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UniProtKB - Q8TBZ5 (ZN502_HUMAN)
Protein
Zinc finger protein 502
Gene
ZNF502
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 177 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 183 – 205 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 211 – 233 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- positive regulation by host of viral process Source: AgBase
- regulation of transcription, DNA-templated Source: GO_Central
- viral release from host cell Source: AgBase
Keywordsi
Molecular function | DNA-binding |
Biological process | Host-virus interaction, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TBZ5 |
SignaLinki | Q8TBZ5 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 502 |
Gene namesi | Name:ZNF502 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23718, ZNF502 |
neXtProti | NX_Q8TBZ5 |
VEuPathDBi | HostDB:ENSG00000196653 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: AgBase
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 91392 |
OpenTargetsi | ENSG00000196653 |
PharmGKBi | PA134866656 |
Miscellaneous databases
Pharosi | Q8TBZ5, Tbio |
Genetic variation databases
BioMutai | ZNF502 |
DMDMi | 45477319 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047623 | 1 – 544 | Zinc finger protein 502Add BLAST | 544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 43 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q8TBZ5 |
jPOSTi | Q8TBZ5 |
MassIVEi | Q8TBZ5 |
MaxQBi | Q8TBZ5 |
PaxDbi | Q8TBZ5 |
PeptideAtlasi | Q8TBZ5 |
PRIDEi | Q8TBZ5 |
ProteomicsDBi | 74060 |
PTM databases
iPTMneti | Q8TBZ5 |
PhosphoSitePlusi | Q8TBZ5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196653, Expressed in secondary oocyte and 200 other tissues |
ExpressionAtlasi | Q8TBZ5, baseline and differential |
Genevisiblei | Q8TBZ5, HS |
Organism-specific databases
HPAi | ENSG00000196653, Low tissue specificity |
Interactioni
Subunit structurei
(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) matrix protein; this interaction probably facilitates viral release.
1 PublicationBinary interactionsi
Q8TBZ5
With | #Exp. | IntAct |
---|---|---|
TRAF1 [Q13077] | 7 | EBI-10273699,EBI-359224 |
M [P0DOE7] from Human respiratory syncytial virus A (strain A2). | 3 | EBI-10273699,EBI-10042882 |
Protein-protein interaction databases
BioGRIDi | 124825, 3 interactors |
IntActi | Q8TBZ5, 3 interactors |
STRINGi | 9606.ENSP00000296091 |
Miscellaneous databases
RNActi | Q8TBZ5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 155 – 177 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 183 – 205 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 211 – 233 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 239 – 261 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 267 – 289 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 295 – 317 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 323 – 345 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 351 – 373 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 379 – 401 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 407 – 429 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 435 – 457 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 463 – 485 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 491 – 513 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 519 – 541 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163095 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8TBZ5 |
OMAi | WETSNIH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TBZ5 |
TreeFami | TF341817 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q8TBZ5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLNMQGAEER DIRRETCPGW VNKNKPALEQ DVCKIDSSGI VVKRFQEDEY
60 70 80 90 100
QDSTFEEKYA CEGMKENSPR EIAESCLFQE GGFGRITFIH KEAPPEIISQ
