TMEM163

Protein namesⁱ	Recommended name: Transmembrane protein 163
Gene namesⁱ	Name:TMEM163
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152128.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25380 TMEM163
neXtProtⁱ	NX_Q8TC26

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 88	CytoplasmicSequence analysisAdd BLAST	88
Transmembraneⁱ	89 – 109	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	110 – 116	ExtracellularSequence analysis	7
Transmembraneⁱ	117 – 137	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	138 – 150	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	151 – 171	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	172 – 187	ExtracellularSequence analysisAdd BLAST	16
Transmembraneⁱ	188 – 208	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	209 – 217	CytoplasmicSequence analysis	9
Transmembraneⁱ	218 – 238	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	239 – 255	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	256 – 276	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	277 – 289	CytoplasmicSequence analysisAdd BLAST	13

Keywords - Cellular componentⁱ

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	81615
Open Targets More...OpenTargetsⁱ	ENSG00000152128
PharmGKBⁱ	PA145148025

Polymorphism and mutation databases

BioMutaⁱ	TMEM163
DMDMⁱ	74730546

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000278539	1 – 289	Transmembrane protein 163Add BLAST		289

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	11	PhosphoserineBy similarity	1
Modified residueⁱ	55	PhosphoserineBy similarity	1
Modified residueⁱ	57	PhosphoserineBy similarity	1
Modified residueⁱ	61	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q8TC26
PaxDbⁱ	Q8TC26
PeptideAtlas More...PeptideAtlasⁱ	Q8TC26
PRIDEⁱ	Q8TC26
ProteomicsDBⁱ	74081 74082 [Q8TC26-2] 74083 [Q8TC26-3]

PTM databases

iPTMnetⁱ	Q8TC26
PhosphoSitePlusⁱ	Q8TC26

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152128 Expressed in 154 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TMEM163
Genevisibleⁱ	Q8TC26 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007224

HPAⁱ

HPA007224

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000281924

STRINGⁱ

9606.ENSP00000281924

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TC26
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TMEM163 family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IE9N Eukaryota ENOG410Z7QG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000001170
HOGENOMⁱ	HOG000294211
HOVERGENⁱ	HBG094063
InParanoidⁱ	Q8TC26
OMAⁱ	VIKFMLG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0JXN
PhylomeDBⁱ	Q8TC26
TreeFamⁱ	TF330782

Family and domain databases

InterProⁱ	View protein in InterPro IPR027469 Cation_efflux_TMD_sf IPR026765 Tmem163
PANTHERⁱ	PTHR31937 PTHR31937, 1 hit
SUPFAMⁱ	SSF161111 SSF161111, 1 hit

Sequences (3)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q8TC26-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER 
        60         70         80         90        100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL 
       110        120        130        140        150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR 
       160        170        180        190        200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC 
       210        220        230        240        250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW 
       260        270        280 
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE

Length:289

Mass (Da):31,469

Last modified:June 1, 2002 - v1

Checksum:ⁱ0255DAE6D7E8487A

GO

Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-68: SDGLEDRG → MLPVSRTC
     153-162: IACVILGVIF → MTISCSVSPF
     163-289: Missing.

« Hide

        10         20         30         40         50
MLPVSRTCLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL ALAVAAFTVS 
        60         70         80         90        100
VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR EYMTISCSVS 

PF

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:102

Mass (Da):11,334

Checksum:ⁱ06F17B8F21B2B5A6

GO

Isoform 3 (identifier: Q8TC26-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-208: Missing.

« Hide

        10         20         30         40         50
MLGKVLTSRA LITDGFNSLV GGVMGFSILL SAEVFKHDSA VWYLDGSIGV 
        60         70         80 
LIGLTIFAYG VKLLIDMVPR VRQTRHYEMF E

Note: No experimental confirmation available. Dubious isoform that could be a cloning artifact.

Show »

Length:81

Mass (Da):8,966

Checksum:ⁱ0E596F8E75C84BA8

GO

Sequence cautionⁱ

The sequence CAH10592 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_023328	1 – 208	Missing in isoform 3. 1 PublicationAdd BLAST	208
Alternative sequenceⁱVSP_023329	1 – 60	Missing in isoform 2. 1 PublicationAdd BLAST	60
Alternative sequenceⁱVSP_023330	61 – 68	SDGLEDRG → MLPVSRTC in isoform 2. 1 Publication	8
Alternative sequenceⁱVSP_023331	153 – 162	IACVILGVIF → MTISCSVSPF in isoform 2. 1 Publication	10
Alternative sequenceⁱVSP_023332	163 – 289	Missing in isoform 2. 1 PublicationAdd BLAST	127

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL122044 mRNA Translation: CAB59180.2 AL833765 mRNA Translation: CAH10592.1 Different initiation. AC013718 Genomic DNA Translation: AAX93249.1 AC110620 Genomic DNA Translation: AAY24144.1 BC026170 mRNA Translation: AAH26170.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2172.1 [Q8TC26-1]
PIRⁱ	T34524
NCBI Reference Sequences More...RefSeqⁱ	NP_112185.1, NM_030923.4 [Q8TC26-1]
UniGeneⁱ	Hs.369471 Hs.595089

