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Entry version 152 (07 Oct 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Ecto-NOX disulfide-thiol exchanger 1

Gene

ENOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 24 minutes and play a role in control of the ultradian cellular biological clock.4 Publications

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cation1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Not inhibited by the antitumor sulfonylurea LY181984, the vabilloid capsaicin, and retinoids.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processBiological rhythms, Electron transport, Transport
LigandCopper, NAD

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TC92

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q8TC92

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ecto-NOX disulfide-thiol exchanger 1
Alternative name(s):
Candidate growth-related and time keeping constitutive hydroquinone [NADH] oxidase
Short name:
cCNOX
Cell proliferation-inducing gene 38 protein
Constitutive Ecto-NOX
Short name:
cNOX
Including the following 2 domains:
Hydroquinone [NADH] oxidase (EC:1.-.-.-)
Protein disulfide-thiol oxidoreductase (EC:1.-.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENOX1
ORF Names:PIG38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000120658.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25474, ENOX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610914, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC92

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
55068

Open Targets

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OpenTargetsi
ENSG00000120658

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162385069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TC92, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ENOX1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74760449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002959001 – 643Ecto-NOX disulfide-thiol exchanger 1Add BLAST643

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q8TC92

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TC92

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TC92

PeptideAtlas

More...
PeptideAtlasi
Q8TC92

PRoteomics IDEntifications database

More...
PRIDEi
Q8TC92

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
6698
74102 [Q8TC92-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC92

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TC92

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lymphocyte cells, breast and breast cancer (at protein level). Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Found also in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120658, Expressed in cortical plate and 176 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TC92, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TC92, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120658, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120385, 18 interactors

Protein interaction database and analysis system

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IntActi
Q8TC92, 14 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000261488

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TC92, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TC92

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 221RRMPROSITE-ProRule annotationAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili307 – 342Sequence analysisAdd BLAST36
Coiled coili425 – 570Sequence analysisAdd BLAST146

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi89 – 139Pro-richAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ENOX family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QQ8G, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000006788

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_019282_1_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TC92

Identification of Orthologs from Complete Genome Data

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OMAi
MEQAKEN

Database of Orthologous Groups

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OrthoDBi
357901at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TC92

TreeFam database of animal gene trees

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TreeFami
TF323802

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12228, RRM_ENOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038876, ENOX
IPR034140, ENOX_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom

The PANTHER Classification System

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PANTHERi
PTHR16001, PTHR16001, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVDAGGVENI TQLPQELPQM MAAAADGLGS IAIDTTQLNM SVTDPTAWAT
60 70 80 90 100
AMNNLGMVPV GLPGQQLVSD SICVPGFDPS LNMMTGITPI NPMIPGLGLV
110 120 130 140 150
PPPPPTEVAV VKEIIHCKSC TLFPQNPNLP PPSTRERPPG CKTVFVGGLP
160 170 180 190 200
ENATEEIIQE VFEQCGDITA IRKSKKNFCH IRFAEEFMVD KAIYLSGYRM
210 220 230 240 250
RLGSSTDKKD SGRLHVDFAQ ARDDFYEWEC KQRMRAREER HRRKLEEDRL
260 270 280 290 300
RPPSPPAIMH YSEHEAALLA EKLKDDSKFS EAITVLLSWI ERGEVNRRSA
310 320 330 340 350
NQFYSMVQSA NSHVRRLMNE KATHEQEMEE AKENFKNALT GILTQFEQIV
360 370 380 390 400
AVFNASTRQK AWDHFSKAQR KNIDIWRKHS EELRNAQSEQ LMGIRREEEM
410 420 430 440 450
EMSDDENCDS PTKKMRVDES ALAAQAYALK EENDSLRWQL DAYRNEVELL
460 470 480 490 500
KQEKEQLFRT EENLTKDQQL QFLQQTMQGM QQQLLTIQEE LNNKKSELEQ
510 520 530 540 550
AKEEQSHTQA LLKVLQEQLK GTKELVETNG HSHEDSNEIN VLTVALVNQD
560 570 580 590 600
RENNIEKRSQ GLKSEKEALL IGIISTFLHV HPFGANIEYL WSYMQQLDSK
610 620 630 640
ISANEIEMLL MRLPRMFKQE FTGVGATLEK RWKLCAFEGI KTT
Length:643
Mass (Da):73,348
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i501DC6905F326610
GO
Isoform 2 (identifier: Q8TC92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-187: Missing.
     421-422: AL → GA
     423-643: Missing.

