UniProtKB - Q8TCW9 (PKR1_HUMAN)
Protein
Prokineticin receptor 1
Gene
PROKR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy.1 Publication
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide Y receptor activity Source: InterPro
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q8TCW9 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | Q8TCW9 |
Names & Taxonomyi
Protein namesi | Recommended name: Prokineticin receptor 1Short name: PK-R1 Alternative name(s): G-protein coupled receptor 73 G-protein coupled receptor ZAQ GPR73a |
Gene namesi | Name:PROKR1 Synonyms:GPR73, PKR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169618.6 |
HGNCi | HGNC:4524, PROKR1 |
MIMi | 607122, gene |
neXtProti | NX_Q8TCW9 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 62 | ExtracellularSequence analysisAdd BLAST | 62 | |
Transmembranei | 63 – 83 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 84 – 98 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 99 – 119 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 120 – 146 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 147 – 167 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 168 – 180 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 181 – 201 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 202 – 232 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 233 – 253 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 254 – 282 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 283 – 303 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 304 – 322 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 323 – 343 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 344 – 393 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10887 |
OpenTargetsi | ENSG00000169618 ENSG00000169621 |
PharmGKBi | PA28916 |
Miscellaneous databases
Pharosi | Q8TCW9, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5649 |
GuidetoPHARMACOLOGYi | 335 |
Polymorphism and mutation databases
BioMutai | PROKR1 |
DMDMi | 33112428 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070079 | 1 – 393 | Prokineticin receptor 1Add BLAST | 393 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 36 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 137 ↔ 217 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8TCW9 |
PeptideAtlasi | Q8TCW9 |
PRIDEi | Q8TCW9 |
ProteomicsDBi | 74182 |
PTM databases
GlyGeni | Q8TCW9, 3 sites |
iPTMneti | Q8TCW9 |
PhosphoSitePlusi | Q8TCW9 |
Expressioni
Tissue specificityi
Localizes to glandular epithelium, stroma and vascular endothelial cells of first trimester decidua (at protein level). Up-regulated in first trimester decidua when compared with non-pregnant endometrium. Expressed in the stomach, throughout the small intestine, colon, rectum, thyroid gland, pituitary gland, salivary gland, adrenal gland, testis, ovary, brain, spleen, prostate and pancreas.1 Publication
Gene expression databases
Bgeei | ENSG00000169618, Expressed in subventricular zone (outer) (primate) and 29 other tissues |
Organism-specific databases
HPAi | ENSG00000169618, Tissue enhanced (adipose tissue, epididymis) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303775 |
Chemistry databases
BindingDBi | Q8TCW9 |
Miscellaneous databases
RNActi | Q8TCW9, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000010591 ENSGT00940000154544 |
HOGENOMi | CLU_009579_6_0_1 |
InParanoidi | Q8TCW9 |
OMAi | AYCLITG |
OrthoDBi | 664455at2759 |
PhylomeDBi | Q8TCW9 |
TreeFami | TF315303 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TCW9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
METTMGFMDD NATNTSTSFL SVLNPHGAHA TSFPFNFSYS DYDMPLDEDE
60 70 80 90 100
