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Protein

Protein FAM45A

Gene

FAM45A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM45A
Gene namesi
Name:FAM45A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119979.15
HGNCiHGNC:31793 FAM45A
neXtProtiNX_Q8TCE6

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134935316

Polymorphism and mutation databases

BioMutaiFAM45A
DMDMi51316043

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870341 – 357Protein FAM45AAdd BLAST357

Proteomic databases

EPDiQ8TCE6
MaxQBiQ8TCE6
PaxDbiQ8TCE6
PeptideAtlasiQ8TCE6
PRIDEiQ8TCE6
ProteomicsDBi74125
74126 [Q8TCE6-2]

PTM databases

iPTMnetiQ8TCE6
PhosphoSitePlusiQ8TCE6

Expressioni

Gene expression databases

BgeeiENSG00000119979
CleanExiHS_FAM45A
GenevisibleiQ8TCE6 HS

Organism-specific databases

HPAiHPA041159

Interactioni

Protein-protein interaction databases

BioGridi135667, 23 interactors
IntActiQ8TCE6, 9 interactors
STRINGi9606.ENSP00000354688

Structurei

3D structure databases

ProteinModelPortaliQ8TCE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140uDENNPROSITE-ProRule annotationAdd BLAST140
Domaini165 – 299cDENNPROSITE-ProRule annotationAdd BLAST135
Domaini301 – 357dDENNPROSITE-ProRule annotationAdd BLAST57

Sequence similaritiesi

Belongs to the FAM45 family.Curated

Phylogenomic databases

eggNOGiENOG410IGIW Eukaryota
ENOG410Z0E9 LUCA
GeneTreeiENSGT00390000014431
HOGENOMiHOG000007594
HOVERGENiHBG051536
InParanoidiQ8TCE6
OMAiMAMGKLH
OrthoDBiEOG091G0E6E
PhylomeDBiQ8TCE6
TreeFamiTF332501

Family and domain databases

InterProiView protein in InterPro
IPR037516 Tripartite_DENN
PROSITEiView protein in PROSITE
PS50211 DENN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TCE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAEVADTQ LMLGVGLIEK DTNGEVLWVW CYPSTTATLR NLLLRKCCLT
60 70 80 90 100
DENKLLHPFV FGQYRRTWFY ITTIEVPDSS ILKKVTHFSI VLTAKDFNPE
110 120 130 140 150
KYAAFTRILC RMYLKHGSPV KMMESYIAVL TKGICQSEEN GSFLSKDFDA
160 170 180 190 200
RKAYLAGSIK DIVSQFGMET VILHTALMLK KRIVVYHPKI EAVQEFTRTL
210 220 230 240 250
PALVWHRQDW TILHSYVHLN ADELEALQMC TGYVAGFVDL EVSNRPDLYD
260 270 280 290 300
VFVNLAESEI TIAPLAKEAM AMGKLHKEMG QLIVQSAEDP EKSESHVIQD
310 320 330 340 350
IALKTREIFT NLAPFSEVSA DGEKRVLNLE ALKQKRFPPA TENFLYHLAA

AEQMLKI
Length:357
Mass (Da):40,513
Last modified:June 1, 2002 - v1
Checksum:iB4AE072A5D9DB379
GO
Isoform 2 (identifier: Q8TCE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MAAAEVADTQLMLGVGLI → MLSSDHLSTV

Note: No experimental confirmation available.
Show »
Length:349
Mass (Da):39,799
Checksum:iF9665CCAFB39D52B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267K → R in BAA90894 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0383011 – 18MAAAE…GVGLI → MLSSDHLSTV in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000031 mRNA Translation: BAA90894.1
AK293136 mRNA Translation: BAG56684.1
AL355598 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49406.1
CH471066 Genomic DNA Translation: EAW49407.1
BC022271 mRNA Translation: AAH22271.1
CCDSiCCDS7609.1 [Q8TCE6-1]
RefSeqiNP_001290040.1, NM_001303111.1 [Q8TCE6-2]
NP_001290041.1, NM_001303112.1
NP_001290042.1, NM_001303113.1
NP_996892.1, NM_207009.3 [Q8TCE6-1]
XP_016871750.1, XM_017016261.1 [Q8TCE6-2]
XP_016871751.1, XM_017016262.1 [Q8TCE6-2]
XP_016871752.1, XM_017016263.1 [Q8TCE6-2]
UniGeneiHs.434241
Hs.567120

Genome annotation databases

EnsembliENST00000361432; ENSP00000354688; ENSG00000119979 [Q8TCE6-1]
GeneIDi404636
KEGGihsa:404636
UCSCiuc001ldw.5 human [Q8TCE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFA45A_HUMAN
AccessioniPrimary (citable) accession number: Q8TCE6
Secondary accession number(s): B1AMV6
, B4DDC3, D3DRC8, Q9NXW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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