UniProtKB - Q8TC12 (RDH11_HUMAN)
Retinol dehydrogenase 11
RDH11
Functioni
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696).
Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448).
Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).
4 PublicationsMiscellaneous
Caution
Catalytic activityi
- EC:1.1.1.3003 Publications
Activity regulationi
Kineticsi
- KM=0.23 µM for NADPH1 Publication
- KM=0.8 µM for NADP1 Publication
- KM=0.5 µM for all-trans-retinal1 Publication
- KM=0.62 µM for 13-cis-retinal1 Publication
- KM=0.19 µM for 9-cis-retinal1 Publication
- KM=1.3 µM for all-trans-retinol1 Publication
- KM=5 µM for (Z)-non-6-enol1 Publication
- Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate1 Publication
- Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as substrate1 Publication
- Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate1 Publication
- Vmax=0.95 nmol/min/mg enzyme with all-trans-retinol as substrate1 Publication
- Vmax=19 nmol/min/mg enzyme with (Z)-non-6-enol1 Publication
: retinol metabolism Pathwayi
This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.2 PublicationsView all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 177 | SubstrateBy similarity | 1 | |
Active sitei | 202 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 48 – 54 | NADPBy similarity | 7 |
GO - Molecular functioni
- 11-cis-retinol dehydrogenase activity Source: RHEA
- NADP-retinol dehydrogenase activity Source: UniProtKB
- NAD-retinol dehydrogenase activity Source: UniProtKB
- oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: Reactome
GO - Biological processi
- cellular detoxification of aldehyde Source: UniProtKB
- retinal metabolic process Source: MGI
- retinoid metabolic process Source: UniProtKB
- retinol metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid metabolism |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.300, 2681 |
PathwayCommonsi | Q8TC12 |
Reactomei | R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision) R-HSA-5365859, RA biosynthesis pathway R-HSA-975634, Retinoid metabolism and transport |
SABIO-RKi | Q8TC12 |
SignaLinki | Q8TC12 |
UniPathwayi | UPA00912 |
Chemistry databases
SwissLipidsi | SLP:000001785 |
Names & Taxonomyi
Protein namesi | Recommended name: Retinol dehydrogenase 11 (EC:1.1.1.3002 Publications)Alternative name(s): Androgen-regulated short-chain dehydrogenase/reductase 11 Publication HCV core-binding protein HCBP12 Prostate short-chain dehydrogenase/reductase 1 Retinal reductase 11 Publication Short name: RalR11 Publication Short chain dehydrogenase/reductase family 7C member 1 |
Gene namesi | Name:RDH11 Synonyms:ARSDR1, PSDR1, SDR7C1 ORF Names:CGI-82 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17964, RDH11 |
MIMi | 607849, gene |
neXtProti | NX_Q8TC12 |
VEuPathDBi | HostDB:ENSG00000072042 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1 – 21 | Helical; Signal-anchor for type II membrane protein2 PublicationsAdd BLAST | 21 | |
Topological domaini | 22 – 318 | Cytoplasmic2 PublicationsAdd BLAST | 297 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS)1 Publication
Keywords - Diseasei
Cataract, DwarfismOrganism-specific databases
DisGeNETi | 51109 |
MalaCardsi | RDH11 |
MIMi | 616108, phenotype |
OpenTargetsi | ENSG00000072042 |
Orphaneti | 436245, Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome |
PharmGKBi | PA134981588 |
Miscellaneous databases
Pharosi | Q8TC12, Tbio |
Chemistry databases
DrugBanki | DB00162, Vitamin A |
Genetic variation databases
BioMutai | RDH11 |
DMDMi | 34395789 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054763 | 1 – 318 | Retinol dehydrogenase 11Add BLAST | 318 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 112 | N6-acetyllysineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8TC12 |
jPOSTi | Q8TC12 |
MassIVEi | Q8TC12 |
MaxQBi | Q8TC12 |
PaxDbi | Q8TC12 |
PeptideAtlasi | Q8TC12 |
PRIDEi | Q8TC12 |
ProteomicsDBi | 3897 74069 [Q8TC12-1] 74070 [Q8TC12-2] |
PTM databases
CarbonylDBi | Q8TC12 |
GlyGeni | Q8TC12, 1 site |
iPTMneti | Q8TC12 |
PhosphoSitePlusi | Q8TC12 |
SwissPalmi | Q8TC12 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000072042, Expressed in prostate gland and 249 other tissues |
ExpressionAtlasi | Q8TC12, baseline and differential |
Genevisiblei | Q8TC12, HS |
Organism-specific databases
HPAi | ENSG00000072042, Tissue enhanced (prostate) |
Interactioni
Subunit structurei
Interacts with SELENOF.
