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Entry version 139 (13 Feb 2019)
Sequence version 2 (03 Apr 2007)
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Protein

TBC1 domain family member 15

Gene

TBC1D15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8854214 TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 15
Alternative name(s):
GTPase-activating protein RAB7
Short name:
GAP for RAB7
Short name:
Rab7-GAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000121749.15

Human Gene Nomenclature Database

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HGNCi
HGNC:25694 TBC1D15

Online Mendelian Inheritance in Man (OMIM)

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MIMi
612662 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC07

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000121749

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134946839

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D15

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811467

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002080422 – 691TBC1 domain family member 15Add BLAST690

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei23PhosphoserineCombined sources1
Modified residuei70PhosphoserineCombined sources1
Modified residuei205PhosphoserineBy similarity1
Modified residuei274PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei675PhosphoserineCombined sources1
Modified residuei689PhosphothreonineCombined sources1
Isoform 2 (identifier: Q8TC07-2)
Modified residuei205PhosphoserineCombined sources1
Isoform 3 (identifier: Q8TC07-3)
Modified residuei213PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q8TC07

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q8TC07

MaxQB - The MaxQuant DataBase

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MaxQBi
Q8TC07

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TC07

PeptideAtlas

More...
PeptideAtlasi
Q8TC07

PRoteomics IDEntifications database

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PRIDEi
Q8TC07

ProteomicsDB human proteome resource

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ProteomicsDBi
74067
74068 [Q8TC07-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC07

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TC07

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000121749 Expressed in 220 organ(s), highest expression level in ectocervix

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TC07 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TC07 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013388
HPA015592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
122296, 71 interactors

Protein interaction database and analysis system

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IntActi
Q8TC07, 20 interactors

Molecular INTeraction database

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MINTi
Q8TC07

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000448182

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q8TC07

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q8TC07

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini346 – 556Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST211

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2197 Eukaryota
COG5210 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156429

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000012710

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057668

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q8TC07

KEGG Orthology (KO)

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KOi
K20168

Identification of Orthologs from Complete Genome Data

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OMAi
FKGGLCH

Database of Orthologous Groups

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OrthoDBi
1495285at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q8TC07

TreeFam database of animal gene trees

More...
TreeFami
TF314296

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR021935 SGSM1/2_RBD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12068 PH_RBD, 1 hit
PF00566 RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00164 TBC, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47923 SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TC07-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGVVSGK IIYEQEGVYI HSSCGKTNDQ DGLISGILRV LEKDAEVIVD
60 70 80 90 100
WRPLDDALDS SSILYARKDS SSVVEWTQAP KERGHRGSEH LNSYEAEWDM
110 120 130 140 150
VNTVSFKRKP HTNGDAPSHR NGKSKWSFLF SLTDLKSIKQ NKEGMGWSYL
160 170 180 190 200
VFCLKDDVVL PALHFHQGDS KLLIESLEKY VVLCESPQDK RTLLVNCQNK
210 220 230 240 250
SLSQSFENLL DEPAYGLIQA GLLDRRKLLW AIHHWKKIKK DPYTATMIGF
260 270 280 290 300
SKVTNYIFDS LRGSDPSTHQ RPPSEMADFL SDAIPGLKIN QQEEPGFEVI
310 320 330 340 350
TRIDLGERPV VQRREPVSLE EWTKNIDSEG RILNVDNMKQ MIFRGGLSHA
360 370 380 390 400
LRKQAWKFLL GYFPWDSTKE ERTQLQKQKT DEYFRMKLQW KSISQEQEKR
410 420 430 440 450
NSRLRDYRSL IEKDVNRTDR TNKFYEGQDN PGLILLHDIL MTYCMYDFDL
460 470 480 490 500
GYVQGMSDLL SPLLYVMENE VDAFWCFASY MDQMHQNFEE QMQGMKTQLI
510 520 530 540 550
QLSTLLRLLD SGFCSYLESQ DSGYLYFCFR WLLIRFKREF SFLDILRLWE
560 570 580 590 600
VMWTELPCTN FHLLLCCAIL ESEKQQIMEK HYGFNEILKH INELSMKIDV
610 620 630 640 650
EDILCKAEAI SLQMVKCKEL PQAVCEILGL QGSEVTTPDS DVGEDENVVM
660 670 680 690
TPCPTSAFQS NALPTLSASG ARNDSPTQIP VSSDVCRLTP A
Length:691
Mass (Da):79,491
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD880DBE4D5758EC7
GO
Isoform 2 (identifier: Q8TC07-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-236: Missing.

