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UniProtKB - Q8TCT0 (CERK1_HUMAN)

Entry version 164 (29 Sep 2021)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Ceramide kinase

Gene

CERK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate (PubMed:11956206, PubMed:16269826, PubMed:19168031).

Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines (PubMed:11956206, PubMed:16269826, PubMed:19168031).

Shows a greater preference for D-erythro isomer of ceramides (PubMed:16269826).

Binds phosphoinositides (PubMed:19168031).

3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+2 Publications, Mg2+2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by sulfatide (PubMed:19168031). Inhibited by sphinganine, sphingenine, and N,N-Dimethylsphingosine (DMS) (PubMed:16269826). Cardiolipin at 0.1 µM significantly increases activity, whereas at concentrations >1 µM has an inhibitory effect (PubMed:27725450).3 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=187 µM for C8 ceramide1 Publication
  2. KM=30 µM for C6 ceramide1 Publication
  3. KM=22 µM for C2 ceramide1 Publication
  4. KM=400 µM for ATP (in the presence of 3 mM Mg2+)1 Publication
  5. KM=32 µM for ATP1 Publication
  1. Vmax=35 nmol/min/mg enzyme for C6 ceramide1 Publication

pH dependencei

Optimum pH is 6.0-7.8.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei197Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei202ATPPROSITE-ProRule annotation1
Binding sitei304ATPPROSITE-ProRule annotation1
Binding sitei310ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi138 – 140ATPPROSITE-ProRule annotation3
Nucleotide bindingi170 – 174ATPPROSITE-ProRule annotation5
Nucleotide bindingi239 – 241ATPPROSITE-ProRule annotation3
Nucleotide bindingi502 – 504ATPPROSITE-ProRule annotation3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
Biological processLipid metabolism
LigandATP-binding, Calcium, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.138, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TCT0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660662, Glycosphingolipid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8TCT0

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001354

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ceramide kinase (EC:2.7.1.1383 Publications)
Short name:
hCERK
Alternative name(s):
Acylsphingosine kinase
Lipid kinase 4
Short name:
LK4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CERK
Synonyms:KIAA1646
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19256, CERK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610307, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TCT0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000100422

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi10L → A: 99% decrease in catalytic activity but no effect on substrate affinity. 1 Publication1
Mutagenesisi10L → I: 71% decrease in catalytic activity but no effect on substrate affinity. 1 Publication1
Mutagenesisi340S → A: 15% decrease in catalytic activity and decreased stability. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		64781

Open Targets

More...OpenTargetsi		ENSG00000100422

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134958321

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TCT0, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1764936

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2473

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CERK

Domain mapping of disease mutations (DMDM)

More...DMDMi		30172885

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001813541 – 537Ceramide kinaseAdd BLAST537

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei340Phosphoserine1 Publication1
Modified residuei408Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TCT0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TCT0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TCT0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TCT0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TCT0

PeptideAtlas

More...PeptideAtlasi		Q8TCT0

PRoteomics IDEntifications database

More...PRIDEi		Q8TCT0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66749
74154 [Q8TCT0-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TCT0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TCT0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High level expression in heart, brain, skeletal muscle, kidney and liver; moderate in peripheral blood leukocytes and thymus; very low in spleen, small intestine, placenta and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100422, Expressed in islet of Langerhans and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TCT0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TCT0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100422, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122291, 67 interactors

Protein interaction database and analysis system

More...IntActi		Q8TCT0, 60 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216264

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8TCT0

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TCT0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TCT0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini128 – 278DAGKcPROSITE-ProRule annotationAdd BLAST151

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 125Required for binding to sulfatide and phosphoinositides1 PublicationAdd BLAST125
Regioni1 – 115Essential for enzyme activity1 PublicationAdd BLAST115
Regioni195 – 198Substrate bindingBy similarity4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1115, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156976

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_013399_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TCT0

Identification of Orthologs from Complete Genome Data

More...OMAi		TICRTNC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TCT0

TreeFam database of animal gene trees

More...TreeFami		TF314514

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.10330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00781, DAGK_cat, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00046, DAGKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111331, SSF111331, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50146, DAGK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGATGAAEPL QSVLWVKQQR CAVSLEPARA LLRWWRSPGP GAGAPGADAC 
        60         70         80         90        100
SVPVSEIIAV EETDVHGKHQ GSGKWQKMEK PYAFTVHCVK RARRHRWKWA 
       110        120        130        140        150
QVTFWCPEEQ LCHLWLQTLR EMLEKLTSRP KHLLVFINPF GGKGQGKRIY 
       160        170        180        190        200
ERKVAPLFTL ASITTDIIVT EHANQAKETL YEINIDKYDG IVCVGGDGMF 
       210        220        230        240        250
SEVLHGLIGR TQRSAGVDQN HPRAVLVPSS LRIGIIPAGS TDCVCYSTVG 
       260        270        280        290        300
TSDAETSALH IVVGDSLAMD VSSVHHNSTL LRYSVSLLGY GFYGDIIKDS 
       310        320        330        340        350
EKKRWLGLAR YDFSGLKTFL SHHCYEGTVS FLPAQHTVGS PRDRKPCRAG 
       360        370        380        390        400
CFVCRQSKQQ LEEEQKKALY GLEAAEDVEE WQVVCGKFLA INATNMSCAC 
       410        420        430        440        450
RRSPRGLSPA AHLGDGSSDL ILIRKCSRFN FLRFLIRHTN QQDQFDFTFV 
       460        470        480        490        500
EVYRVKKFQF TSKHMEDEDS DLKEGGKKRF GHICSSHPSC CCTVSNSSWN 
       510        520        530 
CDGEVLHSPA IEVRVHCQLV RLFARGIEEN PKPDSHS
Length:537
Mass (Da):59,977
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3DBFC0ED8D679F7F
GO
Isoform 2 (identifier: Q8TCT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-198: Missing.