DVTNSRTFFA AKIVIGMALV GIMLVCGIGN FIFIAALVRY KKLRNLTNLL
110 120 130 140 150
IANLAISDFL VAIVCCPFEM DYYVVRQLSW EHGHVLCTSV NYLRTVSLYV
160 170 180 190 200
STNALLAIAI DRYLAIVHPL RPRMKCQTAT GLIALVWTVS ILIAIPSAYF
210 220 230 240 250
TTETVLVIVK SQEKIFCGQI WPVDQQLYYK SYFLFIFGIE FVGPVVTMTL
260 270 280 290 300
CYARISRELW FKAVPGFQTE QIRKRLRCRR KTVLVLMCIL TAYVLCWAPF
310 320 330 340 350
YGFTIVRDFF PTVFVKEKHY LTAFYIVECI AMSNSMINTL CFVTVKNDTV
360 370 380 390
KYFKKIMLLH WKASYNGGKS SADLDLKTIG MPATEEVDCI RLK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 255 – 256 | IS → MT in AAM48127 (PubMed:11886876).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024261 | 40 | S → G. Corresponds to variant dbSNP:rs7570797Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY089976 mRNA Translation: AAM11892.1 AB084080 mRNA Translation: BAC24021.1 AF506287 mRNA Translation: AAM48127.1 AC105054 Genomic DNA Translation: AAY24114.1 EF577399 mRNA Translation: ABQ52419.1 BC100960 mRNA Translation: AAI00961.1 |
CCDSi | CCDS1889.1 |
RefSeqi | NP_620414.1, NM_138964.3 |
Genome annotation databases
Ensembli | ENST00000303786; ENSP00000303775; ENSG00000169618 |
GeneIDi | 10887 |
KEGGi | hsa:10887 |
UCSCi | uc010yqj.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY089976 mRNA Translation: AAM11892.1 AB084080 mRNA Translation: BAC24021.1 AF506287 mRNA Translation: AAM48127.1 AC105054 Genomic DNA Translation: AAY24114.1 EF577399 mRNA Translation: ABQ52419.1 BC100960 mRNA Translation: AAI00961.1 |
CCDSi | CCDS1889.1 |
RefSeqi | NP_620414.1, NM_138964.3 |
3D structure databases
SMRi | Q8TCW9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000303775 |
Chemistry databases
BindingDBi | Q8TCW9 |
ChEMBLi | CHEMBL5649 |
GuidetoPHARMACOLOGYi | 335 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8TCW9, 3 sites |
iPTMneti | Q8TCW9 |
PhosphoSitePlusi | Q8TCW9 |
Polymorphism and mutation databases
BioMutai | PROKR1 |
DMDMi | 33112428 |
Proteomic databases
PaxDbi | Q8TCW9 |
PeptideAtlasi | Q8TCW9 |
PRIDEi | Q8TCW9 |
ProteomicsDBi | 74182 |
Protocols and materials databases
Antibodypediai | 30945, 128 antibodies |
DNASUi | 10887 |
Genome annotation databases
Ensembli | ENST00000303786; ENSP00000303775; ENSG00000169618 |
GeneIDi | 10887 |
KEGGi | hsa:10887 |
UCSCi | uc010yqj.3, human |
Organism-specific databases
CTDi | 10887 |
DisGeNETi | 10887 |
EuPathDBi | HostDB:ENSG00000169618.6 |
GeneCardsi | PROKR1 |
HGNCi | HGNC:4524, PROKR1 |
HPAi | ENSG00000169618, Tissue enhanced (adipose tissue, epididymis) |
MIMi | 607122, gene |
neXtProti | NX_Q8TCW9 |
OpenTargetsi | ENSG00000169618 ENSG00000169621 |
PharmGKBi | PA28916 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT00390000010591 ENSGT00940000154544 |
HOGENOMi | CLU_009579_6_0_1 |
InParanoidi | Q8TCW9 |
OMAi | AYCLITG |
OrthoDBi | 664455at2759 |
PhylomeDBi | Q8TCW9 |
TreeFami | TF315303 |
Enzyme and pathway databases
PathwayCommonsi | Q8TCW9 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | Q8TCW9 |
Miscellaneous databases
BioGRID-ORCSi | 10887, 5 hits in 840 CRISPR screens |
GeneWikii | Prokineticin_receptor_1 |
GenomeRNAii | 10887 |
Pharosi | Q8TCW9, Tchem |
PROi | PR:Q8TCW9 |
RNActi | Q8TCW9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169618, Expressed in subventricular zone (outer) (primate) and 29 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000611, NPY_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01012, NRPEPTIDEYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PKR1_HUMAN | |
Accessioni | Q8TCW9Primary (citable) accession number: Q8TCW9 Secondary accession number(s): A5JUU2, Q53QT9, Q8NFJ7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries