UniProtKB - Q8TC84 (FANK1_HUMAN)

BLAST

>sp|Q8TC84|FANK1_HUMAN Fibronectin type 3 and ankyrin repeat domains protein 1 OS=Homo sapiens OX=9606 GN=FANK1 PE=1 SV=3
MEPQKIMPPSKPHPPVVGKVTHHSIELYWDLEKKAKRQGPQEQWFRFSIEEEDPKMHTYG
IIYTGYATKHVVEGLEPRTLYRFRLKVTSPSGECEYSPLVSVSTTREPISSEHLHRAVSV
NDEDLLVRILQGGRVKVDVPNKFGFTALMVAAQKGYTRLVKILVSNGTDVNLKNGSGKDS
LMLACYAGHLDVVKYLRRHGASWQARDLGGCTALHWAADGGHCSVIEWMIKDGCEVDVVD
TGSGWTPLMRVSAVSGNQRVASLLIDAGANVNVKDRNGKTPLMVAVLNNHEELVQLLLDK
GADASVKNEFGKGVLEMARVFDRQSVVSLLEERKKKQRPKKSCVC

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History
Entry version 134 (07 Nov 2018)
Sequence version 3 (17 Oct 2006)
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Protein

Fibronectin type 3 and ankyrin repeat domains protein 1

Gene

FANK1

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.2 Publications

GO - Biological processⁱ

negative regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20978819
positive regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27060496
positive regulation of DNA-binding transcription factor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20978819
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 27060496

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fibronectin type 3 and ankyrin repeat domains protein 1Curated
Gene namesⁱ	Name:FANK1Imported ORF Names:HSD13Imported, UNQ6504/PRO21382Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000203780.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23527 FANK1
MIMⁱ	611640 gene
neXtProtⁱ	NX_Q8TC84

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92565
Open Targets More...OpenTargetsⁱ	ENSG00000203780
PharmGKBⁱ	PA134976727

Polymorphism and mutation databases

BioMutaⁱ	FANK1
DMDMⁱ	116241361

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000066990	1 – 345	Fibronectin type 3 and ankyrin repeat domains protein 1Add BLAST		345

Post-translational modificationⁱ

Polyubiquitinated. Polyubiquitination leads to proteasomal degradation.1 Publication

Keywords - PTMⁱ

Ubl conjugation

Proteomic databases

PaxDbⁱ	Q8TC84
PeptideAtlas More...PeptideAtlasⁱ	Q8TC84
PRIDEⁱ	Q8TC84
ProteomicsDBⁱ	74098 74099 [Q8TC84-2] 74100 [Q8TC84-3]

PTM databases

iPTMnetⁱ	Q8TC84
PhosphoSitePlusⁱ	Q8TC84

Expressionⁱ

Tissue specificityⁱ

Mostly restricted to testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000203780 Expressed in 144 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_FANK1
ExpressionAtlasⁱ	Q8TC84 baseline and differential

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038413

HPAⁱ

HPA038413

Interactionⁱ

Subunit structureⁱ

Interacts with COPS5; regulates the phosphorylation of JUN and the transcriptional activity of AP-1 (PubMed:20978819). Interacts with RYBP; may prevent the ubiquitin-mediated proteasomal degradation of FANK1 (PubMed:27060496).2 Publications

Protein-protein interaction databases

BioGridⁱ	124956, 7 interactors
STRINGⁱ	9606.ENSP00000357682

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TC84
SMRⁱ	Q8TC84
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	8 – 108	Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST	101
Repeatⁱ	109 – 139	ANK 1Add BLAST	31
Repeatⁱ	143 – 172	ANK 2Add BLAST	30
Repeatⁱ	176 – 205	ANK 3Add BLAST	30
Repeatⁱ	209 – 238	ANK 4Add BLAST	30
Repeatⁱ	243 – 273	ANK 5Add BLAST	31
Repeatⁱ	277 – 306	ANK 6Add BLAST	30

