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Protein

Methyltransferase-like protein 6

Gene

METTL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable methyltransferase.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase-like protein 6 (EC:2.1.1.-)
Gene namesi
Name:METTL6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000206562.11
HGNCiHGNC:28343 METTL6
neXtProtiNX_Q8TCB7

Pathology & Biotechi

Organism-specific databases

DisGeNETi131965
OpenTargetsiENSG00000206562
PharmGKBiPA142671462

Polymorphism and mutation databases

BioMutaiMETTL6
DMDMi269849620

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002044541 – 284Methyltransferase-like protein 6Add BLAST284

Proteomic databases

EPDiQ8TCB7
MaxQBiQ8TCB7
PaxDbiQ8TCB7
PeptideAtlasiQ8TCB7
PRIDEiQ8TCB7
ProteomicsDBi74111
74112 [Q8TCB7-2]

PTM databases

iPTMnetiQ8TCB7
PhosphoSitePlusiQ8TCB7

Expressioni

Gene expression databases

BgeeiENSG00000206562 Expressed in 171 organ(s), highest expression level in body of pancreas
CleanExiHS_METTL6
ExpressionAtlasiQ8TCB7 baseline and differential
GenevisibleiQ8TCB7 HS

Organism-specific databases

HPAiHPA035166

Interactioni

Protein-protein interaction databases

BioGridi126301, 9 interactors
IntActiQ8TCB7, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ8TCB7
SMRiQ8TCB7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410ITBM Eukaryota
ENOG410XSAE LUCA
GeneTreeiENSGT00520000055554
HOGENOMiHOG000182278
HOVERGENiHBG075344
InParanoidiQ8TCB7
KOiK00599
OMAiVDVPRIF
OrthoDBiEOG091G1235
PhylomeDBiQ8TCB7
TreeFamiTF321001

Family and domain databases

InterProiView protein in InterPro
IPR013217 Methyltransf_12
IPR026113 MeTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR22809 PTHR22809, 1 hit
PfamiView protein in Pfam
PF08242 Methyltransf_12, 1 hit
PIRSFiPIRSF037755 Mettl2_prd, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TCB7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASLQRKGLQ ARILTSEEEE KLKRDQTLVS DFKQQKLEQE AQKNWDLFYK
60 70 80 90 100
RNSTNFFKDR HWTTREFEEL RSCREFEDQK LTMLEAGCGV GNCLFPLLEE
110 120 130 140 150
DPNIFAYACD FSPRAIEYVK QNPLYDTERC KVFQCDLTKD DLLDHVPPES
160 170 180 190 200
VDVVMLIFVL SAVHPDKMHL VLQNIYKVLK PGKSVLFRDY GLYDHAMLRF
210 220 230 240 250
KASSKLGENF YVRQDGTRSY FFTDDFLAQL FMDTGYEEVV NEYVFRETVN
260 270 280
KKEGLCVPRV FLQSKFLKPP KNPSPVVLGL DPKS
Length:284
Mass (Da):33,251
Last modified:November 24, 2009 - v2
Checksum:i445CAAE4D669B07F
GO
Isoform 2 (identifier: Q8TCB7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-284: VLKPGKSVLF...PVVLGLDPKS → CHGCSSELRQ...QAVLPPQPLK

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):27,948
Checksum:iCB9EA08A7C2C71F3
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DDX3B4DDX3_HUMAN
Methyltransferase-like protein 6
METTL6
239Annotation score:
H7C1L4H7C1L4_HUMAN
Methyltransferase-like protein 6
METTL6
105Annotation score:
M0R0W0M0R0W0_HUMAN
Methyltransferase-like protein 6
METTL6
137Annotation score:
H7C3H9H7C3H9_HUMAN
Methyltransferase-like protein 6
METTL6
158Annotation score:

Sequence cautioni

The sequence AAH22400 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti67F → L in BAB71574 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008480178 – 284VLKPG…LDPKS → CHGCSSELRQPWDKDDFAVT WDPWSPAIRVLLCHSGWSAV AWTWLTAASTSWAQAVLPPQ PLK in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057791 mRNA Translation: BAB71574.1
AC027125 Genomic DNA No translation available.
BC022400 mRNA Translation: AAH22400.1 Sequence problems.
CCDSiCCDS43056.1 [Q8TCB7-1]
CCDS87051.1 [Q8TCB7-2]
RefSeqiNP_001288721.1, NM_001301792.1
NP_001317591.1, NM_001330662.1 [Q8TCB7-2]
NP_689609.2, NM_152396.3 [Q8TCB7-1]
XP_005264924.1, XM_005264867.3 [Q8TCB7-1]
XP_005264927.1, XM_005264870.4
XP_006713033.1, XM_006712970.3 [Q8TCB7-1]
XP_016861207.1, XM_017005718.1 [Q8TCB7-1]
UniGeneiHs.149487
Hs.655765