Show »
Length:235
Mass (Da):27,686
Checksum:i9EDDBF6F6FFD7675
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti62L → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in AAT08035 (Ref. 2) Curated1
Sequence conflicti279F → S in BAA91442 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05220516E → D1 PublicationCorresponds to variant dbSNP:rs7338624Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0569851 – 187Missing in isoform 2. 1 PublicationAdd BLAST187
Alternative sequenceiVSP_056986421 – 422AL → GA in isoform 2. 1 Publication2
Alternative sequenceiVSP_056987423 – 643Missing in isoform 2. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF432052 mRNA Translation: ABO28524.1
AY513282 mRNA Translation: AAT08035.1
AK000956 mRNA Translation: BAA91442.1
AK299053 mRNA Translation: BAH12937.1
AL136959 Genomic DNA No translation available.
AL161714 Genomic DNA No translation available.
AL162713 Genomic DNA No translation available.
AL445703 Genomic DNA No translation available.
AL138823 Genomic DNA No translation available.
AL607148 Genomic DNA No translation available.
AL627430 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08693.1
BC024178 mRNA Translation: AAH24178.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9389.1 [Q8TC92-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001121087.1, NM_001127615.2 [Q8TC92-1]
NP_001229792.1, NM_001242863.2 [Q8TC92-1]
NP_001334893.1, NM_001347964.1 [Q8TC92-1]
NP_001334894.1, NM_001347965.1 [Q8TC92-1]
NP_001334895.1, NM_001347966.1 [Q8TC92-1]
NP_001334896.1, NM_001347967.1 [Q8TC92-1]
NP_001334897.1, NM_001347968.1 [Q8TC92-1]
NP_001334898.1, NM_001347969.1 [Q8TC92-1]
NP_060463.2, NM_017993.4 [Q8TC92-1]
XP_011533428.1, XM_011535126.2 [Q8TC92-1]
XP_011533429.1, XM_011535127.2 [Q8TC92-1]
XP_016876126.1, XM_017020637.1 [Q8TC92-1]
XP_016876127.1, XM_017020638.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261488; ENSP00000261488; ENSG00000120658 [Q8TC92-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55068

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55068

UCSC genome browser

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UCSCi
uc001uzc.5, human [Q8TC92-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF432052 mRNA Translation: ABO28524.1
AY513282 mRNA Translation: AAT08035.1
AK000956 mRNA Translation: BAA91442.1
AK299053 mRNA Translation: BAH12937.1
AL136959 Genomic DNA No translation available.
AL161714 Genomic DNA No translation available.
AL162713 Genomic DNA No translation available.
AL445703 Genomic DNA No translation available.
AL138823 Genomic DNA No translation available.
AL607148 Genomic DNA No translation available.
AL627430 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08693.1
BC024178 mRNA Translation: AAH24178.1
CCDSiCCDS9389.1 [Q8TC92-1]
RefSeqiNP_001121087.1, NM_001127615.2 [Q8TC92-1]
NP_001229792.1, NM_001242863.2 [Q8TC92-1]
NP_001334893.1, NM_001347964.1 [Q8TC92-1]
NP_001334894.1, NM_001347965.1 [Q8TC92-1]
NP_001334895.1, NM_001347966.1 [Q8TC92-1]
NP_001334896.1, NM_001347967.1 [Q8TC92-1]
NP_001334897.1, NM_001347968.1 [Q8TC92-1]
NP_001334898.1, NM_001347969.1 [Q8TC92-1]
NP_060463.2, NM_017993.4 [Q8TC92-1]
XP_011533428.1, XM_011535126.2 [Q8TC92-1]
XP_011533429.1, XM_011535127.2 [Q8TC92-1]
XP_016876126.1, XM_017020637.1 [Q8TC92-1]
XP_016876127.1, XM_017020638.1

3D structure databases

SMRiQ8TC92
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120385, 18 interactors
IntActiQ8TC92, 14 interactors
STRINGi9606.ENSP00000261488

PTM databases

iPTMnetiQ8TC92
PhosphoSitePlusiQ8TC92

Polymorphism and mutation databases

BioMutaiENOX1
DMDMi74760449

Proteomic databases

MassIVEiQ8TC92
MaxQBiQ8TC92
PaxDbiQ8TC92
PeptideAtlasiQ8TC92
PRIDEiQ8TC92
ProteomicsDBi6698
74102 [Q8TC92-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
23523, 87 antibodies

Genome annotation databases

EnsembliENST00000261488; ENSP00000261488; ENSG00000120658 [Q8TC92-1]
GeneIDi55068
KEGGihsa:55068
UCSCiuc001uzc.5, human [Q8TC92-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55068
DisGeNETi55068
EuPathDBiHostDB:ENSG00000120658.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ENOX1
HGNCiHGNC:25474, ENOX1
HPAiENSG00000120658, Low tissue specificity
MIMi610914, gene
neXtProtiNX_Q8TC92
OpenTargetsiENSG00000120658
PharmGKBiPA162385069

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQ8G, Eukaryota
GeneTreeiENSGT00390000006788
HOGENOMiCLU_019282_1_1_1
InParanoidiQ8TC92
OMAiMEQAKEN
OrthoDBi357901at2759
PhylomeDBiQ8TC92
TreeFamiTF323802

Enzyme and pathway databases

PathwayCommonsiQ8TC92
SIGNORiQ8TC92

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55068, 2 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ENOX1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55068
PharosiQ8TC92, Tbio

Protein Ontology

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PROi
PR:Q8TC92
RNActiQ8TC92, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120658, Expressed in cortical plate and 176 other tissues
ExpressionAtlasiQ8TC92, baseline and differential
GenevisibleiQ8TC92, HS

Family and domain databases

CDDicd12228, RRM_ENOX, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038876, ENOX
IPR034140, ENOX_RRM
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
PANTHERiPTHR16001, PTHR16001, 1 hit
PfamiView protein in Pfam
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00360, RRM, 1 hit
SUPFAMiSSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENOX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC92
Secondary accession number(s): A4GU15
, A6NMH9, B7Z5K1, Q2TU81, Q5VT11, Q9NWE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: June 1, 2002
Last modified: October 7, 2020
This is version 152 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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