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UniProtKB - Q8TC12 (RDH11_HUMAN)

Entry version 165 (18 Sep 2019)
Sequence version 2 (29 Aug 2003)
Previous versions | rss
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Protein

Retinol dehydrogenase 11

Gene

RDH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12226107, PubMed:12036956, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12226107, PubMed:12036956).4 Publications

Miscellaneous

Shows clear specificity for the pro-S hydrogen on C4 of NADPH and the pro-R hydrogen on C15 of retinols.1 Publication

Caution

In contrast to mouse, human RDH11 exhibits little or no activity towards toxic lipid peroxidation products, such as nonanal or 4-hydroxy-nonenal.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

SELENOF decreases the retinol dehydrogenase activity.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Vmax is measured per mg microsomal protein.
  1. KM=0.23 µM for NADPH1 Publication
  2. KM=0.8 µM for NADP1 Publication
  3. KM=0.5 µM for all-trans-retinal1 Publication
  4. KM=0.62 µM for 13-cis-retinal1 Publication
  5. KM=0.19 µM for 9-cis-retinal1 Publication
  6. KM=1.3 µM for all-trans-retinol1 Publication
  7. KM=5 µM for (Z)-non-6-enol1 Publication
  1. Vmax=18 nmol/min/mg enzyme with all-trans-retinal as substrate1 Publication
  2. Vmax=7 nmol/min/mg enzyme with 13-cis-retinal as substrate1 Publication
  3. Vmax=1.6 nmol/min/mg enzyme with 9-cis-retinal as substrate1 Publication
  4. Vmax=0.95 nmol/min/mg enzyme with all-trans-retinol as substrate1 Publication
  5. Vmax=19 nmol/min/mg enzyme with (Z)-non-6-enol1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: retinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.2 Publications
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei177SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei202Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi48 – 54NADPBy similarity7

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandNADP

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS01050-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.1.1.300 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q8TC12

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00912

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001785

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Retinol dehydrogenase 11 (EC:1.1.1.3002 Publications)
Alternative name(s):
Androgen-regulated short-chain dehydrogenase/reductase 11 Publication
HCV core-binding protein HCBP12
Prostate short-chain dehydrogenase/reductase 1
Retinal reductase 11 Publication
Short name:
RalR11 Publication
Short chain dehydrogenase/reductase family 7C member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RDH11
Synonyms:ARSDR1, PSDR1, SDR7C1
ORF Names:CGI-82
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17964 RDH11

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607849 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TC12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1 – 21Helical; Signal-anchor for type II membrane protein2 PublicationsAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 318Cytoplasmic2 PublicationsAdd BLAST297

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinal dystrophy, juvenile cataracts, and short stature syndrome (RDJCSS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by retinal dystrophy resulting in progressive decrease in visual acuity and difficulties with night vision in the first decade of life, development of juvenile cataracts, facial dysmorphism, psychomotor developmental delays, learning disabilities and short stature. Ophthalmological findings include salt-and-pepper retinopathy, attenuation of the arterioles, generalized rod-cone dysfunction, mottled macula at an early age, and peripapillary sparing of the retinal pigment epithelium.
Related information in OMIM

Keywords - Diseasei

Cataract, Dwarfism

Organism-specific databases

DisGeNET

More...DisGeNETi		51109

MalaCards human disease database

More...MalaCardsi		RDH11
MIMi616108 phenotype

Open Targets

More...OpenTargetsi		ENSG00000072042

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		436245 Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134981588

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00162 Vitamin A

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RDH11

Domain mapping of disease mutations (DMDM)

More...DMDMi		34395789

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000547631 – 318Retinol dehydrogenase 11Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112N6-acetyllysineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Not glycosylated.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TC12

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TC12

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TC12

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TC12

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TC12

PeptideAtlas

More...PeptideAtlasi		Q8TC12

PRoteomics IDEntifications database

More...PRIDEi		Q8TC12

ProteomicsDB human proteome resource

More...ProteomicsDBi		3897
74069 [Q8TC12-1]
74070 [Q8TC12-2]