1 PublicationBinary interactionsi
Q8TC12
With | #Exp. | IntAct |
---|---|---|
SELENOF [O60613] | 5 | EBI-2823756,EBI-1052797 |
Protein-protein interaction databases
BioGRIDi | 119298, 97 interactors |
IntActi | Q8TC12, 25 interactors |
MINTi | Q8TC12 |
STRINGi | 9606.ENSP00000370750 |
Miscellaneous databases
RNActi | Q8TC12, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000158191 |
InParanoidi | Q8TC12 |
OMAi | MFALELN |
PhylomeDBi | Q8TC12 |
TreeFami | TF105429 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVELMFPLLL LLLPFLLYMA APQIRKMLSS GVCTSTVQLP GKVVVVTGAN
60 70 80 90 100
TGIGKETAKE LAQRGARVYL ACRDVEKGEL VAKEIQTTTG NQQVLVRKLD
110 120 130 140 150
LSDTKSIRAF AKGFLAEEKH LHVLINNAGV MMCPYSKTAD GFEMHIGVNH
160 170 180 190 200
LGHFLLTHLL LEKLKESAPS RIVNVSSLAH HLGRIHFHNL QGEKFYNAGL
210 220 230 240 250
AYCHSKLANI LFTQELARRL KGSGVTTYSV HPGTVQSELV RHSSFMRWMW
260 270 280 290 300
WLFSFFIKTP QQGAQTSLHC ALTEGLEILS GNHFSDCHVA WVSAQARNET
310
IARRLWDVSC DLLGLPID
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3V234 | G3V234_HUMAN | Retinol dehydrogenase 11 | RDH11 | 186 | Annotation score: | ||
G3V2G6 | G3V2G6_HUMAN | Retinol dehydrogenase 11 | RDH11 | 178 | Annotation score: | ||
G3V3K0 | G3V3K0_HUMAN | Retinol dehydrogenase 11 | RDH11 | 61 | Annotation score: | ||
G3V510 | G3V510_HUMAN | Retinol dehydrogenase 11 | RDH11 | 62 | Annotation score: | ||
H0YJ46 | H0YJ46_HUMAN | Retinol dehydrogenase 11 | RDH11 | 204 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 176 | S → F in AAH51291 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 294 | A → V in AAF89632 (PubMed:11245473).Curated | 1 | |
Sequence conflicti | 316 | P → S in AAH26274 (PubMed:15489334).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008159 | 52 – 64 | Missing in isoform 2. 2 PublicationsAdd BLAST | 13 | |
Alternative sequenceiVSP_046403 | 152 – 221 | Missing in isoform 3. 1 PublicationAdd BLAST | 70 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF167438 mRNA Translation: AAF89632.1 AF395068 mRNA Translation: AAK72049.1 AF151840 mRNA Translation: AAD34077.1 CR457180 mRNA Translation: CAG33461.1 AK289427 mRNA Translation: BAF82116.1 AK293355 mRNA Translation: BAG56871.1 AK314465 mRNA Translation: BAG37073.1 AK074749 mRNA Translation: BAG51997.1 AL049779 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80950.1 BC000112 mRNA Translation: AAH00112.1 BC011727 mRNA Translation: AAH11727.1 BC026274 mRNA Translation: AAH26274.1 BC037302 mRNA Translation: AAH37302.1 BC051291 mRNA Translation: AAH51291.1 DQ426886 mRNA Translation: ABD90542.1 |
CCDSi | CCDS32104.1 [Q8TC12-1] CCDS58326.1 [Q8TC12-3] |
RefSeqi | NP_001239579.1, NM_001252650.1 [Q8TC12-3] NP_057110.3, NM_016026.3 [Q8TC12-1] |
Genome annotation databases
Ensembli | ENST00000381346; ENSP00000370750; ENSG00000072042 ENST00000428130; ENSP00000416395; ENSG00000072042 [Q8TC12-3] ENST00000553384; ENSP00000452079; ENSG00000072042 [Q8TC12-2] |
GeneIDi | 51109 |
KEGGi | hsa:51109 |
MANE-Selecti | ENST00000381346.9; ENSP00000370750.4; NM_016026.4; NP_057110.3 |
