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UniProtKB - Q8TC84 (FANK1_HUMAN)
Protein
Fibronectin type 3 and ankyrin repeat domains protein 1
Gene
FANK1
Organism
Homo sapiens (Human)
Status
Functioni
Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
2 PublicationsGO - Biological processi
- negative regulation of apoptotic process Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of DNA-binding transcription factor activity Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of apoptotic process Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q8TC84 |
SignaLinki | Q8TC84 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibronectin type 3 and ankyrin repeat domains protein 1Curated |
Gene namesi | Name:FANK1Imported ORF Names:HSD13Imported, UNQ6504/PRO21382Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23527, FANK1 |
MIMi | 611640, gene |
neXtProti | NX_Q8TC84 |
VEuPathDBi | HostDB:ENSG00000203780 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytoplasm and Cytosol
- cytosol 1 Publication
Cytoskeleton
- cilium basal body By similarity
Other locations
- cilium By similarity
Cytoskeleton
- ciliary basal body Source: UniProtKB
Cytosol
- cytosol Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- ciliary base Source: Ensembl
- cilium Source: UniProtKB
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoskeleton, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 92565 |
OpenTargetsi | ENSG00000203780 |
PharmGKBi | PA134976727 |
Miscellaneous databases
Pharosi | Q8TC84, Tbio |
Genetic variation databases
BioMutai | FANK1 |
DMDMi | 116241361 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066990 | 1 – 345 | Fibronectin type 3 and ankyrin repeat domains protein 1Add BLAST | 345 |
Post-translational modificationi
Polyubiquitinated. Polyubiquitination leads to proteasomal degradation.1 Publication
Keywords - PTMi
Ubl conjugationProteomic databases
MassIVEi | Q8TC84 |
PaxDbi | Q8TC84 |
PeptideAtlasi | Q8TC84 |
PRIDEi | Q8TC84 |
ProteomicsDBi | 74098 [Q8TC84-1] 74099 [Q8TC84-2] 74100 [Q8TC84-3] |
PTM databases
iPTMneti | Q8TC84 |
PhosphoSitePlusi | Q8TC84 |
Expressioni
Tissue specificityi
Mostly restricted to testis.1 Publication
Gene expression databases
Bgeei | ENSG00000203780, Expressed in right uterine tube and 159 other tissues |
ExpressionAtlasi | Q8TC84, baseline and differential |
Organism-specific databases
HPAi | ENSG00000203780, Tissue enhanced (choroid plexus, fallopian tube, testis) |
Interactioni
Subunit structurei
Binary interactionsi
Q8TC84
Protein-protein interaction databases
BioGRIDi | 124956, 11 interactors |
IntActi | Q8TC84, 13 interactors |
STRINGi | 9606.ENSP00000357682 |
Miscellaneous databases
RNActi | Q8TC84, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 108 | Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST | 101 | |
Repeati | 109 – 139 | ANK 1Add BLAST | 31 | |
Repeati | 143 – 172 | ANK 2Add BLAST | 30 | |
Repeati | 176 – 205 | ANK 3Add BLAST | 30 | |
Repeati | 209 – 238 | ANK 4Add BLAST | 30 | |
Repeati | 243 – 273 | ANK 5Add BLAST | 31 | |
Repeati | 277 – 306 | ANK 6Add BLAST | 30 |
Domaini
The fibronectin type-III domain mediates interaction with COPS5 and RYBP.2 Publications
Keywords - Domaini
ANK repeat, RepeatPhylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160878 |
InParanoidi | Q8TC84 |
OMAi | NFGHRLR |
OrthoDBi | 1514637at2759 |
PhylomeDBi | Q8TC84 |
TreeFami | TF106234 |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 1.25.40.20, 2 hits 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00060, FN3, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS50853, FN3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TC84-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPQKIMPPS KPHPPVVGKV THHSIELYWD LEKKAKRQGP QEQWFRFSIE
60 70 80 90 100
EEDPKMHTYG IIYTGYATKH VVEGLEPRTL YRFRLKVTSP SGECEYSPLV
110 120 130 140 150
SVSTTREPIS SEHLHRAVSV NDEDLLVRIL QGGRVKVDVP NKFGFTALMV
160 170 180 190 200
AAQKGYTRLV KILVSNGTDV NLKNGSGKDS LMLACYAGHL DVVKYLRRHG
210 220 230 240 250
ASWQARDLGG CTALHWAADG GHCSVIEWMI KDGCEVDVVD TGSGWTPLMR
260 270 280 290 300
VSAVSGNQRV ASLLIDAGAN VNVKDRNGKT PLMVAVLNNH EELVQLLLDK
310 320 330 340
GADASVKNEF GKGVLEMARV FDRQSVVSLL EERKKKQRPK KSCVC
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA6NP17 | A6NP17_HUMAN | Fibronectin type 3 and ankyrin repe... | FANK1 | 282 | Annotation score: | ||
