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Entry version 139 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Phosphoethanolamine/phosphocholine phosphatase

Gene

PHOSPHO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005).

Involved in the generation of inorganic phosphate for bone mineralization (By similarity).

Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity).

By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3 µM for PEA1 Publication
  2. KM=11.4 µM for PCho1 Publication

pH dependencei

Optimum pH is 6.7.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32Nucleophile1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi32MagnesiumBy similarity1
Active sitei34Proton donorBy similarity1
Metal bindingi34MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43Substrate1 Publication1
Binding sitei123Substrate1 Publication1
Metal bindingi203MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processMineral balance
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS16266-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.75, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TCT1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483191, Synthesis of PC
R-HSA-1483213, Synthesis of PE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphoethanolamine/phosphocholine phosphatase (EC:3.1.3.751 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHOSPHO11 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16815, PHOSPHO1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TCT1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173868

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32D → N: Abolishes phosphatase activity. 1 Publication1
Mutagenesisi43D → N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-123. 1 Publication1
Mutagenesisi123D → N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-43. 1 Publication1
Mutagenesisi203D → S: Abolishes phosphatase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
162466

Open Targets

More...
OpenTargetsi
ENSG00000173868

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33276

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TCT1, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL6113

Drug and drug target database

More...
DrugBanki
DB00122, Choline

DrugCentral

More...
DrugCentrali
Q8TCT1

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHOSPHO1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74715842

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688291 – 267Phosphoethanolamine/phosphocholine phosphataseAdd BLAST267

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TCT1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TCT1

PeptideAtlas

More...
PeptideAtlasi
Q8TCT1

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCT1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19044
74155 [Q8TCT1-1]
74156 [Q8TCT1-2]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
PHOSPHO1

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCT1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCT1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173868, Expressed in blood and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TCT1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TCT1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000173868, Group enriched (blood, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127819, 58 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TCT1, 54 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406909

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8TCT1

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TCT1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3120, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007741

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_068983_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCT1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GYYNEYM

Database of Orthologous Groups

More...
OrthoDBi
1454608at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCT1

TreeFam database of animal gene trees

More...
TreeFami
TF300112

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412, HAD-like_sf
IPR006384, HAD_hydro_PyrdxlP_Pase-like
IPR023214, HAD_sf
IPR016965, Pase_PHOSPHO-typ

The PANTHER Classification System

More...
PANTHERi
PTHR20889, PTHR20889, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06888, Put_Phosphatase, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF031051, PyrdxlP_Pase_PHOSPHO2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01489, DKMTPPase-SF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCT1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGCFPVSGL RCLSRDGRMA AQGAPRFLLT FDFDETIVDE NSDDSIVRAA
60 70 80 90 100
PGQRLPESLR ATYREGFYNE YMQRVFKYLG EQGVRPRDLS AIYEAIPLSP
110 120 130 140 150
GMSDLLQFVA KQGACFEVIL ISDANTFGVE SSLRAAGHHS LFRRILSNPS
160 170 180 190 200
GPDARGLLAL RPFHTHSCAR CPANMCKHKV LSDYLRERAH DGVHFERLFY
210 220 230 240 250
VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP SSFRASVVPW
260
ETAADVRLHL QQVLKSC
Length:267
Mass (Da):29,713
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i539F65C749D39E81
GO
Isoform 2 (identifier: Q8TCT1-2) [UniParc]FASTAAdd to basket
Also known as: PHOSPHO1-3a

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSGCFPVSGLRCLSR → MCQRLWPANQPLPGGLLPRPLSLAPSSSSSCCSPPCSQ

Show »
Length:290
Mass (Da):32,068
Checksum:iE7E5C497A540C458
GO
Isoform 3 (identifier: Q8TCT1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MSGCFPVSGLRCLSR → MCQRLWPWPANQPLPGGLLPRPLSLAPSSSSSCCSPPCSQ

