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Entry version 141 (02 Jun 2021)
Sequence version 1 (01 Jun 2002)
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Protein

tRNA methyltransferase 10 homolog A

Gene

TRMT10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

S-adenosyl-L-methionine-dependent guanine N1-methyltransferase that catalyzes the formation of N1-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678, PubMed:25053765).

Probably not able to catalyze formation of N1-methyladenine at position 9 (m1A9) in tRNAs (PubMed:23042678).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.221, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TBZ6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6782315, tRNA modification in the nucleus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA methyltransferase 10 homolog A (EC:2.1.1.2212 Publications)
Alternative name(s):
RNA (guanine-9-)-methyltransferase domain-containing protein 2
tRNA (guanine(9)-N(1))-methyltransferase TRMT10A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT10A
Synonyms:RG9MTD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28403, TRMT10A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616013, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TBZ6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145331.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Microcephaly, short stature, and impaired glucose metabolism 1 (MSSGM1)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by microcephaly, mental retardation, short stature, and disturbed glucose metabolism. Additional clinical features include delayed puberty, hypoglycemia-related seizures, hyperinsulinemic hypoglycemia, and early-onset diabetes.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08004627 – 339Missing in MSSGM1. 1 PublicationAdd BLAST313
Natural variantiVAR_08004793 – 339Missing in MSSGM1. 1 PublicationAdd BLAST247
Natural variantiVAR_080048133 – 339Missing in MSSGM1. 1 PublicationAdd BLAST207
Natural variantiVAR_072420206G → R in MSSGM1; results in loss of activity; does not affect affinity for Gly-tRNA. 1 PublicationCorresponds to variant dbSNP:rs587777744EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease variant, Dwarfism, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
93587

MalaCards human disease database

More...
MalaCardsi
TRMT10A
MIMi616033, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000145331

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391408, Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134979919

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TBZ6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRMT10A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74730533

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003113151 – 339tRNA methyltransferase 10 homolog AAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei336PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TBZ6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TBZ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TBZ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TBZ6

PeptideAtlas

More...
PeptideAtlasi
Q8TBZ6

PRoteomics IDEntifications database

More...
PRIDEi
Q8TBZ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
74061

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TBZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TBZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in embryonic and fetal brain. It is expressed throughout the dorsal telencephalon at 8 and 11 weeks of gestation, with highest expression in ventricular zone and marginal zone. Detected in cerebellar cortex and nuclei, but not in dorsal telencephalon, at later stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145331, Expressed in muscle tissue and 171 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TBZ6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TBZ6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145331, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with tRNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
125035, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TBZ6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273962

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TBZ6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1339
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TBZ6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini89 – 279SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd BLAST191

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 90DisorderedSequence analysisAdd BLAST90
Regioni282 – 339DisorderedSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili52 – 81Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 62Basic and acidic residuesSequence analysisAdd BLAST46
Compositional biasi74 – 90Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi292 – 332Basic and acidic residuesSequence analysisAdd BLAST41

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2967, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034384_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TBZ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
QGIGHAQ

Database of Orthologous Groups

More...
OrthoDBi
1396299at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TBZ6

TreeFam database of animal gene trees

More...
TreeFami
TF330972

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1280.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028564, MT_TRM10-typ
IPR038459, MT_TRM10-typ_sf
IPR016653, TRM10/TRM10A
IPR007356, tRNA_m1G_MeTrfase_euk
IPR016009, tRNA_MeTrfase_TRMD/TRM10

The PANTHER Classification System

More...
PANTHERi
PTHR13563, PTHR13563, 1 hit
PTHR13563:SF13, PTHR13563:SF13, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01746, tRNA_m1G_MT, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016323, tRNA_m1G_mtfrase_met, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51675, SAM_MT_TRM10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TBZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSEMLPAFI ETSNVDKKQG INEDQEESQK PRLGEGCEPI SKRQMKKLIK
60 70 80 90 100
QKQWEEQREL RKQKRKEKRK RKKLERQCQM EPNSDGHDRK RVRRDVVHST
110 120 130 140 150
LRLIIDCSFD HLMVLKDIKK LHKQIQRCYA ENRRALHPVQ FYLTSHGGQL
160 170 180 190 200
KKNMDENDKG WVNWKDIHIK PEHYSELIKK EDLIYLTSDS PNILKELDES
210 220 230 240 250
KAYVIGGLVD HNHHKGLTYK QASDYGINHA QLPLGNFVKM NSRKVLAVNH
260 270 280 290 300
VFEIILEYLE TRDWQEAFFT ILPQRKGAVP TDKACESASH DNQSVRMEEG
310 320 330
GSDSDSSEEE YSRNELDSPH EEKQDKENHT ESTVNSLPH
Length:339
Mass (Da):39,719
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1FCDA258DD7CA04D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R954D6R954_HUMAN
RNA (guanine-9-)-methyltransferase ...
TRMT10A
199Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6REK4X6REK4_HUMAN
RNA (guanine-9-)-methyltransferase ...
TRMT10A
205Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292N → F in AAD21019 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08004627 – 339Missing in MSSGM1. 1 PublicationAdd BLAST313
Natural variantiVAR_03722282P → Q in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_08004793 – 339Missing in MSSGM1. 1 PublicationAdd BLAST247
Natural variantiVAR_080048133 – 339Missing in MSSGM1. 1 PublicationAdd BLAST207
Natural variantiVAR_037223133R → Q. Corresponds to variant dbSNP:rs10007569EnsemblClinVar.1
Natural variantiVAR_072420206G → R in MSSGM1; results in loss of activity; does not affect affinity for Gly-tRNA. 1 PublicationCorresponds to variant dbSNP:rs587777744EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK313548 mRNA Translation: BAG36324.1
CH471057 Genomic DNA Translation: EAX06104.1
BC028373 mRNA Translation: AAH28373.1
AF106046 mRNA Translation: AAD21019.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3650.1

