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Entry version 99 (13 Feb 2019)
Sequence version 2 (01 May 2007)
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Protein

Protein FAM71B

Gene

FAM71B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in RNA biogenesis.1 Publication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM71B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM71B
ORF Names:HSD-51, HSD51
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000170613.4

Human Gene Nomenclature Database

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HGNCi
HGNC:28397 FAM71B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC56

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000170613

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671832

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM71B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
146286168

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002856431 – 605Protein FAM71BAdd BLAST605

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei592PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TC56

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q8TC56

PeptideAtlas

More...
PeptideAtlasi
Q8TC56

PRoteomics IDEntifications database

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PRIDEi
Q8TC56

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74089

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC56

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TC56

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170613 Expressed in 11 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TC56 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TC56 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039478
HPA040771

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FRG1.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
127515, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000305596

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8TC56

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TC56

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi441 – 458Bipartite nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 317Ala-richAdd BLAST93

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM71 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IH8C Eukaryota
ENOG410YQV3 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162063

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290696

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG058004

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TC56

Identification of Orthologs from Complete Genome Data

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OMAi
VFNTSMG

Database of Orthologous Groups

More...
OrthoDBi
982161at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TC56

TreeFam database of animal gene trees

More...
TreeFami
TF336050

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022168 DUF3699

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12480 DUF3699, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TC56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNESCLPYY TAHSYSSMSA FKTSMGDLQR QLYNRGEYNI FKYAPMFESN
60 70 80 90 100
FIQINKKGEV IDVHNRVRMV TVGIVCTSPI LPLPDVMVLA QPTKICEQHV
110 120 130 140 150
RWGRFAKGRG RRPVKTLELT RLLPLKFVKI SIHDHEKQQL RLKLATGRTF
160 170 180 190 200
YLQLCPSSDT REDLFCYWEK LVYLLRPPVE SYCSTPTLLS GDAPPEDNKS
210 220 230 240 250
LVAAELHREG DQSETGLYKP CDVSAATSSA YAGGEGIQHA SHGTASAASP
260 270 280 290 300
STSTPGAAEG GAARTAGGMA VAGTATGPRT DVAIAGAAMS PATGAMSIAT
310 320 330 340 350
TKSAGPGQVT TALAGAAIKN PGENESSKSM AGAANISSEG ISLALVGAAS
360 370 380 390 400
TSLEGTSTSM AGAASLSQDS SLSAAFAGSI TTSKCAAERT EGPAVGPLIS
410 420 430 440 450
TLQSEGYMSE RDGSQKVSQP SAEVWNENKE RREKKDRHPS RKSSHHRKAG
460 470 480 490 500
ESHRRRAGDK NQKASSHRSA SGHKNTRDDK KEKGYSNVRG KRHGSSRKSS
510 520 530 540 550
THSSTKKESR TTQELGKNQS ASSTGALQKK ASKISSFLRS LRATPGSKTR
560 570 580 590 600
VTSHDREVDI VAKMVEKQNI EAKVEKAQGG QELEMISGTM TSEKTEMIVF

ETKSI
Length:605
Mass (Da):64,756
Last modified:May 1, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84BF94215309E38A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti280T → A in AAY41236 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032036543A → V1 PublicationCorresponds to variant dbSNP:rs17852327Ensembl.1
Natural variantiVAR_032037564M → T2 PublicationsCorresponds to variant dbSNP:rs31208Ensembl.1
Natural variantiVAR_032038599V → I. Corresponds to variant dbSNP:rs2115480Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK057543 mRNA Translation: BAB71526.1
AY973323 mRNA Translation: AAY41236.1
BC022035 mRNA Translation: AAH22035.1
BC025397 mRNA Translation: AAH25397.1
BC025409 mRNA Translation: AAH25409.1
BC025998 mRNA Translation: AAH25998.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4335.1

NCBI Reference Sequences

More...
RefSeqi
NP_570969.2, NM_130899.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.666099

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302938; ENSP00000305596; ENSG00000170613

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
153745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:153745

UCSC genome browser

More...
UCSCi
uc003lwn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK057543 mRNA Translation: BAB71526.1
AY973323 mRNA Translation: AAY41236.1
BC022035 mRNA Translation: AAH22035.1
BC025397 mRNA Translation: AAH25397.1
BC025409 mRNA Translation: AAH25409.1
BC025998 mRNA Translation: AAH25998.1
CCDSiCCDS4335.1
RefSeqiNP_570969.2, NM_130899.2
UniGeneiHs.666099

3D structure databases

ProteinModelPortaliQ8TC56
SMRiQ8TC56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127515, 2 interactors
STRINGi9606.ENSP00000305596

PTM databases

iPTMnetiQ8TC56
PhosphoSitePlusiQ8TC56

Polymorphism and mutation databases

BioMutaiFAM71B
DMDMi146286168

Proteomic databases

jPOSTiQ8TC56
PaxDbiQ8TC56
PeptideAtlasiQ8TC56
PRIDEiQ8TC56
ProteomicsDBi74089

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
153745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302938; ENSP00000305596; ENSG00000170613
GeneIDi153745
KEGGihsa:153745
UCSCiuc003lwn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
153745
EuPathDBiHostDB:ENSG00000170613.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM71B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0005354
HGNCiHGNC:28397 FAM71B
HPAiHPA039478
HPA040771
neXtProtiNX_Q8TC56
OpenTargetsiENSG00000170613
PharmGKBiPA142671832

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IH8C Eukaryota
ENOG410YQV3 LUCA
GeneTreeiENSGT00940000162063
HOGENOMiHOG000290696
HOVERGENiHBG058004
InParanoidiQ8TC56
OMAiVFNTSMG
OrthoDBi982161at2759
PhylomeDBiQ8TC56
TreeFamiTF336050

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
153745

Protein Ontology

More...
PROi
PR:Q8TC56

Gene expression databases

BgeeiENSG00000170613 Expressed in 11 organ(s), highest expression level in right testis
ExpressionAtlasiQ8TC56 baseline and differential
GenevisibleiQ8TC56 HS

Family and domain databases

InterProiView protein in InterPro
IPR022168 DUF3699
PfamiView protein in Pfam
PF12480 DUF3699, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA71B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC56
Secondary accession number(s): Q1EDD9, Q8TC64, Q96LY8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 13, 2019
This is version 99 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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