Show »
Length:292
Mass (Da):32,351
Checksum:i8D7E3926D78350B5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHH9D6RHH9_HUMAN
Phosphoethanolamine/phosphocholine ...
PHOSPHO1
203Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIT6D6RIT6_HUMAN
Phosphoethanolamine/phosphocholine ...
PHOSPHO1
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L4N1I3L4N1_HUMAN
Phosphoethanolamine/phosphocholine ...
PHOSPHO1
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RB58D6RB58_HUMAN
Phosphoethanolamine/phosphocholine ...
PHOSPHO1
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0406241 – 15MSGCF…RCLSR → MCQRLWPANQPLPGGLLPRP LSLAPSSSSSCCSPPCSQ in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0457091 – 15MSGCF…RCLSR → MCQRLWPWPANQPLPGGLLP RPLSLAPSSSSSCCSPPCSQ in isoform 3. 1 PublicationAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ457189 mRNA Translation: CAD29803.1
AC004797 Genomic DNA No translation available.
BC029931 mRNA No translation available.
BC117187 mRNA Translation: AAI17188.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11547.1 [Q8TCT1-1]
CCDS45726.1 [Q8TCT1-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001137276.1, NM_001143804.1 [Q8TCT1-3]
NP_848595.1, NM_178500.3 [Q8TCT1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310544; ENSP00000311925; ENSG00000173868 [Q8TCT1-1]
ENST00000413580; ENSP00000406909; ENSG00000173868 [Q8TCT1-3]
ENST00000514112; ENSP00000427694; ENSG00000173868 [Q8TCT1-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
162466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:162466

UCSC genome browser

More...
UCSCi
uc002ios.2, human [Q8TCT1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ457189 mRNA Translation: CAD29803.1
AC004797 Genomic DNA No translation available.
BC029931 mRNA No translation available.
BC117187 mRNA Translation: AAI17188.1
CCDSiCCDS11547.1 [Q8TCT1-1]
CCDS45726.1 [Q8TCT1-3]
RefSeqiNP_001137276.1, NM_001143804.1 [Q8TCT1-3]
NP_848595.1, NM_178500.3 [Q8TCT1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi127819, 58 interactors
IntActiQ8TCT1, 54 interactors
STRINGi9606.ENSP00000406909

Chemistry databases

BindingDBiQ8TCT1
ChEMBLiCHEMBL6113
DrugBankiDB00122, Choline
DrugCentraliQ8TCT1

PTM databases

DEPODiPHOSPHO1
iPTMnetiQ8TCT1
PhosphoSitePlusiQ8TCT1

Genetic variation databases

BioMutaiPHOSPHO1
DMDMi74715842

Proteomic databases

MassIVEiQ8TCT1
PaxDbiQ8TCT1
PeptideAtlasiQ8TCT1
PRIDEiQ8TCT1
ProteomicsDBi19044
74155 [Q8TCT1-1]
74156 [Q8TCT1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
30368, 153 antibodies

The DNASU plasmid repository

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DNASUi
162466

Genome annotation databases

EnsembliENST00000310544; ENSP00000311925; ENSG00000173868 [Q8TCT1-1]
ENST00000413580; ENSP00000406909; ENSG00000173868 [Q8TCT1-3]
ENST00000514112; ENSP00000427694; ENSG00000173868 [Q8TCT1-3]
GeneIDi162466
KEGGihsa:162466
UCSCiuc002ios.2, human [Q8TCT1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
162466
DisGeNETi162466

GeneCards: human genes, protein and diseases

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GeneCardsi
PHOSPHO1
HGNCiHGNC:16815, PHOSPHO1
HPAiENSG00000173868, Group enriched (blood, testis)
neXtProtiNX_Q8TCT1
OpenTargetsiENSG00000173868
PharmGKBiPA33276
VEuPathDBiHostDB:ENSG00000173868

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3120, Eukaryota
GeneTreeiENSGT00390000007741
HOGENOMiCLU_068983_0_1_1
InParanoidiQ8TCT1
OMAiGYYNEYM
OrthoDBi1454608at2759
PhylomeDBiQ8TCT1
TreeFamiTF300112

Enzyme and pathway databases

BioCyciMetaCyc:HS16266-MONOMER
BRENDAi3.1.3.75, 2681
PathwayCommonsiQ8TCT1
ReactomeiR-HSA-1483191, Synthesis of PC
R-HSA-1483213, Synthesis of PE

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
162466, 3 hits in 1003 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
162466
PharosiQ8TCT1, Tchem

Protein Ontology

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PROi
PR:Q8TCT1
RNActiQ8TCT1, protein

Gene expression databases

BgeeiENSG00000173868, Expressed in blood and 113 other tissues
ExpressionAtlasiQ8TCT1, baseline and differential
GenevisibleiQ8TCT1, HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412, HAD-like_sf
IPR006384, HAD_hydro_PyrdxlP_Pase-like
IPR023214, HAD_sf
IPR016965, Pase_PHOSPHO-typ
PANTHERiPTHR20889, PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888, Put_Phosphatase, 1 hit
PIRSFiPIRSF031051, PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
TIGRFAMsiTIGR01489, DKMTPPase-SF, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHOP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCT1
Secondary accession number(s): E9PAM0, Q17RU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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