UCSCi | uc001xjv.6, human [Q8TC12-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF167438 mRNA Translation: AAF89632.1 AF395068 mRNA Translation: AAK72049.1 AF151840 mRNA Translation: AAD34077.1 CR457180 mRNA Translation: CAG33461.1 AK289427 mRNA Translation: BAF82116.1 AK293355 mRNA Translation: BAG56871.1 AK314465 mRNA Translation: BAG37073.1 AK074749 mRNA Translation: BAG51997.1 AL049779 Genomic DNA No translation available. CH471061 Genomic DNA Translation: EAW80950.1 BC000112 mRNA Translation: AAH00112.1 BC011727 mRNA Translation: AAH11727.1 BC026274 mRNA Translation: AAH26274.1 BC037302 mRNA Translation: AAH37302.1 BC051291 mRNA Translation: AAH51291.1 DQ426886 mRNA Translation: ABD90542.1 |
CCDSi | CCDS32104.1 [Q8TC12-1] CCDS58326.1 [Q8TC12-3] |
RefSeqi | NP_001239579.1, NM_001252650.1 [Q8TC12-3] NP_057110.3, NM_016026.3 [Q8TC12-1] |
3D structure databases
SMRi | Q8TC12 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119298, 97 interactors |
IntActi | Q8TC12, 25 interactors |
MINTi | Q8TC12 |
STRINGi | 9606.ENSP00000370750 |
Chemistry databases
DrugBanki | DB00162, Vitamin A |
SwissLipidsi | SLP:000001785 |
PTM databases
CarbonylDBi | Q8TC12 |
GlyGeni | Q8TC12, 1 site |
iPTMneti | Q8TC12 |
PhosphoSitePlusi | Q8TC12 |
SwissPalmi | Q8TC12 |
Genetic variation databases
BioMutai | RDH11 |
DMDMi | 34395789 |
Proteomic databases
EPDi | Q8TC12 |
jPOSTi | Q8TC12 |
MassIVEi | Q8TC12 |
MaxQBi | Q8TC12 |
PaxDbi | Q8TC12 |
PeptideAtlasi | Q8TC12 |
PRIDEi | Q8TC12 |
ProteomicsDBi | 3897 74069 [Q8TC12-1] 74070 [Q8TC12-2] |
Protocols and materials databases
Antibodypediai | 12201, 237 antibodies from 27 providers |
DNASUi | 51109 |
Genome annotation databases
Ensembli | ENST00000381346; ENSP00000370750; ENSG00000072042 ENST00000428130; ENSP00000416395; ENSG00000072042 [Q8TC12-3] ENST00000553384; ENSP00000452079; ENSG00000072042 [Q8TC12-2] |
GeneIDi | 51109 |
KEGGi | hsa:51109 |
MANE-Selecti | ENST00000381346.9; ENSP00000370750.4; NM_016026.4; NP_057110.3 |
UCSCi | uc001xjv.6, human [Q8TC12-1] |
Organism-specific databases
CTDi | 51109 |
DisGeNETi | 51109 |
GeneCardsi | RDH11 |
HGNCi | HGNC:17964, RDH11 |
HPAi | ENSG00000072042, Tissue enhanced (prostate) |
MalaCardsi | RDH11 |
MIMi | 607849, gene 616108, phenotype |
neXtProti | NX_Q8TC12 |
OpenTargetsi | ENSG00000072042 |
Orphaneti | 436245, Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome |
PharmGKBi | PA134981588 |
VEuPathDBi | HostDB:ENSG00000072042 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1208, Eukaryota |
GeneTreei | ENSGT00940000158191 |
InParanoidi | Q8TC12 |
OMAi | MFALELN |
PhylomeDBi | Q8TC12 |
TreeFami | TF105429 |
Enzyme and pathway databases
UniPathwayi | UPA00912 |
BRENDAi | 1.1.1.300, 2681 |
PathwayCommonsi | Q8TC12 |
Reactomei | R-HSA-2453902, The canonical retinoid cycle in rods (twilight vision) R-HSA-5365859, RA biosynthesis pathway R-HSA-975634, Retinoid metabolism and transport |
SABIO-RKi | Q8TC12 |
SignaLinki | Q8TC12 |
Miscellaneous databases
BioGRID-ORCSi | 51109, 11 hits in 1045 CRISPR screens |
ChiTaRSi | RDH11, human |
GeneWikii | RDH11 |
GenomeRNAii | 51109 |
Pharosi | Q8TC12, Tbio |
PROi | PR:Q8TC12 |
RNActi | Q8TC12, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072042, Expressed in prostate gland and 249 other tissues |
ExpressionAtlasi | Q8TC12, baseline and differential |
Genevisiblei | Q8TC12, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDH11_HUMAN | |
Accessioni | Q8TC12Primary (citable) accession number: Q8TC12 Secondary accession number(s): A6NDK3 Q9Y391 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2003 |
Last sequence update: | August 29, 2003 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families