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Protein

Transmembrane protein 163

Gene

TMEM163

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May bind zinc and other divalent cations and recruit them to vesicular organelles.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandZinc

Protein family/group databases

TCDBi2.A.4.8.3 the cation diffusion facilitator (cdf) family

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 163
Gene namesi
Name:TMEM163
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000152128.13
HGNCiHGNC:25380 TMEM163
neXtProtiNX_Q8TC26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 88CytoplasmicSequence analysisAdd BLAST88
Transmembranei89 – 109HelicalSequence analysisAdd BLAST21
Topological domaini110 – 116ExtracellularSequence analysis7
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 150CytoplasmicSequence analysisAdd BLAST13
Transmembranei151 – 171HelicalSequence analysisAdd BLAST21
Topological domaini172 – 187ExtracellularSequence analysisAdd BLAST16
Transmembranei188 – 208HelicalSequence analysisAdd BLAST21
Topological domaini209 – 217CytoplasmicSequence analysis9
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 255ExtracellularSequence analysisAdd BLAST17
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 289CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi81615
OpenTargetsiENSG00000152128
PharmGKBiPA145148025

Polymorphism and mutation databases

BioMutaiTMEM163
DMDMi74730546

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002785391 – 289Transmembrane protein 163Add BLAST289

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei57PhosphoserineBy similarity1
Modified residuei61PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TC26
PaxDbiQ8TC26
PeptideAtlasiQ8TC26
PRIDEiQ8TC26
ProteomicsDBi74081
74082 [Q8TC26-2]
74083 [Q8TC26-3]

PTM databases

iPTMnetiQ8TC26
PhosphoSitePlusiQ8TC26

Expressioni

Gene expression databases

BgeeiENSG00000152128 Expressed in 154 organ(s), highest expression level in oocyte
CleanExiHS_TMEM163
GenevisibleiQ8TC26 HS

Organism-specific databases

HPAiHPA007224

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000281924

Structurei

3D structure databases

ProteinModelPortaliQ8TC26
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM163 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9N Eukaryota
ENOG410Z7QG LUCA
GeneTreeiENSGT00390000001170
HOGENOMiHOG000294211
HOVERGENiHBG094063
InParanoidiQ8TC26
OMAiVIKFMLG
OrthoDBiEOG091G0JXN
PhylomeDBiQ8TC26
TreeFamiTF330782

Family and domain databases

InterProiView protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163
PANTHERiPTHR31937 PTHR31937, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TC26-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPAAGIQRR SSQGPTVPPP PRGHAPPAAA PGPAPLSSPV REPPQLEEER
60 70 80 90 100
QVRISESGQF SDGLEDRGLL ESSTRLKPHE AQNYRKKALW VSWFSIIVTL
110 120 130 140 150
ALAVAAFTVS VMRYSASAFG FAFDAILDVL SSAIVLWRYS NAAAVHSAHR
160 170 180 190 200
EYIACVILGV IFLLSSICIV VKAIHDLSTR LLPEVDDFLF SVSILSGILC
210 220 230 240 250
SILAVLKFML GKVLTSRALI TDGFNSLVGG VMGFSILLSA EVFKHDSAVW
260 270 280
YLDGSIGVLI GLTIFAYGVK LLIDMVPRVR QTRHYEMFE
Length:289
Mass (Da):31,469
Last modified:June 1, 2002 - v1
Checksum:i0255DAE6D7E8487A
GO
Isoform 2 (identifier: Q8TC26-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.
     61-68: SDGLEDRG → MLPVSRTC
     153-162: IACVILGVIF → MTISCSVSPF
     163-289: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:102
Mass (Da):11,334
Checksum:i06F17B8F21B2B5A6
GO
Isoform 3 (identifier: Q8TC26-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Note: No experimental confirmation available. Dubious isoform that could be a cloning artifact.
Show »
Length:81
Mass (Da):8,966
Checksum:i0E596F8E75C84BA8
GO

Sequence cautioni

The sequence CAH10592 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0233281 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0233291 – 60Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_02333061 – 68SDGLEDRG → MLPVSRTC in isoform 2. 1 Publication8
Alternative sequenceiVSP_023331153 – 162IACVILGVIF → MTISCSVSPF in isoform 2. 1 Publication10
Alternative sequenceiVSP_023332163 – 289Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1
CCDSiCCDS2172.1 [Q8TC26-1]
PIRiT34524
RefSeqiNP_112185.1, NM_030923.4 [Q8TC26-1]
UniGeneiHs.369471
Hs.595089

Genome annotation databases

EnsembliENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]
GeneIDi81615
KEGGihsa:81615
UCSCiuc002ttx.4 human [Q8TC26-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL122044 mRNA Translation: CAB59180.2
AL833765 mRNA Translation: CAH10592.1 Different initiation.
AC013718 Genomic DNA Translation: AAX93249.1
AC110620 Genomic DNA Translation: AAY24144.1
BC026170 mRNA Translation: AAH26170.1
CCDSiCCDS2172.1 [Q8TC26-1]
PIRiT34524
RefSeqiNP_112185.1, NM_030923.4 [Q8TC26-1]
UniGeneiHs.369471
Hs.595089

3D structure databases

ProteinModelPortaliQ8TC26
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281924

Protein family/group databases

TCDBi2.A.4.8.3 the cation diffusion facilitator (cdf) family

PTM databases

iPTMnetiQ8TC26
PhosphoSitePlusiQ8TC26

Polymorphism and mutation databases

BioMutaiTMEM163
DMDMi74730546

Proteomic databases

EPDiQ8TC26
PaxDbiQ8TC26
PeptideAtlasiQ8TC26
PRIDEiQ8TC26
ProteomicsDBi74081
74082 [Q8TC26-2]
74083 [Q8TC26-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281924; ENSP00000281924; ENSG00000152128 [Q8TC26-1]
GeneIDi81615
KEGGihsa:81615
UCSCiuc002ttx.4 human [Q8TC26-1]

Organism-specific databases

CTDi81615
DisGeNETi81615
EuPathDBiHostDB:ENSG00000152128.13
GeneCardsiTMEM163
HGNCiHGNC:25380 TMEM163
HPAiHPA007224
neXtProtiNX_Q8TC26
OpenTargetsiENSG00000152128
PharmGKBiPA145148025
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE9N Eukaryota
ENOG410Z7QG LUCA
GeneTreeiENSGT00390000001170
HOGENOMiHOG000294211
HOVERGENiHBG094063
InParanoidiQ8TC26
OMAiVIKFMLG
OrthoDBiEOG091G0JXN
PhylomeDBiQ8TC26
TreeFamiTF330782

Miscellaneous databases

ChiTaRSiTMEM163 human
GenomeRNAii81615
PROiPR:Q8TC26

Gene expression databases

BgeeiENSG00000152128 Expressed in 154 organ(s), highest expression level in oocyte
CleanExiHS_TMEM163
GenevisibleiQ8TC26 HS

Family and domain databases

InterProiView protein in InterPro
IPR027469 Cation_efflux_TMD_sf
IPR026765 Tmem163
PANTHERiPTHR31937 PTHR31937, 1 hit
SUPFAMiSSF161111 SSF161111, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM163_HUMAN
AccessioniPrimary (citable) accession number: Q8TC26
Secondary accession number(s): Q53QM3
, Q53SV7, Q69YH3, Q9UFG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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