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Protein

Enkurin

Gene

ENKUR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionCalmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enkurin
Gene namesi
Name:ENKUR
Synonyms:C10orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000151023.16
HGNCiHGNC:28388 ENKUR
MIMi611025 gene
neXtProtiNX_Q8TC29

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151023
PharmGKBiPA165548526

Polymorphism and mutation databases

BioMutaiENKUR
DMDMi71151870

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000869751 – 256EnkurinAdd BLAST256

Proteomic databases

EPDiQ8TC29
PaxDbiQ8TC29
PeptideAtlasiQ8TC29
PRIDEiQ8TC29
ProteomicsDBi74085

PTM databases

iPTMnetiQ8TC29
PhosphoSitePlusiQ8TC29

Expressioni

Gene expression databases

BgeeiENSG00000151023 Expressed in 89 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_C10orf63
ExpressionAtlasiQ8TC29 baseline and differential
GenevisibleiQ8TC29 HS

Organism-specific databases

HPAiHPA037593
HPA037594
HPA061503

Interactioni

Subunit structurei

Binds calmodulin via its IQ domain. Interacts with TRPC1, TRPC2, TRPC5, but not TRPC3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8TC29, 2 interactors
STRINGi9606.ENSP00000331044

Structurei

3D structure databases

ProteinModelPortaliQ8TC29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 252EnkurinPROSITE-ProRule annotationAdd BLAST93
Domaini176 – 187IQAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi83 – 89SH3-bindingSequence analysis7

Domaini

Residues 160-255 contains the TRPC2 binding site.By similarity
The IQ motif is involved in calmodulin binding.By similarity

Keywords - Domaini

SH3-binding

Phylogenomic databases

eggNOGiENOG410IET1 Eukaryota
ENOG410ZNA7 LUCA
GeneTreeiENSGT00390000009461
HOGENOMiHOG000007231
HOVERGENiHBG056756
InParanoidiQ8TC29
OMAiHPVMGIQ
OrthoDBiEOG091G0MPU
PhylomeDBiQ8TC29
TreeFamiTF323892

Family and domain databases

InterProiView protein in InterPro
IPR026150 Enkur
IPR027012 Enkurin_dom
PANTHERiPTHR21490:SF0 PTHR21490:SF0, 1 hit
PfamiView protein in Pfam
PF13864 Enkurin, 1 hit
PROSITEiView protein in PROSITE
PS51665 ENKURIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TC29-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPTCSSECI YNLIPSDLKE PPQPPRYISI FKATVKDDMQ KAKTAMKTMG
60 70 80 90 100
PAKVEVPSPK DFLKKHSKEK TLPPKKNFDR NVPKKPAVPL KTDHPVMGIQ
110 120 130 140 150
SGKNFINTNA ADIIMGVAKK PKPIYVDKRT GDKHDLEPSG LVPKYINKKD
160 170 180 190 200
YGVTPEYICK RNEEIKKAQE DYDRYIQENL KKAAMKRLSD EEREAVLQGL
210 220 230 240 250
KKNWEEVHKE FQSLSVFIDS IPKKIRKQRL EEEMKQLEHD IGIIEKHKII

YIANNA
Length:256
Mass (Da):29,454
Last modified:June 1, 2002 - v1
Checksum:i88F5BA7DD3FA6FE8
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VV23Q5VV23_HUMAN
Chromosome 10 open reading frame 63...
ENKUR C10orf63, hCG_1657569
255Annotation score:
A0A087WUX1A0A087WUX1_HUMAN
Enkurin
ENKUR
194Annotation score:
L7N489L7N489_HUMAN
Enkurin
ENKUR
125Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454125 mRNA Translation: AAS45168.1
AK095021 mRNA Translation: BAC04477.1
AK292495 mRNA Translation: BAF85184.1
AL512598 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86115.1
CH471072 Genomic DNA Translation: EAW86116.1
BC026165 mRNA Translation: AAH26165.1
CCDSiCCDS7146.1
RefSeqiNP_001257312.1, NM_001270383.1
NP_659447.1, NM_145010.3
XP_011517650.1, XM_011519348.1
UniGeneiHs.534486

Genome annotation databases

EnsembliENST00000331161; ENSP00000331044; ENSG00000151023
ENST00000496261; ENSP00000432930; ENSG00000151023
GeneIDi219670
KEGGihsa:219670
UCSCiuc001isg.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY454125 mRNA Translation: AAS45168.1
AK095021 mRNA Translation: BAC04477.1
AK292495 mRNA Translation: BAF85184.1
AL512598 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86115.1
CH471072 Genomic DNA Translation: EAW86116.1
BC026165 mRNA Translation: AAH26165.1
CCDSiCCDS7146.1
RefSeqiNP_001257312.1, NM_001270383.1
NP_659447.1, NM_145010.3
XP_011517650.1, XM_011519348.1
UniGeneiHs.534486

3D structure databases

ProteinModelPortaliQ8TC29
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8TC29, 2 interactors
STRINGi9606.ENSP00000331044

PTM databases

iPTMnetiQ8TC29
PhosphoSitePlusiQ8TC29

Polymorphism and mutation databases

BioMutaiENKUR
DMDMi71151870

Proteomic databases

EPDiQ8TC29
PaxDbiQ8TC29
PeptideAtlasiQ8TC29
PRIDEiQ8TC29
ProteomicsDBi74085

Protocols and materials databases

DNASUi219670
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331161; ENSP00000331044; ENSG00000151023
ENST00000496261; ENSP00000432930; ENSG00000151023
GeneIDi219670
KEGGihsa:219670
UCSCiuc001isg.2 human

Organism-specific databases

CTDi219670
EuPathDBiHostDB:ENSG00000151023.16
GeneCardsiENKUR
HGNCiHGNC:28388 ENKUR
HPAiHPA037593
HPA037594
HPA061503
MIMi611025 gene
neXtProtiNX_Q8TC29
OpenTargetsiENSG00000151023
PharmGKBiPA165548526
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IET1 Eukaryota
ENOG410ZNA7 LUCA
GeneTreeiENSGT00390000009461
HOGENOMiHOG000007231
HOVERGENiHBG056756
InParanoidiQ8TC29
OMAiHPVMGIQ
OrthoDBiEOG091G0MPU
PhylomeDBiQ8TC29
TreeFamiTF323892

Miscellaneous databases

ChiTaRSiENKUR human
GeneWikiiEnkurin
GenomeRNAii219670
PROiPR:Q8TC29
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151023 Expressed in 89 organ(s), highest expression level in bronchial epithelial cell
CleanExiHS_C10orf63
ExpressionAtlasiQ8TC29 baseline and differential
GenevisibleiQ8TC29 HS

Family and domain databases

InterProiView protein in InterPro
IPR026150 Enkur
IPR027012 Enkurin_dom
PANTHERiPTHR21490:SF0 PTHR21490:SF0, 1 hit
PfamiView protein in Pfam
PF13864 Enkurin, 1 hit
PROSITEiView protein in PROSITE
PS51665 ENKURIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENKUR_HUMAN
AccessioniPrimary (citable) accession number: Q8TC29
Secondary accession number(s): A8K8Y0, D3DRV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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