H7C3M3 | H7C3M3_HUMAN | Fibronectin type 3 and ankyrin repe... | FANK1 | 199 | Annotation score: | ||
C9JD80 | C9JD80_HUMAN | Fibronectin type 3 and ankyrin repe... | FANK1 | 123 | Annotation score: | ||
A6NKD7 | A6NKD7_HUMAN | Fibronectin type 3 and ankyrin repe... | FANK1 | 133 | Annotation score: | ||
A0A1B0GX87 | A0A1B0GX87_HUMAN | Fibronectin type 3 and ankyrin repe... | FANK1 | 132 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 5 | K → R in AAH24189 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048296 | 12 | P → L. Corresponds to variant dbSNP:rs17153879Ensembl. | 1 | |
Natural variantiVAR_027896 | 46 | R → S. Corresponds to variant dbSNP:rs17153882Ensembl. | 1 | |
Natural variantiVAR_024176 | 329 | L → V. Corresponds to variant dbSNP:rs1666Ensembl. | 1 | |
Natural variantiVAR_048297 | 343 | C → F. Corresponds to variant dbSNP:rs17153976EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013569 | 106 | R → RPSLSKSLVKIRMVTSVLHG PPTENTG in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_013568 | 325 – 345 | SVVSL…KSCVC → VGMLFLPIKANF in isoform 2. 1 PublicationAdd BLAST | 21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358154 mRNA Translation: AAQ88521.1 BC024189 mRNA Translation: AAH24189.2 AY251163 mRNA Translation: AAP20060.1 |
CCDSi | CCDS31309.1 [Q8TC84-1] |
RefSeqi | NP_660278.3, NM_145235.3 [Q8TC84-1] XP_011538652.1, XM_011540350.2 |
Genome annotation databases
Ensembli | ENST00000368693.6; ENSP00000357682.1; ENSG00000203780.12 |
GeneIDi | 92565 |
KEGGi | hsa:92565 |
MANE-Selecti | ENST00000368693.6; ENSP00000357682.1; NM_145235.5; NP_660278.3 |
UCSCi | uc001ljh.5, human [Q8TC84-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY358154 mRNA Translation: AAQ88521.1 BC024189 mRNA Translation: AAH24189.2 AY251163 mRNA Translation: AAP20060.1 |
CCDSi | CCDS31309.1 [Q8TC84-1] |
RefSeqi | NP_660278.3, NM_145235.3 [Q8TC84-1] XP_011538652.1, XM_011540350.2 |
3D structure databases
AlphaFoldDBi | Q8TC84 |
SMRi | Q8TC84 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124956, 11 interactors |
IntActi | Q8TC84, 13 interactors |
STRINGi | 9606.ENSP00000357682 |
PTM databases
iPTMneti | Q8TC84 |
PhosphoSitePlusi | Q8TC84 |
Genetic variation databases
BioMutai | FANK1 |
DMDMi | 116241361 |
Proteomic databases
MassIVEi | Q8TC84 |
PaxDbi | Q8TC84 |
PeptideAtlasi | Q8TC84 |
PRIDEi | Q8TC84 |
ProteomicsDBi | 74098 [Q8TC84-1] 74099 [Q8TC84-2] 74100 [Q8TC84-3] |
Protocols and materials databases
Antibodypediai | 48696, 97 antibodies from 17 providers |
DNASUi | 92565 |
Genome annotation databases
Ensembli | ENST00000368693.6; ENSP00000357682.1; ENSG00000203780.12 |
GeneIDi | 92565 |
KEGGi | hsa:92565 |
MANE-Selecti | ENST00000368693.6; ENSP00000357682.1; NM_145235.5; NP_660278.3 |
UCSCi | uc001ljh.5, human [Q8TC84-1] |
Organism-specific databases
CTDi | 92565 |
DisGeNETi | 92565 |
GeneCardsi | FANK1 |
HGNCi | HGNC:23527, FANK1 |
HPAi | ENSG00000203780, Tissue enhanced (choroid plexus, fallopian tube, testis) |
MIMi | 611640, gene |
neXtProti | NX_Q8TC84 |
OpenTargetsi | ENSG00000203780 |
PharmGKBi | PA134976727 |
VEuPathDBi | HostDB:ENSG00000203780 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0504, Eukaryota |
GeneTreei | ENSGT00940000160878 |
InParanoidi | Q8TC84 |
OMAi | NFGHRLR |
OrthoDBi | 1514637at2759 |
PhylomeDBi | Q8TC84 |
TreeFami | TF106234 |
Enzyme and pathway databases
PathwayCommonsi | Q8TC84 |
SignaLinki | Q8TC84 |
Miscellaneous databases
BioGRID-ORCSi | 92565, 13 hits in 1047 CRISPR screens |
ChiTaRSi | FANK1, human |
GenomeRNAii | 92565 |
Pharosi | Q8TC84, Tbio |
PROi | PR:Q8TC84 |
RNActi | Q8TC84, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000203780, Expressed in right uterine tube and 159 other tissues |
ExpressionAtlasi | Q8TC84, baseline and differential |
Family and domain databases
CDDi | cd00063, FN3, 1 hit |
Gene3Di | 1.25.40.20, 2 hits 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF12796, Ank_2, 2 hits |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 6 hits SM00060, FN3, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF49265, SSF49265, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 5 hits PS50853, FN3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FANK1_HUMAN | |
Accessioni | Q8TC84Primary (citable) accession number: Q8TC84 Secondary accession number(s): Q6UXY9, Q6X7T6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | October 17, 2006 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot