Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 137 (17 Jun 2020)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

SUN domain-containing protein 5

Gene

SUN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an essential role in anchoring sperm head to the tail. Is responsible for the attachment of the coupling apparatus to the sperm nuclear envelope.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SUN domain-containing protein 5
Alternative name(s):
Sad1 and UNC84 domain-containing protein 5
Sperm-associated antigen 4-like protein
Testis and spermatogenesis-related gene 4 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUN5
Synonyms:SPAG4L, TSARG4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000167098.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16252 SUN5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613942 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 105NuclearSequence analysisAdd BLAST105
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei106 – 122HelicalSequence analysisAdd BLAST17
Topological domaini123 – 379Perinuclear spaceSequence analysisAdd BLAST257

Keywords - Cellular componenti

Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spermatogenic failure 16 (SPGF16)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn infertility disorder caused by spermatogenesis defects and characterized by abnormally shaped spermatozoa in the semen of affected individuals. Most spermatozoa are made up of headless tails, while a small proportion has an abnormal head-tail junction. A few spermatozoa are made up of tailless heads.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077983114G → R in SPGF16; loss of protein expression; impaired localization to nuclear inner membrane. 2 Publications1
Natural variantiVAR_080157159 – 379Missing in SPGF16; in mouse model abolishes interaction with DNAJB13. 1 PublicationAdd BLAST221
Natural variantiVAR_077984162M → K in SPGF16; unknown pathological significance; in mouse model increases interaction with DNAJB13; impaired localization to nuclear inner membrane. 2 PublicationsCorresponds to variant dbSNP:rs886041023EnsemblClinVar.1
Natural variantiVAR_077985261V → M in SPGF16; unknown pathological significance; in mouse model decreases protein solubility as well as impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs886041024EnsemblClinVar.1
Natural variantiVAR_077986275T → M in SPGF16; significant reduction in protein expression; impaired localization to nuclear inner membrane; in mouse model decreases interaction with DNAJB13. 3 PublicationsCorresponds to variant dbSNP:rs756459525EnsemblClinVar.1
Natural variantiVAR_080158284 – 379Missing in SPGF16; significant reduction in protein expression; impaired localization to nuclear inner membrane; in mouse model decreases interaction with DNAJB13. 2 PublicationsAdd BLAST96
Natural variantiVAR_077987348N → I in SPGF16; loss of protein expression; in mouse model impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs758335571Ensembl.1
Natural variantiVAR_077988356R → C in SPGF16; unknown pathological significance; in mouse model impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs754130052EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
140732

MalaCards human disease database

More...
MalaCardsi
SUN5
MIMi617187 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000167098

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
529970 Male infertility due to acephalic spermatozoa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38095

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TC36 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUN5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
27805720

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002189191 – 379SUN domain-containing protein 5Add BLAST379

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly glycosylated in the Golgi apparatus during spermiogenesis.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TC36

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TC36

PeptideAtlas

More...
PeptideAtlasi
Q8TC36

PRoteomics IDEntifications database

More...
PRIDEi
Q8TC36

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74086

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC36

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TC36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Sperm (at protein level) (PubMed:27640305). Widely expressed (PubMed:12621555). Conflictingly shown to be specifically expressed in testis (PubMed:21711156).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000167098 Expressed in right testis and 68 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TC36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TC36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000167098 Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable homotrimer.

Interacts with DNAJB13.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
126678, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TC36, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348496

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TC36 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TC36

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini205 – 364SUNPROSITE-ProRule annotationAdd BLAST160

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili141 – 182Sequence analysisAdd BLAST42

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2687 Eukaryota
ENOG410YM6S LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155225

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TC36

KEGG Orthology (KO)

More...
KOi
K21876

Identification of Orthologs from Complete Genome Data

More...
OMAi
KMEVWQD

Database of Orthologous Groups

More...
OrthoDBi
1569602at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TC36

