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UniProtKB - Q8TCZ2 (C99L2_HUMAN)

Entry version 149 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

CD99 antigen-like protein 2

Gene

CD99L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity).

Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TCZ2

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD99 antigen-like protein 2
Alternative name(s):
MIC2-like protein 1
CD_antigen: CD99
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD99L2
Synonyms:MIC2L1
ORF Names:UNQ1964/PRO4486
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18237, CD99L2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300846, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TCZ2

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000102181.20

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 185ExtracellularSequence analysisAdd BLAST160
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 262CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		83692

Open Targets

More...OpenTargetsi		ENSG00000102181

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30805

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TCZ2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD99L2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74730601

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034009226 – 262CD99 antigen-like protein 2Add BLAST237

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TCZ2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TCZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TCZ2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TCZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TCZ2

PeptideAtlas

More...PeptideAtlasi		Q8TCZ2

PRoteomics IDEntifications database

More...PRIDEi		Q8TCZ2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19570
74199 [Q8TCZ2-1]
74200 [Q8TCZ2-2]
74201 [Q8TCZ2-3]
74202 [Q8TCZ2-4]
74203 [Q8TCZ2-5]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q8TCZ2-1 [Q8TCZ2-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TCZ2, 2 sites, 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TCZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TCZ2

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TCZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in many tissues, with low expression in thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102181, Expressed in frontal cortex and 206 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TCZ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TCZ2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000102181, Tissue enhanced (skeletal)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123726, 29 interactors

Protein interaction database and analysis system

More...IntActi		Q8TCZ2, 26 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000480322

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TCZ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni38 – 181DisorderedSequence analysisAdd BLAST144

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi42 – 60Polar residuesSequence analysisAdd BLAST19
Compositional biasi77 – 92Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi100 – 114Polar residuesSequence analysisAdd BLAST15
Compositional biasi121 – 138Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi151 – 170Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RZ6C, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154344

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_092825_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TCZ2

Identification of Orthologs from Complete Genome Data

More...OMAi		EDIAWGG

Database of Orthologous Groups

More...OrthoDBi		1559463at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TCZ2

TreeFam database of animal gene trees

More...TreeFami		TF332323

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR022078, CD99L2

The PANTHER Classification System

More...PANTHERi		PTHR15076, PTHR15076, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12301, CD99L2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT 
        60         70         80         90        100
TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT 
       110        120        130        140        150
TTKRPVTTRA PANTLGNDFD LADALDDRND RDDGRRKPIA GGGGFSDKDL 
       160        170        180        190        200
EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM VAEPGTIAGV ASALAMALIG 
       210        220        230        240        250
AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ VKYSTLHTQS 
       260 
AEPPPPPEPA RI
Length:262
Mass (Da):27,986
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3A254961DD32C191
GO
Isoform 2 (identifier: Q8TCZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-93: Missing.

Show »
Length:213
Mass (Da):22,833
Checksum:iF90595DAA99BA7D5
GO
Isoform 3 (identifier: Q8TCZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Q → R
     45-116: Missing.

Show »
Length:190
Mass (Da):20,300
Checksum:iF21A43C7F6B319F6
GO
Isoform 4 (identifier: Q8TCZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-145: QPWDHTTTTT...RKPIAGGGGF → PALGMYHKLD...GFKAHLDNPG
     146-262: Missing.

Show »
Length:145
Mass (Da):15,708
Checksum:i777A148801613231
GO
Isoform 5 (identifier: Q8TCZ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: G → GPTEG
     218-219: QQ → QHAAAGQE

Show »
Length:272
Mass (Da):28,907
Checksum:i6A92D41FDA0C5FD4
GO
Isoform 6 (identifier: Q8TCZ2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-165: Missing.

Show »
Length:189
Mass (Da):20,032
Checksum:i9F21AFB2BA02904B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQT8A0A0U1RQT8_HUMAN
CD99 antigen-like protein 2
CD99L2
177Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4H3H0Y4H3_HUMAN
CD99 antigen-like protein 2
CD99L2
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66515 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti109R → I in BAF82889 (PubMed:14702039).Curated1
Sequence conflicti128R → Q in BAG54124 (PubMed:14702039).Curated1
Sequence conflicti170Y → H in BAF82889 (PubMed:14702039).Curated1
Sequence conflicti176P → R in BAF84064 (PubMed:14702039).Curated1
Sequence conflicti229E → G in BAG56778 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03418144 – 145QPWDH…GGGGF → PALGMYHKLDGLKQQNFILS LFWMLEVLYQGVGWATFSLK ALGKNLSLTFPTSGGSRCSL VCGCITPISASVVTWCSPFC VSLLSLTKMLVSGFKAHLDN PG in isoform 4. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_03418244Q → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_03418345 – 116Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_03418445 – 93Missing in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_04181568G → GPTEG in isoform 5. 1 Publication1
Alternative sequenceiVSP_04466393 – 165Missing in isoform 6. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_034185146 – 262Missing in isoform 4. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_041816218 – 219QQ → QHAAAGQE in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY078165 mRNA Translation: AAL86617.1
AY078166 mRNA Translation: AAL86618.1
AY078167 mRNA Translation: AAL86619.1
AL136580 mRNA Translation: CAB66515.1 Frameshift.
AY358837 mRNA Translation: AAQ89196.1
AK290200 mRNA Translation: BAF82889.1
AK291375 mRNA Translation: BAF84064.1
AK293244 mRNA Translation: BAG56778.1
AK125020 mRNA Translation: BAG54124.1
AF002223 Genomic DNA No translation available.
AF274573 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99391.1
CH471169 Genomic DNA Translation: EAW99392.1
CH471169 Genomic DNA Translation: EAW99393.1
CH471169 Genomic DNA Translation: EAW99395.1
BC025729 mRNA Translation: AAH25729.1
BC030536 mRNA Translation: AAH30536.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14697.1 [Q8TCZ2-3]
CCDS14698.1 [Q8TCZ2-2]
CCDS35427.1 [Q8TCZ2-1]
CCDS55527.1 [Q8TCZ2-6]
CCDS76044.1 [Q8TCZ2-5]

