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Entry version 165 (10 Feb 2021)
Sequence version 2 (16 May 2006)
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Protein

Signal peptide peptidase-like 2B

Gene

SPPL2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing (PubMed:16829952, PubMed:16829951, PubMed:17965014, PubMed:19114711, PubMed:22194595). Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus (PubMed:16829952, PubMed:16829951). May play a role in the regulation of innate and adaptive immunity (PubMed:16829952). Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependently of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis (PubMed:23132852).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei359By similarity1
Active sitei421By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TCT7

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5357905, Regulation of TNFR1 signaling

Protein family/group databases

MEROPS protease database

More...
MEROPSi
A22.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Signal peptide peptidase-like 2B1 PublicationImported (EC:3.4.23.-)
Short name:
SPP-like 2B1 Publication
Short name:
SPPL2b1 Publication
Alternative name(s):
Intramembrane protease 41 Publication
Short name:
IMP-41 Publication
Presenilin homologous protein 4
Short name:
PSH4
Presenilin-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPPL2B1 PublicationImported
Synonyms:IMP41 Publication, KIAA1532, PSL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30627, SPPL2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608239, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TCT7

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000005206.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 174Lumenal1 PublicationAdd BLAST149
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei175 – 195HelicalSequence analysisAdd BLAST21
Topological domaini196 – 221CytoplasmicSequence analysisAdd BLAST26
Transmembranei222 – 244HelicalSequence analysisAdd BLAST23
Topological domaini245 – 248LumenalSequence analysis4
Transmembranei249 – 271HelicalSequence analysisAdd BLAST23
Topological domaini272 – 293CytoplasmicSequence analysisAdd BLAST22
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 319LumenalSequence analysis5
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 348CytoplasmicSequence analysis8
Transmembranei349 – 369HelicalSequence analysisAdd BLAST21
Topological domaini370 – 412Lumenal1 PublicationAdd BLAST43
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 445CytoplasmicSequence analysisAdd BLAST12
Transmembranei446 – 466HelicalSequence analysisAdd BLAST21
Topological domaini467 – 470LumenalSequence analysis4
Transmembranei471 – 491HelicalSequence analysisAdd BLAST21
Topological domaini492 – 592Cytoplasmic1 PublicationAdd BLAST101

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi421D → A: Loss of intramembrane-cleaving activity toward ITM2B, TNF and the simian foamy virus envelope glycoprotein gp130. 4 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
56928

Open Targets

More...
OpenTargetsi
ENSG00000005206

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TCT7, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4105912

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPPL2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
97537015

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000007390926 – 592Signal peptide peptidase-like 2BAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated (PubMed:15385547, PubMed:15998642).2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TCT7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TCT7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TCT7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TCT7

PeptideAtlas

More...
PeptideAtlasi
Q8TCT7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCT7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74160 [Q8TCT7-1]
74161 [Q8TCT7-2]
74163 [Q8TCT7-4]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q8TCT7-4 [Q8TCT7-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q8TCT7, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCT7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCT7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in adrenal cortex and mammary gland.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000005206, Expressed in right uterine tube and 188 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TCT7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TCT7, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000005206, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:15998642, PubMed:16873890). Homodimer (PubMed:15998642, PubMed:16873890).

Interacts with ITM2B (PubMed:17965014).

Interacts with TNF (PubMed:16829951).

Interacts with the simian foamy virus envelope glycoprotein gp130 and its processed leader peptide gp18LP; preferentially interacts with the leader peptide gp18LP (PubMed:23132852).

5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
121255, 128 interactors

Protein interaction database and analysis system

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IntActi
Q8TCT7, 113 interactors

Molecular INTeraction database

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MINTi
Q8TCT7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478298

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8TCT7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TCT7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TCT7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini71 – 149PAAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi472 – 474PAL3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi350 – 357Poly-Leu8
Compositional biasi509 – 551Pro-richAdd BLAST43

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PAL motif is required for normal active site conformation. The catalytic domains embedded in the membrane are in the opposite orientation to that of the presenilin protein family; therefore, it is predicted to cleave type II-oriented substrate peptides like the prototypic protease SPP.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase A22B family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2442, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158753

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023799_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCT7

Identification of Orthologs from Complete Genome Data

More...
OMAi
ELAMFWT

Database of Orthologous Groups

More...
OrthoDBi
535101at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCT7

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003137, PA_domain
IPR007369, Peptidase_A22B_SPP
IPR006639, Preselin/SPP
IPR033149, SPPL2B

