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Entry version 144 (08 May 2019)
Sequence version 1 (01 Jun 2002)
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Protein

Piwi-like protein 2

Gene

PIWIL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). Required for PIWIL4/MIWI2 nuclear localization and association with secondary piRNAs antisense (By similarity). Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). Indirectly modulates expression of genes such as PDGFRB, SLC2A1, ITGA6, GJA7, THY1, CD9 and STRA8 (By similarity). When overexpressed, acts as an oncogene by inhibition of apoptosis and promotion of proliferation in tumors (PubMed:16377660). Represses circadian rhythms by promoting the stability and activity of core clock components ARNTL/BMAL1 and CLOCK by inhibiting GSK3B-mediated phosphorylation and ubiquitination-dependent degradation of these proteins (PubMed:28903391).By similarity2 Publications

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei745By similarity1
Active sitei783By similarity1
Active sitei815By similarity1
Active sitei948By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Endonuclease, Hydrolase, Nuclease, RNA-binding
Biological processBiological rhythms, Differentiation, Meiosis, Oogenesis, RNA-mediated gene silencing, Spermatogenesis, Translation regulation
LigandMetal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Piwi-like protein 2 (EC:3.1.26.-By similarity)
Alternative name(s):
Cancer/testis antigen 80
Short name:
CT80
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIWIL2
Synonyms:HILI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17644 PIWIL2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610312 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC59

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55124

Open Targets

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OpenTargetsi
ENSG00000197181

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38461

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PIWIL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730558

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002345691 – 973Piwi-like protein 2Add BLAST973

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47Symmetric dimethylarginineBy similarity1
Modified residuei76Omega-N-methylarginine; by PRMT5; alternateBy similarity1
Modified residuei76Symmetric dimethylarginine; by PRMT5; alternateBy similarity1
Modified residuei97Omega-N-methylarginine; by PRMT5; alternateBy similarity1
Modified residuei97Symmetric dimethylarginine; alternateBy similarity1
Modified residuei102Omega-N-methylarginine; alternateBy similarity1
Modified residuei102Symmetric dimethylarginine; by PRMT5; alternateBy similarity1
Modified residuei146Symmetric dimethylarginineBy similarity1
Modified residuei158Symmetric dimethylarginineBy similarity1
Modified residuei165Symmetric dimethylarginine; by PRMT5By similarity1
Modified residuei551Symmetric dimethylarginine; by PRMT5By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Arginine methylation by PRMT5 is required for the interaction with Tudor domain-containing protein TDRD1 and subsequent localization to the meiotic nuage, also named P granule.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TC59

PeptideAtlas

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PeptideAtlasi
Q8TC59

PRoteomics IDEntifications database

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PRIDEi
Q8TC59

ProteomicsDB human proteome resource

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ProteomicsDBi
74093
74094 [Q8TC59-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q8TC59

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q8TC59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in adult testis and in most tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197181 Expressed in 128 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TC59 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TC59 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DDX4, MAEL, EIF3A, EIF4E, EIF4G, PRMT5 and WDR77 (By similarity). Associates with EIF4E- and EIF4G-containing m7G cap-binding complexes (By similarity). Interacts (when methylated on arginine residues) with TDRD1 and TDRKH/TDRD2 (By similarity). Interacts with TDRD12 (By similarity). Component of the PET complex, at least composed of EXD1, PIWIL2, TDRD12 and piRNAs (By similarity). Interacts with MOV10L1 (By similarity). Interacts with GPAT2 (By similarity). Interacts with TEX19 (By similarity). Interacts with GSK3B (By similarity). Interacts (via PIWI domain) with ARNTL/BMAL1 and CLOCK (PubMed:28903391).By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120431, 7 interactors

Protein interaction database and analysis system

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IntActi
Q8TC59, 9 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000349208

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1973
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O7XX-ray2.92A/B/C/D387-525[»]
3QIRX-ray2.45A/B/C/D386-533[»]

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TC59

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini384 – 496PAZPROSITE-ProRule annotationAdd BLAST113
Domaini668 – 959PiwiPROSITE-ProRule annotationAdd BLAST292

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the argonaute family. Piwi subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1042 Eukaryota
ENOG410XNRH LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00950000183200

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TC59

KEGG Orthology (KO)

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KOi
K02156

Identification of Orthologs from Complete Genome Data

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OMAi
NKEHFQD

Database of Orthologous Groups

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OrthoDBi
220258at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TC59