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q8TC12

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TC12

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TC12

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q8TC12

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in the epithelial cells of prostate, in both basal and luminal secretory cell populations. Expressed at low levels in spleen, thymus, testis, ovary, small intestine, colon, peripherical blood leukocytes, kidney, adrenal gland and fetal liver. Not detected in prostatic fibromuscular stromal cells, endothelial cells, or infiltrating lymphocytes.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By androgens in prostate cancer cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072042 Expressed in 236 organ(s), highest expression level in pigmented layer of retina

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TC12 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TC12 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB046011

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SELENOF.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SELENOFO606135EBI-2823756,EBI-1052797

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		119298, 32 interactors

Protein interaction database and analysis system

More...IntActi		Q8TC12, 17 interactors

Molecular INTeraction database

More...MINTi		Q8TC12

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000370750

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TC12

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1208 Eukaryota
COG1028 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158191

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TC12

KEGG Orthology (KO)

More...KOi		K11152

Identification of Orthologs from Complete Genome Data

More...OMAi		MFALELN

Database of Orthologous Groups

More...OrthoDBi		1032903at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TC12

TreeFam database of animal gene trees

More...TreeFami		TF105429

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106 adh_short, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735 SSF51735, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TC12-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVELMFPLLL LLLPFLLYMA APQIRKMLSS GVCTSTVQLP GKVVVVTGAN 
        60         70         80         90        100
TGIGKETAKE LAQRGARVYL ACRDVEKGEL VAKEIQTTTG NQQVLVRKLD 
       110        120        130        140        150
LSDTKSIRAF AKGFLAEEKH LHVLINNAGV MMCPYSKTAD GFEMHIGVNH 
       160        170        180        190        200
LGHFLLTHLL LEKLKESAPS RIVNVSSLAH HLGRIHFHNL QGEKFYNAGL 
       210        220        230        240        250
AYCHSKLANI LFTQELARRL KGSGVTTYSV HPGTVQSELV RHSSFMRWMW 
       260        270        280        290        300
WLFSFFIKTP QQGAQTSLHC ALTEGLEILS GNHFSDCHVA WVSAQARNET 
       310 
IARRLWDVSC DLLGLPID
Length:318
Mass (Da):35,386
Last modified:August 29, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B0C366552774835
GO
Isoform 2 (identifier: Q8TC12-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-64: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):34,004
Checksum:i6125D5184C99FA29
GO
Isoform 3 (identifier: Q8TC12-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     152-221: Missing.

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):27,402
Checksum:iD10A8E21D83BA33F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V234G3V234_HUMAN
Retinol dehydrogenase 11
RDH11
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3K0G3V3K0_HUMAN
Retinol dehydrogenase 11
RDH11
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V510G3V510_HUMAN
Retinol dehydrogenase 11
RDH11
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2G6G3V2G6_HUMAN
Retinol dehydrogenase 11
RDH11
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJ46H0YJ46_HUMAN
Retinol dehydrogenase 11
RDH11
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti176S → F in AAH51291 (PubMed:15489334).Curated1
Sequence conflicti294A → V in AAF89632 (PubMed:11245473).Curated1
Sequence conflicti316P → S in AAH26274 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00815952 – 64Missing in isoform 2. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_046403152 – 221Missing in isoform 3. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF167438 mRNA Translation: AAF89632.1
AF395068 mRNA Translation: AAK72049.1
AF151840 mRNA Translation: AAD34077.1
CR457180 mRNA Translation: CAG33461.1
AK289427 mRNA Translation: BAF82116.1
AK293355 mRNA Translation: BAG56871.1
AK314465 mRNA Translation: BAG37073.1
AK074749 mRNA Translation: BAG51997.1
AL049779 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80950.1
BC000112 mRNA Translation: AAH00112.1
BC011727 mRNA Translation: AAH11727.1
BC026274 mRNA Translation: AAH26274.1
BC037302 mRNA Translation: AAH37302.1
BC051291 mRNA Translation: AAH51291.1
DQ426886 mRNA Translation: ABD90542.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32104.1 [Q8TC12-1]
CCDS58326.1 [Q8TC12-3]

NCBI Reference Sequences

More...RefSeqi		NP_001239579.1, NM_001252650.1 [Q8TC12-3]
NP_057110.3, NM_016026.3 [Q8TC12-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000381346; ENSP00000370750; ENSG00000072042 [Q8TC12-1]
ENST00000428130; ENSP00000416395; ENSG00000072042 [Q8TC12-3]
ENST00000553384; ENSP00000452079; ENSG00000072042 [Q8TC12-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51109

