UniProtKB - Q8TBZ8 (ZN564_HUMAN)
Protein
Zinc finger protein 564
Gene
ZNF564
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 103 – 125 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 141 – 163 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 169 – 191 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 421 – 443 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 471 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 477 – 499 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 505 – 527 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TBZ8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 564 |
Gene namesi | Name:ZNF564 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31106, ZNF564 |
neXtProti | NX_Q8TBZ8 |
VEuPathDBi | HostDB:ENSG00000249709.7 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nuclear chromatin Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
PharmGKBi | PA134876070 |
Miscellaneous databases
Pharosi | Q8TBZ8, Tdark |
Genetic variation databases
BioMutai | ZNF564 |
DMDMi | 55976746 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047654 | 1 – 553 | Zinc finger protein 564Add BLAST | 553 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 438 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q8TBZ8 |
jPOSTi | Q8TBZ8 |
MassIVEi | Q8TBZ8 |
MaxQBi | Q8TBZ8 |
PaxDbi | Q8TBZ8 |
PeptideAtlasi | Q8TBZ8 |
PRIDEi | Q8TBZ8 |
ProteomicsDBi | 74062 |
PTM databases
iPTMneti | Q8TBZ8 |
PhosphoSitePlusi | Q8TBZ8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000249709, Expressed in calcaneal tendon and 116 other tissues |
ExpressionAtlasi | Q8TBZ8, baseline and differential |
Genevisiblei | Q8TBZ8, HS |
Organism-specific databases
HPAi | ENSG00000249709, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8TBZ8
Protein-protein interaction databases
BioGRIDi | 127844, 38 interactors |
IntActi | Q8TBZ8, 37 interactors |
Miscellaneous databases
RNActi | Q8TBZ8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 83 | KRABPROSITE-ProRule annotationAdd BLAST | 80 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 103 – 125 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 141 – 163 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 169 – 191 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 197 – 219 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 225 – 247 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 253 – 275 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 281 – 303 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 309 – 331 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 415 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 421 – 443 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 449 – 471 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 477 – 499 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 505 – 527 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164420 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8TBZ8 |
OMAi | PEGHQCG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TBZ8 |
TreeFami | TF338854 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q8TBZ8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ
60 70 80 90 100
SIEDWYKNQG RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV
110 120 130 140 150
RPCECSLCGK VFMHHSSLSR HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF
160 170 180 190 200
SSCQSFRRHE RTHTGEKPYA CPECGKAFIS LPSVRRHMIK HTGDGPYKCQ
210 220 230 240 250
ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF QRHMIRHTGD
260 270 280 290 300
GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
310 320 330 340 350
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS
360 370 380 390 400
NVRTHERTHT GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR
410 420 430 440 450
AFDCPSSFQI HERTHTGEKP YECQVCGKAF ISLKRIRKHM ILHTGDGPYK
460 470 480 490 500
CQVCGKAFDC PSSVRTHERT HTGEKPYECK ECGKAFNYAS SIRIHERTHT
510 520 530 540 550
GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL SFITQPSNTC
ENE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZN8 | M0QZN8_HUMAN | Zinc finger protein 564 | ZNF564 | 35 | Annotation score: | ||
C9JLM4 | C9JLM4_HUMAN | Zinc finger protein 564 | ZNF564 | 21 | Annotation score: | ||
F8WD42 | F8WD42_HUMAN | Zinc finger protein 564 | ZNF564 | 69 | Annotation score: |
Sequence cautioni
The sequence AAH28367 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092760 mRNA Translation: BAC03967.1 BC028367 mRNA Translation: AAH28367.2 Different initiation. BC065023 mRNA Translation: AAH65023.2 BC136728 mRNA Translation: AAI36729.1 BC136729 mRNA Translation: AAI36730.1 |
CCDSi | CCDS42505.1 |
RefSeqi | NP_659413.1, NM_144976.3 |
Genome annotation databases
Ensembli | ENST00000339282; ENSP00000340004; ENSG00000249709 |
GeneIDi | 163050 |
KEGGi | hsa:163050 |
UCSCi | uc002mty.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK092760 mRNA Translation: BAC03967.1 BC028367 mRNA Translation: AAH28367.2 Different initiation. BC065023 mRNA Translation: AAH65023.2 BC136728 mRNA Translation: AAI36729.1 BC136729 mRNA Translation: AAI36730.1 |
CCDSi | CCDS42505.1 |
RefSeqi | NP_659413.1, NM_144976.3 |
3D structure databases
SMRi | Q8TBZ8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127844, 38 interactors |
IntActi | Q8TBZ8, 37 interactors |
PTM databases
iPTMneti | Q8TBZ8 |
PhosphoSitePlusi | Q8TBZ8 |
Genetic variation databases
BioMutai | ZNF564 |
DMDMi | 55976746 |
Proteomic databases
EPDi | Q8TBZ8 |
jPOSTi | Q8TBZ8 |
MassIVEi | Q8TBZ8 |
MaxQBi | Q8TBZ8 |
PaxDbi | Q8TBZ8 |
PeptideAtlasi | Q8TBZ8 |
PRIDEi | Q8TBZ8 |
ProteomicsDBi | 74062 |
Protocols and materials databases
Antibodypediai | 49445, 78 antibodies |
Genome annotation databases
Ensembli | ENST00000339282; ENSP00000340004; ENSG00000249709 |
GeneIDi | 163050 |
KEGGi | hsa:163050 |
UCSCi | uc002mty.4, human |
Organism-specific databases
CTDi | 163050 |
GeneCardsi | ZNF564 |
HGNCi | HGNC:31106, ZNF564 |
HPAi | ENSG00000249709, Low tissue specificity |
neXtProti | NX_Q8TBZ8 |
PharmGKBi | PA134876070 |
VEuPathDBi | HostDB:ENSG00000249709.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164420 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q8TBZ8 |
OMAi | PEGHQCG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TBZ8 |
TreeFami | TF338854 |
Enzyme and pathway databases
PathwayCommonsi | Q8TBZ8 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 163050, 5 hits in 876 CRISPR screens |
ChiTaRSi | ZNF564, human |
GenomeRNAii | 163050 |
Pharosi | Q8TBZ8, Tdark |
PROi | PR:Q8TBZ8 |
RNActi | Q8TBZ8, protein |
Gene expression databases
Bgeei | ENSG00000249709, Expressed in calcaneal tendon and 116 other tissues |
ExpressionAtlasi | Q8TBZ8, baseline and differential |
Genevisiblei | Q8TBZ8, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN564_HUMAN | |
Accessioni | Q8TBZ8Primary (citable) accession number: Q8TBZ8 Secondary accession number(s): B9EGT4, Q6P1K6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM