UniProtKB - Q8TC44 (POC1B_HUMAN)

BLAST

>sp|Q8TC44|POC1B_HUMAN POC1 centriolar protein homolog B OS=Homo sapiens OX=9606 GN=POC1B PE=1 SV=1
MASATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK
DVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATA
SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN
NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSG
NYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN
FDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINPKLEVIDLQISTPP
VMDILSFDSTTTTETSGRTLPDKGEEACGYFLNPSLMSPECLPTTTKKKTEDMSDLPCES
QRSIPLAVTDALEHIMEQLNVLTQTVSILEQRLTLTEDKLKDCLENQQKLFSAVQQKS

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History
Entry version 137 (07 Nov 2018)
Sequence version 1 (01 Jun 2002)
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Protein

POC1 centriolar protein homolog B

Gene

POC1B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745).4 Publications

GO - Biological processⁱ

cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23015594
cilium assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20008567
retina homeostasis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 25044745

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cilium biogenesis/degradation

Biological process

Cilium biogenesis/degradation

Enzyme and pathway databases

SignaLinkⁱ	Q8TC44

SignaLinkⁱ

Q8TC44

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POC1 centriolar protein homolog B Alternative name(s): Pix1 Proteome of centriole protein 1B WD repeat-containing protein 51B
Gene namesⁱ	Name:POC1B Synonyms:WDR51B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139323.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30836 POC1B
MIMⁱ	614784 gene
neXtProtⁱ	NX_Q8TC44

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Cone-rod dystrophy 20 (CORD20)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of cone-rod dystrophy, an inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa, due to cone photoreceptors degenerating at a higher rate than rod photoreceptors.

Keywords - Diseaseⁱ

Cone-rod dystrophy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	282809
MalaCards human disease database More...MalaCardsⁱ	POC1B
MIMⁱ	615973 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000139323
Orphanetⁱ	1872 Cone rod dystrophy
PharmGKBⁱ	PA165513299

Polymorphism and mutation databases

BioMutaⁱ	POC1B
DMDMⁱ	74762610

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051410	1 – 478	POC1 centriolar protein homolog BAdd BLAST		478

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	321	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Phosphorylated in mitotic cells that may be mediated by CDK1.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TC44
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q8TC44
PaxDbⁱ	Q8TC44
PeptideAtlas More...PeptideAtlasⁱ	Q8TC44
PRIDEⁱ	Q8TC44
ProteomicsDBⁱ	74088

PTM databases

iPTMnetⁱ	Q8TC44
PhosphoSitePlusⁱ	Q8TC44

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000139323 Expressed in 198 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_WDR51B
ExpressionAtlasⁱ	Q8TC44 baseline and differential
Genevisibleⁱ	Q8TC44 HS

Interactionⁱ

Subunit structureⁱ

Interacts with POC1A (PubMed:23015594). Interacts with FAM161A (PubMed:25018096).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NUDC	Q9Y266	2	EBI-1176274,EBI-357298

With

Entry

#Exp.

IntAct

Notes

NUDC

Q9Y266

EBI-1176274,EBI-357298

Protein-protein interaction databases

BioGridⁱ	129421, 48 interactors
IntActⁱ	Q8TC44, 26 interactors
STRINGⁱ	9606.ENSP00000323302

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TC44
SMRⁱ	Q8TC44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	16 – 55	WD 1Add BLAST	40
Repeatⁱ	58 – 99	WD 2Add BLAST	42
Repeatⁱ	101 – 139	WD 3Add BLAST	39
Repeatⁱ	142 – 181	WD 4Add BLAST	40
Repeatⁱ	183 – 223	WD 5Add BLAST	41
Repeatⁱ	226 – 265	WD 6Add BLAST	40
Repeatⁱ	268 – 307	WD 7Add BLAST	40

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	431 – 470	Sequence analysisAdd BLAST		40

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	370 – 375	Poly-Thr		6

Sequence similaritiesⁱ

Belongs to the WD repeat POC1 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IF90 Eukaryota ENOG410XR4H LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000036743
HOVERGENⁱ	HBG057502
InParanoidⁱ	Q8TC44
KEGG Orthology (KO) More...KOⁱ	K16482
OMAⁱ	WNFKPQA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07ES
PhylomeDBⁱ	Q8TC44
TreeFamⁱ	TF324210