Show »
Length:674
Mass (Da):77,395
Checksum:iA40A9F8838A2EB9E
GO
Isoform 3 (identifier: Q8TC07-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MAAAGVVSGK → MCPGLYPYSSLLEYGRSM
     220-236: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:682
Mass (Da):78,572
Checksum:i02F379CC94953EA9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA93C9JA93_HUMAN
TBC1 domain family member 15
TBC1D15
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VV61F8VV61_HUMAN
TBC1 domain family member 15
TBC1D15
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCB5F8WCB5_HUMAN
TBC1 domain family member 15
TBC1D15
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF35F8WF35_HUMAN
TBC1 domain family member 15
TBC1D15
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDJ1F8WDJ1_HUMAN
TBC1 domain family member 15
TBC1D15
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAX5F8WAX5_HUMAN
TBC1 domain family member 15
TBC1D15
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti52R → G in BAB13971 (PubMed:19077034).Curated1
Sequence conflicti298E → G in BAG60001 (PubMed:14702039).Curated1
Sequence conflicti498Q → R in BAG60001 (PubMed:14702039).Curated1
Sequence conflicti541S → G in AAH28352 (PubMed:16541075).Curated1
Sequence conflicti633S → G in BAB13971 (PubMed:19077034).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0464021 – 10MAAAGVVSGK → MCPGLYPYSSLLEYGRSM in isoform 3. 1 Publication10
Alternative sequenceiVSP_023094220 – 236Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB449901 mRNA Translation: BAH16644.1
AK022147 mRNA Translation: BAB13971.1
AK297626 mRNA Translation: BAG60001.1
AC089984 Genomic DNA No translation available.
AC090109 Genomic DNA No translation available.
BC028352 mRNA Translation: AAH28352.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31858.1 [Q8TC07-1]
CCDS53814.1 [Q8TC07-2]
CCDS55849.1 [Q8TC07-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001139685.2, NM_001146213.1 [Q8TC07-2]
NP_001139686.1, NM_001146214.1 [Q8TC07-3]
NP_073608.4, NM_022771.4 [Q8TC07-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.284630

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000319106; ENSP00000318262; ENSG00000121749 [Q8TC07-3]
ENST00000485960; ENSP00000420678; ENSG00000121749 [Q8TC07-2]
ENST00000550746; ENSP00000448182; ENSG00000121749 [Q8TC07-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
64786

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64786

UCSC genome browser

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UCSCi
uc001swu.4 human [Q8TC07-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449901 mRNA Translation: BAH16644.1
AK022147 mRNA Translation: BAB13971.1
AK297626 mRNA Translation: BAG60001.1
AC089984 Genomic DNA No translation available.
AC090109 Genomic DNA No translation available.
BC028352 mRNA Translation: AAH28352.1
CCDSiCCDS31858.1 [Q8TC07-1]
CCDS53814.1 [Q8TC07-2]
CCDS55849.1 [Q8TC07-3]
RefSeqiNP_001139685.2, NM_001146213.1 [Q8TC07-2]
NP_001139686.1, NM_001146214.1 [Q8TC07-3]
NP_073608.4, NM_022771.4 [Q8TC07-1]
UniGeneiHs.284630

3D structure databases

ProteinModelPortaliQ8TC07
SMRiQ8TC07
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122296, 71 interactors
IntActiQ8TC07, 20 interactors
MINTiQ8TC07
STRINGi9606.ENSP00000448182

PTM databases

iPTMnetiQ8TC07
PhosphoSitePlusiQ8TC07

Polymorphism and mutation databases

BioMutaiTBC1D15
DMDMi143811467

Proteomic databases

EPDiQ8TC07
jPOSTiQ8TC07
MaxQBiQ8TC07
PaxDbiQ8TC07
PeptideAtlasiQ8TC07
PRIDEiQ8TC07
ProteomicsDBi74067
74068 [Q8TC07-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319106; ENSP00000318262; ENSG00000121749 [Q8TC07-3]
ENST00000485960; ENSP00000420678; ENSG00000121749 [Q8TC07-2]
ENST00000550746; ENSP00000448182; ENSG00000121749 [Q8TC07-1]
GeneIDi64786
KEGGihsa:64786
UCSCiuc001swu.4 human [Q8TC07-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64786
EuPathDBiHostDB:ENSG00000121749.15

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D15
HGNCiHGNC:25694 TBC1D15
HPAiHPA013388
HPA015592
MIMi612662 gene
neXtProtiNX_Q8TC07
OpenTargetsiENSG00000121749
PharmGKBiPA134946839

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2197 Eukaryota
COG5210 LUCA
GeneTreeiENSGT00940000156429
HOGENOMiHOG000012710
HOVERGENiHBG057668
InParanoidiQ8TC07
KOiK20168
OMAiFKGGLCH
OrthoDBi1495285at2759
PhylomeDBiQ8TC07
TreeFamiTF314296

Enzyme and pathway databases

ReactomeiR-HSA-8854214 TBC/RABGAPs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D15 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64786

Protein Ontology

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PROi
PR:Q8TC07

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000121749 Expressed in 220 organ(s), highest expression level in ectocervix
ExpressionAtlasiQ8TC07 baseline and differential
GenevisibleiQ8TC07 HS

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR021935 SGSM1/2_RBD
PfamiView protein in Pfam
PF12068 PH_RBD, 1 hit
PF00566 RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086 TBC_RABGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC15_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC07
Secondary accession number(s): B4DMT9
, B9A6L6, J3KNI9, Q9HA83
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: April 3, 2007
Last modified: February 13, 2019
This is version 139 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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