NCBI Reference Sequences

More...RefSeqi		NP_001171737.1, NM_001184808.1 [Q8TCZ2-6]
NP_001229543.1, NM_001242614.1 [Q8TCZ2-5]
NP_113650.2, NM_031462.3 [Q8TCZ2-1]
NP_604394.1, NM_134445.3 [Q8TCZ2-3]
NP_604395.1, NM_134446.3 [Q8TCZ2-2]
XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4]
ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3]
ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1]
ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6]
ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2]
ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83692

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83692

UCSC genome browser

More...UCSCi		uc004fek.4, human [Q8TCZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078165 mRNA Translation: AAL86617.1
AY078166 mRNA Translation: AAL86618.1
AY078167 mRNA Translation: AAL86619.1
AL136580 mRNA Translation: CAB66515.1 Frameshift.
AY358837 mRNA Translation: AAQ89196.1
AK290200 mRNA Translation: BAF82889.1
AK291375 mRNA Translation: BAF84064.1
AK293244 mRNA Translation: BAG56778.1
AK125020 mRNA Translation: BAG54124.1
AF002223 Genomic DNA No translation available.
AF274573 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99391.1
CH471169 Genomic DNA Translation: EAW99392.1
CH471169 Genomic DNA Translation: EAW99393.1
CH471169 Genomic DNA Translation: EAW99395.1
BC025729 mRNA Translation: AAH25729.1
BC030536 mRNA Translation: AAH30536.1
CCDSiCCDS14697.1 [Q8TCZ2-3]
CCDS14698.1 [Q8TCZ2-2]
CCDS35427.1 [Q8TCZ2-1]
CCDS55527.1 [Q8TCZ2-6]
CCDS76044.1 [Q8TCZ2-5]
RefSeqiNP_001171737.1, NM_001184808.1 [Q8TCZ2-6]
NP_001229543.1, NM_001242614.1 [Q8TCZ2-5]
NP_113650.2, NM_031462.3 [Q8TCZ2-1]
NP_604394.1, NM_134445.3 [Q8TCZ2-3]
NP_604395.1, NM_134446.3 [Q8TCZ2-2]
XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123726, 29 interactors
IntActiQ8TCZ2, 26 interactors
STRINGi9606.ENSP00000480322

PTM databases

GlyGeniQ8TCZ2, 2 sites, 2 O-linked glycans (2 sites)
iPTMnetiQ8TCZ2
PhosphoSitePlusiQ8TCZ2
SwissPalmiQ8TCZ2

Genetic variation databases

BioMutaiCD99L2
DMDMi74730601

Proteomic databases

EPDiQ8TCZ2
jPOSTiQ8TCZ2
MassIVEiQ8TCZ2
MaxQBiQ8TCZ2
PaxDbiQ8TCZ2
PeptideAtlasiQ8TCZ2
PRIDEiQ8TCZ2
ProteomicsDBi19570
74199 [Q8TCZ2-1]
74200 [Q8TCZ2-2]
74201 [Q8TCZ2-3]
74202 [Q8TCZ2-4]
74203 [Q8TCZ2-5]
TopDownProteomicsiQ8TCZ2-1 [Q8TCZ2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		50585, 174 antibodies

The DNASU plasmid repository

More...DNASUi		83692

Genome annotation databases

EnsembliENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4]
ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3]
ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1]
ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6]
ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2]
ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]
GeneIDi83692
KEGGihsa:83692
UCSCiuc004fek.4, human [Q8TCZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83692
DisGeNETi83692

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD99L2
HGNCiHGNC:18237, CD99L2
HPAiENSG00000102181, Tissue enhanced (skeletal)
MIMi300846, gene
neXtProtiNX_Q8TCZ2
OpenTargetsiENSG00000102181
PharmGKBiPA30805
VEuPathDBiHostDB:ENSG00000102181.20

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RZ6C, Eukaryota
GeneTreeiENSGT00940000154344
HOGENOMiCLU_092825_0_1_1
InParanoidiQ8TCZ2
OMAiEDIAWGG
OrthoDBi1559463at2759
PhylomeDBiQ8TCZ2
TreeFamiTF332323

Enzyme and pathway databases

PathwayCommonsiQ8TCZ2
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83692, 2 hits in 619 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD99L2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD99L2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83692
PharosiQ8TCZ2, Tbio

Protein Ontology

More...PROi		PR:Q8TCZ2
RNActiQ8TCZ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102181, Expressed in frontal cortex and 206 other tissues
ExpressionAtlasiQ8TCZ2, baseline and differential
GenevisibleiQ8TCZ2, HS

Family and domain databases

InterProiView protein in InterPro
IPR022078, CD99L2
PANTHERiPTHR15076, PTHR15076, 2 hits
PfamiView protein in Pfam
PF12301, CD99L2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiC99L2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCZ2
Secondary accession number(s): A8K2D5
, A8K5R0, B3KWG2, B4DDL7, E7EMK5, E9PD27, Q8TAW2, Q8TCZ0, Q8TCZ1, Q9BQG9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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