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TC44-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASATEDPVL ERYFKGHKAA ITSLDLSPNG KQLATASWDT FLMLWNFKPH 
        60         70         80         90        100
ARAYRYVGHK DVVTSVQFSP HGNLLASASR DRTVRLWIPD KRGKFSEFKA 
       110        120        130        140        150
HTAPVRSVDF SADGQFLATA SEDKSIKVWS MYRQRFLYSL YRHTHWVRCA 
       160        170        180        190        200
KFSPDGRLIV SCSEDKTIKI WDTTNKQCVN NFSDSVGFAN FVDFNPSGTC 
       210        220        230        240        250
IASAGSDQTV KVWDVRVNKL LQHYQVHSGG VNCISFHPSG NYLITASSDG 
       260        270        280        290        300
TLKILDLLEG RLIYTLQGHT GPVFTVSFSK GGELFASGGA DTQVLLWRTN 
       310        320        330        340        350
FDELHCKGLT KRNLKRLHFD SPPHLLDIYP RTPHPHEEKV ETVEINPKLE 
       360        370        380        390        400
VIDLQISTPP VMDILSFDST TTTETSGRTL PDKGEEACGY FLNPSLMSPE 
       410        420        430        440        450
CLPTTTKKKT EDMSDLPCES QRSIPLAVTD ALEHIMEQLN VLTQTVSILE 
       460        470 
QRLTLTEDKL KDCLENQQKL FSAVQQKS

Length:478

Mass (Da):53,668

Last modified:June 1, 2002 - v1

Checksum:ⁱ1D93DBBE05A603E8

Isoform 2 (identifier: Q8TC44-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-42: Missing.

« Hide

        10         20         30         40         50
MLWNFKPHAR AYRYVGHKDV VTSVQFSPHG NLLASASRDR TVRLWIPDKR 
        60         70         80         90        100
GKFSEFKAHT APVRSVDFSA DGQFLATASE DKSIKVWSMY RQRFLYSLYR 
       110        120        130        140        150
HTHWVRCAKF SPDGRLIVSC SEDKTIKIWD TTNKQCVNNF SDSVGFANFV 
       160        170        180        190        200
DFNPSGTCIA SAGSDQTVKV WDVRVNKLLQ HYQVHSGGVN CISFHPSGNY 
       210        220        230        240        250
LITASSDGTL KILDLLEGRL IYTLQGHTGP VFTVSFSKGG ELFASGGADT 
       260        270        280        290        300
QVLLWRTNFD ELHCKGLTKR NLKRLHFDSP PHLLDIYPRT PHPHEEKVET 
       310        320        330        340        350
VEINPKLEVI DLQISTPPVM DILSFDSTTT TETSGRTLPD KGEEACGYFL 
       360        370        380        390        400
NPSLMSPECL PTTTKKKTED MSDLPCESQR SIPLAVTDAL EHIMEQLNVL 
       410        420        430 
TQTVSILEQR LTLTEDKLKD CLENQQKLFS AVQQKS

Note: Gene prediction based on EST data.

Show »

Length:436

Mass (Da):49,104

Checksum:ⁱ0570AE7A1F29DAD6

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8IU52	Q8IU52_HUMAN	POC1 centriolar protein homolog B POC1 centriolar protein homolog B (TUWD12) (WD repeat domain 51B, isoform CRA_c)	POC1B TUWD12, WDR51B, hCG_27606	348	Annotation score:
F8VX21	F8VX21_HUMAN	POC1 centriolar protein homolog B POC1 centriolar protein homolog B	POC1B	91	Annotation score:
F8VPF1	F8VPF1_HUMAN	POC1 centriolar protein homolog B POC1 centriolar protein homolog B	POC1B	93	Annotation score:
F8VV91	F8VV91_HUMAN	POC1 centriolar protein homolog B POC1 centriolar protein homolog B	POC1B	50	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071916	67	Missing in CORD20; disrupts interaction with FAM161A; localization of the mutant is cytosolic without enrichment at specific subcellular sites. 1 Publication		1
Natural variantⁱVAR_071917	106	R → P in CORD20; disrupts interaction with FAM161A; localization of the mutant is cytosolic without enrichment at specific subcellular sites. 3 PublicationsCorresponds to variant dbSNP:rs76216585EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047066	1 – 42	Missing in isoform 2. CuratedAdd BLAST		42

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK074772 mRNA Translation: BAC11198.1 AC010201 Genomic DNA No translation available. AC025034 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97425.1 BC026080 mRNA Translation: AAH26080.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31869.1 [Q8TC44-1] CCDS55859.1 [Q8TC44-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001186706.1, NM_001199777.1 [Q8TC44-2] NP_758440.1, NM_172240.2 [Q8TC44-1]
UniGeneⁱ	Hs.25130 Hs.604487

Genome annotation databases

Ensemblⁱ	ENST00000313546; ENSP00000323302; ENSG00000139323 [Q8TC44-1] ENST00000549035; ENSP00000447916; ENSG00000139323 [Q8TC44-2]
GeneIDⁱ	282809
KEGGⁱ	hsa:282809
UCSC genome browser More...UCSCⁱ	uc001tba.4 human [Q8TC44-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TC44	CDW9/WDR51B		HUMAN		478	UniRef100_Q8TC44
UPI000D098AD7		PANTR		371
Isoform 2 of POC1 centriolar protein homolog B		HUMAN		436
POC1 centriolar protein homolog B		HUMAN		348