TreeFam database of animal gene trees

More...
TreeFami
TF323915

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR030273 SUN5
IPR012919 SUN_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12911:SF39 PTHR12911:SF39, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07738 Sad1_UNC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51469 SUN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TC36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRSSRSPGD PGALLEDVAH NPRPRRIAQR GRNTSRMAED TSPNMNDNIL
60 70 80 90 100
LPVRNNDQAL GLTQCMLGCV SWFTCFACSL RTQAQQVLFN TCRCKLLCQK
110 120 130 140 150
LMEKTGILLL CAFGFWMFSI HLPSKMKVWQ DDSINGPLQS LRLYQEKVRH
160 170 180 190 200
HSGEIQDLRG SMNQLIAKLQ EMEAMSDEQK MAQKIMKMIH GDYIEKPDFA
210 220 230 240 250
LKSIGASIDF EHTSVTYNHE KAHSYWNWIQ LWNYAQPPDV ILEPNVTPGN
260 270 280 290 300
CWAFEGDRGQ VTIQLAQKVY LSNLTLQHIP KTISLSGSLD TAPKDFVIYG
310 320 330 340 350
MEGSPKEEVF LGAFQFQPEN IIQMFPLQNQ PARAFSAVKV KISSNWGNPG
360 370
FTCLYRVRVH GSVAPPREQP HQNPYPKRD
Length:379
Mass (Da):43,081
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FAE87B1CC1DBCDF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A9Z1W8A9Z1W8_HUMAN
SUN domain-containing protein 5
SUN5
354Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TDX8Q5TDX8_HUMAN
SUN domain-containing protein 5
SUN5 SPAG4L, hCG_37630
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TDX9Q5TDX9_HUMAN
SUN domain-containing protein 5
SUN5
152Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01514716E → K. Corresponds to variant dbSNP:rs3746387Ensembl.1
Natural variantiVAR_02667739E → D. Corresponds to variant dbSNP:rs1133358Ensembl.1
Natural variantiVAR_077983114G → R in SPGF16; loss of protein expression; impaired localization to nuclear inner membrane. 2 Publications1
Natural variantiVAR_052285120I → V. Corresponds to variant dbSNP:rs35216976Ensembl.1
Natural variantiVAR_080157159 – 379Missing in SPGF16; in mouse model abolishes interaction with DNAJB13. 1 PublicationAdd BLAST221
Natural variantiVAR_077984162M → K in SPGF16; unknown pathological significance; in mouse model increases interaction with DNAJB13; impaired localization to nuclear inner membrane. 2 PublicationsCorresponds to variant dbSNP:rs886041023EnsemblClinVar.1
Natural variantiVAR_026678174A → T. Corresponds to variant dbSNP:rs17123951Ensembl.1
Natural variantiVAR_077985261V → M in SPGF16; unknown pathological significance; in mouse model decreases protein solubility as well as impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs886041024EnsemblClinVar.1
Natural variantiVAR_077986275T → M in SPGF16; significant reduction in protein expression; impaired localization to nuclear inner membrane; in mouse model decreases interaction with DNAJB13. 3 PublicationsCorresponds to variant dbSNP:rs756459525EnsemblClinVar.1
Natural variantiVAR_080158284 – 379Missing in SPGF16; significant reduction in protein expression; impaired localization to nuclear inner membrane; in mouse model decreases interaction with DNAJB13. 2 PublicationsAdd BLAST96
Natural variantiVAR_077987348N → I in SPGF16; loss of protein expression; in mouse model impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs758335571Ensembl.1
Natural variantiVAR_077988356R → C in SPGF16; unknown pathological significance; in mouse model impairs nuclear inner membrane location and decreases interaction with DNAJB13. 2 PublicationsCorresponds to variant dbSNP:rs754130052EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF401350 mRNA Translation: AAM90665.1
AL139826 Genomic DNA No translation available.
AL121756 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76343.1
BC026118 mRNA Translation: AAH26118.1
BC029528 mRNA Translation: AAH29528.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13209.1

NCBI Reference Sequences

More...
RefSeqi
NP_542406.2, NM_080675.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356173; ENSP00000348496; ENSG00000167098

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140732

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140732

UCSC genome browser

More...
UCSCi
uc002wyi.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF401350 mRNA Translation: AAM90665.1
AL139826 Genomic DNA No translation available.
AL121756 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76343.1
BC026118 mRNA Translation: AAH26118.1
BC029528 mRNA Translation: AAH29528.1
CCDSiCCDS13209.1
RefSeqiNP_542406.2, NM_080675.3

3D structure databases

SMRiQ8TC36
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi126678, 3 interactors
IntActiQ8TC36, 1 interactor
STRINGi9606.ENSP00000348496

PTM databases

iPTMnetiQ8TC36
PhosphoSitePlusiQ8TC36

Polymorphism and mutation databases

BioMutaiSUN5
DMDMi27805720

Proteomic databases

MassIVEiQ8TC36
PaxDbiQ8TC36
PeptideAtlasiQ8TC36
PRIDEiQ8TC36
ProteomicsDBi74086

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25466 103 antibodies

Genome annotation databases

EnsembliENST00000356173; ENSP00000348496; ENSG00000167098
GeneIDi140732
KEGGihsa:140732
UCSCiuc002wyi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140732
DisGeNETi140732
EuPathDBiHostDB:ENSG00000167098.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SUN5
HGNCiHGNC:16252 SUN5
HPAiENSG00000167098 Tissue enriched (testis)
MalaCardsiSUN5
MIMi613942 gene
617187 phenotype
neXtProtiNX_Q8TC36
OpenTargetsiENSG00000167098
Orphaneti529970 Male infertility due to acephalic spermatozoa
PharmGKBiPA38095

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2687 Eukaryota
ENOG410YM6S LUCA
GeneTreeiENSGT00940000155225
InParanoidiQ8TC36
KOiK21876
OMAiKMEVWQD
OrthoDBi1569602at2759
PhylomeDBiQ8TC36
TreeFamiTF323915

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
140732 5 hits in 779 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SPAG4L

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140732
PharosiQ8TC36 Tbio

Protein Ontology

More...
PROi
PR:Q8TC36
RNActiQ8TC36 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000167098 Expressed in right testis and 68 other tissues
ExpressionAtlasiQ8TC36 baseline and differential
GenevisibleiQ8TC36 HS

Family and domain databases

Gene3Di2.60.120.260, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR030273 SUN5
IPR012919 SUN_dom
PANTHERiPTHR12911:SF39 PTHR12911:SF39, 1 hit
PfamiView protein in Pfam
PF07738 Sad1_UNC, 1 hit
PROSITEiView protein in PROSITE
PS51469 SUN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUN5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC36
Secondary accession number(s): A6NJ82, Q5T9R0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: June 1, 2002
Last modified: June 17, 2020
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again