi | 141 – 144 | Poly-Gly | 4 | |
Compositional biasi | 253 – 259 | Poly-Pro | 7 |
Sequence similaritiesi
Belongs to the CD99 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502RZ6C, Eukaryota |
GeneTreei | ENSGT00940000154344 |
HOGENOMi | CLU_092825_0_1_1 |
InParanoidi | Q8TCZ2 |
OMAi | EDIAWGG |
OrthoDBi | 1559463at2759 |
PhylomeDBi | Q8TCZ2 |
TreeFami | TF332323 |
Family and domain databases
InterProi | View protein in InterPro IPR022078, CD99L2 |
PANTHERi | PTHR15076, PTHR15076, 2 hits |
Pfami | View protein in Pfam PF12301, CD99L2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TCZ2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT
60 70 80 90 100
TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT
110 120 130 140 150
TTKRPVTTRA PANTLGNDFD LADALDDRND RDDGRRKPIA GGGGFSDKDL
160 170 180 190 200
EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM VAEPGTIAGV ASALAMALIG
210 220 230 240 250
AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ VKYSTLHTQS
260
AEPPPPPEPA RI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0U1RQT8 | A0A0U1RQT8_HUMAN | CD99 antigen-like protein 2 | CD99L2 | 177 | Annotation score: | ||
H0Y4H3 | H0Y4H3_HUMAN | CD99 antigen-like protein 2 | CD99L2 | 157 | Annotation score: |
Sequence cautioni
The sequence CAB66515 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 109 | R → I in BAF82889 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 128 | R → Q in BAG54124 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 170 | Y → H in BAF82889 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 176 | P → R in BAF84064 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 229 | E → G in BAG56778 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034181 | 44 – 145 | QPWDH…GGGGF → PALGMYHKLDGLKQQNFILS LFWMLEVLYQGVGWATFSLK ALGKNLSLTFPTSGGSRCSL VCGCITPISASVVTWCSPFC VSLLSLTKMLVSGFKAHLDN PG in isoform 4. 1 PublicationAdd BLAST | 102 | |
Alternative sequenceiVSP_034182 | 44 | Q → R in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_034183 | 45 – 116 | Missing in isoform 3. 1 PublicationAdd BLAST | 72 | |
Alternative sequenceiVSP_034184 | 45 – 93 | Missing in isoform 2. 2 PublicationsAdd BLAST | 49 | |
Alternative sequenceiVSP_041815 | 68 | G → GPTEG in isoform 5. 1 Publication | 1 | |
Alternative sequenceiVSP_044663 | 93 – 165 | Missing in isoform 6. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_034185 | 146 – 262 | Missing in isoform 4. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_041816 | 218 – 219 | QQ → QHAAAGQE in isoform 5. 1 Publication | 2 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4] ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3] ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1] ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6] ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2] ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5] |
GeneIDi | 83692 |
KEGGi | hsa:83692 |
UCSCi | uc004fek.4, human [Q8TCZ2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123726, 29 interactors |
IntActi | Q8TCZ2, 26 interactors |
STRINGi | 9606.ENSP00000480322 |
PTM databases
GlyGeni | Q8TCZ2, 2 sites, 2 O-linked glycans (2 sites) |
iPTMneti | Q8TCZ2 |
PhosphoSitePlusi | Q8TCZ2 |
SwissPalmi | Q8TCZ2 |
Genetic variation databases
BioMutai | CD99L2 |
DMDMi | 74730601 |
Proteomic databases
EPDi | Q8TCZ2 |
jPOSTi | Q8TCZ2 |
MassIVEi | Q8TCZ2 |
MaxQBi | Q8TCZ2 |
PaxDbi | Q8TCZ2 |
PeptideAtlasi | Q8TCZ2 |
PRIDEi | Q8TCZ2 |
ProteomicsDBi | 19570 74199 [Q8TCZ2-1] 74200 [Q8TCZ2-2] 74201 [Q8TCZ2-3] 74202 [Q8TCZ2-4] 74203 [Q8TCZ2-5] |
TopDownProteomicsi | Q8TCZ2-1 [Q8TCZ2-1] |
Protocols and materials databases
Antibodypediai | 50585, 173 antibodies |
DNASUi | 83692 |
Genome annotation databases
Ensembli | ENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4] ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3] ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1] ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6] ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2] ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5] |
GeneIDi | 83692 |
KEGGi | hsa:83692 |
UCSCi | uc004fek.4, human [Q8TCZ2-1] |
Organism-specific databases
CTDi | 83692 |
DisGeNETi | 83692 |
GeneCardsi | CD99L2 |
HGNCi | HGNC:18237, CD99L2 |
HPAi | ENSG00000102181, Tissue enhanced (skeletal) |
MIMi | 300846, gene |
neXtProti | NX_Q8TCZ2 |
OpenTargetsi | ENSG00000102181 |
PharmGKBi | PA30805 |
VEuPathDBi | HostDB:ENSG00000102181.20 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZ6C, Eukaryota |
GeneTreei | ENSGT00940000154344 |
HOGENOMi | CLU_092825_0_1_1 |
InParanoidi | Q8TCZ2 |
OMAi | EDIAWGG |
OrthoDBi | 1559463at2759 |
PhylomeDBi | Q8TCZ2 |
TreeFami | TF332323 |
Enzyme and pathway databases
PathwayCommonsi | Q8TCZ2 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
Miscellaneous databases
BioGRID-ORCSi | 83692, 2 hits in 619 CRISPR screens |
ChiTaRSi | CD99L2, human |
GeneWikii | CD99L2 |
GenomeRNAii | 83692 |
Pharosi | Q8TCZ2, Tbio |
PROi | PR:Q8TCZ2 |
RNActi | Q8TCZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102181, Expressed in frontal cortex and 206 other tissues |
ExpressionAtlasi | Q8TCZ2, baseline and differential |
Genevisiblei | Q8TCZ2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR022078, CD99L2 |
PANTHERi | PTHR15076, PTHR15076, 2 hits |
Pfami | View protein in Pfam PF12301, CD99L2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | C99L2_HUMAN | |
Accessioni | Q8TCZ2Primary (citable) accession number: Q8TCZ2 Secondary accession number(s): A8K2D5 Q9BQG9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 10, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families