Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

CD99 antigen-like protein 2

Gene

CD99L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen-like protein 2
Alternative name(s):
MIC2-like protein 1
CD_antigen: CD99
Gene namesi
Name:CD99L2
Synonyms:MIC2L1
ORF Names:UNQ1964/PRO4486
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102181.20
HGNCiHGNC:18237 CD99L2
MIMi300846 gene
neXtProtiNX_Q8TCZ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 185ExtracellularSequence analysisAdd BLAST160
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Topological domaini207 – 262CytoplasmicSequence analysisAdd BLAST56

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102181
PharmGKBiPA30805

Polymorphism and mutation databases

BioMutaiCD99L2
DMDMi74730601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000034009226 – 262CD99 antigen-like protein 2Add BLAST237

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TCZ2
MaxQBiQ8TCZ2
PaxDbiQ8TCZ2
PeptideAtlasiQ8TCZ2
PRIDEiQ8TCZ2
ProteomicsDBi74199
74200 [Q8TCZ2-2]
74201 [Q8TCZ2-3]
74202 [Q8TCZ2-4]
74203 [Q8TCZ2-5]
TopDownProteomicsiQ8TCZ2-1 [Q8TCZ2-1]

PTM databases

iPTMnetiQ8TCZ2
PhosphoSitePlusiQ8TCZ2
SwissPalmiQ8TCZ2

Expressioni

Tissue specificityi

Expressed in many tissues, with low expression in thymus.1 Publication

Gene expression databases

BgeeiENSG00000102181 Expressed in 192 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CD99L2
ExpressionAtlasiQ8TCZ2 baseline and differential
GenevisibleiQ8TCZ2 HS

Organism-specific databases

HPAiHPA038782
HPA038783
HPA061400

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123726, 18 interactors
IntActiQ8TCZ2, 20 interactors
STRINGi9606.ENSP00000359403

Structurei

3D structure databases

ProteinModelPortaliQ8TCZ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi49 – 54Poly-Thr6
Compositional biasi99 – 102Poly-Thr4
Compositional biasi141 – 144Poly-Gly4
Compositional biasi253 – 259Poly-Pro7

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J1MW Eukaryota
ENOG410YNQK LUCA
GeneTreeiENSGT00530000063944
HOGENOMiHOG000233665
HOVERGENiHBG067989
InParanoidiQ8TCZ2
OMAiRWDRVTT
OrthoDBiEOG091G0YLT
PhylomeDBiQ8TCZ2
TreeFamiTF332323

Family and domain databases

InterProiView protein in InterPro
IPR022078 CD99L2
PANTHERiPTHR15076 PTHR15076, 2 hits
PfamiView protein in Pfam
PF12301 CD99L2, 2 hits

Sequences (6+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAWRSAFLV CLAFSLATLV QRGSGDFDDF NLEDAVKETS SVKQPWDHTT
60 70 80 90 100
TTTTNRPGTT RAPAKPPGSG LDLADALDDQ DDGRRKPGIG GRERWNHVTT
110 120 130 140 150
TTKRPVTTRA PANTLGNDFD LADALDDRND RDDGRRKPIA GGGGFSDKDL
160 170 180 190 200
EDIVGGGEYK PDKGKGDGRY GSNDDPGSGM VAEPGTIAGV ASALAMALIG
210 220 230 240 250
AVSSYISYQQ KKFCFSIQQG LNADYVKGEN LEAVVCEEPQ VKYSTLHTQS
260
AEPPPPPEPA RI
Length:262
Mass (Da):27,986
Last modified:June 1, 2002 - v1
Checksum:i3A254961DD32C191
GO
Isoform 2 (identifier: Q8TCZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-93: Missing.

Show »
Length:213
Mass (Da):22,833
Checksum:iF90595DAA99BA7D5
GO
Isoform 3 (identifier: Q8TCZ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-44: Q → R
     45-116: Missing.

Show »
Length:190
Mass (Da):20,300
Checksum:iF21A43C7F6B319F6
GO
Isoform 4 (identifier: Q8TCZ2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-145: QPWDHTTTTT...RKPIAGGGGF → PALGMYHKLD...GFKAHLDNPG
     146-262: Missing.

