UniProtKB - Q8TCB6 (O51E1_HUMAN)
Protein
Olfactory receptor 51E1
Gene
OR51E1
Organism
Homo sapiens (Human)
Status
Functioni
Odorant receptor.Curated
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
- olfactory receptor activity Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Biological process | Olfaction, Sensory transduction |
Enzyme and pathway databases
PathwayCommonsi | Q8TCB6 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Olfactory receptor 51E1Alternative name(s): D-GPCR G-protein coupled receptor 164 Olfactory receptor 52A3 Prostate-overexpressed G protein-coupled receptor Prostate-specific G protein-coupled receptor 2 |
Gene namesi | Name:OR51E1 Synonyms:GPR164, OR51E1P, OR52A3P, POGR, PSGR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15194, OR51E1 |
MIMi | 611267, gene |
neXtProti | NX_Q8TCB6 |
VEuPathDBi | HostDB:ENSG00000180785.8 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 27 | ExtracellularSequence analysisAdd BLAST | 27 | |
Transmembranei | 28 – 48 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 49 – 56 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 57 – 77 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 78 – 101 | ExtracellularSequence analysisAdd BLAST | 24 | |
Transmembranei | 102 – 122 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 123 – 141 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 198 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 199 – 219 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 220 – 238 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 239 – 259 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 260 – 274 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 275 – 295 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 296 – 317 | CytoplasmicSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 143503 |
PharmGKBi | PA32371 |
Miscellaneous databases
Pharosi | Q8TCB6, Tbio |
Genetic variation databases
BioMutai | OR51E1 |
DMDMi | 38372839 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150750 | 1 – 317 | Olfactory receptor 51E1Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 90 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 99 ↔ 191 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q8TCB6 |
PRIDEi | Q8TCB6 |
ProteomicsDBi | 74110 |
PTM databases
GlyGeni | Q8TCB6, 2 sites |
Expressioni
Tissue specificityi
Highly expressed in prostate. Very low levels may be detected in some other tissues, such as placenta, skeletal muscle, heart, ovary and testis. Up-regulated in prostate cancers.2 Publications
Gene expression databases
Bgeei | ENSG00000180785, Expressed in secondary oocyte and 99 other tissues |
ExpressionAtlasi | Q8TCB6, baseline and differential |
Genevisiblei | Q8TCB6, HS |
Organism-specific databases
HPAi | ENSG00000180785, Tissue enhanced (placenta, prostate) |
Interactioni
Binary interactionsi
Q8TCB6
With | #Exp. | IntAct |
---|---|---|
KCTD17 [Q8N5Z5] | 3 | EBI-12141505,EBI-743960 |
Protein-protein interaction databases
BioGRIDi | 126808, 2 interactors |
IntActi | Q8TCB6, 1 interactor |
STRINGi | 9606.ENSP00000380155 |
Miscellaneous databases
RNActi | Q8TCB6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVRN, Eukaryota |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8TCB6 |
OMAi | FHVTTHT |
OrthoDBi | 1159837at2759 |
PhylomeDBi | Q8TCB6 |
TreeFami | TF342735 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8TCB6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI
60 70 80 90 100
VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL
110 120 130 140 150
LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA
160 170 180 190 200
VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY
210 220 230 240 250
GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF
260 270 280 290 300
IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI
310
RQRILRLFHV ATHASEP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PKL6 | E9PKL6_HUMAN | Olfactory receptor 51E1 | OR51E1 | 72 | Annotation score: |
Sequence cautioni
The sequence AAU07996 differs from that shown. Reason: Erroneous initiation.Curated
The sequence DAA04767 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 305 | L → P in AAU07996 (PubMed:15313197).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057577 | 9 | S → N. Corresponds to variant dbSNP:rs17224476Ensembl. | 1 | |
Natural variantiVAR_034317 | 10 | S → N. Corresponds to variant dbSNP:rs17224476Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY698056 mRNA Translation: AAU07996.1 Different initiation. AB065787 Genomic DNA Translation: BAC06006.1 AY775731 mRNA Translation: AAV54110.1 AK293091 mRNA Translation: BAF85780.1 CH471064 Genomic DNA Translation: EAW68832.1 BC022401 mRNA Translation: AAH22401.1 BK004369 Genomic DNA Translation: DAA04767.1 Different initiation. |
RefSeqi | NP_689643.2, NM_152430.3 |
Genome annotation databases
Ensembli | ENST00000396952; ENSP00000380155; ENSG00000180785 |
GeneIDi | 143503 |
KEGGi | hsa:143503 |
UCSCi | uc001lzi.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Human Olfactory Receptor Data Exploratorium (HORDE) |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY698056 mRNA Translation: AAU07996.1 Different initiation. AB065787 Genomic DNA Translation: BAC06006.1 AY775731 mRNA Translation: AAV54110.1 AK293091 mRNA Translation: BAF85780.1 CH471064 Genomic DNA Translation: EAW68832.1 BC022401 mRNA Translation: AAH22401.1 BK004369 Genomic DNA Translation: DAA04767.1 Different initiation. |
RefSeqi | NP_689643.2, NM_152430.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 126808, 2 interactors |
IntActi | Q8TCB6, 1 interactor |
STRINGi | 9606.ENSP00000380155 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q8TCB6, 2 sites |
Genetic variation databases
BioMutai | OR51E1 |
DMDMi | 38372839 |
Proteomic databases
PaxDbi | Q8TCB6 |
PRIDEi | Q8TCB6 |
ProteomicsDBi | 74110 |
Protocols and materials databases
Antibodypediai | 23519, 182 antibodies |
Genome annotation databases
Ensembli | ENST00000396952; ENSP00000380155; ENSG00000180785 |
GeneIDi | 143503 |
KEGGi | hsa:143503 |
UCSCi | uc001lzi.5, human |
Organism-specific databases
CTDi | 143503 |
DisGeNETi | 143503 |
GeneCardsi | OR51E1 |
HGNCi | HGNC:15194, OR51E1 |
HPAi | ENSG00000180785, Tissue enhanced (placenta, prostate) |
MIMi | 611267, gene |
neXtProti | NX_Q8TCB6 |
PharmGKBi | PA32371 |
VEuPathDBi | HostDB:ENSG00000180785.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVRN, Eukaryota |
HOGENOMi | CLU_012526_0_0_1 |
InParanoidi | Q8TCB6 |
OMAi | FHVTTHT |
OrthoDBi | 1159837at2759 |
PhylomeDBi | Q8TCB6 |
TreeFami | TF342735 |
Enzyme and pathway databases
PathwayCommonsi | Q8TCB6 |
Reactomei | R-HSA-381753, Olfactory Signaling Pathway |
Miscellaneous databases
BioGRID-ORCSi | 143503, 57 hits in 504 CRISPR screens |
ChiTaRSi | OR51E1, human |
GeneWikii | OR51E1 |
GenomeRNAii | 143503 |
Pharosi | Q8TCB6, Tbio |
PROi | PR:Q8TCB6 |
RNActi | Q8TCB6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000180785, Expressed in secondary oocyte and 99 other tissues |
ExpressionAtlasi | Q8TCB6, baseline and differential |
Genevisiblei | Q8TCB6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000725, Olfact_rcpt |
Pfami | View protein in Pfam PF13853, 7tm_4, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00245, OLFACTORYR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | O51E1_HUMAN | |
Accessioni | Q8TCB6Primary (citable) accession number: Q8TCB6 Secondary accession number(s): A8KAM6 Q6IF93 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families