Show »
Length:339
Mass (Da):37,781
Checksum:iA4C2ACDFF2E6F3D0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFD8F8WFD8_HUMAN
Ceramide kinase
CERK
185Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053685191I → V. Corresponds to variant dbSNP:rs16995615Ensembl.1
Natural variantiVAR_053686211T → M. Corresponds to variant dbSNP:rs9306515Ensembl.1
Natural variantiVAR_053687306L → F. Corresponds to variant dbSNP:rs13057352Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569441 – 198Missing in isoform 2. 1 PublicationAdd BLAST198

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB079066 mRNA Translation: BAC01154.1
AJ457828 mRNA Translation: CAD29884.1
CR456404 mRNA Translation: CAG30290.1
AK291476 mRNA Translation: BAF84165.1
AL096766 Genomic DNA No translation available.
AL118516 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73440.1
CH471138 Genomic DNA Translation: EAW73442.1
BC067255 mRNA Translation: AAH67255.1
BC126940 mRNA Translation: AAI26941.1
AB051433 mRNA Translation: BAB33316.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14077.1 [Q8TCT0-1]

NCBI Reference Sequences

More...RefSeqi		NP_073603.2, NM_022766.5 [Q8TCT0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216264; ENSP00000216264; ENSG00000100422 [Q8TCT0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64781

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64781

UCSC genome browser

More...UCSCi		uc003bia.4, human [Q8TCT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079066 mRNA Translation: BAC01154.1
AJ457828 mRNA Translation: CAD29884.1
CR456404 mRNA Translation: CAG30290.1
AK291476 mRNA Translation: BAF84165.1
AL096766 Genomic DNA No translation available.
AL118516 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73440.1
CH471138 Genomic DNA Translation: EAW73442.1
BC067255 mRNA Translation: AAH67255.1
BC126940 mRNA Translation: AAI26941.1
AB051433 mRNA Translation: BAB33316.1
CCDSiCCDS14077.1 [Q8TCT0-1]
RefSeqiNP_073603.2, NM_022766.5 [Q8TCT0-1]

3D structure databases

SMRiQ8TCT0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi122291, 67 interactors
IntActiQ8TCT0, 60 interactors
STRINGi9606.ENSP00000216264

Chemistry databases

BindingDBiQ8TCT0
ChEMBLiCHEMBL1764936
GuidetoPHARMACOLOGYi2473
SwissLipidsiSLP:000001354

PTM databases

iPTMnetiQ8TCT0
PhosphoSitePlusiQ8TCT0

Genetic variation databases

BioMutaiCERK
DMDMi30172885

Proteomic databases

EPDiQ8TCT0
jPOSTiQ8TCT0
MassIVEiQ8TCT0
MaxQBiQ8TCT0
PaxDbiQ8TCT0
PeptideAtlasiQ8TCT0
PRIDEiQ8TCT0
ProteomicsDBi66749
74154 [Q8TCT0-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		326, 323 antibodies

The DNASU plasmid repository

More...DNASUi		64781

Genome annotation databases

EnsembliENST00000216264; ENSP00000216264; ENSG00000100422 [Q8TCT0-1]
GeneIDi64781
KEGGihsa:64781
UCSCiuc003bia.4, human [Q8TCT0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64781
DisGeNETi64781

GeneCards: human genes, protein and diseases

More...GeneCardsi		CERK
HGNCiHGNC:19256, CERK
HPAiENSG00000100422, Low tissue specificity
MIMi610307, gene
neXtProtiNX_Q8TCT0
OpenTargetsiENSG00000100422
PharmGKBiPA134958321
VEuPathDBiHostDB:ENSG00000100422

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1115, Eukaryota
GeneTreeiENSGT00940000156976
HOGENOMiCLU_013399_2_2_1
InParanoidiQ8TCT0
OMAiTICRTNC
PhylomeDBiQ8TCT0
TreeFamiTF314514

Enzyme and pathway databases

BRENDAi2.7.1.138, 2681
PathwayCommonsiQ8TCT0
ReactomeiR-HSA-1660662, Glycosphingolipid metabolism
SABIO-RKiQ8TCT0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64781, 4 hits in 1023 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CERK, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CERK

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64781
PharosiQ8TCT0, Tchem

Protein Ontology

More...PROi		PR:Q8TCT0
RNActiQ8TCT0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100422, Expressed in islet of Langerhans and 223 other tissues
ExpressionAtlasiQ8TCT0, baseline and differential
GenevisibleiQ8TCT0, HS

Family and domain databases

Gene3Di3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438, ATP-NAD_kinase_N
IPR001206, Diacylglycerol_kinase_cat_dom
IPR016064, NAD/diacylglycerol_kinase_sf
PfamiView protein in Pfam
PF00781, DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00046, DAGKc, 1 hit
SUPFAMiSSF111331, SSF111331, 1 hit
PROSITEiView protein in PROSITE
PS50146, DAGK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCERK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCT0
Secondary accession number(s): A0JNT4
, A8K611, Q6NX59, Q9BYB3, Q9UGE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: June 1, 2002
Last modified: September 29, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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