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Entry version 146 (16 Oct 2019)
Sequence version 2 (08 Nov 2002)
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Protein

Signal peptide peptidase-like 2A

Gene

SPPL2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17557115, PubMed:17965014). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952). Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD) (PubMed:17557115). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus envelope glycoprotein gp130 independently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).5 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei351By similarity1
Active sitei412By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5357905 Regulation of TNFR1 signaling

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A22.007

Transport Classification Database

More...
TCDBi
1.A.54.3.2 the presenilin er ca(2+) leak channel (presenilin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide peptidase-like 2A1 PublicationImported (EC:3.4.23.-)
Short name:
SPP-like 2A1 Publication
Short name:
SPPL2a1 Publication
Alternative name(s):
Intramembrane protease 31 Publication
Short name:
IMP-31 Publication
Presenilin-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPPL2A1 PublicationImported
Synonyms:IMP31 Publication, PSL2
ORF Names:PSEC0147
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30227 SPPL2A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608238 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TCT8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 172Lumenal1 PublicationAdd BLAST147
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei173 – 193HelicalSequence analysisAdd BLAST21
Topological domaini194 – 220CytoplasmicSequence analysisAdd BLAST27
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Topological domaini242 – 247LumenalSequence analysis6
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Topological domaini269 – 285CytoplasmicSequence analysisAdd BLAST17
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Topological domaini307 – 311LumenalSequence analysis5
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 340CytoplasmicSequence analysis8
Transmembranei341 – 361HelicalSequence analysisAdd BLAST21
Topological domaini362 – 399Lumenal1 PublicationAdd BLAST38
Transmembranei400 – 420HelicalSequence analysisAdd BLAST21
Topological domaini421 – 437CytoplasmicSequence analysisAdd BLAST17
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 460LumenalSequence analysis2
Transmembranei461 – 481HelicalSequence analysisAdd BLAST21
Topological domaini482 – 520Cytoplasmic1 PublicationAdd BLAST39

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi412D → A: Loss of intramembrane-cleaving activity toward FASLG, ITM2B, TNF and the simian foamy virus envelope glycoprotein gp130. 4 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84888

Open Targets

More...
OpenTargetsi
ENSG00000138600

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TCT8

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105833

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPPL2A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
25008981

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007391026 – 520Signal peptide peptidase-like 2AAdd BLAST495

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi149N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi155N-linked (GlcNAc...) (complex) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TCT8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TCT8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TCT8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TCT8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TCT8

PeptideAtlas

More...
PeptideAtlasi
Q8TCT8

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCT8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74164

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1746

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCT8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCT8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TCT8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000138600 Expressed in 203 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TCT8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TCT8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036062
HPA067304

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITM2B (PubMed:17965014).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SGTAO437656EBI-750784,EBI-347996

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124328, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TCT8, 5 interactors

Molecular INTeraction database

More...
MINTi
Q8TCT8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261854

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 151PAAdd BLAST89

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi463 – 465PAL3
Motifi495 – 498YXXo lysosomal targeting motif4

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP. The C-terminal tail is necessary for lysosomal transport.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2442 Eukaryota
ENOG410ZP52 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157722

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231496

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCT8

KEGG Orthology (KO)

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KOi
K09596

Identification of Orthologs from Complete Genome Data

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OMAi
WGTCHFL

Database of Orthologous Groups

More...
OrthoDBi
535101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCT8

TreeFam database of animal gene trees

More...
TreeFami
TF319186

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033151 SPPL2a

The PANTHER Classification System

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PANTHERi
PTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02225 PA, 1 hit
PF04258 Peptidase_A22B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00730 PSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TCT8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPQRRLSPA GAALLWGFLL QLTAAQEAIL HASGNGTTKD YCMLYNPYWT
60 70 80 90 100
ALPSTLENAT SISLMNLTST PLCNLSDIPP VGIKSKAVVV PWGSCHFLEK
110 120 130 140 150
ARIAQKGGAE AMLVVNNSVL FPPSGNRSEF PDVKILIAFI SYKDFRDMNQ
160 170 180 190 200
TLGDNITVKM YSPSWPNFDY TMVVIFVIAV FTVALGGYWS GLVELENLKA
210 220 230 240 250
VTTEDREMRK KKEEYLTFSP LTVVIFVVIC CVMMVLLYFF YKWLVYVMIA
260 270 280 290 300
IFCIASAMSL YNCLAALIHK IPYGQCTIAC RGKNMEVRLI FLSGLCIAVA
310 320 330 340 350
VVWAVFRNED RWAWILQDIL GIAFCLNLIK TLKLPNFKSC VILLGLLLLY
360 370 380 390 400
DVFFVFITPF ITKNGESIMV ELAAGPFGNN EKLPVVIRVP KLIYFSVMSV
410 420 430 440 450
CLMPVSILGF GDIIVPGLLI AYCRRFDVQT GSSYIYYVSS TVAYAIGMIL
460 470 480 490 500
TFVVLVLMKK GQPALLYLVP CTLITASVVA WRRKEMKKFW KGNSYQMMDH
510 520
LDCATNEENP VISGEQIVQQ
Length:520
Mass (Da):58,143
Last modified:November 8, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7A933A6504507DC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNA2H0YNA2_HUMAN
Signal peptide peptidase-like 2A
SPPL2A
356Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNA7H0YNA7_HUMAN
Signal peptide peptidase-like 2A
SPPL2A
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55117 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD13133 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti126N → D in BAB55117 (PubMed:14702039).Curated1
Sequence conflicti271I → T in BAC11630 (PubMed:16303743).Curated1
Sequence conflicti406S → L in BAC11630 (PubMed:16303743).Curated1
Sequence conflicti446I → F in BAC11630 (PubMed:16303743).Curated1
Sequence conflicti511V → E in BAB55117 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05179090V → I. Corresponds to variant dbSNP:rs8034443Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ345028 mRNA Translation: CAC87789.1
AY169314 mRNA Translation: AAO12539.1
AK027446 mRNA Translation: BAB55117.1 Different initiation.
AK315651 mRNA Translation: BAG38017.1
AK075454 mRNA Translation: BAC11630.1
CH471082 Genomic DNA Translation: EAW77410.1
BC025740 mRNA Translation: AAH25740.1
AJ420896 mRNA Translation: CAD13133.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS10138.1

