Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 126 (11 Dec 2019)
Sequence version 2 (21 Aug 2007)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nuclear protein MDM1

Gene

MDM1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • microtubule binding Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear protein MDM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MDM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000111554.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29917 MDM1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613813 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TC05

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9 – 15SEYQRNF → AAAQRNA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 189-A--A-195; 232-A--A-238 and 306-A--A-312. 7
Mutagenesisi189 – 195SEYQRQF → AAAQRQA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 232-A--A-238 and 306-A--A-312. 7
Mutagenesisi232 – 238TEYKRNF → AAAKRNA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 189-A--A-195 and 306-A--A-312. 7
Mutagenesisi306 – 312SEYRAKF → AAARAKA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 189-A--A-195 and 232-A--A-238. 7

Organism-specific databases

DisGeNET

More...
DisGeNETi
56890

Open Targets

More...
OpenTargetsi
ENSG00000111554

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134879752

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TC05 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MDM1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
156632525

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002990591 – 714Nuclear protein MDM1Add BLAST714

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei83PhosphoserineCombined sources1
Modified residuei123PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei242PhosphoserineCombined sources1
Modified residuei263PhosphoserineCombined sources1
Modified residuei314PhosphoserineBy similarity1
Modified residuei560PhosphoserineBy similarity1
Modified residuei584PhosphoserineCombined sources1
Modified residuei648PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TC05

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TC05

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TC05

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TC05

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TC05

PeptideAtlas

More...
PeptideAtlasi
Q8TC05

PRoteomics IDEntifications database

More...
PRIDEi
Q8TC05

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
17412
74064 [Q8TC05-1]
74065 [Q8TC05-2]
74066 [Q8TC05-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TC05

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TC05

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111554 Expressed in 207 organ(s), highest expression level in fundus of stomach

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TC05 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TC05 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA040411
HPA041594

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121220, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TC05, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302537

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TC05 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi9 – 15ST]-E-Y-X(3)-F motif 1; required for efficient microtubule binding and stabilization1 Publication7
Motifi189 – 195ST]-E-Y-X(3)-F motif 2; required for efficient microtubule binding and stabilization1 Publication7
Motifi232 – 238ST]-E-Y-X(3)-F motif 3; required for efficient microtubule binding and stabilization1 Publication7
Motifi306 – 312ST]-E-Y-X(3)-F motif 4; required for efficient microtubule binding and stabilization1 Publication7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MDM1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II1Y Eukaryota
ENOG410Y0E2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004106

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113507

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TC05

KEGG Orthology (KO)

More...
KOi
K17886

Identification of Orthologs from Complete Genome Data

More...
OMAi
MNTEYRS

Database of Orthologous Groups

More...
OrthoDBi
350018at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TC05

