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Protein

Rhophilin-1

Gene

RHPN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has no enzymatic activity. May serve as a target for Rho, and interact with some cytoskeletal component upon Rho binding or relay a Rho signal to other molecules.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rhophilin-1Curated
Alternative name(s):
GTP-Rho-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RHPN1Imported
Synonyms:KIAA1929
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000158106.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19973 RHPN1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601031 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TCX5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
114822

Open Targets

More...
OpenTargetsi
ENSG00000158106

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134987144

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RHPN1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173334

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002188951 – 670Rhophilin-1Add BLAST670

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TCX5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TCX5

PeptideAtlas

More...
PeptideAtlasi
Q8TCX5

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCX5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74188
74189

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCX5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCX5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158106 Expressed in 173 organ(s), highest expression level in left lobe of thyroid gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_RHPN1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TCX5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024288
HPA024671

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds specifically to GTP-Rho. Interacts with ROPN1.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125372, 41 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TCX5, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000289013

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TCX5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TCX5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 97REM-1PROSITE-ProRule annotationAdd BLAST75
Domaini108 – 457BRO1PROSITE-ProRule annotationAdd BLAST350
Domaini513 – 592PDZPROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PDZ domain mediates interaction with ROPN1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RHPN family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2220 Eukaryota
ENOG410XQX6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153837

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046725

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG067197

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCX5

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNPFRRT

Database of Orthologous Groups

More...
OrthoDBi
641122at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCX5

TreeFam database of animal gene trees

More...
TreeFami
TF323502

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.280, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03097 BRO1, 1 hit
PF02185 HR1, 1 hit
PF00595 PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01041 BRO1, 1 hit
SM00742 Hr1, 1 hit
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46585 SSF46585, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51180 BRO1, 1 hit
PS50106 PDZ, 1 hit
PS51860 REM_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TCX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILEERPDGA GAGEESPRLQ GCDSLTQIQC GQLQSRRAQI HQQIDKELQM
60 70 80 90 100
RTGAENLYRA TSNNRVRETV ALELSYVNSN LQLLKEELEE LSGGVDPGRH
110 120 130 140 150
GSEAVTVPMI PLGLKETKEL DWSTPLKELI SVHFGEDGAS YEAEIRELEA
160 170 180 190 200
LRQAMRTPSR NESGLELLTA YYNQLCFLDA RFLTPARSLG LFFHWYDSLT
210 220 230 240 250
GVPAQQRALA FEKGSVLFNI GALHTQIGAR QDRSCTEGAR RAMEAFQRAA
260 270 280 290 300
GAFSLLRENF SHAPSPDMSA ASLCALEQLM MAQAQECVFE GLSPPASMAP
310 320 330 340 350
QDCLAQLRLA QEAAQVAAEY RLVHRTMAQP PVHDYVPVSW TALVHVKAEY
360 370 380 390 400
FRSLAHYHVA MALCDGSPAT EGELPTHEQV FLQPPTSSKP RGPVLPQELE
410 420 430 440 450
ERRQLGKAHL KRAILGQEEA LRLHALCRVL REVDLLRAVI SQTLQRSLAK
460 470 480 490 500
YAELDREDDF CEAAEAPDIQ PKTHQKPEAR MPRLSQGKGP DIFHRLGPLS
510 520 530 540 550
VFSAKNRWRL VGPVHLTRGE GGFGLTLRGD SPVLIAAVIP GSQAAAAGLK
560 570 580 590 600
EGDYIVSVNG QPCRWWRHAE VVTELKAAGE AGASLQVVSL LPSSRLPSLG
610 620 630 640 650
DRRPVLLGPR GLLRSQREHG CKTPASTWAS PRPLLNWSRK AQQGKTGGCP
660 670
QPCAPVKPAP PSSLKHPGWP
Length:670
Mass (Da):73,590
Last modified:September 12, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE8C01B716465FF0
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL89809 differs from that shown. Intron retention.Curated
The sequence BAB67822 differs from that shown. Intron retention.Curated
The sequence BAB67822 differs from that shown. Reason: Frameshift at position 361.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY082588 mRNA Translation: AAL89809.1 Sequence problems.
BC025767 mRNA Translation: AAH25767.1
AB067516 mRNA Translation: BAB67822.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47927.1

NCBI Reference Sequences

More...
RefSeqi
NP_443156.2, NM_052924.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.521912

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000289013; ENSP00000289013; ENSG00000158106

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
114822

UCSC genome browser

More...
UCSCi
uc003yyb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY082588 mRNA Translation: AAL89809.1 Sequence problems.
BC025767 mRNA Translation: AAH25767.1
AB067516 mRNA Translation: BAB67822.1 Sequence problems.
CCDSiCCDS47927.1
RefSeqiNP_443156.2, NM_052924.2
UniGeneiHs.521912

3D structure databases

ProteinModelPortaliQ8TCX5
SMRiQ8TCX5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125372, 41 interactors
IntActiQ8TCX5, 13 interactors
STRINGi9606.ENSP00000289013

PTM databases

iPTMnetiQ8TCX5
PhosphoSitePlusiQ8TCX5

Polymorphism and mutation databases

BioMutaiRHPN1
DMDMi30173334

Proteomic databases

EPDiQ8TCX5
PaxDbiQ8TCX5
PeptideAtlasiQ8TCX5
PRIDEiQ8TCX5
ProteomicsDBi74188
74189

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289013; ENSP00000289013; ENSG00000158106
GeneIDi114822
UCSCiuc003yyb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
114822
DisGeNETi114822
EuPathDBiHostDB:ENSG00000158106.12

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RHPN1
HGNCiHGNC:19973 RHPN1
HPAiHPA024288
HPA024671
MIMi601031 gene
neXtProtiNX_Q8TCX5
OpenTargetsiENSG00000158106
PharmGKBiPA134987144

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2220 Eukaryota
ENOG410XQX6 LUCA
GeneTreeiENSGT00940000153837
HOGENOMiHOG000046725
HOVERGENiHBG067197
InParanoidiQ8TCX5
OMAiWNPFRRT
OrthoDBi641122at2759
PhylomeDBiQ8TCX5
TreeFamiTF323502

Enzyme and pathway databases

ReactomeiR-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RHPN1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
114822

Protein Ontology

More...
PROi
PR:Q8TCX5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000158106 Expressed in 173 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_RHPN1
GenevisibleiQ8TCX5 HS

Family and domain databases

Gene3Di1.25.40.280, 1 hit
InterProiView protein in InterPro
IPR004328 BRO1_dom
IPR038499 BRO1_sf
IPR011072 HR1_rho-bd
IPR036274 HR1_rpt_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF03097 BRO1, 1 hit
PF02185 HR1, 1 hit
PF00595 PDZ, 1 hit
SMARTiView protein in SMART
SM01041 BRO1, 1 hit
SM00742 Hr1, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46585 SSF46585, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS51180 BRO1, 1 hit
PS50106 PDZ, 1 hit
PS51860 REM_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHPN1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCX5
Secondary accession number(s): Q8TAV1, Q96PV9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: September 12, 2018
Last modified: January 16, 2019
This is version 135 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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