Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamate receptor ionotropic, NMDA 3A

Gene

GRIN3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).By similarity

GO - Molecular functioni

  • calcium channel activity Source: Ensembl
  • glycine binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • NMDA glutamate receptor activity Source: UniProtKB
  • protein phosphatase 2A binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3A
Short name:
GluN3A
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3A
Short name:
NMDAR3A
Short name:
NR3A
NMDAR-L
Gene namesi
Name:GRIN3A
Synonyms:KIAA1973
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000198785.4
HGNCiHGNC:16767 GRIN3A
MIMi606650 gene
neXtProtiNX_Q8TCU5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 674ExtracellularSequence analysisAdd BLAST651
Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 748CytoplasmicSequence analysisAdd BLAST53
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 930ExtracellularSequence analysisAdd BLAST161
Transmembranei931 – 951HelicalSequence analysisAdd BLAST21
Topological domaini952 – 1115CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi116443
OpenTargetsiENSG00000198785
PharmGKBiPA28983

Chemistry databases

ChEMBLiCHEMBL4787
DrugBankiDB00659 Acamprosate
DB06151 Acetylcysteine
DB00915 Amantadine
DB00289 Atomoxetine
DB01161 Chloroprocaine
DB00514 Dextromethorphan
DB00898 Ethanol
DB00392 Ethopropazine
DB00949 Felbamate
DB00996 Gabapentin
DB06741 Gavestinel
DB01159 Halothane
DB01221 Ketamine
DB06738 Ketobemidone
DB00142 L-Glutamic Acid
DB01043 Memantine
DB00333 Methadone
DB04896 Milnacipran
DB04926 Neramexane
DB01173 Orphenadrine
DB00312 Pentobarbital
DB03575 Phencyclidine
DB01174 Phenobarbital
DB01708 Prasterone
DB00721 Procaine
DB01549 Rolicyclidine
DB00418 Secobarbital
DB01520 Tenocyclidine
DB00193 Tramadol

Polymorphism and mutation databases

BioMutaiGRIN3A
DMDMi212276445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000001156824 – 1115Glutamate receptor ionotropic, NMDA 3AAdd BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi886N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8TCU5
PeptideAtlasiQ8TCU5
PRIDEiQ8TCU5
ProteomicsDBi74174

PTM databases

iPTMnetiQ8TCU5
PhosphoSitePlusiQ8TCU5

Expressioni

Developmental stagei

Expressed in fetal brain.

Gene expression databases

BgeeiENSG00000198785 Expressed in 91 organ(s), highest expression level in dorsolateral prefrontal cortex
CleanExiHS_GRIN3A
GenevisibleiQ8TCU5 HS

Interactioni

Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels. Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB. Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125508, 2 interactors
STRINGi9606.ENSP00000355155

Structurei

3D structure databases

ProteinModelPortaliQ8TCU5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni951 – 987PPP2CB binding siteBy similarityAdd BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1058 – 1109Sequence analysisAdd BLAST52

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1053 Eukaryota
ENOG410XNUR LUCA
GeneTreeiENSGT00910000143978
HOGENOMiHOG000231528
HOVERGENiHBG052634
InParanoidiQ8TCU5
KOiK05213
OMAiTQFGVMP
OrthoDBiEOG091G00PT
PhylomeDBiQ8TCU5
TreeFamiTF314731