TreeFam database of animal gene trees

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TreeFami
TF354206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR014811 ArgoL1
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08699 ArgoL1, 1 hit
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01163 DUF1785, 1 hit
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC59-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPFRPSFRG QSPIHPSQCQ AVRMPGCWPQ ASKPLDPALG RGAPAGRGHV
60 70 80 90 100
FGKPEEPSTQ RGPAQRESVG LVSMFRGLGI ETVSKTPLKR EMLPSGRGIL
110 120 130 140 150
GRGLSANLVR KDREELSPTF WDPKVLAAGD SKMAETSVGW SRTLGRGSSD
160 170 180 190 200
ASLLPLGRAA GGISREVDKP PCTFSTPSRG PPQLSSPPAL PQSPLHSPDR
210 220 230 240 250
PLVLTVEHKE KELIVKQGSK GTPQSLGLNL VKIQCHNEAV YQYHVTFSPN
260 270 280 290 300
VECKSMRFGM LKDHQAVTGN VTAFDGSILY LPVKLQQVLE LKSQRKTDSA
310 320 330 340 350
EISIKIQMTK ILEPCSDLCI PFYNVVFRRV MKLLDMKLVG RNFYDPTSAM
360 370 380 390 400
VLQQHRLQIW PGYAASIRRT DGGLFLLADV SHKVIRNDCV LDVMHAIYQQ
410 420 430 440 450
NKEHFQDECT KLLVGNIVIT RYNNRTYRID DVDWNKTPKD SFTMSDGKEI
460 470 480 490 500
TFLEYYSKNY GITVKEEDQP LLIHRPSERQ DNHGMLLKGE ILLLPELSFM
510 520 530 540 550
TGIPEKMKKD FRAMKDLAQQ INLSPKQHHS ALECLLQRIA KNEAATNELM
560 570 580 590 600
RWGLRLQKDV HKIEGRVLPM ERINLKNTSF ITSQELNWVK EVTRDPSILT
610 620 630 640 650
IPMHFWALFY PKRAMDQARE LVNMLEKIAG PIGMRMSPPA WVELKDDRIE
660 670 680 690 700
TYVRTIQSTL GAEGKIQMVV CIIMGPRDDL YGAIKKLCCV QSPVPSQVVN
710 720 730 740 750
VRTIGQPTRL RSVAQKILLQ INCKLGGELW GVDIPLKQLM VIGMDVYHDP
760 770 780 790 800
SRGMRSVVGF VASINLTLTK WYSRVVFQMP HQEIVDSLKL CLVGSLKKFY
810 820 830 840 850
EVNHCLPEKI VVYRDGVSDG QLKTVANYEI PQLQKCFEAF ENYQPKMVVF
860 870 880 890 900
VVQKKISTNL YLAAPQNFVT PTPGTVVDHT ITSCEWVDFY LLAHHVRQGC
910 920 930 940 950
GIPTHYVCVL NTANLSPDHM QRLTFKLCHM YWNWPGTIRV PAPCKYAHKL
960 970
AFLSGHILHH EPAIQLCENL FFL
Length:973
Mass (Da):109,849
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC44398136B144CA0
GO
Isoform 2 (identifier: Q8TC59-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     887-922: Missing.

Show »
Length:937
Mass (Da):105,760
Checksum:i5888D266DD32416C
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB55155 differs from that shown. Reason: Erroneous termination at position 421. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18Q → R in BAG61134 (PubMed:14702039).Curated1
Sequence conflicti581I → T in BAF98721 (PubMed:14702039).Curated1
Sequence conflicti685K → N in BAA91558 (PubMed:14702039).Curated1
Sequence conflicti720Q → R in BAF98724 (PubMed:14702039).Curated1
Sequence conflicti887V → G in BAF83727 (PubMed:14702039).Curated1
Sequence conflicti961E → G in BAB55155 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036664887 – 922Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB079367 mRNA Translation: BAC81342.1
HQ651229 mRNA Translation: ADV17663.1
AK001213 mRNA Translation: BAA91558.1 Different initiation.
AK027497 mRNA Translation: BAB55155.1 Sequence problems.
AK291038 mRNA Translation: BAF83727.1
AK292440 mRNA Translation: BAF85129.1
AK299068 mRNA Translation: BAG61134.1
AK315830 mRNA Translation: BAF98721.1
AK315833 mRNA Translation: BAF98724.1
BC025995 mRNA Translation: AAH25995.1
BC111751 mRNA Translation: AAI11752.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS6029.1 [Q8TC59-1]
CCDS83261.1 [Q8TC59-2]

