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UniProtKB - Q8TCY5 (MRAP_HUMAN)

Entry version 149 (10 Feb 2021)
Sequence version 2 (17 Oct 2006)
Previous versions | rss
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Protein

Melanocortin-2 receptor accessory protein

Gene

MRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TCY5

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q8TCY5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanocortin-2 receptor accessory protein
Alternative name(s):
B27
Fat cell-specific low molecular weight protein
Fat tissue-specific low MW protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRAP
Synonyms:C21orf61, FALP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1304, MRAP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		609196, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TCY5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000170262.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glucocorticoid deficiency 2 (GCCD2)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of glucocorticoid deficiency, a rare autosomal recessive disorder characterized by resistance to ACTH action on the adrenal cortex, adrenal insufficiency and an inability of the adrenal cortex to produce cortisol. It usually presents in the neonatal period or in early childhood with episodes of hypoglycemia and other symptoms related to cortisol deficiency, including failure to thrive, recurrent illnesses or infections, convulsions, and shock. In a small number of patients hypoglycemia can be sufficiently severe and persistent that it leads to serious long-term neurological damage or death. The diagnosis is readily confirmed with a low plasma cortisol measurement in the presence of an elevated ACTH level, and normal aldosterone and plasma renin measurements.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		56246

MalaCards human disease database

More...MalaCardsi		MRAP
MIMi607398, phenotype

Open Targets

More...OpenTargetsi		ENSG00000170262

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		361, Familial glucocorticoid deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25856

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TCY5, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MRAP

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242634

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965701 – 172Melanocortin-2 receptor accessory proteinAdd BLAST172

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TCY5

PRoteomics IDEntifications database

More...PRIDEi		Q8TCY5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74191 [Q8TCY5-4]
74192 [Q8TCY5-1]
74193 [Q8TCY5-2]
74194 [Q8TCY5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TCY5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TCY5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adrenal cortex, testis, breast, thyroid, lymph node, ovary and fat. Expressed in adipose tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000170262, Expressed in right adrenal gland and 118 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TCY5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000170262, Group enriched (adipose tissue, adrenal gland, breast)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer.

Forms antiparallel homodimers and heterodimers with MRAP2.

Interacts with MC1R, MC2R, MC3R, MC4R and MC5R.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121114, 3 interactors

Database of interacting proteins

More...DIPi		DIP-29948N

Protein interaction database and analysis system

More...IntActi		Q8TCY5, 9 interactors

Molecular INTeraction database

More...MINTi		Q8TCY5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000382684

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TCY5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRAP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502SB3E, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00650000093475

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_133578_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TCY5

Identification of Orthologs from Complete Genome Data

More...OMAi		HPTCPWS

Database of Orthologous Groups

More...OrthoDBi		1583183at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TCY5

TreeFam database of animal gene trees

More...TreeFami		TF338691

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028111, MRAP

The PANTHER Classification System

More...PANTHERi		PTHR28675, PTHR28675, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15183, MRAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 4 (identifier: Q8TCY5-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MANGTNASAP YYSYEYYLDY LDLIPVDEKK LKAHKHSIVI AFWVSLAAFV 
        60         70         80         90        100
VLLFLILLYM SWSASPQMRN SPKHHQTCPW SHGLNLHLCI QKCLPCHREP 
       110        120        130        140        150
LATSQAQASS VEPGSRTGPD QPLRQESSST LPLGGFQTHP TLLWELTLNG 
       160        170 
GPLVRSKPSE PPPGDRTSQL QS
Length:172
Mass (Da):19,136
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F93F39B40FAAFEA
GO
Isoform 1 (identifier: Q8TCY5-1) [UniParc]FASTAAdd to basket
Also known as: Alpha, MRAP-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     68-68: M → MR

Show »
Length:173
Mass (Da):19,292
Checksum:i7F6A2A3D99045107
GO
Isoform 2 (identifier: Q8TCY5-2) [UniParc]FASTAAdd to basket
Also known as: Beta, MRAP-beta

The sequence of this isoform differs from the canonical sequence as follows:
     69-101: RNSPKHHQTCPWSHGLNLHLCIQKCLPCHREPL → SFNTDESLLHSEVLPQTRAISCDELQAPREEGAA
     102-172: Missing.

