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Protein

Ecto-NOX disulfide-thiol exchanger 1

Gene

ENOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.4 Publications

Cofactori

Cu cation1 Publication

Activity regulationi

Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processBiological rhythms, Electron transport, Transport
LigandCopper, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-NOX disulfide-thiol exchanger 1
Alternative name(s):
Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
Short name:
cCNOX
Cell proliferation-inducing gene 38 protein
Constitutive Ecto-NOX
Short name:
cNOX
Including the following 2 domains:
Hydroquinone [NADH] oxidase (EC:1.-.-.-)
Protein disulfide-thiol oxidoreductase (EC:1.-.-.-)
Gene namesi
Name:ENOX1
ORF Names:PIG38
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000120658.12
HGNCiHGNC:25474 ENOX1
MIMi610914 gene
neXtProtiNX_Q8TC92

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi55068
OpenTargetsiENSG00000120658
PharmGKBiPA162385069

Polymorphism and mutation databases

BioMutaiENOX1
DMDMi74760449

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002959001 – 643Ecto-NOX disulfide-thiol exchanger 1Add BLAST643

Proteomic databases

EPDiQ8TC92
MaxQBiQ8TC92
PaxDbiQ8TC92
PeptideAtlasiQ8TC92
PRIDEiQ8TC92
ProteomicsDBi74102

PTM databases

iPTMnetiQ8TC92
PhosphoSitePlusiQ8TC92

Expressioni

Tissue specificityi

Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.

Gene expression databases

BgeeiENSG00000120658 Expressed in 160 organ(s), highest expression level in frontal cortex
CleanExiHS_ENOX1
ExpressionAtlasiQ8TC92 baseline and differential
GenevisibleiQ8TC92 HS

Organism-specific databases

HPAiHPA038355

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi120385, 16 interactors
IntActiQ8TC92, 13 interactors
STRINGi9606.ENSP00000261488

Structurei

3D structure databases

ProteinModelPortaliQ8TC92
SMRiQ8TC92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini142 – 221RRMPROSITE-ProRule annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili307 – 342Sequence analysisAdd BLAST36
Coiled coili425 – 570Sequence analysisAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi89 – 139Pro-richAdd BLAST51

Sequence similaritiesi

Belongs to the ENOX family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEVY Eukaryota
ENOG410XVWG LUCA
GeneTreeiENSGT00390000006788
HOGENOMiHOG000049275
HOVERGENiHBG051083
InParanoidiQ8TC92
OMAiFCAFEGI
OrthoDBiEOG091G038C
PhylomeDBiQ8TC92
TreeFamiTF323802

Family and domain databases

CDDicd12228 RRM_ENOX, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038876 ENOX
IPR034140 ENOX_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR16001 PTHR16001, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT
60 70 80 90 100
AMNNLGMVPV GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV
110 120 130 140 150
PPPPPTEVAV VKEIIHCKSC TLFPQNPNLP PPSTRERPPG CKTVFVGGLP
160 170 180 190 200
ENATEEIIQE VFEQCGDITA IRKSKKNFCH IRFAEEFMVD KAIYLSGYRM
210 220 230 240 250
RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER HRRKLEEDRL
260 270 280 290 300
RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA
310 320 330 340 350
NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV
360 370 380 390 400
AVFNASTRQK AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM
410 420 430 440 450
EMSDDENCDS PTKKMRVDES ALAAQAYALK EENDSLRWQL DAYRNEVELL
460 470 480 490 500
KQEKEQLFRT EENLTKDQQL QFLQQTMQGM QQQLLTIQEE LNNKKSELEQ
510 520 530 540 550
AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN VLTVALVNQD
560 570 580 590 600
RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK
610 620 630 640
ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT
Length:643
Mass (Da):73,348
Last modified:June 1, 2002 - v1
Checksum:i501DC6905F326610
GO
Isoform 2 (identifier: Q8TC92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.
     421-422: AL → GA
     423-643: Missing.

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):27,686
Checksum:i9EDDBF6F6FFD7675
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62L → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in BAA91442 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05220516E → D1 PublicationCorresponds to variant dbSNP:rs7338624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0569851 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_056986421 – 422AL → GA in isoform 2. 1 Publication2
Alternative sequenceiVSP_056987423 – 643Missing in isoform 2. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF432052 mRNA Translation: ABO28524.1
AY513282 mRNA Translation: AAT08035.1
AK000956 mRNA Translation: BAA91442.1
AK299053 mRNA Translation: BAH12937.1
AL136959 Genomic DNA No translation available.
AL161714 Genomic DNA No translation available.
AL162713 Genomic DNA No translation available.
AL445703 Genomic DNA No translation available.
AL138823 Genomic DNA No translation available.
AL607148 Genomic DNA No translation available.
AL627430 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08693.1
BC024178 mRNA Translation: AAH24178.1
CCDSiCCDS9389.1 [Q8TC92-1]
RefSeqiNP_001121087.1, NM_001127615.2 [Q8TC92-1]
NP_001229792.1, NM_001242863.2 [Q8TC92-1]
NP_001334893.1, NM_001347964.1 [Q8TC92-1]
NP_001334894.1, NM_001347965.1 [Q8TC92-1]
NP_001334895.1, NM_001347966.1 [Q8TC92-1]
NP_001334896.1, NM_001347967.1 [Q8TC92-1]
NP_001334897.1, NM_001347968.1 [Q8TC92-1]
NP_001334898.1, NM_001347969.1 [Q8TC92-1]
NP_060463.2, NM_017993.4 [Q8TC92-1]
XP_011533428.1, XM_011535126.2 [Q8TC92-1]
XP_011533429.1, XM_011535127.2 [Q8TC92-1]
XP_016876126.1, XM_017020637.1 [Q8TC92-1]
XP_016876127.1, XM_017020638.1
UniGeneiHs.128258