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51109

UCSC genome browser

More...UCSCi		uc001xjv.6 human [Q8TC12-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167438 mRNA Translation: AAF89632.1
AF395068 mRNA Translation: AAK72049.1
AF151840 mRNA Translation: AAD34077.1
CR457180 mRNA Translation: CAG33461.1
AK289427 mRNA Translation: BAF82116.1
AK293355 mRNA Translation: BAG56871.1
AK314465 mRNA Translation: BAG37073.1
AK074749 mRNA Translation: BAG51997.1
AL049779 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW80950.1
BC000112 mRNA Translation: AAH00112.1
BC011727 mRNA Translation: AAH11727.1
BC026274 mRNA Translation: AAH26274.1
BC037302 mRNA Translation: AAH37302.1
BC051291 mRNA Translation: AAH51291.1
DQ426886 mRNA Translation: ABD90542.1
CCDSiCCDS32104.1 [Q8TC12-1]
CCDS58326.1 [Q8TC12-3]
RefSeqiNP_001239579.1, NM_001252650.1 [Q8TC12-3]
NP_057110.3, NM_016026.3 [Q8TC12-1]

3D structure databases

SMRiQ8TC12
ModBaseiSearch...

Protein-protein interaction databases

BioGridi119298, 32 interactors
IntActiQ8TC12, 17 interactors
MINTiQ8TC12
STRINGi9606.ENSP00000370750

Chemistry databases

DrugBankiDB00162 Vitamin A
SwissLipidsiSLP:000001785

PTM databases

CarbonylDBiQ8TC12
iPTMnetiQ8TC12
PhosphoSitePlusiQ8TC12
SwissPalmiQ8TC12

Polymorphism and mutation databases

BioMutaiRDH11
DMDMi34395789

Proteomic databases

EPDiQ8TC12
jPOSTiQ8TC12
MassIVEiQ8TC12
MaxQBiQ8TC12
PaxDbiQ8TC12
PeptideAtlasiQ8TC12
PRIDEiQ8TC12
ProteomicsDBi3897
74069 [Q8TC12-1]
74070 [Q8TC12-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		51109
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381346; ENSP00000370750; ENSG00000072042 [Q8TC12-1]
ENST00000428130; ENSP00000416395; ENSG00000072042 [Q8TC12-3]
ENST00000553384; ENSP00000452079; ENSG00000072042 [Q8TC12-2]
GeneIDi51109
KEGGihsa:51109
UCSCiuc001xjv.6 human [Q8TC12-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51109
DisGeNETi51109

GeneCards: human genes, protein and diseases

More...GeneCardsi		RDH11
HGNCiHGNC:17964 RDH11
HPAiCAB046011
MalaCardsiRDH11
MIMi607849 gene
616108 phenotype
neXtProtiNX_Q8TC12
OpenTargetsiENSG00000072042
Orphaneti436245 Retinitis pigmentosa-juvenile cataract-short stature-intellectual disability syndrome
PharmGKBiPA134981588

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1208 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00940000158191
InParanoidiQ8TC12
KOiK11152
OMAiMFALELN
OrthoDBi1032903at2759
PhylomeDBiQ8TC12
TreeFamiTF105429

Enzyme and pathway databases

UniPathwayiUPA00912
BioCyciMetaCyc:HS01050-MONOMER
BRENDAi1.1.1.300 2681
ReactomeiR-HSA-2453902 The canonical retinoid cycle in rods (twilight vision)
R-HSA-5365859 RA biosynthesis pathway
R-HSA-975634 Retinoid metabolism and transport
SABIO-RKiQ8TC12

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RDH11 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RDH11

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51109

Pharos

More...Pharosi		Q8TC12

Protein Ontology

More...PROi		PR:Q8TC12

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072042 Expressed in 236 organ(s), highest expression level in pigmented layer of retina
ExpressionAtlasiQ8TC12 baseline and differential
GenevisibleiQ8TC12 HS

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDH11_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC12
Secondary accession number(s): A6NDK3
, A8K062, B2RB26, B4DDW0, Q0QD40, Q6IAH5, Q9NRW0, Q9Y391
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: August 29, 2003
Last modified: September 18, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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