Show »
Length:102
Mass (Da):11,519
Checksum:i7FA8FCF335B43DA3
GO
Isoform 3 (identifier: Q8TCY5-3) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Show »
Length:113
Mass (Da):12,338
Checksum:i968FDEF0D68ECCCA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0038621 – 59Missing in isoform 3. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_02102068M → MR in isoform 1. 1 Publication1
Alternative sequenceiVSP_00386369 – 101RNSPK…HREPL → SFNTDESLLHSEVLPQTRAI SCDELQAPREEGAA in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_003864102 – 172Missing in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF483549 mRNA Translation: AAL86908.1
AY079152 mRNA Translation: AAL80042.1
AF454915 mRNA Translation: AAL51048.1
AF454916 mRNA Translation: AAL51049.1
BC062721 mRNA Translation: AAH62721.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13612.1 [Q8TCY5-2]
CCDS13613.1 [Q8TCY5-4]

NCBI Reference Sequences

More...RefSeqi		NP_001272323.1, NM_001285394.1 [Q8TCY5-3]
NP_848932.1, NM_178817.3 [Q8TCY5-4]
NP_996781.1, NM_206898.1 [Q8TCY5-2]
XP_006724091.1, XM_006724028.3
XP_016883896.1, XM_017028407.1 [Q8TCY5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000303645; ENSP00000306697; ENSG00000170262 [Q8TCY5-4]
ENST00000339944; ENSP00000343661; ENSG00000170262 [Q8TCY5-2]
ENST00000399784; ENSP00000382684; ENSG00000170262 [Q8TCY5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		56246

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:56246

UCSC genome browser

More...UCSCi		uc002ypj.4, human [Q8TCY5-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF483549 mRNA Translation: AAL86908.1
AY079152 mRNA Translation: AAL80042.1
AF454915 mRNA Translation: AAL51048.1
AF454916 mRNA Translation: AAL51049.1
BC062721 mRNA Translation: AAH62721.1
CCDSiCCDS13612.1 [Q8TCY5-2]
CCDS13613.1 [Q8TCY5-4]
RefSeqiNP_001272323.1, NM_001285394.1 [Q8TCY5-3]
NP_848932.1, NM_178817.3 [Q8TCY5-4]
NP_996781.1, NM_206898.1 [Q8TCY5-2]
XP_006724091.1, XM_006724028.3
XP_016883896.1, XM_017028407.1 [Q8TCY5-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121114, 3 interactors
DIPiDIP-29948N
IntActiQ8TCY5, 9 interactors
MINTiQ8TCY5
STRINGi9606.ENSP00000382684

PTM databases

iPTMnetiQ8TCY5
PhosphoSitePlusiQ8TCY5

Genetic variation databases

BioMutaiMRAP
DMDMi116242634

Proteomic databases

PaxDbiQ8TCY5
PRIDEiQ8TCY5
ProteomicsDBi74191 [Q8TCY5-4]
74192 [Q8TCY5-1]
74193 [Q8TCY5-2]
74194 [Q8TCY5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		22543, 134 antibodies

The DNASU plasmid repository

More...DNASUi		56246

Genome annotation databases

EnsembliENST00000303645; ENSP00000306697; ENSG00000170262 [Q8TCY5-4]
ENST00000339944; ENSP00000343661; ENSG00000170262 [Q8TCY5-2]
ENST00000399784; ENSP00000382684; ENSG00000170262 [Q8TCY5-4]
GeneIDi56246
KEGGihsa:56246
UCSCiuc002ypj.4, human [Q8TCY5-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		56246
DisGeNETi56246

GeneCards: human genes, protein and diseases

More...GeneCardsi		MRAP
HGNCiHGNC:1304, MRAP
HPAiENSG00000170262, Group enriched (adipose tissue, adrenal gland, breast)
MalaCardsiMRAP
MIMi607398, phenotype
609196, gene
neXtProtiNX_Q8TCY5
OpenTargetsiENSG00000170262
Orphaneti361, Familial glucocorticoid deficiency
PharmGKBiPA25856
VEuPathDBiHostDB:ENSG00000170262.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502SB3E, Eukaryota
GeneTreeiENSGT00650000093475
HOGENOMiCLU_133578_0_0_1
InParanoidiQ8TCY5
OMAiHPTCPWS
OrthoDBi1583183at2759
PhylomeDBiQ8TCY5
TreeFamiTF338691

Enzyme and pathway databases

PathwayCommonsiQ8TCY5
SIGNORiQ8TCY5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		56246, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MRAP, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		56246
PharosiQ8TCY5, Tbio

Protein Ontology

More...PROi		PR:Q8TCY5
RNActiQ8TCY5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000170262, Expressed in right adrenal gland and 118 other tissues
GenevisibleiQ8TCY5, HS

Family and domain databases

InterProiView protein in InterPro
IPR028111, MRAP
PANTHERiPTHR28675, PTHR28675, 1 hit
PfamiView protein in Pfam
PF15183, MRAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCY5
Secondary accession number(s): Q5EBR3
, Q8TDB7, Q8WXC1, Q8WXC2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: October 17, 2006
Last modified: February 10, 2021
This is version 149 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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