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UniProtKB - Q8TC26 (TM163_HUMAN)
Protein
Transmembrane protein 163
Gene
TMEM163
Organism
Homo sapiens (Human)
Status
Functioni
May bind zinc and other divalent cations and recruit them to vesicular organelles.
By similarityGO - Molecular functioni
- zinc ion binding Source: UniProtKB
GO - Biological processi
- zinc ion import into synaptic vesicle Source: Ensembl
Keywordsi
Ligand | Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TC26 |
SignaLinki | Q8TC26 |
Protein family/group databases
TCDBi | 2.A.4.8.3, the cation diffusion facilitator (cdf) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 163 |
Gene namesi | Name:TMEM163 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25380, TMEM163 |
MIMi | 618978, gene |
neXtProti | NX_Q8TC26 |
VEuPathDBi | HostDB:ENSG00000152128 |
Subcellular locationi
Endosome
- Early endosome membrane By similarity
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein By similarity
Note: Glutamatergic synaptic vesicles.By similarity
Endosome
- early endosome membrane Source: UniProtKB
Other locations
- integral component of synaptic vesicle membrane Source: UniProtKB
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 88 | CytoplasmicSequence analysisAdd BLAST | 88 | |
Transmembranei | 89 – 109 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 110 – 116 | ExtracellularSequence analysis | 7 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 150 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 151 – 171 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 172 – 187 | ExtracellularSequence analysisAdd BLAST | 16 | |
Transmembranei | 188 – 208 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 209 – 217 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 218 – 238 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 255 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 256 – 276 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 277 – 289 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Endosome, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 81615 |
OpenTargetsi | ENSG00000152128 |
PharmGKBi | PA145148025 |
Miscellaneous databases
Pharosi | Q8TC26, Tbio |
Genetic variation databases
BioMutai | TMEM163 |
DMDMi | 74730546 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000278539 | 1 – 289 | Transmembrane protein 163Add BLAST | 289 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 11 | PhosphoserineBy similarity | 1 | |
Modified residuei | 55 | PhosphoserineBy similarity | 1 | |
Modified residuei | 57 | PhosphoserineBy similarity | 1 | |
Modified residuei | 61 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q8TC26 |
MassIVEi | Q8TC26 |
PaxDbi | Q8TC26 |
PeptideAtlasi | Q8TC26 |
PRIDEi | Q8TC26 |
ProteomicsDBi | 74081 [Q8TC26-1] 74082 [Q8TC26-2] 74083 [Q8TC26-3] |
PTM databases
iPTMneti | Q8TC26 |
PhosphoSitePlusi | Q8TC26 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152128, Expressed in oocyte and 169 other tissues |
Genevisiblei | Q8TC26, HS |
Organism-specific databases
HPAi | ENSG00000152128, Tissue enhanced (brain, pancreas) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123550, 1 interactor |
IntActi | Q8TC26, 1 interactor |
STRINGi | 9606.ENSP00000281924 |
Miscellaneous databases
RNActi | Q8TC26, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 65 | DisorderedSequence analysisAdd BLAST | 65 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 40 | Pro residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the TMEM163 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QW7B, Eukaryota |
GeneTreei | ENSGT00390000001170 |
HOGENOMi | CLU_081161_0_0_1 |
InParanoidi | Q8TC26 |
OMAi | IMRYSAS |
OrthoDBi | 1547703at2759 |
PhylomeDBi | Q8TC26 |
TreeFami | TF330782 |
Family and domain databases
Gene3Di | 1.20.1510.10, 1 hit |
InterProi | View protein in InterPro IPR027469, Cation_efflux_TMD_sf IPR026765, Tmem163 |
PANTHERi | PTHR31937, PTHR31937, 1 hit |
SUPFAMi | SSF161111, SSF161111, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q8TC26-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER
60 70 80 90 100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL
110 120 130 140 150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR
160 170 180 190 200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC
210 220 230 240 250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW
260 270 280
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE
Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-60: Missing.
