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Protein

WAP four-disulfide core domain protein 5

Gene

WFDC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative acid-stable proteinase inhibitor.

GO - Molecular functioni

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.003

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 5
Alternative name(s):
Putative protease inhibitor WAP1
p53-responsive gene 5 protein
Gene namesi
Name:WFDC5
Synonyms:PRG5, WAP1
ORF Names:UNQ3036/PRO9842
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000175121.11
HGNCiHGNC:20477 WFDC5
MIMi605161 gene
neXtProtiNX_Q8TCV5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi149708
OpenTargetsiENSG00000175121
PharmGKBiPA134885667

Polymorphism and mutation databases

BioMutaiWFDC5
DMDMi26401313

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004138225 – 224WAP four-disulfide core domain protein 5Add BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 62PROSITE-ProRule annotation
Disulfide bondi41 ↔ 66PROSITE-ProRule annotation
Disulfide bondi49 ↔ 61PROSITE-ProRule annotation
Disulfide bondi55 ↔ 70PROSITE-ProRule annotation
Disulfide bondi81 ↔ 109PROSITE-ProRule annotation
Disulfide bondi88 ↔ 113PROSITE-ProRule annotation
Disulfide bondi96 ↔ 108PROSITE-ProRule annotation
Disulfide bondi102 ↔ 117PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8TCV5
PeptideAtlasiQ8TCV5
PRIDEiQ8TCV5
ProteomicsDBi74178
74179 [Q8TCV5-2]

Expressioni

Inductioni

By p53/TP53.1 Publication

Gene expression databases

BgeeiENSG00000175121 Expressed in 78 organ(s), highest expression level in skin of abdomen
CleanExiHS_WFDC5
GenevisibleiQ8TCV5 HS

Interactioni

Protein-protein interaction databases

BioGridi127236, 7 interactors
IntActiQ8TCV5, 1 interactor
STRINGi9606.ENSP00000361875

Structurei

3D structure databases

ProteinModelPortaliQ8TCV5
SMRiQ8TCV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 73WAP 1PROSITE-ProRule annotationAdd BLAST47
Domaini74 – 121WAP 2PROSITE-ProRule annotationAdd BLAST48

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IZEK Eukaryota
ENOG4111D8G LUCA
GeneTreeiENSGT00730000111369
HOGENOMiHOG000154853
InParanoidiQ8TCV5
OMAiLQPIHPW
OrthoDBiEOG091G0XEE
PhylomeDBiQ8TCV5
TreeFamiTF338375

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
IPR029714 WFDC5
PANTHERiPTHR19441:SF39 PTHR19441:SF39, 1 hit
PfamiView protein in Pfam
PF00095 WAP, 2 hits
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 2 hits
SUPFAMiSSF57256 SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390 WAP, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TCV5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRTQSLLLLG ALLAVGSQLP AVFGRKKGEK SGGCPPDDGP CLLSVPDQCV
60 70 80 90 100
EDSQCPLTRK CCYRACFRQC VPRVSVKLGS CPEDQLRCLS PMNHLCHKDS
110 120 130 140 150
DCSGKKRCCH SACGRDCRDP ARGTAPGCPG QANSDLGSVA LHLSWGPTER
160 170 180 190 200
VHDGRPGALP AGQHYLYQRW FQPSDNHWPA DTSLQPIHPW FLLLGVKVHS
210 220
LSSEEGLCIT PVLCTTAIRA SHPS
Note: Gene prediction confirmed by EST data.
Length:224
Mass (Da):24,238
Last modified:June 1, 2002 - v1
Checksum:i305CC59024058F15
GO
Isoform 2 (identifier: Q8TCV5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-224: Missing.