TreeFam database of animal gene trees

More...
TreeFami
TF331015

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029136 MDM1

The PANTHER Classification System

More...
PANTHERi
PTHR32078 PTHR32078, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15501 MDM1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TC05-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPVRFKGLSE YQRNFLWKKS YLSESCNSSV GRKYPWAGLR SDQLGITKEP
60 70 80 90 100
SFISKRRVPY HDPQISKSLE WNGAISESNV VASPEPEAPE TPKSQEAEQK
110 120 130 140 150
DVTQERVHSL EASRVPKRTR SHSADSRAEG ASDVENNEGV TNHTPVNENV
160 170 180 190 200
ELEHSTKVLS ENVDNGLDRL LRKKAGLTVV PSYNALRNSE YQRQFVWKTS
210 220 230 240 250
KETAPAFAAN QVFHNKSQFV PPFKGNSVIH ETEYKRNFKG LSPVKEPKLR
260 270 280 290 300
NDLRENRNLE TVSPERKSNK IDDRLKLEAE MELKDLHQPK RKLTPWKHQR
310 320 330 340 350
LGKVNSEYRA KFLSPAQYLY KAGAWTHVKG NMPNQVKELR EKAEFYRKRV
360 370 380 390 400
QGTHFSRDHL NQILSDSNCC WDVSSTTSSE GTVSSNIRAL DLAGDPTSHK
410 420 430 440 450
TLQKCPSTEP EEKGNIVEEQ PQKNTTEKLG VSAPTIPVRR RLAWDTENTS
460 470 480 490 500
EDVQKQPGEK EEEDDNEEEG DRKTGKQAFM GEQEKLDVRE KSKADKMKEG
510 520 530 540 550
SDSSVSSEKG GRLPTPKLRE LGGIQRTHHD LTTPAVGGAV LVSPSKMKPP
560 570 580 590 600
APEQRKRMTS QDCLETSKND FTKKESRAVS LLTSPAAGIK TVDPLPLRED
610 620 630 640 650
SEDNIHKFAE ATLPVSKIPK YPTNPPGQLP SPPHVPSYWH PSRRIQGSLR
660 670 680 690 700
DPEFQHNVGK ARMNNLQLPQ HEAFNDEDED RLSEISARSA ASSLRAFQTL
710
ARAKKRKENF WGKT
Length:714
Mass (Da):80,735
Last modified:August 21, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i301E3A89A5BFF13B
GO
Isoform 2 (identifier: Q8TC05-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-222: LDRLLRKKAG...FHNKSQFVPP → VGIFTAFLFK...NRLLTLVIVN
     223-714: Missing.

Show »
Length:222
Mass (Da):25,069
Checksum:i0CC6F35EADC1F98D
GO
Isoform 3 (identifier: Q8TC05-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-69: ITKEPSFISKRRVPYHDPQISKSL → NQGRCRTKIQHSDISSLLILVCST
     70-714: Missing.

Show »
Length:69
Mass (Da):7,926
Checksum:i51190BA06D5CD344
GO
Isoform 4 (identifier: Q8TC05-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     167-211: Missing.
     335-335: Q → QGSLNAMWYAE

Show »
Length:679
Mass (Da):76,709
Checksum:i0C31971CCCC30AFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H529F5H529_HUMAN
Nuclear protein MDM1
MDM1
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGX6H0YGX6_HUMAN
Nuclear protein MDM1
MDM1
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H804F5H804_HUMAN
Nuclear protein MDM1
MDM1
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y301H0Y301_HUMAN
Nuclear protein MDM1
MDM1
30Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti42D → Y in BAG59777 (PubMed:14702039).Curated1
Sequence conflicti458G → E in BAG59777 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034782103T → I1 PublicationCorresponds to variant dbSNP:rs962976Ensembl.1
Natural variantiVAR_034783383V → I. Corresponds to variant dbSNP:rs17224810Ensembl.1
Natural variantiVAR_034784489R → H2 PublicationsCorresponds to variant dbSNP:rs2306393Ensembl.1
Natural variantiVAR_034785552P → L1 PublicationCorresponds to variant dbSNP:rs2306392Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02754446 – 69ITKEP…ISKSL → NQGRCRTKIQHSDISSLLIL VCST in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_02754570 – 714Missing in isoform 3. 1 PublicationAdd BLAST645
Alternative sequenceiVSP_027546167 – 222LDRLL…QFVPP → VGIFTAFLFKSIEFFIGFIV ISVILHFVFQNFPLLFSCLM SIRIVDNRLLTLVIVN in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_046400167 – 211Missing in isoform 4. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_027547223 – 714Missing in isoform 2. 1 PublicationAdd BLAST492
Alternative sequenceiVSP_046401335Q → QGSLNAMWYAE in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF267851 mRNA Translation: AAF78952.1
AK297311 mRNA Translation: BAG59777.1
AC022511 Genomic DNA No translation available.
BC022042 mRNA Translation: AAH22042.1
BC028355 mRNA Translation: AAH28355.1
AF007130 mRNA Translation: AAC19149.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44938.1 [Q8TC05-2]
CCDS55841.1 [Q8TC05-4]
CCDS55842.1 [Q8TC05-3]
CCDS8983.1 [Q8TC05-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001191957.1, NM_001205028.1 [Q8TC05-4]
NP_001191958.1, NM_001205029.1 [Q8TC05-3]
NP_059136.2, NM_017440.4 [Q8TC05-1]
NP_064513.1, NM_020128.2 [Q8TC05-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000303145; ENSP00000302537; ENSG00000111554 [Q8TC05-1]
ENST00000393543; ENSP00000377175; ENSG00000111554 [Q8TC05-3]
ENST00000411698; ENSP00000391006; ENSG00000111554 [Q8TC05-4]
ENST00000430606; ENSP00000408694; ENSG00000111554 [Q8TC05-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56890