Note: No experimental confirmation available.
Show »
Length:145
Mass (Da):15,708
Checksum:i777A148801613231
GO
Isoform 5 (identifier: Q8TCZ2-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: G → GPTEG
     218-219: QQ → QHAAAGQE

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):28,907
Checksum:i6A92D41FDA0C5FD4
GO
Isoform 6 (identifier: Q8TCZ2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     93-165: Missing.

Note: No experimental confirmation available.
Show »
Length:189
Mass (Da):20,032
Checksum:i9F21AFB2BA02904B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RQT8A0A0U1RQT8_HUMAN
CD99 antigen-like protein 2
CD99L2
177Annotation score:
H0Y4H3H0Y4H3_HUMAN
CD99 antigen-like protein 2
CD99L2
157Annotation score:

Sequence cautioni

The sequence CAB66515 differs from that shown. Reason: Frameshift at position 156.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109R → I in BAF82889 (PubMed:14702039).Curated1
Sequence conflicti128R → Q in BAG54124 (PubMed:14702039).Curated1
Sequence conflicti170Y → H in BAF82889 (PubMed:14702039).Curated1
Sequence conflicti176P → R in BAF84064 (PubMed:14702039).Curated1
Sequence conflicti229E → G in BAG56778 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03418144 – 145QPWDH…GGGGF → PALGMYHKLDGLKQQNFILS LFWMLEVLYQGVGWATFSLK ALGKNLSLTFPTSGGSRCSL VCGCITPISASVVTWCSPFC VSLLSLTKMLVSGFKAHLDN PG in isoform 4. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_03418244Q → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_03418345 – 116Missing in isoform 3. 1 PublicationAdd BLAST72
Alternative sequenceiVSP_03418445 – 93Missing in isoform 2. 2 PublicationsAdd BLAST49
Alternative sequenceiVSP_04181568G → GPTEG in isoform 5. 1 Publication1
Alternative sequenceiVSP_04466393 – 165Missing in isoform 6. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_034185146 – 262Missing in isoform 4. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_041816218 – 219QQ → QHAAAGQE in isoform 5. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078165 mRNA Translation: AAL86617.1
AY078166 mRNA Translation: AAL86618.1
AY078167 mRNA Translation: AAL86619.1
AL136580 mRNA Translation: CAB66515.1 Frameshift.
AY358837 mRNA Translation: AAQ89196.1
AK290200 mRNA Translation: BAF82889.1
AK291375 mRNA Translation: BAF84064.1
AK293244 mRNA Translation: BAG56778.1
AK125020 mRNA Translation: BAG54124.1
AF002223 Genomic DNA No translation available.
AF274573 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99391.1
CH471169 Genomic DNA Translation: EAW99392.1
CH471169 Genomic DNA Translation: EAW99393.1
CH471169 Genomic DNA Translation: EAW99395.1
BC025729 mRNA Translation: AAH25729.1
BC030536 mRNA Translation: AAH30536.1
CCDSiCCDS14697.1 [Q8TCZ2-3]
CCDS14698.1 [Q8TCZ2-2]
CCDS35427.1 [Q8TCZ2-1]
CCDS55527.1 [Q8TCZ2-6]
CCDS76044.1 [Q8TCZ2-5]
RefSeqiNP_001171737.1, NM_001184808.1 [Q8TCZ2-6]
NP_001229543.1, NM_001242614.1 [Q8TCZ2-5]
NP_113650.2, NM_031462.3 [Q8TCZ2-1]
NP_604394.1, NM_134445.3 [Q8TCZ2-3]
NP_604395.1, NM_134446.3 [Q8TCZ2-2]
XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]
UniGeneiHs.522805