Domainⁱ

Keywords - Domainⁱ

ANK repeat, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148967
HOGENOMⁱ	HOG000293255
HOVERGENⁱ	HBG051552
InParanoidⁱ	Q8TC84
OMAⁱ	QFLVKRM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IMO
PhylomeDBⁱ	Q8TC84
TreeFamⁱ	TF106234

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00204 ANK, 2 hits cd00063 FN3, 1 hit
Gene3Dⁱ	1.25.40.20, 2 hits 2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 6 hits SM00060 FN3, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 5 hits PS50853 FN3, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TC84-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPQKIMPPS KPHPPVVGKV THHSIELYWD LEKKAKRQGP QEQWFRFSIE 
        60         70         80         90        100
EEDPKMHTYG IIYTGYATKH VVEGLEPRTL YRFRLKVTSP SGECEYSPLV 
       110        120        130        140        150
SVSTTREPIS SEHLHRAVSV NDEDLLVRIL QGGRVKVDVP NKFGFTALMV 
       160        170        180        190        200
AAQKGYTRLV KILVSNGTDV NLKNGSGKDS LMLACYAGHL DVVKYLRRHG 
       210        220        230        240        250
ASWQARDLGG CTALHWAADG GHCSVIEWMI KDGCEVDVVD TGSGWTPLMR 
       260        270        280        290        300
VSAVSGNQRV ASLLIDAGAN VNVKDRNGKT PLMVAVLNNH EELVQLLLDK 
       310        320        330        340 
GADASVKNEF GKGVLEMARV FDRQSVVSLL EERKKKQRPK KSCVC

Length:345

Mass (Da):38,341

Last modified:October 17, 2006 - v3

Checksum:ⁱ47C16DE1ABF814E5

Isoform 2 (identifier: Q8TC84-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
325-345: SVVSLLEERKKKQRPKKSCVC → VGMLFLPIKANF

« Hide

        10         20         30         40         50
MEPQKIMPPS KPHPPVVGKV THHSIELYWD LEKKAKRQGP QEQWFRFSIE 
        60         70         80         90        100
EEDPKMHTYG IIYTGYATKH VVEGLEPRTL YRFRLKVTSP SGECEYSPLV 
       110        120        130        140        150
SVSTTREPIS SEHLHRAVSV NDEDLLVRIL QGGRVKVDVP NKFGFTALMV 
       160        170        180        190        200
AAQKGYTRLV KILVSNGTDV NLKNGSGKDS LMLACYAGHL DVVKYLRRHG 
       210        220        230        240        250
ASWQARDLGG CTALHWAADG GHCSVIEWMI KDGCEVDVVD TGSGWTPLMR 
       260        270        280        290        300
VSAVSGNQRV ASLLIDAGAN VNVKDRNGKT PLMVAVLNNH EELVQLLLDK 
       310        320        330 
GADASVKNEF GKGVLEMARV FDRQVGMLFL PIKANF

Show »

Length:336

Mass (Da):37,245

Checksum:ⁱA78CFF7A8585AA9D

Isoform 3 (identifier: Q8TC84-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
106-106: R → RPSLSKSLVKIRMVTSVLHGPPTENTG

« Hide

        10         20         30         40         50
MEPQKIMPPS KPHPPVVGKV THHSIELYWD LEKKAKRQGP QEQWFRFSIE 
        60         70         80         90        100
EEDPKMHTYG IIYTGYATKH VVEGLEPRTL YRFRLKVTSP SGECEYSPLV 
       110        120        130        140        150
SVSTTRPSLS KSLVKIRMVT SVLHGPPTEN TGEPISSEHL HRAVSVNDED 
       160        170        180        190        200
LLVRILQGGR VKVDVPNKFG FTALMVAAQK GYTRLVKILV SNGTDVNLKN 
       210        220        230        240        250
GSGKDSLMLA CYAGHLDVVK YLRRHGASWQ ARDLGGCTAL HWAADGGHCS 
       260        270        280        290        300
VIEWMIKDGC EVDVVDTGSG WTPLMRVSAV SGNQRVASLL IDAGANVNVK 
       310        320        330        340        350
DRNGKTPLMV AVLNNHEELV QLLLDKGADA SVKNEFGKGV LEMARVFDRQ 
       360        370 
SVVSLLEERK KKQRPKKSCV C

Note: No experimental confirmation available.

