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Protein

Protein CIP2A

Gene

CIP2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.1 Publication

Miscellaneous

Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.2 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CIP2ACurated
Alternative name(s):
Cancerous inhibitor of PP2A1 Publication
p90 autoantigen1 Publication
Gene namesi
Name:CIP2AImported
Synonyms:KIAA1524
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163507.13
HGNCiHGNC:29302 CIP2A
MIMi610643 gene
neXtProtiNX_Q8TCG1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi230N → E: Reduces binding to PPP2R5C. 1 Publication1
Mutagenesisi522R → D: Decreases homodimerization. Reduces binding to PPP2R5C. Decreases protein level. 1 Publication1
Mutagenesisi533L → E: Decreases homodimerization. Reduces binding to PPP2R5C. Decreases protein level. 1 Publication1

Organism-specific databases

DisGeNETi57650
OpenTargetsiENSG00000163507
PharmGKBiPA134887850

Chemistry databases

ChEMBLiCHEMBL2146355

Polymorphism and mutation databases

BioMutaiKIAA1524
DMDMi147647143

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002871411 – 905Protein CIP2AAdd BLAST905

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei573PhosphoserineCombined sources1
Modified residuei904PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TCG1
MaxQBiQ8TCG1
PaxDbiQ8TCG1
PeptideAtlasiQ8TCG1
PRIDEiQ8TCG1
ProteomicsDBi74132
74133 [Q8TCG1-2]

PTM databases

iPTMnetiQ8TCG1
PhosphoSitePlusiQ8TCG1

Expressioni

Tissue specificityi

Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000163507 Expressed in 114 organ(s), highest expression level in kidney
CleanExiHS_KIAA1524
ExpressionAtlasiQ8TCG1 baseline and differential
GenevisibleiQ8TCG1 HS

Organism-specific databases

HPAiHPA039570

Interactioni

Subunit structurei

Homodimer (PubMed:28174209). Interacts with MYC (PubMed:17632056). Interacts with PPP2R5C; this interaction stabilizes CIP2A (PubMed:28174209). Interacts with PPP2R1A; this interaction stabilizes CIP2A (PubMed:28174209).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121687, 67 interactors
IntActiQ8TCG1, 14 interactors
MINTiQ8TCG1
STRINGi9606.ENSP00000295746

Structurei

Secondary structure

1905
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TCG1
SMRiQ8TCG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 245Required for interaction with PPP2R5C1 PublicationAdd BLAST87
Regioni388 – 558Required for homodimerization1 PublicationAdd BLAST171

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili637 – 883Sequence analysisAdd BLAST247

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ1I Eukaryota
ENOG4110856 LUCA
GeneTreeiENSGT00390000006861
HOVERGENiHBG107688
InParanoidiQ8TCG1
PhylomeDBiQ8TCG1
TreeFamiTF328534

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCG1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDSTACLKSL LLTVSQYKAV KSEANATQLL RHLEVISGQK LTRLFTSNQI
60 70 80 90 100
LTSECLSCLV ELLEDPNISA SLILSIIGLL SQLAVDIETR DCLQNTYNLN
110 120 130 140 150
SVLAGVVCRS SHTDSVFLQC IQLLQKLTYN VKIFYSGANI DELITFLIDH
160 170 180 190 200
IQSSEDELKM PCLGLLANLC RHNLSVQTHI KTLSNVKSFY RTLITLLAHS
210 220 230 240 250
SLTVVVFALS ILSSLTLNEE VGEKLFHARN IHQTFQLIFN ILINGDGTLT
260 270 280 290 300
RKYSVDLLMD LLKNPKIADY LTRYEHFSSC LHQVLGLLNG KDPDSSSKVL
310 320 330 340 350
ELLLAFCSVT QLRHMLTQMM FEQSPPGSAT LGSHTKCLEP TVALLRWLSQ
360 370 380 390 400
PLDGSENCSV LALELFKEIF EDVIDAANCS SADRFVTLLL PTILDQLQFT
410 420 430 440 450
EQNLDEALTR KKCERIAKAI EVLLTLCGDD TLKMHIAKIL TTVKCTTLIE
460 470 480 490 500
QQFTYGKIDL GFGTKVADSE LCKLAADVIL KTLDLINKLK PLVPGMEVSF
510 520 530 540 550
YKILQDPRLI TPLAFALTSD NREQVQSGLR ILLEAAPLPD FPALVLGESI
560 570 580 590 600
AANNAYRQQE TEHIPRKMPW QSSNHSFPTS IKCLTPHLKD GVPGLNIEEL
610 620 630 640 650
IEKLQSGMVV KDQICDVRIS DIMDVYEMKL STLASKESRL QDLLETKALA
660 670 680 690 700
LAQADRLIAQ HRCQRTQAET EARTLASMLR EVERKNEELS VLLKAQQVES
710 720 730 740 750
ERAQSDIEHL FQHNRKLESV AEEHEILTKS YMELLQRNES TEKKNKDLQI
760 770 780 790 800
TCDSLNKQIE TVKKLNESLK EQNEKSIAQL IEKEEQRKEV QNQLVDREHK
810 820 830 840 850
LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE QIRKELSIKA
860 870 880 890 900
SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET

VNLSI
Length:905
Mass (Da):102,185
Last modified:May 15, 2007 - v2
Checksum:iDAB9CCC03BCEA304
GO
Isoform 2 (identifier: Q8TCG1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-159: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,579
Checksum:i926A1001A55C4248
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X211A0A087X211_HUMAN
Protein CIP2A
CIP2A
906Annotation score:
F8WAX6F8WAX6_HUMAN
Protein CIP2A
CIP2A
121Annotation score:
F8WF26F8WF26_HUMAN
Protein CIP2A
CIP2A
48Annotation score:

Sequence cautioni

The sequence AAH63433 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA96048 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14305 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti412 – 415KCER → NVKG in CAD28489 (PubMed:17974005).Curated4
Sequence conflicti419A → S in AAL11632 (PubMed:12118381).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046939126K → R. Corresponds to variant dbSNP:rs7648496Ensembl.1
Natural variantiVAR_046940229R → Q. Corresponds to variant dbSNP:rs2278911Ensembl.1
Natural variantiVAR_046941409T → I. Corresponds to variant dbSNP:rs9856308Ensembl.1
Natural variantiVAR_046942447T → A. Corresponds to variant dbSNP:rs34944683Ensembl.1
Natural variantiVAR_046943494P → L. Corresponds to variant dbSNP:rs13083928Ensembl.1
Natural variantiVAR_046944572S → A. Corresponds to variant dbSNP:rs34172460Ensembl.1
Natural variantiVAR_046945680R → T. Corresponds to variant dbSNP:rs6777766Ensembl.1
Natural variantiVAR_046946759I → V. Corresponds to variant dbSNP:rs13071874Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0253361 – 159Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA Translation: AAL11632.1
AB040957 mRNA Translation: BAA96048.1 Different initiation.
AL713689 mRNA Translation: CAD28489.1
BC017659 mRNA Translation: AAH17659.1
BC063433 mRNA Translation: AAH63433.1 Different initiation.
BC130564 mRNA Translation: AAI30565.1
BC136371 mRNA Translation: AAI36372.1
AK022912 mRNA Translation: BAB14305.1 Different initiation.
CCDSiCCDS33812.1 [Q8TCG1-1]
RefSeqiNP_065941.2, NM_020890.2 [Q8TCG1-1]
XP_006713780.1, XM_006713717.2 [Q8TCG1-2]
XP_011511358.1, XM_011513056.1 [Q8TCG1-2]
UniGeneiHs.591308

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507 [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507 [Q8TCG1-2]
GeneIDi57650
KEGGihsa:57650
UCSCiuc003dxb.5 human [Q8TCG1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF334474 mRNA Translation: AAL11632.1
AB040957 mRNA Translation: BAA96048.1 Different initiation.
AL713689 mRNA Translation: CAD28489.1
BC017659 mRNA Translation: AAH17659.1
BC063433 mRNA Translation: AAH63433.1 Different initiation.
BC130564 mRNA Translation: AAI30565.1
BC136371 mRNA Translation: AAI36372.1
AK022912 mRNA Translation: BAB14305.1 Different initiation.
CCDSiCCDS33812.1 [Q8TCG1-1]
RefSeqiNP_065941.2, NM_020890.2 [Q8TCG1-1]
XP_006713780.1, XM_006713717.2 [Q8TCG1-2]
XP_011511358.1, XM_011513056.1 [Q8TCG1-2]
UniGeneiHs.591308

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5UFLX-ray3.00A/B1-560[»]
ProteinModelPortaliQ8TCG1
SMRiQ8TCG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121687, 67 interactors
IntActiQ8TCG1, 14 interactors
MINTiQ8TCG1
STRINGi9606.ENSP00000295746

Chemistry databases

ChEMBLiCHEMBL2146355

PTM databases

iPTMnetiQ8TCG1
PhosphoSitePlusiQ8TCG1

Polymorphism and mutation databases

BioMutaiKIAA1524
DMDMi147647143

Proteomic databases

EPDiQ8TCG1
MaxQBiQ8TCG1
PaxDbiQ8TCG1
PeptideAtlasiQ8TCG1
PRIDEiQ8TCG1
ProteomicsDBi74132
74133 [Q8TCG1-2]

Protocols and materials databases

DNASUi57650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295746; ENSP00000295746; ENSG00000163507 [Q8TCG1-1]
ENST00000491772; ENSP00000419487; ENSG00000163507 [Q8TCG1-2]
GeneIDi57650
KEGGihsa:57650
UCSCiuc003dxb.5 human [Q8TCG1-1]

Organism-specific databases

CTDi57650
DisGeNETi57650
EuPathDBiHostDB:ENSG00000163507.13
GeneCardsiCIP2A
H-InvDBiHIX0003530
HGNCiHGNC:29302 CIP2A
HPAiHPA039570
MIMi610643 gene
neXtProtiNX_Q8TCG1
OpenTargetsiENSG00000163507
PharmGKBiPA134887850
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ1I Eukaryota
ENOG4110856 LUCA
GeneTreeiENSGT00390000006861
HOVERGENiHBG107688
InParanoidiQ8TCG1
PhylomeDBiQ8TCG1
TreeFamiTF328534

Miscellaneous databases

ChiTaRSiKIAA1524 human
GeneWikiiKIAA1524
GenomeRNAii57650
PROiPR:Q8TCG1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163507 Expressed in 114 organ(s), highest expression level in kidney
CleanExiHS_KIAA1524
ExpressionAtlasiQ8TCG1 baseline and differential
GenevisibleiQ8TCG1 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
SUPFAMiSSF48371 SSF48371, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCIP2A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCG1
Secondary accession number(s): A1L4J7
, B9EGC3, Q6P4G6, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: October 10, 2018
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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