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Protein

Solute carrier family 22 member 8

Gene

SLC22A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone-3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • anion:anion antiporter activity Source: Reactome
  • inorganic anion exchanger activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDetoxification, Ion transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-561048 Organic anion transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.1.19.34 the major facilitator superfamily (mfs)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 22 member 8
Alternative name(s):
Organic anion transporter 3
Short name:
hOAT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC22A8
Synonyms:OAT3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000149452.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10972 SLC22A8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607581 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TCC7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicSequence analysis9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 30HelicalSequence analysisAdd BLAST21
Topological domaini31 – 123ExtracellularSequence analysisAdd BLAST93
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 154CytoplasmicSequence analysis10
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176ExtracellularSequence analysis1
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 212CytoplasmicSequence analysisAdd BLAST15
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 236ExtracellularSequence analysis3
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 327CytoplasmicSequence analysisAdd BLAST70
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 354ExtracellularSequence analysis6
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 386CytoplasmicSequence analysisAdd BLAST11
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 411ExtracellularSequence analysis4
Transmembranei412 – 432HelicalSequence analysisAdd BLAST21
Topological domaini433 – 471CytoplasmicSequence analysisAdd BLAST39
Transmembranei472 – 492HelicalSequence analysisAdd BLAST21
Topological domaini493 – 542ExtracellularSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9376

Open Targets

More...
OpenTargetsi
ENSG00000149452

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA389

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1641348

Drug and drug target database

More...
DrugBanki
DB00787 Aciclovir
DB00718 Adefovir Dipivoxil
DB00437 Allopurinol
DB00345 Aminohippuric acid
DB00168 Aspartame
DB09060 Avibactam
DB00181 Baclofen
DB03793 Benzoic Acid
DB01053 Benzylpenicillin
DB00887 Bumetanide
DB04519 Caprylic acid
DB01414 Cefacetrile
DB01140 Cefadroxil
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01212 Ceftriaxone
DB00567 Cephalexin
DB02659 Cholic Acid
DB01597 Cilastatin
DB00501 Cimetidine
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB08912 Dabrafenib
DB04133 Degraded Cephaloridine
DB05804 dehydroepiandrosterone sulfate
DB00586 Diclofenac
DB00390 Digoxin
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB09272 Eluxadoline
DB00584 Enalapril
DB00783 Estradiol
DB00927 Famotidine
DB00695 Furosemide
DB01004 Ganciclovir
DB03553 Glutaric Acid
DB00536 Guanidine
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00583 L-Carnitine
DB00279 Liothyronine
DB01583 Liotrix
DB01065 Melatonin
DB01033 Mercaptopurine
DB00563 Methotrexate
DB06710 Methyltestosterone
DB01017 Minocycline
DB01051 Novobiocin
DB00198 Oseltamivir
DB01092 Ouabain
DB03902 Oxalic Acid
DB00595 Oxytetracycline
DB00812 Phenylbutazone
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00908 Quinidine
DB00863 Ranitidine
DB00936 Salicylic acid
DB06335 Saxagliptin
DB00139 Succinic acid
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00469 Tenoxicam
DB00624 Testosterone
DB00759 Tetracycline
DB08837 Tetraethylammonium
DB01650 trans-2-hydroxycinnamic acid
DB08844 Uric Acid
DB00577 Valaciclovir
DB00313 Valproic Acid
DB00495 Zidovudine

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1027

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC22A8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730587

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002734391 – 542Solute carrier family 22 member 8Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei4PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TCC7

PeptideAtlas

More...
PeptideAtlasi
Q8TCC7

PRoteomics IDEntifications database

More...
PRIDEi
Q8TCC7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74117
74118 [Q8TCC7-2]
74119 [Q8TCC7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TCC7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TCC7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q8TCC7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000149452 Expressed in 53 organ(s), highest expression level in pigmented layer of retina

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC22A8

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TCC7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TCC7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044174

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114777, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TCC7, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337335

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8TCC7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TCC7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255 Eukaryota
COG0477 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154901

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234569

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108433

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TCC7

KEGG Orthology (KO)