NCBI Reference Sequences

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RefSeqi
NP_001129193.1, NM_001135721.1 [Q8TC59-1]
NP_001317409.1, NM_001330480.1 [Q8TC59-2]
NP_060538.2, NM_018068.3 [Q8TC59-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356766; ENSP00000349208; ENSG00000197181 [Q8TC59-1]
ENST00000454009; ENSP00000406956; ENSG00000197181 [Q8TC59-1]
ENST00000521356; ENSP00000428267; ENSG00000197181 [Q8TC59-2]
ENST00000611073; ENSP00000478103; ENSG00000197181 [Q8TC59-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55124

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55124

UCSC genome browser

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UCSCi
uc011kzf.2 human [Q8TC59-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079367 mRNA Translation: BAC81342.1
HQ651229 mRNA Translation: ADV17663.1
AK001213 mRNA Translation: BAA91558.1 Different initiation.
AK027497 mRNA Translation: BAB55155.1 Sequence problems.
AK291038 mRNA Translation: BAF83727.1
AK292440 mRNA Translation: BAF85129.1
AK299068 mRNA Translation: BAG61134.1
AK315830 mRNA Translation: BAF98721.1
AK315833 mRNA Translation: BAF98724.1
BC025995 mRNA Translation: AAH25995.1
BC111751 mRNA Translation: AAI11752.1
CCDSiCCDS6029.1 [Q8TC59-1]
CCDS83261.1 [Q8TC59-2]
RefSeqiNP_001129193.1, NM_001135721.1 [Q8TC59-1]
NP_001317409.1, NM_001330480.1 [Q8TC59-2]
NP_060538.2, NM_018068.3 [Q8TC59-1]

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3O7XX-ray2.92A/B/C/D387-525[»]
3QIRX-ray2.45A/B/C/D386-533[»]
SMRiQ8TC59
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120431, 7 interactors
IntActiQ8TC59, 9 interactors
STRINGi9606.ENSP00000349208

PTM databases

iPTMnetiQ8TC59
PhosphoSitePlusiQ8TC59

Polymorphism and mutation databases

BioMutaiPIWIL2
DMDMi74730558

Proteomic databases

PaxDbiQ8TC59
PeptideAtlasiQ8TC59
PRIDEiQ8TC59
ProteomicsDBi74093
74094 [Q8TC59-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
55124
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356766; ENSP00000349208; ENSG00000197181 [Q8TC59-1]
ENST00000454009; ENSP00000406956; ENSG00000197181 [Q8TC59-1]
ENST00000521356; ENSP00000428267; ENSG00000197181 [Q8TC59-2]
ENST00000611073; ENSP00000478103; ENSG00000197181 [Q8TC59-2]
GeneIDi55124
KEGGihsa:55124
UCSCiuc011kzf.2 human [Q8TC59-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55124
DisGeNETi55124

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PIWIL2
HGNCiHGNC:17644 PIWIL2
MIMi610312 gene
neXtProtiNX_Q8TC59
OpenTargetsiENSG00000197181
PharmGKBiPA38461

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1042 Eukaryota
ENOG410XNRH LUCA
GeneTreeiENSGT00950000183200
InParanoidiQ8TC59
KOiK02156
OMAiNKEHFQD
OrthoDBi220258at2759
PhylomeDBiQ8TC59
TreeFamiTF354206

Enzyme and pathway databases

ReactomeiR-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PIWIL2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55124

Protein Ontology

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PROi
PR:Q8TC59

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197181 Expressed in 128 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiQ8TC59 baseline and differential
GenevisibleiQ8TC59 HS

Family and domain databases

Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR014811 ArgoL1
IPR003100 PAZ_dom
IPR036085 PAZ_dom_sf
IPR003165 Piwi
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF08699 ArgoL1, 1 hit
PF02170 PAZ, 1 hit
PF02171 Piwi, 1 hit
SMARTiView protein in SMART
SM01163 DUF1785, 1 hit
SM00949 PAZ, 1 hit
SM00950 Piwi, 1 hit
SUPFAMiSSF101690 SSF101690, 1 hit
SSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS50821 PAZ, 1 hit
PS50822 PIWI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIWL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC59
Secondary accession number(s): A8K4S3
, A8K8S5, B0AZN9, B0AZP2, B4DR22, E7ECA4, Q96SW6, Q9NW28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: June 1, 2002
Last modified: May 8, 2019
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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