Show »

Length:371

Mass (Da):41,072

Checksum:ⁱ45D09153B1E30635

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A6NH44	A6NH44_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1 (Fibronectin type III and ankyrin repeat domains 1, isoform CRA_d)	FANK1 hCG_40943	339	Annotation score:
A6NP17	A6NP17_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1	282	Annotation score:
H7C3M3	H7C3M3_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1	199	Annotation score:
A6NKD7	A6NKD7_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1	133	Annotation score:
C9JD80	C9JD80_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1	123	Annotation score:
A0A1B0GX87	A0A1B0GX87_HUMAN	Fibronectin type 3 and ankyrin repe... Fibronectin type 3 and ankyrin repeat domains protein 1	FANK1	132	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	5	K → R in AAH24189 (PubMed:15489334).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_048296	12	P → L. Corresponds to variant dbSNP:rs17153879Ensembl.	1
Natural variantⁱVAR_027896	46	R → S. Corresponds to variant dbSNP:rs17153882Ensembl.	1
Natural variantⁱVAR_024176	329	L → V. Corresponds to variant dbSNP:rs1666Ensembl.	1
Natural variantⁱVAR_048297	343	C → F. Corresponds to variant dbSNP:rs17153976Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013569	106	R → RPSLSKSLVKIRMVTSVLHG PPTENTG in isoform 3. 1 Publication		1
Alternative sequenceⁱVSP_013568	325 – 345	SVVSL…KSCVC → VGMLFLPIKANF in isoform 2. 1 PublicationAdd BLAST		21

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358154 mRNA Translation: AAQ88521.1 BC024189 mRNA Translation: AAH24189.2 AY251163 mRNA Translation: AAP20060.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31309.1 [Q8TC84-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_660278.3, NM_145235.3 [Q8TC84-1] XP_011538652.1, XM_011540350.2
UniGeneⁱ	Hs.352591

Genome annotation databases

Ensemblⁱ	ENST00000368693; ENSP00000357682; ENSG00000203780 [Q8TC84-1]
GeneIDⁱ	92565
KEGGⁱ	hsa:92565
UCSC genome browser More...UCSCⁱ	uc001ljh.5 human [Q8TC84-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TC84	Fibronectin type III and ankyrin repeat domains 1		CHLSB		400	UniRef90_Q8TC84
Uncharacterized protein		CERAT		396
Uncharacterized protein		PAPAN		396
Uncharacterized protein		MACFA		396
Uncharacterized protein		PONAB		358
+30
Q8TC84-3	Uncharacterized protein (Fragment)		MACMU		367	UniRef90_Q8TC84-3
Uncharacterized protein (Fragment)		MACFA		367
UPI0005D00BC0		HUMAN		381
UPI000CEFD9D4		PONAB		380
UPI000C2AF4EA		Ugandan red Colobus		371
+8

Protein	Similar proteins		Species	Score	Length	Source
Q8TC84	Fibronectin type 3 and ankyrin repeat domains protein 1		BOVIN		345	UniRef50_Q8TC84
Fibronectin type 3 and ankyrin repeat domains 1 protein		RAT		344
Fibronectin type 3 and ankyrin repeat domains 1 protein	)	MOUSE		344
Fibronectin type III and ankyrin repeat domains 1		CHLSB		400
Uncharacterized protein		PAPAN		396
+147
Q8TC84-3	Uncharacterized protein (Fragment)		MACMU		367	UniRef50_Q8TC84-3
Uncharacterized protein (Fragment)		MACFA		367
Uncharacterized protein (Fragment)		AILME		311
Uncharacterized protein		MANLE		308
Uncharacterized protein		RHIBE		305
+48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY358154 mRNA Translation: AAQ88521.1 BC024189 mRNA Translation: AAH24189.2 AY251163 mRNA Translation: AAP20060.1
CCDSⁱ	CCDS31309.1 [Q8TC84-1]
RefSeqⁱ	NP_660278.3, NM_145235.3 [Q8TC84-1] XP_011538652.1, XM_011540350.2
UniGeneⁱ	Hs.352591

