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UniProtKB - Q8TBZ8 (ZN564_HUMAN)

Entry version 159 (10 Feb 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Zinc finger protein 564

Gene

ZNF564

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TBZ8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 564
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF564
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:31106, ZNF564

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TBZ8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000249709.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134876070

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TBZ8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF564

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976746

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476541 – 553Zinc finger protein 564Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TBZ8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TBZ8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TBZ8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TBZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TBZ8

PeptideAtlas

More...PeptideAtlasi		Q8TBZ8

PRoteomics IDEntifications database

More...PRIDEi		Q8TBZ8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74062

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TBZ8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TBZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000249709, Expressed in calcaneal tendon and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TBZ8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TBZ8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000249709, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q8TBZ8
With#Exp.IntAct
ALAS1 [P13196]6EBI-10273713,EBI-3905054
CALCOCO2 [Q13137]3EBI-10273713,EBI-739580
CARD10 [Q9BWT7]3EBI-10273713,EBI-3866279
CBY2 [Q8NA61]3EBI-10273713,EBI-741724
CBY2 - isoform 2 [Q8NA61-2]3EBI-10273713,EBI-11524851
CCDC125 [Q86Z20]3EBI-10273713,EBI-11977221
CCDC136 - isoform 2 [Q96JN2-2]3EBI-10273713,EBI-10171416
CCDC85B [Q15834]3EBI-10273713,EBI-739674
CCNDBP1 [O95273]3EBI-10273713,EBI-748961
FHL5 [Q5TD97]3EBI-10273713,EBI-750641
GOLGA7B [Q2TAP0]3EBI-10273713,EBI-13310443
GOPC [Q9HD26]3EBI-10273713,EBI-349832
HSF2BP [O75031]3EBI-10273713,EBI-7116203
KRT31 [Q15323]3EBI-10273713,EBI-948001
KRT40 [Q6A162]3EBI-10273713,EBI-10171697
KRTAP10-7 [P60409]6EBI-10273713,EBI-10172290
KRTAP10-9 [P60411]3EBI-10273713,EBI-10172052
KRTAP2-4 [Q9BYR9]3EBI-10273713,EBI-14065470
LDOC1 [O95751]3EBI-10273713,EBI-740738
LIMS1 - isoform 3 [P48059-3]3EBI-10273713,EBI-12864460
LMNA [P02545]3EBI-10273713,EBI-351935
MAGEA1 [P43355]4EBI-10273713,EBI-740978
MDFI [Q99750]6EBI-10273713,EBI-724076
MEOX2 [P50222]3EBI-10273713,EBI-748397
MID2 - isoform 2 [Q9UJV3-2]6EBI-10273713,EBI-10172526
MTUS2 - isoform 2 [Q5JR59-3]4EBI-10273713,EBI-11522433
NDUFB7 [P17568]3EBI-10273713,EBI-1246238
PLAGL2 [Q9UPG8]3EBI-10273713,EBI-2876622
PNMA1 [Q8ND90]3EBI-10273713,EBI-302345
PPP1R16B [Q96T49]4EBI-10273713,EBI-10293968
REL [Q04864]3EBI-10273713,EBI-307352
RPGRIP1 [Q96KN7]3EBI-10273713,EBI-1050213
TADA2A [O75478]3EBI-10273713,EBI-742268
TRAF1 [Q13077]6EBI-10273713,EBI-359224
TRIM23 [P36406]6EBI-10273713,EBI-740098
TRIM41 [Q8WV44]3EBI-10273713,EBI-725997

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127844, 38 interactors

Protein interaction database and analysis system

More...IntActi		Q8TBZ8, 37 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TBZ8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TBZ8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 83KRABPROSITE-ProRule annotationAdd BLAST80

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri103 – 125C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri141 – 163C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri169 – 191C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri505 – 527C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164420

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_44_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TBZ8