Family and domain databases

InterProiView protein in InterPro
IPR019594 Glu/Gly-bd
IPR001508 Iono_rcpt_met
IPR001320 Iontro_rcpt
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00060 Lig_chan, 1 hit
PF10613 Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177 NMDARECEPTOR
SMARTiView protein in SMART
SM00918 Lig_chan-Glu_bd, 1 hit
SM00079 PBPe, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TCU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV
60 70 80 90 100
GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS
110 120 130 140 150
TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV
160 170 180 190 200
VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP
210 220 230 240 250
QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA
260 270 280 290 300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN
310 320 330 340 350
LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP
360 370 380 390 400
ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV
410 420 430 440 450
ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR
460 470 480 490 500
VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA
510 520 530 540 550
QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND
560 570 580 590 600
SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV
610 620 630 640 650
GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS
660 670 680 690 700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP
710 720 730 740 750
FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA
760 770 780 790 800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES
810 820 830 840 850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD
860 870 880 890 900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM
910 920 930 940 950
DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI
960 970 980 990 1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV
1010 1020 1030 1040 1050
EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP
1060 1070 1080 1090 1100
RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK
1110
TELEEYQRTS RTCES
Length:1,115
Mass (Da):125,465
Last modified:November 4, 2008 - v2
Checksum:i0FEEC995F6AAF940
GO

Sequence cautioni

The sequence BAB85559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti559S → N in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti977Q → R in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti1073N → I in AAL40734 (PubMed:11735224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07989272S → I1 PublicationCorresponds to variant dbSNP:rs558734093Ensembl.1
Natural variantiVAR_079893111R → G Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079894116G → S1 PublicationCorresponds to variant dbSNP:rs111415222Ensembl.1
Natural variantiVAR_079895227 – 1115Missing 1 PublicationAdd BLAST889
Natural variantiVAR_079896337R → W1 PublicationCorresponds to variant dbSNP:rs773593066Ensembl.1
Natural variantiVAR_019672362V → M1 PublicationCorresponds to variant dbSNP:rs10989591Ensembl.1
Natural variantiVAR_079897373G → R Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079898375I → T1 PublicationCorresponds to variant dbSNP:rs144427058Ensembl.1
Natural variantiVAR_079899434S → P1 PublicationCorresponds to variant dbSNP:rs776062103Ensembl.1
Natural variantiVAR_047150480R → H. Corresponds to variant dbSNP:rs34755188Ensembl.1
Natural variantiVAR_019673487G → R2 PublicationsCorresponds to variant dbSNP:rs10989589Ensembl.1
Natural variantiVAR_079900493Y → F1 PublicationCorresponds to variant dbSNP:rs773322226Ensembl.1
Natural variantiVAR_079901508 – 1115Missing Probable disease-associated mutation found in a patient with schizophrenia. 1 PublicationAdd BLAST608
Natural variantiVAR_079902565N → S1 PublicationCorresponds to variant dbSNP:rs371244839Ensembl.1
Natural variantiVAR_079903586K → N1 PublicationCorresponds to variant dbSNP:rs142284927Ensembl.1
Natural variantiVAR_079904641V → L Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079905793R → S1 PublicationCorresponds to variant dbSNP:rs144770241Ensembl.1
Natural variantiVAR_019674835D → N1 PublicationCorresponds to variant dbSNP:rs10989563Ensembl.1
Natural variantiVAR_079906921T → M1 PublicationCorresponds to variant dbSNP:rs144712629Ensembl.1
Natural variantiVAR_079907956Y → H1 PublicationCorresponds to variant dbSNP:rs141253502Ensembl.1
Natural variantiVAR_0799081028I → N Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs755464674Ensembl.1
Natural variantiVAR_0196751041R → Q2 PublicationsCorresponds to variant dbSNP:rs3739722Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416558 mRNA Translation: AAL40734.1
AJ416950 mRNA Translation: CAC95229.2
AB075853 mRNA Translation: BAB85559.1 Different initiation.
AL591377 Genomic DNA No translation available.
AL356516 Genomic DNA No translation available.
BC167432 mRNA Translation: AAI67432.1
CCDSiCCDS6758.1
RefSeqiNP_597702.2, NM_133445.2
UniGeneiHs.654783

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785
GeneIDi116443
KEGGihsa:116443
UCSCiuc004bbp.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNMD3A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCU5
Secondary accession number(s): B3DLF9
, Q5VTR3, Q8TF29, Q8WXI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again