NCBI Reference Sequences

More...
RefSeqi
NP_001128137.1, NM_001134665.2
NP_001128138.1, NM_001134666.2
NP_689505.1, NM_152292.4
XP_005263409.1, XM_005263352.3
XP_006714480.1, XM_006714417.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273962; ENSP00000273962; ENSG00000145331
ENST00000394876; ENSP00000378342; ENSG00000145331
ENST00000394877; ENSP00000378343; ENSG00000145331

Database of genes from NCBI RefSeq genomes

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GeneIDi
93587

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:93587

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK313548 mRNA Translation: BAG36324.1
CH471057 Genomic DNA Translation: EAX06104.1
BC028373 mRNA Translation: AAH28373.1
AF106046 mRNA Translation: AAD21019.1
CCDSiCCDS3650.1
RefSeqiNP_001128137.1, NM_001134665.2
NP_001128138.1, NM_001134666.2
NP_689505.1, NM_152292.4
XP_005263409.1, XM_005263352.3
XP_006714480.1, XM_006714417.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FMWX-ray2.00A/B82-277[»]
SMRiQ8TBZ6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125035, 15 interactors
IntActiQ8TBZ6, 5 interactors
STRINGi9606.ENSP00000273962

PTM databases

iPTMnetiQ8TBZ6
PhosphoSitePlusiQ8TBZ6

Genetic variation databases

BioMutaiTRMT10A
DMDMi74730533

Proteomic databases

EPDiQ8TBZ6
jPOSTiQ8TBZ6
MassIVEiQ8TBZ6
PaxDbiQ8TBZ6
PeptideAtlasiQ8TBZ6
PRIDEiQ8TBZ6
ProteomicsDBi74061

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14880, 88 antibodies

The DNASU plasmid repository

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DNASUi
93587

Genome annotation databases

EnsembliENST00000273962; ENSP00000273962; ENSG00000145331
ENST00000394876; ENSP00000378342; ENSG00000145331
ENST00000394877; ENSP00000378343; ENSG00000145331
GeneIDi93587
KEGGihsa:93587

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
93587
DisGeNETi93587

GeneCards: human genes, protein and diseases

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GeneCardsi
TRMT10A
HGNCiHGNC:28403, TRMT10A
HPAiENSG00000145331, Low tissue specificity
MalaCardsiTRMT10A
MIMi616013, gene
616033, phenotype
neXtProtiNX_Q8TBZ6
OpenTargetsiENSG00000145331
Orphaneti391408, Primary microcephaly-mild intellectual disability-young-onset diabetes syndrome
PharmGKBiPA134979919
VEuPathDBiHostDB:ENSG00000145331.13

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2967, Eukaryota
GeneTreeiENSGT00530000063169
HOGENOMiCLU_034384_7_0_1
InParanoidiQ8TBZ6
OMAiQGIGHAQ
OrthoDBi1396299at2759
PhylomeDBiQ8TBZ6
TreeFamiTF330972

Enzyme and pathway databases

BRENDAi2.1.1.221, 2681
PathwayCommonsiQ8TBZ6
ReactomeiR-HSA-6782315, tRNA modification in the nucleus and cytosol

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
93587, 25 hits in 992 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
93587
PharosiQ8TBZ6, Tbio

Protein Ontology

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PROi
PR:Q8TBZ6
RNActiQ8TBZ6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000145331, Expressed in muscle tissue and 171 other tissues
ExpressionAtlasiQ8TBZ6, baseline and differential
GenevisibleiQ8TBZ6, HS

Family and domain databases

Gene3Di3.40.1280.30, 1 hit
InterProiView protein in InterPro
IPR028564, MT_TRM10-typ
IPR038459, MT_TRM10-typ_sf
IPR016653, TRM10/TRM10A
IPR007356, tRNA_m1G_MeTrfase_euk
IPR016009, tRNA_MeTrfase_TRMD/TRM10
PANTHERiPTHR13563, PTHR13563, 1 hit
PTHR13563:SF13, PTHR13563:SF13, 1 hit
PfamiView protein in Pfam
PF01746, tRNA_m1G_MT, 1 hit
PIRSFiPIRSF016323, tRNA_m1G_mtfrase_met, 1 hit
PROSITEiView protein in PROSITE
PS51675, SAM_MT_TRM10, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM10A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBZ6
Secondary accession number(s): B2R8X7, Q9Y2T9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2002
Last modified: June 2, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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