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Entry version 114 (08 May 2019)
Sequence version 2 (20 May 2008)
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Protein

Up-regulator of cell proliferation

Gene

URGCP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cell cycle progression through the regulation of cyclin D1 expression. May participate in the development of hepatocellular carcinoma (HCC) by promoting hepatocellular growth and survival. May play an important role in development of gastric cancer.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Up-regulator of cell proliferation
Alternative name(s):
HBV X protein up-regulated gene 4 protein
HBxAg up-regulated gene 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:URGCP
Synonyms:KIAA1507Imported, URG4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30890 URGCP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610337 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q8TCY9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55665

Open Targets

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OpenTargetsi
ENSG00000106608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165618458

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
URGCP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
189038114

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003371481 – 931Up-regulator of cell proliferationAdd BLAST931

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TCY9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TCY9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TCY9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TCY9

PeptideAtlas

More...
PeptideAtlasi
Q8TCY9

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCY9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74196
74197 [Q8TCY9-2]
74198 [Q8TCY9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in hepatitis B virus-infected liver and in HCC cells. Also highly expressed in well-differentiated gastric cancer tissues and various gastric cancer cell lines.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By HBxAg. Up-regulated in gastric cancer tissues and also in gastric cancer cell lines (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000106608 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TCY9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TCY9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019879
HPA020134
HPA029468

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120797, 12 interactors

Protein interaction database and analysis system

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IntActi
Q8TCY9, 2 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000396918

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini689 – 929VLIG-type GAdd BLAST241

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG57 Eukaryota
ENOG410Y9GN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154390

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCY9

Identification of Orthologs from Complete Genome Data

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OMAi
YWDTADD

Database of Orthologous Groups

More...
OrthoDBi
31942at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCY9

TreeFam database of animal gene trees

More...
TreeFami
TF335271

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030383 G_VLIG_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00326 GTP1OBG

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51717 G_VLIG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASPGIEVEL LGKGHSDLGE VAPEIKASER RTAVAIADLE WREMEGDDCE
60 70 80 90 100
FRYGDGTNEA QDNDFPTVER SRLQEMLSLL GLETYQVQKL SLQDSLQISF
110 120 130 140 150
DSMKNWAPQV PKDLPWNFLR KLQALNADAR NTTMVLDVLP DARPVEKESQ
160 170 180 190 200
MEEEIIYWDP ADDLAADIYS FSELPTPDTP VNPLDLLCAL LLSSDSFLQQ
210 220 230 240 250
EIALKMALCQ FALPLVLPDS ENHYHTFLLW AMRGIVRTWW SQPPRGMGSF
260 270 280 290 300
REDSVVLSRA PAFAFVRMDV SSNSKSQLLN AVLSPGHRQW DCFWHRDLNL
310 320 330 340 350
GTNAREISDG LVEISWFFPS GREDLDIFPE PVAFLNLRGD IGSHWLQFKL
360 370 380 390 400
LTEISSAVFI LTDNISKKEY KLLYSMKEST TKYYFILSPY RGKRNTNLRF
410 420 430 440 450
LNKLIPVLKI DHSHVLVKVS STDSDSFVKR IRAIVGNVLR APCRRVSVED
460 470 480 490 500
MAHAARKLGL KVDEDCEECQ KAKDRMERIT RKIKDSDAYR RDELRLQGDP
510 520 530 540 550
WRKAAQVEKE FCQLQWAVDP PEKHRAELRR RLLELRMQQN GHDPSSGVQE
560 570 580 590 600
FISGISSPSL SEKQYFLRWM EWGLARVAQP RLRQPPETLL TLRPKHGGTT
610 620 630 640 650
DVGEPLWPEP LGVEHFLREM GQFYEAESCL VEAGRLPAGQ RRFAHFPGLA
660 670 680 690 700
SELLLTGLPL ELIDGSTLSM PVRWVTGLLK ELHVRLERRS RLVVLSTVGV
710 720 730 740 750
PGTGKSTLLN TMFGLRFATG KSCGPRGAFM QLITVAEGFS QDLGCDHILV
760 770 780 790 800
IDSGGLIGGA LTSAGDRFEL EASLATLLMG LSNVTVISLA ETKDIPAAIL
810 820 830 840 850
HAFLRLEKTG HMPNYQFVYQ NLHDVSVPGP RPRDKRQLLD PPGDLSRAAA
860 870 880 890 900
QMEKQGDGFR ALAGLAFCDP EKQHIWHIPG LWHGAPPMAA VSLAYSEAIF
910 920 930
ELKRCLLENI RNGLSNQNKN IQQLIELVRR L
Length:931
Mass (Da):104,987
Last modified:May 20, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE0D67A555FD20134
GO
Isoform 22 Publications (identifier: Q8TCY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     6-14: Missing.

