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Entry version 114 (22 Apr 2020)
Sequence version 1 (01 Jun 2002)
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Protein

Transmembrane protein 163

Gene

TMEM163

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandZinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.4.8.3 the cation diffusion facilitator (cdf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 163
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM163
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25380 TMEM163

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC26

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 88CytoplasmicSequence analysisAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 116ExtracellularSequence analysis7
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 187ExtracellularSequence analysisAdd BLAST16
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 217CytoplasmicSequence analysis9
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255ExtracellularSequence analysisAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 289CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81615

Open Targets

More...
OpenTargetsi
ENSG00000152128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145148025

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TC26 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM163

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730546

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002785391 – 289Transmembrane protein 163Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TC26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TC26

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TC26

PeptideAtlas

More...
PeptideAtlasi
Q8TC26

PRoteomics IDEntifications database

More...
PRIDEi
Q8TC26

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74081 [Q8TC26-1]
74082 [Q8TC26-2]
74083 [Q8TC26-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TC26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000152128 Expressed in oocyte and 153 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TC26 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000152128 Tissue enhanced (brain, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000281924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TC26 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE9N Eukaryota
ENOG410Z7QG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001170

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_081161_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TC26

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKHNSAV

Database of Orthologous Groups

More...
OrthoDBi
1547703at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TC26

TreeFam database of animal gene trees

More...
TreeFami
TF330782

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163

The PANTHER Classification System

More...
PANTHERi
PTHR31937 PTHR31937, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161111 SSF161111, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER
60 70 80 90 100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL
110 120 130 140 150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR
160 170 180 190 200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC
210 220 230 240 250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW
260 270 280
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE
Length:289
Mass (Da):31,469
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0255DAE6D7E8487A
GO
Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-68: SDGLEDRG → MLPVSRTC
     153-162: IACVILGVIF → MTISCSVSPF
     163-289: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:102
Mass (Da):11,334
Checksum:i06F17B8F21B2B5A6
GO
Isoform 3 (identifier: Q8TC26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Note: Dubious isoform that could be a cloning artifact.Curated
Show »
Length:81
Mass (Da):8,966
Checksum:i0E596F8E75C84BA8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH10592 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233281 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0233291 – 60Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_02333061 – 68SDGLEDRG → MLPVSRTC in isoform 2. 1 Publication8
Alternative sequenceiVSP_023331153 – 162IACVILGVIF → MTISCSVSPF in isoform 2. 1 Publication10
Alternative sequenceiVSP_023332163 – 289Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2172.1 [Q8TC26-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T34524

NCBI Reference Sequences

More...
RefSeqi
NP_112185.1, NM_030923.4 [Q8TC26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
81615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:81615

UCSC genome browser

More...
UCSCi
uc002ttx.4 human [Q8TC26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1
CCDSiCCDS2172.1 [Q8TC26-1]
PIRiT34524
RefSeqiNP_112185.1, NM_030923.4 [Q8TC26-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000281924

Protein family/group databases

TCDBi2.A.4.8.3 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ8TC26
PhosphoSitePlusiQ8TC26

Polymorphism and mutation databases

BioMutaiTMEM163
DMDMi74730546

Proteomic databases

jPOSTiQ8TC26
MassIVEiQ8TC26
PaxDbiQ8TC26
PeptideAtlasiQ8TC26
PRIDEiQ8TC26
ProteomicsDBi74081 [Q8TC26-1]
74082 [Q8TC26-2]
74083 [Q8TC26-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33555 36 antibodies

Genome annotation databases

EnsembliENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]
GeneIDi81615
KEGGihsa:81615
UCSCiuc002ttx.4 human [Q8TC26-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
81615
DisGeNETi81615

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM163
HGNCiHGNC:25380 TMEM163
HPAiENSG00000152128 Tissue enhanced (brain, pancreas)
neXtProtiNX_Q8TC26
OpenTargetsiENSG00000152128
PharmGKBiPA145148025

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE9N Eukaryota
ENOG410Z7QG LUCA
GeneTreeiENSGT00390000001170
HOGENOMiCLU_081161_0_0_1
InParanoidiQ8TC26
OMAiFKHNSAV
OrthoDBi1547703at2759
PhylomeDBiQ8TC26
TreeFamiTF330782

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM163 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
81615
PharosiQ8TC26 Tbio

Protein Ontology

More...
PROi
PR:Q8TC26
RNActiQ8TC26 protein

Gene expression databases

BgeeiENSG00000152128 Expressed in oocyte and 153 other tissues
GenevisibleiQ8TC26 HS

Family and domain databases

InterProiView protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163
PANTHERiPTHR31937 PTHR31937, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM163_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC26
Secondary accession number(s): Q53QM3
, Q53SV7, Q69YH3, Q9UFG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2002
Last modified: April 22, 2020
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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