NCBI Reference Sequences

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RefSeqi
NP_116191.2, NM_032802.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000261854; ENSP00000261854; ENSG00000138600

Database of genes from NCBI RefSeq genomes

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GeneIDi
84888

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84888

UCSC genome browser

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UCSCi
uc001zyv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ345028 mRNA Translation: CAC87789.1
AY169314 mRNA Translation: AAO12539.1
AK027446 mRNA Translation: BAB55117.1 Different initiation.
AK315651 mRNA Translation: BAG38017.1
AK075454 mRNA Translation: BAC11630.1
CH471082 Genomic DNA Translation: EAW77410.1
BC025740 mRNA Translation: AAH25740.1
AJ420896 mRNA Translation: CAD13133.1 Different initiation.
CCDSiCCDS10138.1
RefSeqiNP_116191.2, NM_032802.3

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124328, 4 interactors
IntActiQ8TCT8, 5 interactors
MINTiQ8TCT8
STRINGi9606.ENSP00000261854

Chemistry databases

ChEMBLiCHEMBL4105833

Protein family/group databases

MEROPSiA22.007
TCDBi1.A.54.3.2 the presenilin er ca(2+) leak channel (presenilin) family

PTM databases

GlyConnecti1746
iPTMnetiQ8TCT8
PhosphoSitePlusiQ8TCT8
SwissPalmiQ8TCT8

Polymorphism and mutation databases

BioMutaiSPPL2A
DMDMi25008981

Proteomic databases

EPDiQ8TCT8
jPOSTiQ8TCT8
MassIVEiQ8TCT8
MaxQBiQ8TCT8
PaxDbiQ8TCT8
PeptideAtlasiQ8TCT8
PRIDEiQ8TCT8
ProteomicsDBi74164

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
84888

Genome annotation databases

EnsembliENST00000261854; ENSP00000261854; ENSG00000138600
GeneIDi84888
KEGGihsa:84888
UCSCiuc001zyv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84888
DisGeNETi84888

GeneCards: human genes, protein and diseases

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GeneCardsi
SPPL2A
HGNCiHGNC:30227 SPPL2A
HPAiHPA036062
HPA067304
MIMi608238 gene
neXtProtiNX_Q8TCT8
OpenTargetsiENSG00000138600

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2442 Eukaryota
ENOG410ZP52 LUCA
GeneTreeiENSGT00940000157722
HOGENOMiHOG000231496
InParanoidiQ8TCT8
KOiK09596
OMAiWGTCHFL
OrthoDBi535101at2759
PhylomeDBiQ8TCT8
TreeFamiTF319186

Enzyme and pathway databases

ReactomeiR-HSA-5357905 Regulation of TNFR1 signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SPPL2A human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SPPL2A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84888
PharosiQ8TCT8

Protein Ontology

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PROi
PR:Q8TCT8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000138600 Expressed in 203 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8TCT8 baseline and differential
GenevisibleiQ8TCT8 HS

Family and domain databases

InterProiView protein in InterPro
IPR003137 PA_domain
IPR007369 Peptidase_A22B_SPP
IPR006639 Preselin/SPP
IPR033151 SPPL2a
PANTHERiPTHR12174 PTHR12174, 1 hit
PTHR12174:SF34 PTHR12174:SF34, 1 hit
PfamiView protein in Pfam
PF02225 PA, 1 hit
PF04258 Peptidase_A22B, 1 hit
SMARTiView protein in SMART
SM00730 PSN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCT8
Secondary accession number(s): B2RDS0, Q8TAW1, Q96SZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 16, 2019
This is version 146 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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