Show »
Length:922
Mass (Da):104,048
Checksum:iB23066996FC078F6
GO
Isoform 3 (identifier: Q8TCY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.

Note: No experimental confirmation available.
Show »
Length:856
Mass (Da):96,666
Checksum:i612B22D2EE695AF9
GO
Isoform 4 (identifier: Q8TCY9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.

Note: Gene prediction based on EST data.
Show »
Length:888
Mass (Da):100,373
Checksum:i9BD44C1C803ED5AB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0W2C9J0W2_HUMAN
Up-regulator of cell proliferation
URGCP
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JKA8C9JKA8_HUMAN
Up-regulator of cell proliferation
URGCP
163Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDN0F8WDN0_HUMAN
Up-regulator of cell proliferation
URGCP
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCC3F8WCC3_HUMAN
Up-regulator of cell proliferation
URGCP
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91312 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA96031 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45880 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAH18244 differs from that shown. Reason: Frameshift at position 5.Curated
The sequence CAH18244 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6Missing in CAH18244 (PubMed:17974005).Curated1
Sequence conflicti290W → C in CAE45880 (PubMed:17974005).Curated1
Sequence conflicti390Y → H in CAH18244 (PubMed:17974005).Curated1
Sequence conflicti432R → Q in CAH18244 (PubMed:17974005).Curated1
Sequence conflicti516W → R in CAE45880 (PubMed:17974005).Curated1
Sequence conflicti544P → S in AAL83710 (PubMed:12082552).Curated1
Sequence conflicti601D → G in BAA91312 (PubMed:14702039).Curated1
Sequence conflicti620M → V in BAA96031 (PubMed:10819331).Curated1
Sequence conflicti718A → V in CAE45880 (PubMed:17974005).Curated1
Sequence conflicti760A → S in CAH18244 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051479697T → A. Corresponds to variant dbSNP:rs2232106Ensembl.1
Natural variantiVAR_051480756L → F. Corresponds to variant dbSNP:rs2232107Ensembl.1
Natural variantiVAR_043668779M → L2 PublicationsCorresponds to variant dbSNP:rs2232108Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0339421 – 75Missing in isoform 3. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_0470681 – 43Missing in isoform 4. CuratedAdd BLAST43
Alternative sequenceiVSP_0527996 – 14Missing in isoform 2. 2 Publications9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY078404 mRNA Translation: AAL83710.1
AB040940 mRNA Translation: BAA96031.1 Different initiation.
AL833744 mRNA Translation: CAH56246.1
BX640797 mRNA Translation: CAE45880.1 Different initiation.
CR749398 mRNA Translation: CAH18244.1 Sequence problems.
AC004985 mRNA No translation available.
BC018426 mRNA Translation: AAH18426.2
AK000661 mRNA Translation: BAA91312.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43572.1 [Q8TCY9-4]
CCDS47577.1 [Q8TCY9-2]
CCDS47578.1 [Q8TCY9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001071131.1, NM_001077663.2 [Q8TCY9-1]
NP_001071132.1, NM_001077664.2 [Q8TCY9-4]
NP_001277004.1, NM_001290075.1 [Q8TCY9-4]
NP_001277005.1, NM_001290076.1 [Q8TCY9-4]
NP_060390.3, NM_017920.4 [Q8TCY9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336086; ENSP00000336872; ENSG00000106608 [Q8TCY9-4]
ENST00000402306; ENSP00000384955; ENSG00000106608 [Q8TCY9-2]
ENST00000443736; ENSP00000392136; ENSG00000106608 [Q8TCY9-4]
ENST00000453200; ENSP00000396918; ENSG00000106608 [Q8TCY9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55665

