Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Pyridoxal phosphate phosphatase PHOSPHO2

Gene

PHOSPHO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphatase that has high activity toward pyridoxal 5'-phosphate (PLP). Also active at much lower level toward pyrophosphate, phosphoethanolamine (PEA), phosphocholine (PCho), phospho-l-tyrosine, fructose-6-phosphate, p-nitrophenyl phosphate, and h-glycerophosphate.

Catalytic activityi

Pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate.1 Publication

Cofactori

Mg2+By similarity

Kineticsi

  1. KM=45.5 µM for pyridoxal 5'-phosphate1 Publication
  1. Vmax=633 nmol/min/mg enzyme with pyridoxal 5'-phosphate as substrate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8NucleophileBy similarity1
Metal bindingi8MagnesiumBy similarity1
Active sitei10Proton donorBy similarity1
Metal bindingi10MagnesiumBy similarity1
Binding sitei19SubstrateBy similarity1
Binding sitei99SubstrateBy similarity1
Metal bindingi179MagnesiumBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:HS07168-MONOMER
SABIO-RKiQ8TCD6

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal phosphate phosphatase PHOSPHO2 (EC:3.1.3.74)
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000144362.11
HGNCiHGNC:28316 PHOSPHO2
neXtProtiNX_Q8TCD6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000144362
PharmGKBiPA134947617

Polymorphism and mutation databases

BioMutaiPHOSPHO2
DMDMi74730590

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688331 – 241Pyridoxal phosphate phosphatase PHOSPHO2Add BLAST241

Proteomic databases

PaxDbiQ8TCD6
PeptideAtlasiQ8TCD6
PRIDEiQ8TCD6
ProteomicsDBi74123

PTM databases

DEPODiQ8TCD6
iPTMnetiQ8TCD6
PhosphoSitePlusiQ8TCD6

Expressioni

Gene expression databases

BgeeiENSG00000144362 Expressed in 185 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8TCD6 baseline and differential
GenevisibleiQ8TCD6 HS

Organism-specific databases

HPAiHPA034726
HPA034727

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi138930, 5 interactors
IntActiQ8TCD6, 8 interactors
STRINGi9606.ENSP00000352782

Structurei

3D structure databases

ProteinModelPortaliQ8TCD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3120 Eukaryota
ENOG4111NAQ LUCA
GeneTreeiENSGT00390000007741
HOGENOMiHOG000231038
HOVERGENiHBG080058
InParanoidiQ8TCD6
KOiK13248
OMAiSPNMCKG
OrthoDBiEOG091G0GZ1
PhylomeDBiQ8TCD6
TreeFamiTF300112

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016965 Pase_PHOSPHO-typ
IPR006384 PyrdxlP_Pase-rel
PANTHERiPTHR20889 PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888 Put_Phosphatase, 1 hit
PIRSFiPIRSF031051 PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TCD6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKILLVFDFD NTIIDDNSDT WIVQCAPNKK LPIELRDSYR KGFWTEFMGR
60 70 80 90 100
VFKYLGDKGV REHEMKRAVT SLPFTPGMVE LFNFIRKNKD KFDCIIISDS
110 120 130 140 150
NSVFIDWVLE AASFHDIFDK VFTNPAAFNS NGHLTVENYH THSCNRCPKN
160 170 180 190 200
LCKKVVLIEF VDKQLQQGVN YTQIVYIGDG GNDVCPVTFL KNDDVAMPRK
210 220 230 240
GYTLQKTLSR MSQNLEPMEY SVVVWSSGVD IISHLQFLIK D
Length:241
Mass (Da):27,769
Last modified:June 1, 2002 - v1
Checksum:iC9F0447F2A1A5FFA
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4G2C9J4G2_HUMAN
Pyridoxal phosphate phosphatase PHO...
PHOSPHO2
135Annotation score:
C9JZQ7C9JZQ7_HUMAN
Pyridoxal phosphate phosphatase PHO...
PHOSPHO2
55Annotation score:
C9JD35C9JD35_HUMAN
Pyridoxal phosphate phosphatase PHO...
PHOSPHO2
49Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062092206K → E. Corresponds to variant dbSNP:rs56036676Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314915 mRNA Translation: BAG37427.1
AC016772 Genomic DNA Translation: AAY24234.1
CH471058 Genomic DNA Translation: EAX11262.1
CH471058 Genomic DNA Translation: EAX11263.1
BC022324 mRNA Translation: AAH22324.1
BC106013 mRNA Translation: AAI06014.1
CCDSiCCDS33319.1
RefSeqiNP_001008489.1, NM_001008489.3
NP_001186214.1, NM_001199285.1
NP_001186215.1, NM_001199286.1
NP_001186216.1, NM_001199287.1
NP_001186217.1, NM_001199288.1
UniGeneiHs.745233

