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UniProtKB - Q8TCD1 (CR032_HUMAN)
Protein
UPF0729 protein C18orf32
Gene
C18orf32
Organism
Homo sapiens (Human)
Status
Functioni
May activate the NF-kappa-B signaling pathway.
1 PublicationGO - Biological processi
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q8TCD1 |
SignaLinki | Q8TCD1 |
Names & Taxonomyi
Protein namesi | Recommended name: UPF0729 protein C18orf32Alternative name(s): Putative NF-kappa-B-activating protein 200 |
Gene namesi | Name:C18orf32 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31690, C18orf32 |
neXtProti | NX_Q8TCD1 |
VEuPathDBi | HostDB:ENSG00000177576 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 1 Publication
Other locations
- Lipid droplet 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Other locations
- lipid droplet Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Lipid dropletPathology & Biotechi
Organism-specific databases
PharmGKBi | PA162378602 |
Miscellaneous databases
Pharosi | Q8TCD1, Tdark |
Genetic variation databases
BioMutai | C18orf32 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000321908 | 1 – 76 | UPF0729 protein C18orf32Add BLAST | 76 |
Post-translational modificationi
Undergoes ER-associated degradation (ERAD).1 Publication
Proteomic databases
EPDi | Q8TCD1 |
jPOSTi | Q8TCD1 |
MassIVEi | Q8TCD1 |
MaxQBi | Q8TCD1 |
PaxDbi | Q8TCD1 |
PeptideAtlasi | Q8TCD1 |
PRIDEi | Q8TCD1 |
ProteomicsDBi | 74120 |
PTM databases
iPTMneti | Q8TCD1 |
PhosphoSitePlusi | Q8TCD1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000177576, Expressed in C1 segment of cervical spinal cord and 116 other tissues |
Genevisiblei | Q8TCD1, HS |
Organism-specific databases
HPAi | ENSG00000177576, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DERL1 and AMFR.
1 PublicationProtein-protein interaction databases
BioGRIDi | 139005, 11 interactors |
IntActi | Q8TCD1, 7 interactors |
MINTi | Q8TCD1 |
Miscellaneous databases
RNActi | Q8TCD1, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 37 | Necessary for its localzation to the endoplasmic reticulum and lipid dropletsAdd BLAST | 37 | |
Regioni | 46 – 76 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the UPF0729 family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000018741 |
HOGENOMi | CLU_191635_0_0_1 |
InParanoidi | Q8TCD1 |
OMAi | PIINTFW |
PhylomeDBi | Q8TCD1 |
TreeFami | TF324662 |
Family and domain databases
InterProi | View protein in InterPro IPR026776, UPF0729 |
PANTHERi | PTHR13456, PTHR13456, 1 hit |
Pfami | View protein in Pfam PF14975, DUF4512, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TCD1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVCIPCIVIP VLLWIYKKFL EPYIYPLVSP FVSRIWPKKA IQESNDTNKG
60 70
KVNFKGADMN GLPTKGPTEI CDKKKD
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_039374 | 37 | P → H. Corresponds to variant dbSNP:rs11537626Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097012 mRNA Translation: BAC77365.1 AK291882 mRNA Translation: BAF84571.1 BC022357 mRNA Translation: AAH22357.1 BC093004 mRNA Translation: AAH93004.1 |
CCDSi | CCDS32831.1 |
RefSeqi | NP_001030177.1, NM_001035005.3 NP_001186275.1, NM_001199346.1 |
Genome annotation databases
Ensembli | ENST00000318240; ENSP00000323199; ENSG00000177576 ENST00000582392; ENSP00000462538; ENSG00000177576 ENST00000613385; ENSP00000480941; ENSG00000177576 |
GeneIDi | 497661 |
KEGGi | hsa:497661 |
MANE-Selecti | ENST00000318240.8; ENSP00000323199.3; NM_001035005.4; NP_001030177.1 |
UCSCi | uc002ldk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB097012 mRNA Translation: BAC77365.1 AK291882 mRNA Translation: BAF84571.1 BC022357 mRNA Translation: AAH22357.1 BC093004 mRNA Translation: AAH93004.1 |
CCDSi | CCDS32831.1 |
RefSeqi | NP_001030177.1, NM_001035005.3 NP_001186275.1, NM_001199346.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 139005, 11 interactors |
IntActi | Q8TCD1, 7 interactors |
MINTi | Q8TCD1 |
PTM databases
iPTMneti | Q8TCD1 |
PhosphoSitePlusi | Q8TCD1 |
Genetic variation databases
BioMutai | C18orf32 |
Proteomic databases
EPDi | Q8TCD1 |
jPOSTi | Q8TCD1 |
MassIVEi | Q8TCD1 |
MaxQBi | Q8TCD1 |
PaxDbi | Q8TCD1 |
PeptideAtlasi | Q8TCD1 |
PRIDEi | Q8TCD1 |
ProteomicsDBi | 74120 |
Protocols and materials databases
Antibodypediai | 42028, 33 antibodies from 16 providers |
DNASUi | 497661 |
Genome annotation databases
Ensembli | ENST00000318240; ENSP00000323199; ENSG00000177576 ENST00000582392; ENSP00000462538; ENSG00000177576 ENST00000613385; ENSP00000480941; ENSG00000177576 |
GeneIDi | 497661 |
KEGGi | hsa:497661 |
MANE-Selecti | ENST00000318240.8; ENSP00000323199.3; NM_001035005.4; NP_001030177.1 |
UCSCi | uc002ldk.3, human |
Organism-specific databases
CTDi | 497661 |
GeneCardsi | C18orf32 |
HGNCi | HGNC:31690, C18orf32 |
HPAi | ENSG00000177576, Low tissue specificity |
neXtProti | NX_Q8TCD1 |
PharmGKBi | PA162378602 |
VEuPathDBi | HostDB:ENSG00000177576 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00390000018741 |
HOGENOMi | CLU_191635_0_0_1 |
InParanoidi | Q8TCD1 |
OMAi | PIINTFW |
PhylomeDBi | Q8TCD1 |
TreeFami | TF324662 |
Enzyme and pathway databases
PathwayCommonsi | Q8TCD1 |
SignaLinki | Q8TCD1 |
Miscellaneous databases
BioGRID-ORCSi | 497661, 14 hits in 962 CRISPR screens |
GenomeRNAii | 497661 |
Pharosi | Q8TCD1, Tdark |
PROi | PR:Q8TCD1 |
RNActi | Q8TCD1, protein |
Gene expression databases
Bgeei | ENSG00000177576, Expressed in C1 segment of cervical spinal cord and 116 other tissues |
Genevisiblei | Q8TCD1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026776, UPF0729 |
PANTHERi | PTHR13456, PTHR13456, 1 hit |
Pfami | View protein in Pfam PF14975, DUF4512, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CR032_HUMAN | |
Accessioni | Q8TCD1Primary (citable) accession number: Q8TCD1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 18
Human chromosome 18: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families