3D structure databases

ProteinModelPortalⁱ	Q8TC84
SMRⁱ	Q8TC84
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124956, 7 interactors
STRINGⁱ	9606.ENSP00000357682

PTM databases

iPTMnetⁱ	Q8TC84
PhosphoSitePlusⁱ	Q8TC84

Polymorphism and mutation databases

BioMutaⁱ	FANK1
DMDMⁱ	116241361

Proteomic databases

PaxDbⁱ	Q8TC84
PeptideAtlasⁱ	Q8TC84
PRIDEⁱ	Q8TC84
ProteomicsDBⁱ	74098 74099 [Q8TC84-2] 74100 [Q8TC84-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000368693; ENSP00000357682; ENSG00000203780 [Q8TC84-1]
GeneIDⁱ	92565
KEGGⁱ	hsa:92565
UCSCⁱ	uc001ljh.5 human [Q8TC84-1]

Organism-specific databases

CTDⁱ	92565
DisGeNETⁱ	92565
EuPathDBⁱ	HostDB:ENSG00000203780.10
GeneCardsⁱ	FANK1
H-InvDBⁱ	HIX0009297
HGNCⁱ	HGNC:23527 FANK1
HPAⁱ	HPA038413
MIMⁱ	611640 gene
neXtProtⁱ	NX_Q8TC84
OpenTargetsⁱ	ENSG00000203780
PharmGKBⁱ	PA134976727
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0504 Eukaryota COG0666 LUCA
GeneTreeⁱ	ENSGT00920000148967
HOGENOMⁱ	HOG000293255
HOVERGENⁱ	HBG051552
InParanoidⁱ	Q8TC84
OMAⁱ	QFLVKRM
OrthoDBⁱ	EOG091G0IMO
PhylomeDBⁱ	Q8TC84
TreeFamⁱ	TF106234

Miscellaneous databases

ChiTaRSⁱ	FANK1 human
GenomeRNAiⁱ	92565
Protein Ontology More...PROⁱ	PR:Q8TC84
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000203780 Expressed in 144 organ(s), highest expression level in right uterine tube
CleanExⁱ	HS_FANK1
ExpressionAtlasⁱ	Q8TC84 baseline and differential

Family and domain databases

CDDⁱ	cd00204 ANK, 2 hits cd00063 FN3, 1 hit
Gene3Dⁱ	1.25.40.20, 2 hits 2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR002110 Ankyrin_rpt IPR020683 Ankyrin_rpt-contain_dom IPR036770 Ankyrin_rpt-contain_sf IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold
Pfamⁱ	View protein in Pfam PF12796 Ank_2, 1 hit
PRINTSⁱ	PR01415 ANKYRIN
SMARTⁱ	View protein in SMART SM00248 ANK, 6 hits SM00060 FN3, 1 hit
SUPFAMⁱ	SSF48403 SSF48403, 1 hit SSF49265 SSF49265, 1 hit
PROSITEⁱ	View protein in PROSITE PS50297 ANK_REP_REGION, 1 hit PS50088 ANK_REPEAT, 5 hits PS50853 FN3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FANK1_HUMAN
Accessionⁱ	Q8TC84Primary (citable) accession number: Q8TC84 Secondary accession number(s): Q6UXY9, Q6X7T6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
	Last sequence update:	October 17, 2006
	Last modified:	November 7, 2018
	This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM

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UniProtKB - Q8TC84 (FANK1_HUMAN)

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Fibronectin type 3 and ankyrin repeat domains protein 1

FANK1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