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UniProtKB - Q8TCU5 (NMD3A_HUMAN)

Entry version 167 (23 Feb 2022)
Sequence version 2 (04 Nov 2008)
Previous versions | rss
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Protein

Glutamate receptor ionotropic, NMDA 3A

Gene

GRIN3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. During the development of neural circuits, plays a role in the synaptic refinement period, restricting spine maturation and growth. By competing with GIT1 interaction with ARHGEF7/beta-PIX, may reduce GIT1/ARHGEF7-regulated local activation of RAC1, hence affecting signaling and limiting the maturation and growth of inactive synapses. May also play a role in PPP2CB-NMDAR mediated signaling mechanism.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport
LigandCalcium, Magnesium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TCU5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9609736, Assembly and cell surface presentation of NMDA receptors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TCU5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glutamate receptor ionotropic, NMDA 3A
Short name:
GluN3A
Alternative name(s):
N-methyl-D-aspartate receptor subtype 3A
Short name:
NMDAR3A
Short name:
NR3A
NMDAR-L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GRIN3A
Synonyms:KIAA1973
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16767, GRIN3A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606650, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TCU5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198785

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 674ExtracellularSequence analysisAdd BLAST651
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei675 – 695HelicalSequence analysisAdd BLAST21
Topological domaini696 – 748CytoplasmicSequence analysisAdd BLAST53
Transmembranei749 – 769HelicalSequence analysisAdd BLAST21
Topological domaini770 – 930ExtracellularSequence analysisAdd BLAST161
Transmembranei931 – 951HelicalSequence analysisAdd BLAST21
Topological domaini952 – 1115CytoplasmicSequence analysisAdd BLAST164

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		116443

Open Targets

More...OpenTargetsi		ENSG00000198785

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28983

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TCU5, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4787

Drug and drug target database

More...DrugBanki		DB00659, Acamprosate
DB06151, Acetylcysteine
DB00915, Amantadine
DB01238, Aripiprazole
DB00289, Atomoxetine
DB00514, Dextromethorphan
DB00843, Donepezil
DB00228, Enflurane
DB11823, Esketamine
DB00898, Ethanol
DB13146, Fluciclovine (18F)
DB06741, Gavestinel
DB00142, Glutamic acid
DB00874, Guaifenesin
DB01159, Halothane
DB01221, Ketamine
DB06738, Ketobemidone
DB09409, Magnesium acetate tetrahydrate
DB09481, Magnesium carbonate
DB01043, Memantine
DB00333, Methadone
DB04896, Milnacipran
DB04926, Neramexane
DB01173, Orphenadrine
DB00312, Pentobarbital
DB03575, Phencyclidine
DB01174, Phenobarbital
DB01708, Prasterone
DB00721, Procaine
DB00392, Profenamine
DB01549, Rolicyclidine
DB00418, Secobarbital
DB01520, Tenocyclidine
DB00193, Tramadol

DrugCentral

More...DrugCentrali		Q8TCU5

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GRIN3A

Domain mapping of disease mutations (DMDM)

More...DMDMi		212276445

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001156824 – 1115Glutamate receptor ionotropic, NMDA 3AAdd BLAST1092

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi145N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi426N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi439N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi549N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi565N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi886N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TCU5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TCU5

PeptideAtlas

More...PeptideAtlasi		Q8TCU5

PRoteomics IDEntifications database

More...PRIDEi		Q8TCU5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74174

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q8TCU5, 11 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TCU5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TCU5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in fetal brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198785, Expressed in dorsolateral prefrontal cortex and 118 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TCU5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198785, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Does not form functional homomeric channels.

Found in a complex with GRIN1, GRIN2A or GRIN2B and PPP2CB (By similarity). Probably interacts with PPP2CB. No complex with PPP2CB is detected when NMDARs are stimulated by NMDA (PubMed:11588171).

Interacts (via C-terminus) with GIT1, but not with GRIA1/GluA1, nor with synaptophysin/SYP; this interaction competes with GIT1 interaction with ARHGEF7/beta-PIX (By similarity).

By similarity1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		125508, 6 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q8TCU5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000355155

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TCU5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TCU5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 118DisorderedSequence analysisAdd BLAST60
Regioni951 – 987PPP2CB binding siteBy similarityAdd BLAST37
Regioni1062 – 1095GIT1-bindingBy similarityAdd BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1058 – 1109Sequence analysisAdd BLAST52

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR3A/GRIN3A subfamily. [View classification]Curated

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1053, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002039_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TCU5

Identification of Orthologs from Complete Genome Data

More...OMAi		MPPELHW

Database of Orthologous Groups

More...OrthoDBi		188544at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TCU5

TreeFam database of animal gene trees

More...TreeFami		TF314731

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00177, NMDARECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TCU5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRLSLWWLL SRVCLLLPPP CALVLAGVPS SSSHPQPCQI LKRIGHAVRV 
        60         70         80         90        100
GAVHLQPWTT APRAASRAPD DSRAGAQRDE PEPGTRRSPA PSPGARWLGS 
       110        120        130        140        150
TLHGRGPPGS RKPGEGARAE ALWPRDALLF AVDNLNRVEG LLPYNLSLEV 
       160        170        180        190        200
VMAIEAGLGD LPLLPFSSPS SPWSSDPFSF LQSVCHTVVV QGVSALLAFP 
       210        220        230        240        250
QSQGEMMELD LVSLVLHIPV ISIVRHEFPR ESQNPLHLQL SLENSLSSDA 
       260        270        280        290        300
DVTVSILTMN NWYNFSLLLC QEDWNITDFL LLTQNNSKFH LGSIINITAN 
       310        320        330        340        350
LPSTQDLLSF LQIQLESIKN STPTVVMFGC DMESIRRIFE ITTQFGVMPP 
       360        370        380        390        400
ELRWVLGDSQ NVEELRTEGL PLGLIAHGKT TQSVFEHYVQ DAMELVARAV 
       410        420        430        440        450
ATATMIQPEL ALIPSTMNCM EVETTNLTSG QYLSRFLANT TFRGLSGSIR 
       460        470        480        490        500
VKGSTIVSSE NNFFIWNLQH DPMGKPMWTR LGSWQGGKIV MDYGIWPEQA 
       510        520        530        540        550
QRHKTHFQHP SKLHLRVVTL IEHPFVFTRE VDDEGLCPAG QLCLDPMTND 
       560        570        580        590        600
SSTLDSLFSS LHSSNDTVPI KFKKCCYGYC IDLLEKIAED MNFDFDLYIV 
       610        620        630        640        650
GDGKYGAWKN GHWTGLVGDL LRGTAHMAVT SFSINTARSQ VIDFTSPFFS 
       660        670        680        690        700
TSLGILVRTR DTAAPIGAFM WPLHWTMWLG IFVALHITAV FLTLYEWKSP 
       710        720        730        740        750
FGLTPKGRNR SKVFSFSSAL NICYALLFGR TVAIKPPKCW TGRFLMNLWA 
       760        770        780        790        800
IFCMFCLSTY TANLAAVMVG EKIYEELSGI HDPKLHHPSQ GFRFGTVRES 
       810        820        830        840        850
SAEDYVRQSF PEMHEYMRRY NVPATPDGVE YLKNDPEKLD AFIMDKALLD 
       860        870        880        890        900
YEVSIDADCK LLTVGKPFAI EGYGIGLPPN SPLTANISEL ISQYKSHGFM 
       910        920        930        940        950
DMLHDKWYRV VPCGKRSFAV TETLQMGIKH FSGLFVLLCI GFGLSILTTI 
       960        970        980        990       1000
GEHIVYRLLL PRIKNKSKLQ YWLHTSQRLH RAINTSFIEE KQQHFKTKRV 
      1010       1020       1030       1040       1050
EKRSNVGPRQ LTVWNTSNLS HDNRRKYIFS DEEGQNQLGI RIHQDIPLPP 
      1060       1070       1080       1090       1100
RRRELPALRT TNGKADSLNV SRNSVMQELS ELEKQIQVIR QELQLAVSRK 
      1110 
TELEEYQRTS RTCES
Length:1,115
Mass (Da):125,465
Last modified:November 4, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FEEC995F6AAF940
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85559 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti559S → N in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti977Q → R in AAL40734 (PubMed:11735224).Curated1
Sequence conflicti1073N → I in AAL40734 (PubMed:11735224).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07989272S → I1 PublicationCorresponds to variant dbSNP:rs558734093Ensembl.1
Natural variantiVAR_079893111R → G Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079894116G → S1 PublicationCorresponds to variant dbSNP:rs111415222Ensembl.1
Natural variantiVAR_079895227 – 1115Missing 1 PublicationAdd BLAST889
Natural variantiVAR_079896337R → W1 PublicationCorresponds to variant dbSNP:rs773593066Ensembl.1
Natural variantiVAR_019672362V → M1 PublicationCorresponds to variant dbSNP:rs10989591Ensembl.1
Natural variantiVAR_079897373G → R Found in a patient with autism spectrum disorder; unknown pathological significance. 1 Publication1
Natural variantiVAR_079898375I → T1 PublicationCorresponds to variant dbSNP:rs144427058Ensembl.1
Natural variantiVAR_079899434S → P1 PublicationCorresponds to variant dbSNP:rs776062103Ensembl.1
Natural variantiVAR_047150480R → H. Corresponds to variant dbSNP:rs34755188Ensembl.1
Natural variantiVAR_019673487G → R2 PublicationsCorresponds to variant dbSNP:rs10989589Ensembl.1
Natural variantiVAR_079900493Y → F1 PublicationCorresponds to variant dbSNP:rs773322226Ensembl.1
Natural variantiVAR_079901508 – 1115Missing Probable disease-associated variant found in a patient with schizophrenia. 1 PublicationAdd BLAST608
Natural variantiVAR_079902565N → S1 PublicationCorresponds to variant dbSNP:rs371244839Ensembl.1
Natural variantiVAR_079903586K → N1 PublicationCorresponds to variant dbSNP:rs142284927Ensembl.1
Natural variantiVAR_079904641V → L Found in a patient with autism spectrum disorder; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1360008284Ensembl.1
Natural variantiVAR_079905793R → S1 PublicationCorresponds to variant dbSNP:rs144770241Ensembl.1
Natural variantiVAR_019674835D → N1 PublicationCorresponds to variant dbSNP:rs10989563Ensembl.1
Natural variantiVAR_079906921T → M1 PublicationCorresponds to variant dbSNP:rs144712629Ensembl.1
Natural variantiVAR_079907956Y → H1 PublicationCorresponds to variant dbSNP:rs141253502Ensembl.1
Natural variantiVAR_0799081028I → N Found in a patient with schizophrenia; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs755464674Ensembl.1
Natural variantiVAR_0196751041R → Q2 PublicationsCorresponds to variant dbSNP:rs3739722Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF416558 mRNA Translation: AAL40734.1
AJ416950 mRNA Translation: CAC95229.2
AB075853 mRNA Translation: BAB85559.1 Different initiation.
AL591377 Genomic DNA No translation available.
AL356516 Genomic DNA No translation available.
BC167432 mRNA Translation: AAI67432.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6758.1

NCBI Reference Sequences

More...RefSeqi		NP_597702.2, NM_133445.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361820; ENSP00000355155; ENSG00000198785

Database of genes from NCBI RefSeq genomes

More...GeneIDi		116443

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:116443

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000361820.6; ENSP00000355155.3; NM_133445.3; NP_597702.2

UCSC genome browser

More...UCSCi		uc004bbp.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416558 mRNA Translation: AAL40734.1
AJ416950 mRNA Translation: CAC95229.2
AB075853 mRNA Translation: BAB85559.1 Different initiation.
AL591377 Genomic DNA No translation available.
AL356516 Genomic DNA No translation available.
BC167432 mRNA Translation: AAI67432.1
CCDSiCCDS6758.1
RefSeqiNP_597702.2, NM_133445.2

3D structure databases

SMRiQ8TCU5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi125508, 6 interactors
CORUMiQ8TCU5
STRINGi9606.ENSP00000355155

Chemistry databases

ChEMBLiCHEMBL4787
DrugBankiDB00659, Acamprosate
DB06151, Acetylcysteine
DB00915, Amantadine
DB01238, Aripiprazole
DB00289, Atomoxetine
DB00514, Dextromethorphan
DB00843, Donepezil
DB00228, Enflurane
DB11823, Esketamine
DB00898, Ethanol
DB13146, Fluciclovine (18F)
DB06741, Gavestinel
DB00142, Glutamic acid
DB00874, Guaifenesin
DB01159, Halothane
DB01221, Ketamine
DB06738, Ketobemidone
DB09409, Magnesium acetate tetrahydrate
DB09481, Magnesium carbonate
DB01043, Memantine
DB00333, Methadone
DB04896, Milnacipran
DB04926, Neramexane
DB01173, Orphenadrine
DB00312, Pentobarbital
DB03575, Phencyclidine
DB01174, Phenobarbital
DB01708, Prasterone
DB00721, Procaine
DB00392, Profenamine
DB01549, Rolicyclidine
DB00418, Secobarbital
DB01520, Tenocyclidine
DB00193, Tramadol
DrugCentraliQ8TCU5

PTM databases

GlyGeniQ8TCU5, 11 sites, 1 O-linked glycan (1 site)
iPTMnetiQ8TCU5
PhosphoSitePlusiQ8TCU5

Genetic variation databases

BioMutaiGRIN3A
DMDMi212276445

Proteomic databases

MassIVEiQ8TCU5
PaxDbiQ8TCU5
PeptideAtlasiQ8TCU5
PRIDEiQ8TCU5
ProteomicsDBi74174

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		54489, 27 antibodies from 8 providers

The DNASU plasmid repository

More...DNASUi		116443

Genome annotation databases

EnsembliENST00000361820; ENSP00000355155; ENSG00000198785
GeneIDi116443
KEGGihsa:116443
MANE-SelectiENST00000361820.6; ENSP00000355155.3; NM_133445.3; NP_597702.2
UCSCiuc004bbp.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		116443
DisGeNETi116443

GeneCards: human genes, protein and diseases

More...GeneCardsi		GRIN3A
HGNCiHGNC:16767, GRIN3A
HPAiENSG00000198785, Tissue enhanced (brain)
MIMi606650, gene
neXtProtiNX_Q8TCU5
OpenTargetsiENSG00000198785
PharmGKBiPA28983
VEuPathDBiHostDB:ENSG00000198785

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1053, Eukaryota
GeneTreeiENSGT00940000158571
HOGENOMiCLU_002039_0_0_1
InParanoidiQ8TCU5
OMAiMPPELHW
OrthoDBi188544at2759
PhylomeDBiQ8TCU5
TreeFamiTF314731

Enzyme and pathway databases

PathwayCommonsiQ8TCU5
ReactomeiR-HSA-9609736, Assembly and cell surface presentation of NMDA receptors
SignaLinkiQ8TCU5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		116443, 5 hits in 1034 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		GRIN3A, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GRIN3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		116443
PharosiQ8TCU5, Tclin

Protein Ontology

More...PROi		PR:Q8TCU5
RNActiQ8TCU5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198785, Expressed in dorsolateral prefrontal cortex and 118 other tissues
GenevisibleiQ8TCU5, HS

Family and domain databases

InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR019594, Glu/Gly-bd
IPR001508, Iono_rcpt_met
IPR001320, Iontro_rcpt
IPR028082, Peripla_BP_I
PfamiView protein in Pfam
PF01094, ANF_receptor, 1 hit
PF00060, Lig_chan, 1 hit
PF10613, Lig_chan-Glu_bd, 1 hit
PRINTSiPR00177, NMDARECEPTOR
SMARTiView protein in SMART
SM00918, Lig_chan-Glu_bd, 1 hit
SM00079, PBPe, 1 hit
SUPFAMiSSF53822, SSF53822, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNMD3A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCU5
Secondary accession number(s): B3DLF9
, Q5VTR3, Q8TF29, Q8WXI6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: November 4, 2008
Last modified: February 23, 2022
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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