More...
KOi
K08205

Identification of Orthologs from Complete Genome Data

More...
OMAi
AWFSTGF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0738

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TCC7

TreeFam database of animal gene trees

More...
TreeFami
TF315847

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06174 MFS, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00083 Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473 SSF103473, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00898 2A0119, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850 MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCC7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTFSEILDRV GSMGHFQFLH VAILGLPILN MANHNLLQIF TAATPVHHCR
60 70 80 90 100
PPHNASTGPW VLPMGPNGKP ERCLRFVHPP NASLPNDTQR AMEPCLDGWV
110 120 130 140 150
YNSTKDSIVT EWDLVCNSNK LKEMAQSIFM AGILIGGLVL GDLSDRFGRR
160 170 180 190 200
PILTCSYLLL AASGSGAAFS PTFPIYMVFR FLCGFGISGI TLSTVILNVE
210 220 230 240 250
WVPTRMRAIM STALGYCYTF GQFILPGLAY AIPQWRWLQL TVSIPFFVFF
260 270 280 290 300
LSSWWTPESI RWLVLSGKSS KALKILRRVA VFNGKKEEGE RLSLEELKLN
310 320 330 340 350
LQKEISLAKA KYTASDLFRI PMLRRMTFCL SLAWFATGFA YYSLAMGVEE
360 370 380 390 400
FGVNLYILQI IFGGVDVPAK FITILSLSYL GRHTTQAAAL LLAGGAILAL
410 420 430 440 450
TFVPLDLQTV RTVLAVFGKG CLSSSFSCLF LYTSELYPTV IRQTGMGVSN
460 470 480 490 500
LWTRVGSMVS PLVKITGEVQ PFIPNIIYGI TALLGGSAAL FLPETLNQPL
510 520 530 540
PETIEDLENW SLRAKKPKQE PEVEKASQRI PLQPHGPGLG SS
Length:542
Mass (Da):59,856
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i22799360D91B4CCF
GO
Isoform 2 (identifier: Q8TCC7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     510-510: W → WSVTASGPPR

Note: No experimental confirmation available.
Show »
Length:551
Mass (Da):60,709
Checksum:i0F202C686929638A
GO
Isoform 5 (identifier: Q8TCC7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-123: Missing.

Note: No experimental confirmation available.
Show »
Length:419
Mass (Da):46,120
Checksum:i3BBFC757CEE06790
GO
Isoform 3 (identifier: Q8TCC7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-345: Missing.
     406-455: DLQTVRTVLA...MGVSNLWTRV → GERLGLPQNP...SGAQGLSSRK
     456-542: Missing.