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55665

UCSC genome browser

More...
UCSCi
uc003tiu.4 human [Q8TCY9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078404 mRNA Translation: AAL83710.1
AB040940 mRNA Translation: BAA96031.1 Different initiation.
AL833744 mRNA Translation: CAH56246.1
BX640797 mRNA Translation: CAE45880.1 Different initiation.
CR749398 mRNA Translation: CAH18244.1 Sequence problems.
AC004985 mRNA No translation available.
BC018426 mRNA Translation: AAH18426.2
AK000661 mRNA Translation: BAA91312.1 Different initiation.
CCDSiCCDS43572.1 [Q8TCY9-4]
CCDS47577.1 [Q8TCY9-2]
CCDS47578.1 [Q8TCY9-1]
RefSeqiNP_001071131.1, NM_001077663.2 [Q8TCY9-1]
NP_001071132.1, NM_001077664.2 [Q8TCY9-4]
NP_001277004.1, NM_001290075.1 [Q8TCY9-4]
NP_001277005.1, NM_001290076.1 [Q8TCY9-4]
NP_060390.3, NM_017920.4 [Q8TCY9-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120797, 12 interactors
IntActiQ8TCY9, 2 interactors
STRINGi9606.ENSP00000396918

PTM databases

iPTMnetiQ8TCY9
PhosphoSitePlusiQ8TCY9

Polymorphism and mutation databases

BioMutaiURGCP
DMDMi189038114

Proteomic databases

EPDiQ8TCY9
jPOSTiQ8TCY9
MaxQBiQ8TCY9
PaxDbiQ8TCY9
PeptideAtlasiQ8TCY9
PRIDEiQ8TCY9
ProteomicsDBi74196
74197 [Q8TCY9-2]
74198 [Q8TCY9-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55665
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336086; ENSP00000336872; ENSG00000106608 [Q8TCY9-4]
ENST00000402306; ENSP00000384955; ENSG00000106608 [Q8TCY9-2]
ENST00000443736; ENSP00000392136; ENSG00000106608 [Q8TCY9-4]
ENST00000453200; ENSP00000396918; ENSG00000106608 [Q8TCY9-1]
GeneIDi55665
KEGGihsa:55665
UCSCiuc003tiu.4 human [Q8TCY9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55665
DisGeNETi55665

GeneCards: human genes, protein and diseases

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GeneCardsi
URGCP
HGNCiHGNC:30890 URGCP
HPAiHPA019879
HPA020134
HPA029468
MIMi610337 gene
neXtProtiNX_Q8TCY9
OpenTargetsiENSG00000106608
PharmGKBiPA165618458

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG57 Eukaryota
ENOG410Y9GN LUCA
GeneTreeiENSGT00940000154390
InParanoidiQ8TCY9
OMAiYWDTADD
OrthoDBi31942at2759
PhylomeDBiQ8TCY9
TreeFamiTF335271

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
URG4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55665

Protein Ontology

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PROi
PR:Q8TCY9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000106608 Expressed in 220 organ(s), highest expression level in cerebellar hemisphere
ExpressionAtlasiQ8TCY9 baseline and differential
GenevisibleiQ8TCY9 HS

Family and domain databases

InterProiView protein in InterPro
IPR030383 G_VLIG_dom
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51717 G_VLIG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiURGCP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCY9
Secondary accession number(s): E9PFF6
, Q658M4, Q68DH6, Q6MZZ5, Q8WV98, Q9NWR7, Q9P221
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 8, 2019
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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