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Entry version 134 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Phosphoethanolamine/phosphocholine phosphatase

Gene

PHOSPHO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3 µM for PEA1 Publication
  2. KM=11.4 µM for PCho1 Publication

    pH dependencei

    Optimum pH is 6.7.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei32NucleophileCurated1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi32MagnesiumCurated1
    Active sitei34Proton donorBy similarity1
    Metal bindingi34MagnesiumBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei43SubstrateCurated1
    Binding sitei123SubstrateCurated1
    Metal bindingi203MagnesiumCurated1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processMineral balance
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS16266-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.1.3.75, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q8TCT1

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1483191, Synthesis of PC
    R-HSA-1483213, Synthesis of PE

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphoethanolamine/phosphocholine phosphatase (EC:3.1.3.75)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000173868.11

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16815, PHOSPHO1

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8TCT1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32D → N: Abolishes phosphatase activity. 1 Publication1
    Mutagenesisi43D → N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-123. 1 Publication1
    Mutagenesisi123D → N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-43. 1 Publication1
    Mutagenesisi203D → S: Abolishes phosphatase activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    162466

    Open Targets

    More...
    OpenTargetsi
    ENSG00000173868

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA33276

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8TCT1, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL6113

    Drug and drug target database

    More...
    DrugBanki
    DB00122, Choline
    DB14006, Choline salicylate

    DrugCentral

    More...
    DrugCentrali
    Q8TCT1

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PHOSPHO1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74715842

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000688291 – 267Phosphoethanolamine/phosphocholine phosphataseAdd BLAST267

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8TCT1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8TCT1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8TCT1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8TCT1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    19044
    74155 [Q8TCT1-1]
    74156 [Q8TCT1-2]

    PTM databases

    DEPOD human dephosphorylation database

    More...
    DEPODi
    PHOSPHO1

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8TCT1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8TCT1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000173868, Expressed in blood and 111 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8TCT1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8TCT1, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000173868, Group enriched (blood, testis)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    127819, 58 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8TCT1, 54 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000406909

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q8TCT1

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8TCT1, protein

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3120, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000007741

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_068983_0_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8TCT1

    KEGG Orthology (KO)

    More...
    KOi
    K06124

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    LGPYHSH

    Database of Orthologous Groups

    More...
    OrthoDBi
    1454608at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8TCT1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300112

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.50.1000, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036412, HAD-like_sf
    IPR023214, HAD_sf
    IPR016965, Pase_PHOSPHO-typ
    IPR006384, PyrdxlP_Pase-rel

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR20889, PTHR20889, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF06888, Put_Phosphatase, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF031051, PyrdxlP_Pase_PHOSPHO2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56784, SSF56784, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01489, DKMTPPase-SF, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8TCT1-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MSGCFPVSGL RCLSRDGRMA AQGAPRFLLT FDFDETIVDE NSDDSIVRAA
    60 70 80 90 100
    PGQRLPESLR ATYREGFYNE YMQRVFKYLG EQGVRPRDLS AIYEAIPLSP
    110 120 130 140 150
    GMSDLLQFVA KQGACFEVIL ISDANTFGVE SSLRAAGHHS LFRRILSNPS
    160 170 180 190 200
    GPDARGLLAL RPFHTHSCAR CPANMCKHKV LSDYLRERAH DGVHFERLFY
    210 220 230 240 250
    VGDGANDFCP MGLLAGGDVA FPRRGYPMHR LIQEAQKAEP SSFRASVVPW
    260
    ETAADVRLHL QQVLKSC
    Length:267
    Mass (Da):29,713
    Last modified:June 1, 2002 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i539F65C749D39E81
    GO
    Isoform 2 (identifier: Q8TCT1-2) [UniParc]FASTAAdd to basket
    Also known as: PHOSPHO1-3a

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MSGCFPVSGLRCLSR → MCQRLWPANQPLPGGLLPRPLSLAPSSSSSCCSPPCSQ

    Show »
    Length:290
    Mass (Da):32,068
    Checksum:iE7E5C497A540C458
    GO
    Isoform 3 (identifier: Q8TCT1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-15: MSGCFPVSGLRCLSR → MCQRLWPWPANQPLPGGLLPRPLSLAPSSSSSCCSPPCSQ

    Show »
    Length:292
    Mass (Da):32,351
    Checksum:i8D7E3926D78350B5
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    D6RHH9D6RHH9_HUMAN
    Phosphoethanolamine/phosphocholine ...
    PHOSPHO1
    203Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RIT6D6RIT6_HUMAN
    Phosphoethanolamine/phosphocholine ...
    PHOSPHO1
    111Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    D6RB58D6RB58_HUMAN
    Phosphoethanolamine/phosphocholine ...
    PHOSPHO1
    166Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    I3L4N1I3L4N1_HUMAN
    Phosphoethanolamine/phosphocholine ...
    PHOSPHO1
    86Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0406241 – 15MSGCF…RCLSR → MCQRLWPANQPLPGGLLPRP LSLAPSSSSSCCSPPCSQ in isoform 2. 1 PublicationAdd BLAST15
    Alternative sequenceiVSP_0457091 – 15MSGCF…RCLSR → MCQRLWPWPANQPLPGGLLP RPLSLAPSSSSSCCSPPCSQ in isoform 3. 1 PublicationAdd BLAST15

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ457189 mRNA Translation: CAD29803.1
    AC004797 Genomic DNA No translation available.
    BC029931 mRNA No translation available.
    BC117187 mRNA Translation: AAI17188.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11547.1 [Q8TCT1-1]
    CCDS45726.1 [Q8TCT1-3]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001137276.1, NM_001143804.1 [Q8TCT1-3]
    NP_848595.1, NM_178500.3 [Q8TCT1-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000310544; ENSP00000311925; ENSG00000173868 [Q8TCT1-1]
    ENST00000413580; ENSP00000406909; ENSG00000173868 [Q8TCT1-3]
    ENST00000514112; ENSP00000427694; ENSG00000173868 [Q8TCT1-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    162466

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:162466

    UCSC genome browser

    More...
    UCSCi
    uc002ios.2, human [Q8TCT1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ457189 mRNA Translation: CAD29803.1
    AC004797 Genomic DNA No translation available.
    BC029931 mRNA No translation available.
    BC117187 mRNA Translation: AAI17188.1
    CCDSiCCDS11547.1 [Q8TCT1-1]
    CCDS45726.1 [Q8TCT1-3]
    RefSeqiNP_001137276.1, NM_001143804.1 [Q8TCT1-3]
    NP_848595.1, NM_178500.3 [Q8TCT1-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGRIDi127819, 58 interactors
    IntActiQ8TCT1, 54 interactors
    STRINGi9606.ENSP00000406909

    Chemistry databases

    BindingDBiQ8TCT1
    ChEMBLiCHEMBL6113
    DrugBankiDB00122, Choline
    DB14006, Choline salicylate
    DrugCentraliQ8TCT1

    PTM databases

    DEPODiPHOSPHO1
    iPTMnetiQ8TCT1
    PhosphoSitePlusiQ8TCT1

    Polymorphism and mutation databases

    BioMutaiPHOSPHO1
    DMDMi74715842

    Proteomic databases

    MassIVEiQ8TCT1
    PaxDbiQ8TCT1
    PeptideAtlasiQ8TCT1
    PRIDEiQ8TCT1
    ProteomicsDBi19044
    74155 [Q8TCT1-1]
    74156 [Q8TCT1-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    30368, 147 antibodies

    Genome annotation databases

    EnsembliENST00000310544; ENSP00000311925; ENSG00000173868 [Q8TCT1-1]
    ENST00000413580; ENSP00000406909; ENSG00000173868 [Q8TCT1-3]
    ENST00000514112; ENSP00000427694; ENSG00000173868 [Q8TCT1-3]
    GeneIDi162466
    KEGGihsa:162466
    UCSCiuc002ios.2, human [Q8TCT1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    162466
    DisGeNETi162466
    EuPathDBiHostDB:ENSG00000173868.11

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PHOSPHO1
    HGNCiHGNC:16815, PHOSPHO1
    HPAiENSG00000173868, Group enriched (blood, testis)
    neXtProtiNX_Q8TCT1
    OpenTargetsiENSG00000173868
    PharmGKBiPA33276

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3120, Eukaryota
    GeneTreeiENSGT00390000007741
    HOGENOMiCLU_068983_0_1_1
    InParanoidiQ8TCT1
    KOiK06124
    OMAiLGPYHSH
    OrthoDBi1454608at2759
    PhylomeDBiQ8TCT1
    TreeFamiTF300112

    Enzyme and pathway databases

    BioCyciMetaCyc:HS16266-MONOMER
    BRENDAi3.1.3.75, 2681
    PathwayCommonsiQ8TCT1
    ReactomeiR-HSA-1483191, Synthesis of PC
    R-HSA-1483213, Synthesis of PE

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    162466, 3 hits in 867 CRISPR screens

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    162466
    PharosiQ8TCT1, Tchem

    Protein Ontology

    More...
    PROi
    PR:Q8TCT1
    RNActiQ8TCT1, protein

    Gene expression databases

    BgeeiENSG00000173868, Expressed in blood and 111 other tissues
    ExpressionAtlasiQ8TCT1, baseline and differential
    GenevisibleiQ8TCT1, HS

    Family and domain databases

    Gene3Di3.40.50.1000, 1 hit
    InterProiView protein in InterPro
    IPR036412, HAD-like_sf
    IPR023214, HAD_sf
    IPR016965, Pase_PHOSPHO-typ
    IPR006384, PyrdxlP_Pase-rel
    PANTHERiPTHR20889, PTHR20889, 1 hit
    PfamiView protein in Pfam
    PF06888, Put_Phosphatase, 1 hit
    PIRSFiPIRSF031051, PyrdxlP_Pase_PHOSPHO2, 1 hit
    SUPFAMiSSF56784, SSF56784, 1 hit
    TIGRFAMsiTIGR01489, DKMTPPase-SF, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHOP1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCT1
    Secondary accession number(s): E9PAM0, Q17RU6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: June 1, 2002
    Last modified: October 7, 2020
    This is version 134 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families
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