Protein	Similar proteins		Species	Score	Length	Source
Q8TC44	CDW9/WDR51B		HUMAN		478	UniRef90_Q8TC44
Uncharacterized protein		CALJA		545
Uncharacterized protein		AOTNA		503
POC1 centriolar protein B		SAIBB		481
POC1 centriolar protein B		PANTR		478
+38

Protein	Similar proteins		Species	Score	Length	Source
Q8TC44	POC1 centriolar protein homolog B		PONAB		451	UniRef50_Q8TC44
CDW9/WDR51B		HUMAN		478
Uncharacterized protein		CALJA		545
Uncharacterized protein		AOTNA		503
POC1 centriolar protein B		SAIBB		481
+306

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK074772 mRNA Translation: BAC11198.1 AC010201 Genomic DNA No translation available. AC025034 Genomic DNA No translation available. CH471054 Genomic DNA Translation: EAW97425.1 BC026080 mRNA Translation: AAH26080.1
CCDSⁱ	CCDS31869.1 [Q8TC44-1] CCDS55859.1 [Q8TC44-2]
RefSeqⁱ	NP_001186706.1, NM_001199777.1 [Q8TC44-2] NP_758440.1, NM_172240.2 [Q8TC44-1]
UniGeneⁱ	Hs.25130 Hs.604487

3D structure databases

ProteinModelPortalⁱ	Q8TC44
SMRⁱ	Q8TC44
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129421, 48 interactors
IntActⁱ	Q8TC44, 26 interactors
STRINGⁱ	9606.ENSP00000323302

PTM databases

iPTMnetⁱ	Q8TC44
PhosphoSitePlusⁱ	Q8TC44

Polymorphism and mutation databases

BioMutaⁱ	POC1B
DMDMⁱ	74762610

Proteomic databases

EPDⁱ	Q8TC44
MaxQBⁱ	Q8TC44
PaxDbⁱ	Q8TC44
PeptideAtlasⁱ	Q8TC44
PRIDEⁱ	Q8TC44
ProteomicsDBⁱ	74088

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	282809
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000313546; ENSP00000323302; ENSG00000139323 [Q8TC44-1] ENST00000549035; ENSP00000447916; ENSG00000139323 [Q8TC44-2]
GeneIDⁱ	282809
KEGGⁱ	hsa:282809
UCSCⁱ	uc001tba.4 human [Q8TC44-1]

Organism-specific databases

CTDⁱ	282809
DisGeNETⁱ	282809
EuPathDBⁱ	HostDB:ENSG00000139323.13
GeneCardsⁱ	POC1B
HGNCⁱ	HGNC:30836 POC1B
MalaCardsⁱ	POC1B
MIMⁱ	614784 gene 615973 phenotype
neXtProtⁱ	NX_Q8TC44
OpenTargetsⁱ	ENSG00000139323
Orphanetⁱ	1872 Cone rod dystrophy
PharmGKBⁱ	PA165513299
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IF90 Eukaryota ENOG410XR4H LUCA
GeneTreeⁱ	ENSGT00810000125363
HOGENOMⁱ	HOG000036743
HOVERGENⁱ	HBG057502
InParanoidⁱ	Q8TC44
KOⁱ	K16482
OMAⁱ	WNFKPQA
OrthoDBⁱ	EOG091G07ES
PhylomeDBⁱ	Q8TC44
TreeFamⁱ	TF324210

Enzyme and pathway databases

SignaLinkⁱ	Q8TC44

SignaLinkⁱ

Q8TC44

Miscellaneous databases

ChiTaRSⁱ	POC1B human
GenomeRNAiⁱ	282809
Protein Ontology More...PROⁱ	PR:Q8TC44
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139323 Expressed in 198 organ(s), highest expression level in epithelial cell of pancreas
CleanExⁱ	HS_WDR51B
ExpressionAtlasⁱ	Q8TC44 baseline and differential
Genevisibleⁱ	Q8TC44 HS

Family and domain databases

Gene3Dⁱ	2.130.10.10, 3 hits
InterProⁱ	View protein in InterPro IPR020472 G-protein_beta_WD-40_rep IPR015943 WD40/YVTN_repeat-like_dom_sf IPR001680 WD40_repeat IPR019775 WD40_repeat_CS IPR017986 WD40_repeat_dom IPR036322 WD40_repeat_dom_sf
Pfamⁱ	View protein in Pfam PF00400 WD40, 7 hits
PRINTSⁱ	PR00320 GPROTEINBRPT
SMARTⁱ	View protein in SMART SM00320 WD40, 7 hits
SUPFAMⁱ	SSF50978 SSF50978, 1 hit
PROSITEⁱ	View protein in PROSITE PS00678 WD_REPEATS_1, 3 hits PS50082 WD_REPEATS_2, 7 hits PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	POC1B_HUMAN
Accessionⁱ	Q8TC44Primary (citable) accession number: Q8TC44 Secondary accession number(s): G3V1X0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - Q8TC44 (POC1B_HUMAN)

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POC1 centriolar protein homolog B

POC1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