Genome annotation databases

Ensemblⁱ	ENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]
GeneIDⁱ	81615
KEGGⁱ	hsa:81615
UCSC genome browser More...UCSCⁱ	uc002ttx.4 human [Q8TC26-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q8TC26	TMEM163 isoform 1		PANTR		289	UniRef100_Q8TC26
Transmembrane protein 163		CHLSB		178
Transmembrane protein 163		SAIBB		221
Uncharacterized protein		COLAP		221
Uncharacterized protein		MANLE		221

Protein	Similar proteins		Species	Score	Length	Source
Q8TC26	TMEM163 isoform 1		PANTR		289	UniRef90_Q8TC26
Transmembrane protein 163		CHLSB		178
Transmembrane protein 163		SAIBB		221
Uncharacterized protein		COLAP		221
Uncharacterized protein		MANLE		221
+17

Protein	Similar proteins		Species	Score	Length	Source
Q8TC26	TMEM163 isoform 1		PANTR		289	UniRef50_Q8TC26
Transmembrane protein 163		CHLSB		178
Transmembrane protein 163		SAIBB		221
Uncharacterized protein		COLAP		221
Uncharacterized protein		MANLE		221
+67
Q8TC26-2	Transmembrane protein 163		TUPCH		85	UniRef50_Q8TC26-2
Q8TC26-3	Uncharacterized protein		RHIRO		181	UniRef50_Q8TC26-3
Uncharacterized protein		RHIBE		221
Transmembrane protein 163		MUSPF		178
transmembrane protein 163 isoform X2		URSMA		178
Transmembrane protein 163 (Fragment)		FUKDA		181
+6

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL122044 mRNA Translation: CAB59180.2 AL833765 mRNA Translation: CAH10592.1 Different initiation. AC013718 Genomic DNA Translation: AAX93249.1 AC110620 Genomic DNA Translation: AAY24144.1 BC026170 mRNA Translation: AAH26170.1
CCDSⁱ	CCDS2172.1 [Q8TC26-1]
PIRⁱ	T34524
RefSeqⁱ	NP_112185.1, NM_030923.4 [Q8TC26-1]
UniGeneⁱ	Hs.369471 Hs.595089

3D structure databases

ProteinModelPortalⁱ	Q8TC26
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000281924

STRINGⁱ

9606.ENSP00000281924

Protein family/group databases

TCDBⁱ	2.A.4.8.3 the cation diffusion facilitator (cdf) family

TCDBⁱ

2.A.4.8.3 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetⁱ	Q8TC26
PhosphoSitePlusⁱ	Q8TC26

Polymorphism and mutation databases

BioMutaⁱ	TMEM163
DMDMⁱ	74730546

Proteomic databases

EPDⁱ	Q8TC26
PaxDbⁱ	Q8TC26
PeptideAtlasⁱ	Q8TC26
PRIDEⁱ	Q8TC26
ProteomicsDBⁱ	74081 74082 [Q8TC26-2] 74083 [Q8TC26-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]
GeneIDⁱ	81615
KEGGⁱ	hsa:81615
UCSCⁱ	uc002ttx.4 human [Q8TC26-1]

Organism-specific databases

CTDⁱ	81615
DisGeNETⁱ	81615
EuPathDBⁱ	HostDB:ENSG00000152128.13
GeneCardsⁱ	TMEM163
HGNCⁱ	HGNC:25380 TMEM163
HPAⁱ	HPA007224
neXtProtⁱ	NX_Q8TC26
OpenTargetsⁱ	ENSG00000152128
PharmGKBⁱ	PA145148025
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE9N Eukaryota ENOG410Z7QG LUCA
GeneTreeⁱ	ENSGT00390000001170
HOGENOMⁱ	HOG000294211
HOVERGENⁱ	HBG094063
InParanoidⁱ	Q8TC26
OMAⁱ	VIKFMLG
OrthoDBⁱ	EOG091G0JXN
PhylomeDBⁱ	Q8TC26
TreeFamⁱ	TF330782

Miscellaneous databases

ChiTaRSⁱ	TMEM163 human
GenomeRNAiⁱ	81615
Protein Ontology More...PROⁱ	PR:Q8TC26

Gene expression databases

Bgeeⁱ	ENSG00000152128 Expressed in 154 organ(s), highest expression level in oocyte
CleanExⁱ	HS_TMEM163
Genevisibleⁱ	Q8TC26 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR027469 Cation_efflux_TMD_sf IPR026765 Tmem163
PANTHERⁱ	PTHR31937 PTHR31937, 1 hit
SUPFAMⁱ	SSF161111 SSF161111, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TM163_HUMAN
Accessionⁱ	Q8TC26Primary (citable) accession number: Q8TC26 Secondary accession number(s): Q53QM3 , Q53SV7, Q69YH3, Q9UFG3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TC26 (TM163_HUMAN)

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Transmembrane protein 163

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Other locations

Endosome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