Note: No experimental confirmation available.
Show »
Length:110
Mass (Da):11,502
Checksum:i0050E6499A6446CB
GO
Isoform 4 (identifier: Q8TCC7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):49,821
Checksum:iB1E5B7631D8BED48
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BXN9H7BXN9_HUMAN
Solute carrier family 22 (Organic a...
SLC22A8 hCG_21316
533Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD19357 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAD92929 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150Missing in AAD19357 (PubMed:10049739).Curated1
Sequence conflicti151P → T in AAD19357 (PubMed:10049739).Curated1
Sequence conflicti271K → E in BAB47393 (Ref. 2) Curated1
Sequence conflicti286Missing in AAD19357 (PubMed:10049739).Curated1
Sequence conflicti411R → E in AAD19357 (PubMed:10049739).Curated1
Sequence conflicti478 – 480YGI → FTGS in AAD19357 (PubMed:10049739).Curated3
Sequence conflicti526A → T in BAG60589 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030146129F → L. Corresponds to variant dbSNP:rs11568479Ensembl.1
Natural variantiVAR_030147149R → S Complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs45566039Ensembl.1
Natural variantiVAR_030148260I → R Complete loss of function. 1 PublicationCorresponds to variant dbSNP:rs11568493Ensembl.1
Natural variantiVAR_030149277R → W Reduced function. 1 PublicationCorresponds to variant dbSNP:rs11568492Ensembl.1
Natural variantiVAR_030150281V → A in 6% of African-Americans. Corresponds to variant dbSNP:rs45438191Ensembl.1
Natural variantiVAR_030151305I → F in 3.5% of Asian-American; reduced function. 1 PublicationCorresponds to variant dbSNP:rs11568482Ensembl.1
Natural variantiVAR_030152389A → V1 PublicationCorresponds to variant dbSNP:rs749944923Ensembl.1
Natural variantiVAR_030153448V → I. Corresponds to variant dbSNP:rs11568486Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0225621 – 345Missing in isoform 3. 1 PublicationAdd BLAST345
Alternative sequenceiVSP_0458241 – 123Missing in isoform 5. CuratedAdd BLAST123
Alternative sequenceiVSP_0452721 – 91Missing in isoform 4. 1 PublicationAdd BLAST91
Alternative sequenceiVSP_022563406 – 455DLQTV…LWTRV → GERLGLPQNPLEEAARLGAR DFTAGSASKSLCYLEQVPAL SGAQGLSSRK in isoform 3. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_022564456 – 542Missing in isoform 3. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_022565510W → WSVTASGPPR in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF097491 mRNA Translation: AAD19357.1 Frameshift.
AB042505 mRNA Translation: BAB47393.1
AK298341 mRNA Translation: BAG60589.1
AB209692 mRNA Translation: BAD92929.1 Different initiation.
AP001858 Genomic DNA No translation available.
BC022387 mRNA Translation: AAH22387.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53643.1 [Q8TCC7-5]
CCDS53644.1 [Q8TCC7-4]
CCDS8042.1 [Q8TCC7-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001171661.1, NM_001184732.1 [Q8TCC7-1]
NP_001171662.1, NM_001184733.1 [Q8TCC7-4]
NP_001171665.1, NM_001184736.1 [Q8TCC7-5]
NP_004245.2, NM_004254.3 [Q8TCC7-1]
XP_011543666.1, XM_011545364.1 [Q8TCC7-5]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.266223

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000336232; ENSP00000337335; ENSG00000149452 [Q8TCC7-1]
ENST00000430500; ENSP00000398548; ENSG00000149452 [Q8TCC7-1]
ENST00000535878; ENSP00000443368; ENSG00000149452 [Q8TCC7-5]
ENST00000545207; ENSP00000441658; ENSG00000149452 [Q8TCC7-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9376

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9376

UCSC genome browser

More...
UCSCi
uc001nwo.4 human [Q8TCC7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF097491 mRNA Translation: AAD19357.1 Frameshift.
AB042505 mRNA Translation: BAB47393.1
AK298341 mRNA Translation: BAG60589.1
AB209692 mRNA Translation: BAD92929.1 Different initiation.
AP001858 Genomic DNA No translation available.
BC022387 mRNA Translation: AAH22387.1
CCDSiCCDS53643.1 [Q8TCC7-5]
CCDS53644.1 [Q8TCC7-4]
CCDS8042.1 [Q8TCC7-1]
RefSeqiNP_001171661.1, NM_001184732.1 [Q8TCC7-1]
NP_001171662.1, NM_001184733.1 [Q8TCC7-4]
NP_001171665.1, NM_001184736.1 [Q8TCC7-5]
NP_004245.2, NM_004254.3 [Q8TCC7-1]
XP_011543666.1, XM_011545364.1 [Q8TCC7-5]
UniGeneiHs.266223

3D structure databases

ProteinModelPortaliQ8TCC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114777, 2 interactors
IntActiQ8TCC7, 1 interactor
STRINGi9606.ENSP00000337335