The PANTHER Classification System

More...
PANTHERi
PTHR12174, PTHR12174, 1 hit
PTHR12174:SF39, PTHR12174:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02225, PA, 1 hit
PF04258, Peptidase_A22B, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00730, PSN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCT7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAVAAALA RLLAAFLLLA AQVACEYGMV HVVSQAGGPE GKDYCILYNP
60 70 80 90 100
QWAHLPHDLS KASFLQLRNW TASLLCSAAD LPARGFSNQI PLVARGNCTF
110 120 130 140 150
YEKVRLAQGS GARGLLIVSR ERLVPPGGNK TQYDEIGIPV ALLSYKDMLD
160 170 180 190 200
IFTRFGRTVR AALYAPKEPV LDYNMVIIFI MAVGTVAIGG YWAGSRDVKK
210 220 230 240 250
RYMKHKRDDG PEKQEDEAVD VTPVMTCVFV VMCCSMLVLL YYFYDLLVYV
260 270 280 290 300
VIGIFCLASA TGLYSCLAPC VRRLPFGKCR IPNNSLPYFH KRPQARMLLL
310 320 330 340 350
ALFCVAVSVV WGVFRNEDQW AWVLQDALGI AFCLYMLKTI RLPTFKACTL
360 370 380 390 400
LLLVLFLYDI FFVFITPFLT KSGSSIMVEV ATGPSDSATR EKLPMVLKVP
410 420 430 440 450
RLNSSPLALC DRPFSLLGFG DILVPGLLVA YCHRFDIQVQ SSRVYFVACT
460 470 480 490 500
IAYGVGLLVT FVALALMQRG QPALLYLVPC TLVTSCAVAL WRRELGVFWT
510 520 530 540 550
GSGFAKVLPP SPWAPAPADG PQPPKDSATP LSPQPPSEEP ATSPWPAEQS
560 570 580 590
PKSRTSEEMG AGAPMREPGS PAESEGRDQA QPSPVTQPGA SA
Length:592
Mass (Da):64,644
Last modified:May 16, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F49370F16D36AA0
GO
Isoform 2 (identifier: Q8TCT7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-592: Missing.

Show »
Length:319
Mass (Da):35,295
Checksum:i5EFEEB110C4C7D7B
GO
Isoform 4 (identifier: Q8TCT7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     506-511: KVLPPS → VNTSLL
     512-592: Missing.

Show »
Length:511
Mass (Da):56,431
Checksum:i6B496A9879E9D57F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT77A0A087WT77_HUMAN
Signal peptide peptidase-like 2B
SPPL2B
165Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ50A0A087WZ50_HUMAN
Signal peptide peptidase-like 2B
SPPL2B
291Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWL4A0A087WWL4_HUMAN
Signal peptide peptidase-like 2B
SPPL2B
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WZ93A0A087WZ93_HUMAN
Signal peptide peptidase-like 2B
SPPL2B
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC05601 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAG45441 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA96056 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAB96951 differs from that shown. Probable cloning artifact.Curated
The sequence CAB96951 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059780574S → P. Corresponds to variant dbSNP:rs10402284Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_005204320 – 592Missing in isoform 2. 1 PublicationAdd BLAST273
Alternative sequenceiVSP_009221506 – 511KVLPPS → VNTSLL in isoform 4. 1 Publication6
Alternative sequenceiVSP_009222512 – 592Missing in isoform 4. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ345027 mRNA Translation: CAC87788.1
AJ420897 mRNA Translation: CAD13134.1
AY169315 mRNA Translation: AAO12540.1
AB040965 mRNA Translation: BAA96056.1 Different initiation.
AC004410 Genomic DNA Translation: AAC05601.1 Sequence problems.
AC005258 Genomic DNA Translation: AAG45441.1 Different initiation.
CH471139 Genomic DNA Translation: EAW69383.1
CH471139 Genomic DNA Translation: EAW69388.1
BC001788 mRNA Translation: AAH01788.2
BC028391 mRNA Translation: AAH28391.2
BC093046 mRNA Translation: AAH93046.1
AL365405 mRNA Translation: CAB96951.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS74252.1 [Q8TCT7-1]
CCDS74253.1 [Q8TCT7-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001070706.1, NM_001077238.1 [Q8TCT7-4]
NP_694533.1, NM_152988.2 [Q8TCT7-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000610743; ENSP00000478510; ENSG00000005206 [Q8TCT7-4]
ENST00000613503; ENSP00000478298; ENSG00000005206 [Q8TCT7-1]
ENST00000618220; ENSP00000480813; ENSG00000005206 [Q8TCT7-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56928