Genome annotation databases

EnsembliENST00000261488; ENSP00000261488; ENSG00000120658 [Q8TC92-1]
GeneIDi55068
KEGGihsa:55068
UCSCiuc001uzc.5 human [Q8TC92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF432052 mRNA Translation: ABO28524.1
AY513282 mRNA Translation: AAT08035.1
AK000956 mRNA Translation: BAA91442.1
AK299053 mRNA Translation: BAH12937.1
AL136959 Genomic DNA No translation available.
AL161714 Genomic DNA No translation available.
AL162713 Genomic DNA No translation available.
AL445703 Genomic DNA No translation available.
AL138823 Genomic DNA No translation available.
AL607148 Genomic DNA No translation available.
AL627430 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08693.1
BC024178 mRNA Translation: AAH24178.1
CCDSiCCDS9389.1 [Q8TC92-1]
RefSeqiNP_001121087.1, NM_001127615.2 [Q8TC92-1]
NP_001229792.1, NM_001242863.2 [Q8TC92-1]
NP_001334893.1, NM_001347964.1 [Q8TC92-1]
NP_001334894.1, NM_001347965.1 [Q8TC92-1]
NP_001334895.1, NM_001347966.1 [Q8TC92-1]
NP_001334896.1, NM_001347967.1 [Q8TC92-1]
NP_001334897.1, NM_001347968.1 [Q8TC92-1]
NP_001334898.1, NM_001347969.1 [Q8TC92-1]
NP_060463.2, NM_017993.4 [Q8TC92-1]
XP_011533428.1, XM_011535126.2 [Q8TC92-1]
XP_011533429.1, XM_011535127.2 [Q8TC92-1]
XP_016876126.1, XM_017020637.1 [Q8TC92-1]
XP_016876127.1, XM_017020638.1
UniGeneiHs.128258

3D structure databases

ProteinModelPortaliQ8TC92
SMRiQ8TC92
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120385, 16 interactors
IntActiQ8TC92, 13 interactors
STRINGi9606.ENSP00000261488

PTM databases

iPTMnetiQ8TC92
PhosphoSitePlusiQ8TC92

Polymorphism and mutation databases

BioMutaiENOX1
DMDMi74760449

Proteomic databases

EPDiQ8TC92
MaxQBiQ8TC92
PaxDbiQ8TC92
PeptideAtlasiQ8TC92
PRIDEiQ8TC92
ProteomicsDBi74102

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261488; ENSP00000261488; ENSG00000120658 [Q8TC92-1]
GeneIDi55068
KEGGihsa:55068
UCSCiuc001uzc.5 human [Q8TC92-1]

Organism-specific databases

CTDi55068
DisGeNETi55068
EuPathDBiHostDB:ENSG00000120658.12
GeneCardsiENOX1
H-InvDBiHIX0011276
HGNCiHGNC:25474 ENOX1
HPAiHPA038355
MIMi610914 gene
neXtProtiNX_Q8TC92
OpenTargetsiENSG00000120658
PharmGKBiPA162385069
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEVY Eukaryota
ENOG410XVWG LUCA
GeneTreeiENSGT00390000006788
HOGENOMiHOG000049275
HOVERGENiHBG051083
InParanoidiQ8TC92
OMAiFCAFEGI
OrthoDBiEOG091G038C
PhylomeDBiQ8TC92
TreeFamiTF323802

Miscellaneous databases

ChiTaRSiENOX1 human
GenomeRNAii55068
PROiPR:Q8TC92
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120658 Expressed in 160 organ(s), highest expression level in frontal cortex
CleanExiHS_ENOX1
ExpressionAtlasiQ8TC92 baseline and differential
GenevisibleiQ8TC92 HS

Family and domain databases

CDDicd12228 RRM_ENOX, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038876 ENOX
IPR034140 ENOX_RRM
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR16001 PTHR16001, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENOX1_HUMAN
AccessioniPrimary (citable) accession number: Q8TC92
Secondary accession number(s): A4GU15
, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q9NWE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: October 10, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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