Identification of Orthologs from Complete Genome Data

More...OMAi		PEGHQCG

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TBZ8

TreeFam database of animal gene trees

More...TreeFami		TF338854

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q8TBZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ 
        60         70         80         90        100
SIEDWYKNQG RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV 
       110        120        130        140        150
RPCECSLCGK VFMHHSSLSR HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF 
       160        170        180        190        200
SSCQSFRRHE RTHTGEKPYA CPECGKAFIS LPSVRRHMIK HTGDGPYKCQ 
       210        220        230        240        250
ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF QRHMIRHTGD 
       260        270        280        290        300
GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM 
       310        320        330        340        350
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS 
       360        370        380        390        400
NVRTHERTHT GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR 
       410        420        430        440        450
AFDCPSSFQI HERTHTGEKP YECQVCGKAF ISLKRIRKHM ILHTGDGPYK 
       460        470        480        490        500
CQVCGKAFDC PSSVRTHERT HTGEKPYECK ECGKAFNYAS SIRIHERTHT 
       510        520        530        540        550
GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL SFITQPSNTC 

ENE
Length:553
Mass (Da):63,735
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE5DB6E5D47EE019
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZN8M0QZN8_HUMAN
Zinc finger protein 564
ZNF564
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JLM4C9JLM4_HUMAN
Zinc finger protein 564
ZNF564
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WD42F8WD42_HUMAN
Zinc finger protein 564
ZNF564
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH28367 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK092760 mRNA Translation: BAC03967.1
BC028367 mRNA Translation: AAH28367.2 Different initiation.
BC065023 mRNA Translation: AAH65023.2
BC136728 mRNA Translation: AAI36729.1
BC136729 mRNA Translation: AAI36730.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42505.1

NCBI Reference Sequences

More...RefSeqi		NP_659413.1, NM_144976.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339282; ENSP00000340004; ENSG00000249709

Database of genes from NCBI RefSeq genomes

More...GeneIDi		163050

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:163050

UCSC genome browser

More...UCSCi		uc002mty.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092760 mRNA Translation: BAC03967.1
BC028367 mRNA Translation: AAH28367.2 Different initiation.
BC065023 mRNA Translation: AAH65023.2
BC136728 mRNA Translation: AAI36729.1
BC136729 mRNA Translation: AAI36730.1
CCDSiCCDS42505.1
RefSeqiNP_659413.1, NM_144976.3

3D structure databases

SMRiQ8TBZ8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127844, 38 interactors
IntActiQ8TBZ8, 37 interactors

PTM databases

iPTMnetiQ8TBZ8
PhosphoSitePlusiQ8TBZ8

Genetic variation databases

BioMutaiZNF564
DMDMi55976746

Proteomic databases

EPDiQ8TBZ8
jPOSTiQ8TBZ8
MassIVEiQ8TBZ8
MaxQBiQ8TBZ8
PaxDbiQ8TBZ8
PeptideAtlasiQ8TBZ8
PRIDEiQ8TBZ8
ProteomicsDBi74062

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49445, 78 antibodies

Genome annotation databases

EnsembliENST00000339282; ENSP00000340004; ENSG00000249709
GeneIDi163050
KEGGihsa:163050
UCSCiuc002mty.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		163050

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF564
HGNCiHGNC:31106, ZNF564
HPAiENSG00000249709, Low tissue specificity
neXtProtiNX_Q8TBZ8
PharmGKBiPA134876070
VEuPathDBiHostDB:ENSG00000249709.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164420
HOGENOMiCLU_002678_44_5_1
InParanoidiQ8TBZ8
OMAiPEGHQCG
OrthoDBi1318335at2759
PhylomeDBiQ8TBZ8
TreeFamiTF338854

Enzyme and pathway databases

PathwayCommonsiQ8TBZ8
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		163050, 5 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF564, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		163050
PharosiQ8TBZ8, Tdark

Protein Ontology

More...PROi		PR:Q8TBZ8
RNActiQ8TBZ8, protein

Gene expression databases

BgeeiENSG00000249709, Expressed in calcaneal tendon and 116 other tissues
ExpressionAtlasiQ8TBZ8, baseline and differential
GenevisibleiQ8TBZ8, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 15 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 15 hits
PS50157, ZINC_FINGER_C2H2_2, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN564_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBZ8
Secondary accession number(s): B9EGT4, Q6P1K6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: June 1, 2002
Last modified: February 10, 2021
This is version 159 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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