Genome annotation databases

EnsembliENST00000359744; ENSP00000352782; ENSG00000144362
ENST00000616481; ENSP00000481680; ENSG00000144362
ENST00000616524; ENSP00000481046; ENSG00000144362
ENST00000617738; ENSP00000481857; ENSG00000144362
GeneIDi493911
KEGGihsa:493911
UCSCiuc002ufg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK314915 mRNA Translation: BAG37427.1
AC016772 Genomic DNA Translation: AAY24234.1
CH471058 Genomic DNA Translation: EAX11262.1
CH471058 Genomic DNA Translation: EAX11263.1
BC022324 mRNA Translation: AAH22324.1
BC106013 mRNA Translation: AAI06014.1
CCDSiCCDS33319.1
RefSeqiNP_001008489.1, NM_001008489.3
NP_001186214.1, NM_001199285.1
NP_001186215.1, NM_001199286.1
NP_001186216.1, NM_001199287.1
NP_001186217.1, NM_001199288.1
UniGeneiHs.745233

3D structure databases

ProteinModelPortaliQ8TCD6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138930, 5 interactors
IntActiQ8TCD6, 8 interactors
STRINGi9606.ENSP00000352782

PTM databases

DEPODiQ8TCD6
iPTMnetiQ8TCD6
PhosphoSitePlusiQ8TCD6

Polymorphism and mutation databases

BioMutaiPHOSPHO2
DMDMi74730590

Proteomic databases

PaxDbiQ8TCD6
PeptideAtlasiQ8TCD6
PRIDEiQ8TCD6
ProteomicsDBi74123

Protocols and materials databases

DNASUi493911
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359744; ENSP00000352782; ENSG00000144362
ENST00000616481; ENSP00000481680; ENSG00000144362
ENST00000616524; ENSP00000481046; ENSG00000144362
ENST00000617738; ENSP00000481857; ENSG00000144362
GeneIDi493911
KEGGihsa:493911
UCSCiuc002ufg.4 human

Organism-specific databases

CTDi493911
EuPathDBiHostDB:ENSG00000144362.11
GeneCardsiPHOSPHO2
HGNCiHGNC:28316 PHOSPHO2
HPAiHPA034726
HPA034727
neXtProtiNX_Q8TCD6
OpenTargetsiENSG00000144362
PharmGKBiPA134947617
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3120 Eukaryota
ENOG4111NAQ LUCA
GeneTreeiENSGT00390000007741
HOGENOMiHOG000231038
HOVERGENiHBG080058
InParanoidiQ8TCD6
KOiK13248
OMAiSPNMCKG
OrthoDBiEOG091G0GZ1
PhylomeDBiQ8TCD6
TreeFamiTF300112

Enzyme and pathway databases

BioCyciMetaCyc:HS07168-MONOMER
SABIO-RKiQ8TCD6

Miscellaneous databases

GenomeRNAii493911
PROiPR:Q8TCD6

Gene expression databases

BgeeiENSG00000144362 Expressed in 185 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ8TCD6 baseline and differential
GenevisibleiQ8TCD6 HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR016965 Pase_PHOSPHO-typ
IPR006384 PyrdxlP_Pase-rel
PANTHERiPTHR20889 PTHR20889, 1 hit
PfamiView protein in Pfam
PF06888 Put_Phosphatase, 1 hit
PIRSFiPIRSF031051 PyrdxlP_Pase_PHOSPHO2, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR01489 DKMTPPase-SF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHOP2_HUMAN
AccessioniPrimary (citable) accession number: Q8TCD6
Secondary accession number(s): B2RC30, D3DPC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again