Genome annotation databases

EnsembliENST00000383789; ENSP00000373299; ENSG00000206562 [Q8TCB7-2]
ENST00000383790; ENSP00000373300; ENSG00000206562 [Q8TCB7-1]
ENST00000443029; ENSP00000407613; ENSG00000206562 [Q8TCB7-1]
GeneIDi131965
KEGGihsa:131965
UCSCiuc003bzs.2 human [Q8TCB7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057791 mRNA Translation: BAB71574.1
AC027125 Genomic DNA No translation available.
BC022400 mRNA Translation: AAH22400.1 Sequence problems.
CCDSiCCDS43056.1 [Q8TCB7-1]
CCDS87051.1 [Q8TCB7-2]
RefSeqiNP_001288721.1, NM_001301792.1
NP_001317591.1, NM_001330662.1 [Q8TCB7-2]
NP_689609.2, NM_152396.3 [Q8TCB7-1]
XP_005264924.1, XM_005264867.3 [Q8TCB7-1]
XP_005264927.1, XM_005264870.4
XP_006713033.1, XM_006712970.3 [Q8TCB7-1]
XP_016861207.1, XM_017005718.1 [Q8TCB7-1]
UniGeneiHs.149487
Hs.655765

3D structure databases

ProteinModelPortaliQ8TCB7
SMRiQ8TCB7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126301, 9 interactors
IntActiQ8TCB7, 1 interactor

PTM databases

iPTMnetiQ8TCB7
PhosphoSitePlusiQ8TCB7

Polymorphism and mutation databases

BioMutaiMETTL6
DMDMi269849620

Proteomic databases

EPDiQ8TCB7
MaxQBiQ8TCB7
PaxDbiQ8TCB7
PeptideAtlasiQ8TCB7
PRIDEiQ8TCB7
ProteomicsDBi74111
74112 [Q8TCB7-2]

Protocols and materials databases

DNASUi131965
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000383789; ENSP00000373299; ENSG00000206562 [Q8TCB7-2]
ENST00000383790; ENSP00000373300; ENSG00000206562 [Q8TCB7-1]
ENST00000443029; ENSP00000407613; ENSG00000206562 [Q8TCB7-1]
GeneIDi131965
KEGGihsa:131965
UCSCiuc003bzs.2 human [Q8TCB7-1]

Organism-specific databases

CTDi131965
DisGeNETi131965
EuPathDBiHostDB:ENSG00000206562.11
GeneCardsiMETTL6
HGNCiHGNC:28343 METTL6
HPAiHPA035166
neXtProtiNX_Q8TCB7
OpenTargetsiENSG00000206562
PharmGKBiPA142671462
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITBM Eukaryota
ENOG410XSAE LUCA
GeneTreeiENSGT00520000055554
HOGENOMiHOG000182278
HOVERGENiHBG075344
InParanoidiQ8TCB7
KOiK00599
OMAiVDVPRIF
OrthoDBiEOG091G1235
PhylomeDBiQ8TCB7
TreeFamiTF321001

Miscellaneous databases

GenomeRNAii131965
PROiPR:Q8TCB7

Gene expression databases

BgeeiENSG00000206562 Expressed in 171 organ(s), highest expression level in body of pancreas
CleanExiHS_METTL6
ExpressionAtlasiQ8TCB7 baseline and differential
GenevisibleiQ8TCB7 HS

Family and domain databases

InterProiView protein in InterPro
IPR013217 Methyltransf_12
IPR026113 MeTrfase
IPR029063 SAM-dependent_MTases
PANTHERiPTHR22809 PTHR22809, 1 hit
PfamiView protein in Pfam
PF08242 Methyltransf_12, 1 hit
PIRSFiPIRSF037755 Mettl2_prd, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMETL6_HUMAN
AccessioniPrimary (citable) accession number: Q8TCB7
Secondary accession number(s): Q96LU4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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