Chemistry databases

BindingDBiQ8TCC7
ChEMBLiCHEMBL1641348
DrugBankiDB00787 Aciclovir
DB00718 Adefovir Dipivoxil
DB00437 Allopurinol
DB00345 Aminohippuric acid
DB00168 Aspartame
DB09060 Avibactam
DB00181 Baclofen
DB03793 Benzoic Acid
DB01053 Benzylpenicillin
DB00887 Bumetanide
DB04519 Caprylic acid
DB01414 Cefacetrile
DB01140 Cefadroxil
DB00456 Cefalotin
DB01326 Cefamandole
DB01327 Cefazolin
DB01329 Cefoperazone
DB00493 Cefotaxime
DB01212 Ceftriaxone
DB00567 Cephalexin
DB02659 Cholic Acid
DB01597 Cilastatin
DB00501 Cimetidine
DB00286 Conjugated Equine Estrogens
DB02527 Cyclic Adenosine Monophosphate
DB08912 Dabrafenib
DB04133 Degraded Cephaloridine
DB05804 dehydroepiandrosterone sulfate
DB00586 Diclofenac
DB00390 Digoxin
DB01160 Dinoprost Tromethamine
DB00917 Dinoprostone
DB00254 Doxycycline
DB09272 Eluxadoline
DB00584 Enalapril
DB00783 Estradiol
DB00927 Famotidine
DB00695 Furosemide
DB01004 Ganciclovir
DB03553 Glutaric Acid
DB00536 Guanidine
DB01050 Ibuprofen
DB00328 Indomethacin
DB01009 Ketoprofen
DB00583 L-Carnitine
DB00279 Liothyronine
DB01583 Liotrix
DB01065 Melatonin
DB01033 Mercaptopurine
DB00563 Methotrexate
DB06710 Methyltestosterone
DB01017 Minocycline
DB01051 Novobiocin
DB00198 Oseltamivir
DB01092 Ouabain
DB03902 Oxalic Acid
DB00595 Oxytetracycline
DB00812 Phenylbutazone
DB00554 Piroxicam
DB00175 Pravastatin
DB01032 Probenecid
DB00908 Quinidine
DB00863 Ranitidine
DB00936 Salicylic acid
DB06335 Saxagliptin
DB00139 Succinic acid
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00469 Tenoxicam
DB00624 Testosterone
DB00759 Tetracycline
DB08837 Tetraethylammonium
DB01650 trans-2-hydroxycinnamic acid
DB08844 Uric Acid
DB00577 Valaciclovir
DB00313 Valproic Acid
DB00495 Zidovudine
GuidetoPHARMACOLOGYi1027

Protein family/group databases

TCDBi2.A.1.19.34 the major facilitator superfamily (mfs)

PTM databases

iPTMnetiQ8TCC7
PhosphoSitePlusiQ8TCC7
SwissPalmiQ8TCC7

Polymorphism and mutation databases

BioMutaiSLC22A8
DMDMi74730587

Proteomic databases

PaxDbiQ8TCC7
PeptideAtlasiQ8TCC7
PRIDEiQ8TCC7
ProteomicsDBi74117
74118 [Q8TCC7-2]
74119 [Q8TCC7-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9376
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336232; ENSP00000337335; ENSG00000149452 [Q8TCC7-1]
ENST00000430500; ENSP00000398548; ENSG00000149452 [Q8TCC7-1]
ENST00000535878; ENSP00000443368; ENSG00000149452 [Q8TCC7-5]
ENST00000545207; ENSP00000441658; ENSG00000149452 [Q8TCC7-4]
GeneIDi9376
KEGGihsa:9376
UCSCiuc001nwo.4 human [Q8TCC7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9376
DisGeNETi9376
EuPathDBiHostDB:ENSG00000149452.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC22A8
HGNCiHGNC:10972 SLC22A8
HPAiHPA044174
MIMi607581 gene
neXtProtiNX_Q8TCC7
OpenTargetsiENSG00000149452
PharmGKBiPA389

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00940000154901
HOGENOMiHOG000234569
HOVERGENiHBG108433
InParanoidiQ8TCC7
KOiK08205
OMAiAWFSTGF
OrthoDBiEOG091G0738
PhylomeDBiQ8TCC7
TreeFamiTF315847

Enzyme and pathway databases

ReactomeiR-HSA-561048 Organic anion transport

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SLC22A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9376

Protein Ontology

More...
PROi
PR:Q8TCC7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000149452 Expressed in 53 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC22A8
ExpressionAtlasiQ8TCC7 baseline and differential
GenevisibleiQ8TCC7 HS

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR004749 Orgcat_transp/SVOP
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00898 2A0119, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS22A8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TCC7
Secondary accession number(s): B4DPH7
, F5GWA8, F5H5J1, O95820, Q59EW9, Q96TC1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: June 1, 2002
Last modified: December 5, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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