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UniProtKB - Q8TC26 (TM163_HUMAN)

Entry version 124 (25 May 2022)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

Transmembrane protein 163

Gene

TMEM163

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandZinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TC26

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q8TC26

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.4.8.3, the cation diffusion facilitator (cdf) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 163
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM163
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25380, TMEM163

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618978, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TC26

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152128

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 88CytoplasmicSequence analysisAdd BLAST88
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 116ExtracellularSequence analysis7
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 187ExtracellularSequence analysisAdd BLAST16
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 217CytoplasmicSequence analysis9
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255ExtracellularSequence analysisAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 289CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		81615

Open Targets

More...OpenTargetsi		ENSG00000152128

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145148025

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TC26, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM163

Domain mapping of disease mutations (DMDM)

More...DMDMi		74730546

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002785391 – 289Transmembrane protein 163Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TC26

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TC26

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TC26

PeptideAtlas

More...PeptideAtlasi		Q8TC26

PRoteomics IDEntifications database

More...PRIDEi		Q8TC26

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74081 [Q8TC26-1]
74082 [Q8TC26-2]
74083 [Q8TC26-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TC26

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TC26

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152128, Expressed in oocyte and 169 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TC26, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152128, Tissue enhanced (brain, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123550, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q8TC26, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000281924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TC26, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q8TC26

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TC26

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 65DisorderedSequence analysisAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 40Pro residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QW7B, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001170

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_081161_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TC26

Identification of Orthologs from Complete Genome Data

More...OMAi		IMRYSAS

Database of Orthologous Groups

More...OrthoDBi		1547703at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TC26

TreeFam database of animal gene trees

More...TreeFami		TF330782

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1510.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027469, Cation_efflux_TMD_sf
IPR026765, Tmem163

The PANTHER Classification System

More...PANTHERi		PTHR31937, PTHR31937, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF161111, SSF161111, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER 
        60         70         80         90        100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL 
       110        120        130        140        150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR 
       160        170        180        190        200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC 
       210        220        230        240        250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW 
       260        270        280 
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE
Length:289
Mass (Da):31,469
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0255DAE6D7E8487A
GO
Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-68: SDGLEDRG → MLPVSRTC
     153-162: IACVILGVIF → MTISCSVSPF
     163-289: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:102
Mass (Da):11,334
Checksum:i06F17B8F21B2B5A6
GO
Isoform 3 (identifier: Q8TC26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Note: Dubious isoform that could be a cloning artifact.Curated
Show »
Length:81
Mass (Da):8,966
Checksum:i0E596F8E75C84BA8
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH10592 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0233281 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0233291 – 60Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_02333061 – 68SDGLEDRG → MLPVSRTC in isoform 2. 1 Publication8
Alternative sequenceiVSP_023331153 – 162IACVILGVIF → MTISCSVSPF in isoform 2. 1 Publication10
Alternative sequenceiVSP_023332163 – 289Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2172.1 [Q8TC26-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T34524

NCBI Reference Sequences

More...RefSeqi		NP_112185.1, NM_030923.4 [Q8TC26-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000281924.6; ENSP00000281924.6; ENSG00000152128.13

Database of genes from NCBI RefSeq genomes

More...GeneIDi		81615

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:81615

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000281924.6; ENSP00000281924.6; NM_030923.5; NP_112185.1

UCSC genome browser

More...UCSCi		uc002ttx.4, human [Q8TC26-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1
CCDSiCCDS2172.1 [Q8TC26-1]
PIRiT34524
RefSeqiNP_112185.1, NM_030923.4 [Q8TC26-1]

3D structure databases

AlphaFoldDBiQ8TC26
SMRiQ8TC26
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123550, 1 interactor
IntActiQ8TC26, 1 interactor
STRINGi9606.ENSP00000281924

Protein family/group databases

TCDBi2.A.4.8.3, the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ8TC26
PhosphoSitePlusiQ8TC26

Genetic variation databases

BioMutaiTMEM163
DMDMi74730546

Proteomic databases

jPOSTiQ8TC26
MassIVEiQ8TC26
PaxDbiQ8TC26
PeptideAtlasiQ8TC26
PRIDEiQ8TC26
ProteomicsDBi74081 [Q8TC26-1]
74082 [Q8TC26-2]
74083 [Q8TC26-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33555, 38 antibodies from 14 providers

The DNASU plasmid repository

More...DNASUi		81615

Genome annotation databases

EnsembliENST00000281924.6; ENSP00000281924.6; ENSG00000152128.13
GeneIDi81615
KEGGihsa:81615
MANE-SelectiENST00000281924.6; ENSP00000281924.6; NM_030923.5; NP_112185.1
UCSCiuc002ttx.4, human [Q8TC26-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		81615
DisGeNETi81615

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM163
HGNCiHGNC:25380, TMEM163
HPAiENSG00000152128, Tissue enhanced (brain, pancreas)
MIMi618978, gene
neXtProtiNX_Q8TC26
OpenTargetsiENSG00000152128
PharmGKBiPA145148025
VEuPathDBiHostDB:ENSG00000152128

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QW7B, Eukaryota
GeneTreeiENSGT00390000001170
HOGENOMiCLU_081161_0_0_1
InParanoidiQ8TC26
OMAiIMRYSAS
OrthoDBi1547703at2759
PhylomeDBiQ8TC26
TreeFamiTF330782

Enzyme and pathway databases

PathwayCommonsiQ8TC26
SignaLinkiQ8TC26

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		81615, 13 hits in 1071 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM163, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		81615
PharosiQ8TC26, Tbio

Protein Ontology

More...PROi		PR:Q8TC26
RNActiQ8TC26, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152128, Expressed in oocyte and 169 other tissues
GenevisibleiQ8TC26, HS

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR027469, Cation_efflux_TMD_sf
IPR026765, Tmem163
PANTHERiPTHR31937, PTHR31937, 1 hit
SUPFAMiSSF161111, SSF161111, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM163_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC26
Secondary accession number(s): Q53QM3
, Q53SV7, Q69YH3, Q9UFG3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2002
Last modified: May 25, 2022
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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