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Protein

Disintegrin and metalloproteinase domain-containing protein 32

Gene

ADAM32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein.By similarity

GO - Molecular functioni

Protein family/group databases

MEROPSiM12.953

Names & Taxonomyi

Protein namesi
Recommended name:
Disintegrin and metalloproteinase domain-containing protein 32
Short name:
ADAM 32
Gene namesi
Name:ADAM32
ORF Names:UNQ5982/PRO21340
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000197140.14
HGNCiHGNC:15479 ADAM32
neXtProtiNX_Q8TC27

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini175 – 682ExtracellularSequence analysisAdd BLAST508
Transmembranei683 – 703HelicalSequence analysisAdd BLAST21
Topological domaini704 – 787CytoplasmicSequence analysisAdd BLAST84

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi203102
OpenTargetsiENSG00000197140
PharmGKBiPA134932610

Polymorphism and mutation databases

BioMutaiADAM32
DMDMi296434389

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 161 PublicationAdd BLAST16
PropeptideiPRO_000002913817 – 174Sequence analysisAdd BLAST158
ChainiPRO_0000029139175 – 787Disintegrin and metalloproteinase domain-containing protein 32Add BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17PhosphoserineCombined sources1
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi295 ↔ 378By similarity
Disulfide bondi337 ↔ 362By similarity
Disulfide bondi339 ↔ 344By similarity
Disulfide bondi450 ↔ 471By similarity
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi598N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi626 ↔ 636By similarity
Disulfide bondi630 ↔ 642By similarity
Disulfide bondi644 ↔ 653By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8TC27
PaxDbiQ8TC27
PeptideAtlasiQ8TC27
PRIDEiQ8TC27
ProteomicsDBi74084

PTM databases

iPTMnetiQ8TC27
PhosphoSitePlusiQ8TC27

Expressioni

Tissue specificityi

Testis specific.1 Publication

Gene expression databases

BgeeiENSG00000197140
CleanExiHS_ADAM32
ExpressionAtlasiQ8TC27 baseline and differential
GenevisibleiQ8TC27 HS

Organism-specific databases

HPAiHPA044156
HPA062151

Interactioni

Protein-protein interaction databases

BioGridi128451, 26 interactors
IntActiQ8TC27, 1 interactor
STRINGi9606.ENSP00000369238

Structurei

3D structure databases

ProteinModelPortaliQ8TC27
SMRiQ8TC27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 383Peptidase M12BPROSITE-ProRule annotationAdd BLAST198
Domaini391 – 479DisintegrinPROSITE-ProRule annotationAdd BLAST89
Domaini622 – 654EGF-likePROSITE-ProRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi480 – 502Cys-richAdd BLAST23

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
GeneTreeiENSGT00910000144019
HOGENOMiHOG000230883
HOVERGENiHBG103628
InParanoidiQ8TC27
KOiK16070
OMAiPLYLEMH
OrthoDBiEOG091G02F0
PhylomeDBiQ8TC27
TreeFamiTF314733

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TC27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRLWLLLAG LCGLLASRPG FQNSLLQIVI PEKIQTNTND SSEIEYEQIS
60 70 80 90 100
YIIPIDEKLY TVHLKQRYFL ADNFMIYLYN QGSMNTYSSD IQTQCYYQGN
110 120 130 140 150
IEGYPDSMVT LSTCSGLRGI LQFENVSYGI EPLESAVEFQ HVLYKLKNED
160 170 180 190 200
NDIAIFIDRS LKEQPMDDNI FISEKSEPAV PDLFPLYLEM HIVVDKTLYD
210 220 230 240 250
YWGSDSMIVT NKVIEIVGLA NSMFTQFKVT IVLSSLELWS DENKISTVGE
260 270 280 290 300
ADELLQKFLE WKQSYLNLRP HDIAYLLIYM DYPRYLGAVF PGTMCITRYS
310 320 330 340 350
AGVALYPKEI TLEAFAVIVT QMLALSLGIS YDDPKKCQCS ESTCIMNPEV
360 370 380 390 400
VQSNGVKTFS SCSLRSFQNF ISNVGVKCLQ NKPQMQKKSP KPVCGNGRLE
410 420 430 440 450
GNEICDCGTE AQCGPASCCD FRTCVLKDGA KCYKGLCCKD CQILQSGVEC
460 470 480 490 500
RPKAHPECDI AENCNGTSPE CGPDITLING LSCKNNKFIC YDGDCHDLDA
510 520 530 540 550
RCESVFGKGS RNAPFACYEE IQSQSDRFGN CGRDRNNKYV FCGWRNLICG
560 570 580 590 600
RLVCTYPTRK PFHQENGDVI YAFVRDSVCI TVDYKLPRTV PDPLAVKNGS
610 620 630 640 650
QCDIGRVCVN RECVESRIIK ASAHVCSQQC SGHGVCDSRN KCHCSPGYKP
660 670 680 690 700
PNCQIRSKGF SIFPEEDMGS IMERASGKTE NTWLLGFLIA LPILIVTTAI
710 720 730 740 750
VLARKQLKKW FAKEEEFPSS ESKSEGSTQT YASQSSSEGS TQTYASQTRS
760 770 780
ESSSQADTSK SKSEDSAEAY TSRSKSQDST QTQSSSN
Length:787
Mass (Da):87,948
Last modified:May 18, 2010 - v2
Checksum:i841EDA9EFF483A2C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05524198Q → R1 PublicationCorresponds to variant dbSNP:rs17856744Ensembl.1
Natural variantiVAR_055242160S → G1 PublicationCorresponds to variant dbSNP:rs17852343Ensembl.1
Natural variantiVAR_055243327L → V. Corresponds to variant dbSNP:rs9643859Ensembl.1
Natural variantiVAR_051591467T → S2 PublicationsCorresponds to variant dbSNP:rs7845771Ensembl.1
Natural variantiVAR_055244658K → N. Corresponds to variant dbSNP:rs13277386Ensembl.1
Natural variantiVAR_061739778D → E. Corresponds to variant dbSNP:rs28705715Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358739 mRNA Translation: AAQ89099.1
AC105091 Genomic DNA No translation available.
AC105185 Genomic DNA No translation available.
BC026085 mRNA Translation: AAH26085.1
BC026169 mRNA Translation: AAH26169.1
BC028702 mRNA Translation: AAH28702.1
BC030014 mRNA Translation: AAH30014.1
BC030698 mRNA Translation: AAH30698.1
BC034975 mRNA Translation: AAH34975.1
CCDSiCCDS47846.1
RefSeqiNP_001300923.1, NM_001313994.1
NP_659441.3, NM_145004.6
UniGeneiHs.521545

Genome annotation databases

EnsembliENST00000379907; ENSP00000369238; ENSG00000197140
ENST00000615420; ENSP00000484817; ENSG00000275594
GeneIDi203102
KEGGihsa:203102
UCSCiuc003xmt.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiADA32_HUMAN
AccessioniPrimary (citable) accession number: Q8TC27
Secondary accession number(s): Q8TC42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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