Show »
Length:123
Mass (Da):13,313
Checksum:i255B5501B24F54F4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172Q → R in AF147078 (PubMed:10441517).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05747497H → Y1 PublicationCorresponds to variant dbSNP:rs17422688Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006756124 – 224Missing in isoform 2. 3 PublicationsAdd BLAST101

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038181 mRNA Translation: AAK72468.1
AY358822 mRNA Translation: AAQ89181.1
Z93016 Genomic DNA No translation available.
BC039173 mRNA Translation: AAH39173.1
AF147078 mRNA No translation available.
CCDSiCCDS33475.1 [Q8TCV5-2]
RefSeqiNP_663627.1, NM_145652.3 [Q8TCV5-2]
XP_011526903.1, XM_011528601.1 [Q8TCV5-2]
XP_011526904.1, XM_011528602.1 [Q8TCV5-2]
UniGeneiHs.375031

Genome annotation databases

EnsembliENST00000307971; ENSP00000312381; ENSG00000175121 [Q8TCV5-1]
ENST00000372789; ENSP00000361875; ENSG00000175121 [Q8TCV5-2]
GeneIDi149708
KEGGihsa:149708
UCSCiuc002xne.2 human [Q8TCV5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY038181 mRNA Translation: AAK72468.1
AY358822 mRNA Translation: AAQ89181.1
Z93016 Genomic DNA No translation available.
BC039173 mRNA Translation: AAH39173.1
AF147078 mRNA No translation available.
CCDSiCCDS33475.1 [Q8TCV5-2]
RefSeqiNP_663627.1, NM_145652.3 [Q8TCV5-2]
XP_011526903.1, XM_011528601.1 [Q8TCV5-2]
XP_011526904.1, XM_011528602.1 [Q8TCV5-2]
UniGeneiHs.375031

3D structure databases

ProteinModelPortaliQ8TCV5
SMRiQ8TCV5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127236, 7 interactors
IntActiQ8TCV5, 1 interactor
STRINGi9606.ENSP00000361875

Protein family/group databases

MEROPSiI17.003

Polymorphism and mutation databases

BioMutaiWFDC5
DMDMi26401313

Proteomic databases

PaxDbiQ8TCV5
PeptideAtlasiQ8TCV5
PRIDEiQ8TCV5
ProteomicsDBi74178
74179 [Q8TCV5-2]

Protocols and materials databases

DNASUi149708
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307971; ENSP00000312381; ENSG00000175121 [Q8TCV5-1]
ENST00000372789; ENSP00000361875; ENSG00000175121 [Q8TCV5-2]
GeneIDi149708
KEGGihsa:149708
UCSCiuc002xne.2 human [Q8TCV5-1]

Organism-specific databases

CTDi149708
DisGeNETi149708
EuPathDBiHostDB:ENSG00000175121.11
GeneCardsiWFDC5
HGNCiHGNC:20477 WFDC5
MIMi605161 gene
neXtProtiNX_Q8TCV5
OpenTargetsiENSG00000175121
PharmGKBiPA134885667
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEK Eukaryota
ENOG4111D8G LUCA
GeneTreeiENSGT00730000111369
HOGENOMiHOG000154853
InParanoidiQ8TCV5
OMAiLQPIHPW
OrthoDBiEOG091G0XEE
PhylomeDBiQ8TCV5
TreeFamiTF338375

Miscellaneous databases

GeneWikiiWFDC5
GenomeRNAii149708
PROiPR:Q8TCV5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175121 Expressed in 78 organ(s), highest expression level in skin of abdomen
CleanExiHS_WFDC5
GenevisibleiQ8TCV5 HS

Family and domain databases

Gene3Di4.10.75.10, 2 hits
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR008197 WAP_dom
IPR029714 WFDC5
PANTHERiPTHR19441:SF39 PTHR19441:SF39, 1 hit
PfamiView protein in Pfam
PF00095 WAP, 2 hits
PRINTSiPR00003 4DISULPHCORE
SMARTiView protein in SMART
SM00217 WAP, 2 hits
SUPFAMiSSF57256 SSF57256, 2 hits
PROSITEiView protein in PROSITE
PS51390 WAP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiWFDC5_HUMAN
AccessioniPrimary (citable) accession number: Q8TCV5
Secondary accession number(s): Q5H981, Q6UWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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