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56890

UCSC genome browser

More...
UCSCi
uc001stz.3 human [Q8TC05-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267851 mRNA Translation: AAF78952.1
AK297311 mRNA Translation: BAG59777.1
AC022511 Genomic DNA No translation available.
BC022042 mRNA Translation: AAH22042.1
BC028355 mRNA Translation: AAH28355.1
AF007130 mRNA Translation: AAC19149.1
CCDSiCCDS44938.1 [Q8TC05-2]
CCDS55841.1 [Q8TC05-4]
CCDS55842.1 [Q8TC05-3]
CCDS8983.1 [Q8TC05-1]
RefSeqiNP_001191957.1, NM_001205028.1 [Q8TC05-4]
NP_001191958.1, NM_001205029.1 [Q8TC05-3]
NP_059136.2, NM_017440.4 [Q8TC05-1]
NP_064513.1, NM_020128.2 [Q8TC05-2]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121220, 5 interactors
IntActiQ8TC05, 8 interactors
STRINGi9606.ENSP00000302537

PTM databases

iPTMnetiQ8TC05
PhosphoSitePlusiQ8TC05

Polymorphism and mutation databases

BioMutaiMDM1
DMDMi156632525

Proteomic databases

EPDiQ8TC05
jPOSTiQ8TC05
MassIVEiQ8TC05
MaxQBiQ8TC05
PaxDbiQ8TC05
PeptideAtlasiQ8TC05
PRIDEiQ8TC05
ProteomicsDBi17412
74064 [Q8TC05-1]
74065 [Q8TC05-2]
74066 [Q8TC05-3]

Genome annotation databases

EnsembliENST00000303145; ENSP00000302537; ENSG00000111554 [Q8TC05-1]
ENST00000393543; ENSP00000377175; ENSG00000111554 [Q8TC05-3]
ENST00000411698; ENSP00000391006; ENSG00000111554 [Q8TC05-4]
ENST00000430606; ENSP00000408694; ENSG00000111554 [Q8TC05-2]
GeneIDi56890
KEGGihsa:56890
UCSCiuc001stz.3 human [Q8TC05-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56890
DisGeNETi56890
EuPathDBiHostDB:ENSG00000111554.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MDM1
HGNCiHGNC:29917 MDM1
HPAiHPA040411
HPA041594
MIMi613813 gene
neXtProtiNX_Q8TC05
OpenTargetsiENSG00000111554
PharmGKBiPA134879752

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II1Y Eukaryota
ENOG410Y0E2 LUCA
GeneTreeiENSGT00390000004106
HOGENOMiHOG000113507
InParanoidiQ8TC05
KOiK17886
OMAiMNTEYRS
OrthoDBi350018at2759
PhylomeDBiQ8TC05
TreeFamiTF331015

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MDM1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56890
PharosiQ8TC05 Tbio

Protein Ontology

More...
PROi
PR:Q8TC05
RNActiQ8TC05 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000111554 Expressed in 207 organ(s), highest expression level in fundus of stomach
ExpressionAtlasiQ8TC05 baseline and differential
GenevisibleiQ8TC05 HS

Family and domain databases

InterProiView protein in InterPro
IPR029136 MDM1
PANTHERiPTHR32078 PTHR32078, 1 hit
PfamiView protein in Pfam
PF15501 MDM1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDM1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TC05
Secondary accession number(s): B4DM65
, E7EPQ3, O43406, Q8WTV9, Q9NR04
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: December 11, 2019
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again