Genome annotation databases

EnsembliENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4]
ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3]
ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1]
ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6]
ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2]
ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]
GeneIDi83692
KEGGihsa:83692
UCSCiuc004fek.4 human [Q8TCZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078165 mRNA Translation: AAL86617.1
AY078166 mRNA Translation: AAL86618.1
AY078167 mRNA Translation: AAL86619.1
AL136580 mRNA Translation: CAB66515.1 Frameshift.
AY358837 mRNA Translation: AAQ89196.1
AK290200 mRNA Translation: BAF82889.1
AK291375 mRNA Translation: BAF84064.1
AK293244 mRNA Translation: BAG56778.1
AK125020 mRNA Translation: BAG54124.1
AF002223 Genomic DNA No translation available.
AF274573 Genomic DNA No translation available.
CH471169 Genomic DNA Translation: EAW99391.1
CH471169 Genomic DNA Translation: EAW99392.1
CH471169 Genomic DNA Translation: EAW99393.1
CH471169 Genomic DNA Translation: EAW99395.1
BC025729 mRNA Translation: AAH25729.1
BC030536 mRNA Translation: AAH30536.1
CCDSiCCDS14697.1 [Q8TCZ2-3]
CCDS14698.1 [Q8TCZ2-2]
CCDS35427.1 [Q8TCZ2-1]
CCDS55527.1 [Q8TCZ2-6]
CCDS76044.1 [Q8TCZ2-5]
RefSeqiNP_001171737.1, NM_001184808.1 [Q8TCZ2-6]
NP_001229543.1, NM_001242614.1 [Q8TCZ2-5]
NP_113650.2, NM_031462.3 [Q8TCZ2-1]
NP_604394.1, NM_134445.3 [Q8TCZ2-3]
NP_604395.1, NM_134446.3 [Q8TCZ2-2]
XP_011529504.1, XM_011531202.2 [Q8TCZ2-4]
UniGeneiHs.522805

3D structure databases

ProteinModelPortaliQ8TCZ2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123726, 18 interactors
IntActiQ8TCZ2, 20 interactors
STRINGi9606.ENSP00000359403

PTM databases

iPTMnetiQ8TCZ2
PhosphoSitePlusiQ8TCZ2
SwissPalmiQ8TCZ2

Polymorphism and mutation databases

BioMutaiCD99L2
DMDMi74730601

Proteomic databases

EPDiQ8TCZ2
MaxQBiQ8TCZ2
PaxDbiQ8TCZ2
PeptideAtlasiQ8TCZ2
PRIDEiQ8TCZ2
ProteomicsDBi74199
74200 [Q8TCZ2-2]
74201 [Q8TCZ2-3]
74202 [Q8TCZ2-4]
74203 [Q8TCZ2-5]
TopDownProteomicsiQ8TCZ2-1 [Q8TCZ2-1]

Protocols and materials databases

DNASUi83692
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346693; ENSP00000489222; ENSG00000102181 [Q8TCZ2-4]
ENST00000355149; ENSP00000347275; ENSG00000102181 [Q8TCZ2-3]
ENST00000370377; ENSP00000359403; ENSG00000102181 [Q8TCZ2-1]
ENST00000437787; ENSP00000394858; ENSG00000102181 [Q8TCZ2-6]
ENST00000466436; ENSP00000417697; ENSG00000102181 [Q8TCZ2-2]
ENST00000613030; ENSP00000480322; ENSG00000102181 [Q8TCZ2-5]
GeneIDi83692
KEGGihsa:83692
UCSCiuc004fek.4 human [Q8TCZ2-1]

Organism-specific databases

CTDi83692
EuPathDBiHostDB:ENSG00000102181.20
GeneCardsiCD99L2
HGNCiHGNC:18237 CD99L2
HPAiHPA038782
HPA038783
HPA061400
MIMi300846 gene
neXtProtiNX_Q8TCZ2
OpenTargetsiENSG00000102181
PharmGKBiPA30805
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1MW Eukaryota
ENOG410YNQK LUCA
GeneTreeiENSGT00530000063944
HOGENOMiHOG000233665
HOVERGENiHBG067989
InParanoidiQ8TCZ2
OMAiRWDRVTT
OrthoDBiEOG091G0YLT
PhylomeDBiQ8TCZ2
TreeFamiTF332323

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiCD99L2 human
GeneWikiiCD99L2
GenomeRNAii83692
PROiPR:Q8TCZ2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102181 Expressed in 192 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_CD99L2
ExpressionAtlasiQ8TCZ2 baseline and differential
GenevisibleiQ8TCZ2 HS

Family and domain databases

InterProiView protein in InterPro
IPR022078 CD99L2
PANTHERiPTHR15076 PTHR15076, 2 hits
PfamiView protein in Pfam
PF12301 CD99L2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiC99L2_HUMAN
AccessioniPrimary (citable) accession number: Q8TCZ2
Secondary accession number(s): A8K2D5
, A8K5R0, B3KWG2, B4DDL7, E7EMK5, E9PD27, Q8TAW2, Q8TCZ0, Q8TCZ1, Q9BQG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again