61-68: SDGLEDRG → MLPVSRTC
153-162: IACVILGVIF → MTISCSVSPF
163-289: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Sequence cautioni
The sequence CAH10592 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_023328 | 1 – 208 | Missing in isoform 3. 1 PublicationAdd BLAST | 208 | |
Alternative sequenceiVSP_023329 | 1 – 60 | Missing in isoform 2. 1 PublicationAdd BLAST | 60 | |
Alternative sequenceiVSP_023330 | 61 – 68 | SDGLEDRG → MLPVSRTC in isoform 2. 1 Publication | 8 | |
Alternative sequenceiVSP_023331 | 153 – 162 | IACVILGVIF → MTISCSVSPF in isoform 2. 1 Publication | 10 | |
Alternative sequenceiVSP_023332 | 163 – 289 | Missing in isoform 2. 1 PublicationAdd BLAST | 127 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL122044 mRNA Translation: CAB59180.2 AL833765 mRNA Translation: CAH10592.1 Different initiation. AC013718 Genomic DNA Translation: AAX93249.1 AC110620 Genomic DNA Translation: AAY24144.1 BC026170 mRNA Translation: AAH26170.1 |
CCDSi | CCDS2172.1 [Q8TC26-1] |
PIRi | T34524 |
RefSeqi | NP_112185.1, NM_030923.4 [Q8TC26-1] |
Genome annotation databases
Ensembli | ENST00000281924.6; ENSP00000281924.6; ENSG00000152128.13 |
GeneIDi | 81615 |
KEGGi | hsa:81615 |
MANE-Selecti | ENST00000281924.6; ENSP00000281924.6; NM_030923.5; NP_112185.1 |
UCSCi | uc002ttx.4, human [Q8TC26-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL122044 mRNA Translation: CAB59180.2 AL833765 mRNA Translation: CAH10592.1 Different initiation. AC013718 Genomic DNA Translation: AAX93249.1 AC110620 Genomic DNA Translation: AAY24144.1 BC026170 mRNA Translation: AAH26170.1 |
CCDSi | CCDS2172.1 [Q8TC26-1] |
PIRi | T34524 |
RefSeqi | NP_112185.1, NM_030923.4 [Q8TC26-1] |
3D structure databases
AlphaFoldDBi | Q8TC26 |
SMRi | Q8TC26 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123550, 1 interactor |
IntActi | Q8TC26, 1 interactor |
STRINGi | 9606.ENSP00000281924 |
Protein family/group databases
TCDBi | 2.A.4.8.3, the cation diffusion facilitator (cdf) family |
PTM databases
iPTMneti | Q8TC26 |
PhosphoSitePlusi | Q8TC26 |
Genetic variation databases
BioMutai | TMEM163 |
DMDMi | 74730546 |
Proteomic databases
jPOSTi | Q8TC26 |
MassIVEi | Q8TC26 |
PaxDbi | Q8TC26 |
PeptideAtlasi | Q8TC26 |
PRIDEi | Q8TC26 |
ProteomicsDBi | 74081 [Q8TC26-1] 74082 [Q8TC26-2] 74083 [Q8TC26-3] |
Protocols and materials databases
Antibodypediai | 33555, 38 antibodies from 14 providers |
DNASUi | 81615 |
Genome annotation databases
Ensembli | ENST00000281924.6; ENSP00000281924.6; ENSG00000152128.13 |
GeneIDi | 81615 |
KEGGi | hsa:81615 |
MANE-Selecti | ENST00000281924.6; ENSP00000281924.6; NM_030923.5; NP_112185.1 |
UCSCi | uc002ttx.4, human [Q8TC26-1] |
Organism-specific databases
CTDi | 81615 |
DisGeNETi | 81615 |
GeneCardsi | TMEM163 |
HGNCi | HGNC:25380, TMEM163 |
HPAi | ENSG00000152128, Tissue enhanced (brain, pancreas) |
MIMi | 618978, gene |
neXtProti | NX_Q8TC26 |
OpenTargetsi | ENSG00000152128 |
PharmGKBi | PA145148025 |
VEuPathDBi | HostDB:ENSG00000152128 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QW7B, Eukaryota |
GeneTreei | ENSGT00390000001170 |
HOGENOMi | CLU_081161_0_0_1 |
InParanoidi | Q8TC26 |
OMAi | IMRYSAS |
OrthoDBi | 1547703at2759 |
PhylomeDBi | Q8TC26 |
TreeFami | TF330782 |
Enzyme and pathway databases
PathwayCommonsi | Q8TC26 |
SignaLinki | Q8TC26 |
Miscellaneous databases
BioGRID-ORCSi | 81615, 13 hits in 1071 CRISPR screens |
ChiTaRSi | TMEM163, human |
GenomeRNAii | 81615 |
Pharosi | Q8TC26, Tbio |
PROi | PR:Q8TC26 |
RNActi | Q8TC26, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152128, Expressed in oocyte and 169 other tissues |
Genevisiblei | Q8TC26, HS |
Family and domain databases
Gene3Di | 1.20.1510.10, 1 hit |
InterProi | View protein in InterPro IPR027469, Cation_efflux_TMD_sf IPR026765, Tmem163 |
PANTHERi | PTHR31937, PTHR31937, 1 hit |
SUPFAMi | SSF161111, SSF161111, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TM163_HUMAN | |
Accessioni | Q8TC26Primary (citable) accession number: Q8TC26 Secondary accession number(s): Q53QM3 Q9UFG3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 20, 2007 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families