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56928

UCSC genome browser

More...
UCSCi
uc032hjm.2, human [Q8TCT7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ345027 mRNA Translation: CAC87788.1
AJ420897 mRNA Translation: CAD13134.1
AY169315 mRNA Translation: AAO12540.1
AB040965 mRNA Translation: BAA96056.1 Different initiation.
AC004410 Genomic DNA Translation: AAC05601.1 Sequence problems.
AC005258 Genomic DNA Translation: AAG45441.1 Different initiation.
CH471139 Genomic DNA Translation: EAW69383.1
CH471139 Genomic DNA Translation: EAW69388.1
BC001788 mRNA Translation: AAH01788.2
BC028391 mRNA Translation: AAH28391.2
BC093046 mRNA Translation: AAH93046.1
AL365405 mRNA Translation: CAB96951.1 Sequence problems.
CCDSiCCDS74252.1 [Q8TCT7-1]
CCDS74253.1 [Q8TCT7-4]
RefSeqiNP_001070706.1, NM_001077238.1 [Q8TCT7-4]
NP_694533.1, NM_152988.2 [Q8TCT7-1]

3D structure databases

SMRiQ8TCT7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121255, 128 interactors
IntActiQ8TCT7, 113 interactors
MINTiQ8TCT7
STRINGi9606.ENSP00000478298

Chemistry databases

BindingDBiQ8TCT7
ChEMBLiCHEMBL4105912

Protein family/group databases

MEROPSiA22.004

PTM databases

GlyGeniQ8TCT7, 2 sites
iPTMnetiQ8TCT7
PhosphoSitePlusiQ8TCT7

Genetic variation databases

BioMutaiSPPL2B
DMDMi97537015

Proteomic databases

EPDiQ8TCT7
jPOSTiQ8TCT7
MassIVEiQ8TCT7
MaxQBiQ8TCT7
PeptideAtlasiQ8TCT7
PRIDEiQ8TCT7
ProteomicsDBi74160 [Q8TCT7-1]
74161 [Q8TCT7-2]
74163 [Q8TCT7-4]
TopDownProteomicsiQ8TCT7-4 [Q8TCT7-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3352, 68 antibodies

The DNASU plasmid repository

More...
DNASUi
56928

Genome annotation databases

EnsembliENST00000610743; ENSP00000478510; ENSG00000005206 [Q8TCT7-4]
ENST00000613503; ENSP00000478298; ENSG00000005206 [Q8TCT7-1]
ENST00000618220; ENSP00000480813; ENSG00000005206 [Q8TCT7-2]
GeneIDi56928
KEGGihsa:56928
UCSCiuc032hjm.2, human [Q8TCT7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56928
DisGeNETi56928

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPPL2B
HGNCiHGNC:30627, SPPL2B
HPAiENSG00000005206, Low tissue specificity
MIMi608239, gene
neXtProtiNX_Q8TCT7
OpenTargetsiENSG00000005206
VEuPathDBiHostDB:ENSG00000005206.16

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2442, Eukaryota
GeneTreeiENSGT00940000158753
HOGENOMiCLU_023799_2_1_1
InParanoidiQ8TCT7
OMAiELAMFWT
OrthoDBi535101at2759
PhylomeDBiQ8TCT7

Enzyme and pathway databases

PathwayCommonsiQ8TCT7
ReactomeiR-HSA-5357905, Regulation of TNFR1 signaling

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
56928, 5 hits in 98 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SPPL2B, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPPL2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56928
PharosiQ8TCT7, Tbio

Protein Ontology

More...
PROi
PR:Q8TCT7
RNActiQ8TCT7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000005206, Expressed in right uterine tube and 188 other tissues
ExpressionAtlasiQ8TCT7, baseline and differential
GenevisibleiQ8TCT7, HS

Family and domain databases

InterProiView protein in InterPro
IPR003137, PA_domain
IPR007369, Peptidase_A22B_SPP
IPR006639, Preselin/SPP
IPR033149, SPPL2B
PANTHERiPTHR12174, PTHR12174, 1 hit
PTHR12174:SF39, PTHR12174:SF39, 1 hit
PfamiView protein in Pfam
PF02225, PA, 1 hit
PF04258, Peptidase_A22B, 1 hit
SMARTiView protein in SMART
SM00730, PSN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPP2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCT7
Secondary accession number(s): D6W609
, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 16, 2006
Last modified: February 10, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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