110 120 130 140 150
GYNFEKSLLL TSSLVTRLRV STEESLHQWE TSNIQTNDIS DQSKCPTLCT
160 170 180 190 200
QKKSWKCNEC GKTFTQSSSL TQHQRTHTGE RPYTCEECGK AFSRSSFLVQ
210 220 230 240 250
HQRIHTGVKP YGCEQCGKTF RCRSFLTQHQ RIHTGEKPYK CNECGNSFRN
260 270 280 290 300
HSHLTEHQRI HTGEKPYKCN RCGKAFNQNT HLIHHQRIHT GEKPYICSEC
310 320 330 340 350
GSSFRKHSNL TQHQRIHTGE KPHKCDECGK TFQTKANLSQ HQRIHSGEKP
360 370 380 390 400
YKCKECGKAF CQSPSLIKHQ RIHTGEKPYK CKECGKAFTQ STPLTKHQRI
410 420 430 440 450
HTGERPYKCS ECGKAFIQSI CLIRHQRSHT GEKPYKCNEC GKGFNQNTCL
460 470 480 490 500
TQHMRIHTGE KPYKCKECGK AFAHSSSLTE HHRTHTGEKL YKCSECEKTF
510 520 530 540
RKYAHLSEHY RIHTGEKPYE CIECGKFFRH SSVLFRHQKL HSGD
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JLT3 | C9JLT3_HUMAN | Zinc finger protein 502 | ZNF502 | 155 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033574 | 28 | L → P. Corresponds to variant dbSNP:rs6798400Ensembl. | 1 | |
Natural variantiVAR_061953 | 174 | Q → R. Corresponds to variant dbSNP:rs56084453Ensembl. | 1 | |
Natural variantiVAR_024220 | 243 | E → A. Corresponds to variant dbSNP:rs7640654Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC028377 mRNA Translation: AAH28377.1 |
CCDSi | CCDS2719.1 |
RefSeqi | NP_001127912.1, NM_001134440.1 NP_001127913.1, NM_001134441.1 NP_001127914.1, NM_001134442.1 NP_001269809.1, NM_001282880.1 NP_149987.2, NM_033210.4 XP_016862929.1, XM_017007440.1 |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC028377 mRNA Translation: AAH28377.1 |
CCDSi | CCDS2719.1 |
RefSeqi | NP_001127912.1, NM_001134440.1 NP_001127913.1, NM_001134441.1 NP_001127914.1, NM_001134442.1 NP_001269809.1, NM_001282880.1 NP_149987.2, NM_033210.4 XP_016862929.1, XM_017007440.1 |
3D structure databases
AlphaFoldDBi | Q8TBZ5 |
SMRi | Q8TBZ5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124825, 3 interactors |
IntActi | Q8TBZ5, 3 interactors |
STRINGi | 9606.ENSP00000296091 |
PTM databases
iPTMneti | Q8TBZ5 |
PhosphoSitePlusi | Q8TBZ5 |
Genetic variation databases
BioMutai | ZNF502 |
DMDMi | 45477319 |
Proteomic databases
EPDi | Q8TBZ5 |
jPOSTi | Q8TBZ5 |
MassIVEi | Q8TBZ5 |
MaxQBi | Q8TBZ5 |
PaxDbi | Q8TBZ5 |
PeptideAtlasi | Q8TBZ5 |
PRIDEi | Q8TBZ5 |
ProteomicsDBi | 74060 |
Protocols and materials databases
Antibodypediai | 29472, 117 antibodies from 17 providers |
DNASUi | 91392 |
Genome annotation databases
Organism-specific databases
CTDi | 91392 |
DisGeNETi | 91392 |
GeneCardsi | ZNF502 |
HGNCi | HGNC:23718, ZNF502 |
HPAi | ENSG00000196653, Low tissue specificity |
neXtProti | NX_Q8TBZ5 |
OpenTargetsi | ENSG00000196653 |
PharmGKBi | PA134866656 |
VEuPathDBi | HostDB:ENSG00000196653 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000163095 |
HOGENOMi | CLU_002678_44_0_1 |
InParanoidi | Q8TBZ5 |
OMAi | WETSNIH |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q8TBZ5 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q8TBZ5 |
SignaLinki | Q8TBZ5 |
Miscellaneous databases
BioGRID-ORCSi | 91392, 4 hits in 1090 CRISPR screens |
GenomeRNAii | 91392 |
Pharosi | Q8TBZ5, Tbio |
PROi | PR:Q8TBZ5 |
RNActi | Q8TBZ5, protein |
Gene expression databases
Bgeei | ENSG00000196653, Expressed in secondary oocyte and 200 other tissues |
ExpressionAtlasi | Q8TBZ5, baseline and differential |
Genevisiblei | Q8TBZ5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 12 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 14 hits |
SUPFAMi | SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 14 hits PS50157, ZINC_FINGER_C2H2_2, 14 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN502_HUMAN | |
Accessioni | Q8TBZ5Primary (citable) accession number: Q8TBZ5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2004 |
Last sequence update: | June 1, 2002 | |
Last modified: | May 25, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families