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Entry version 157 (26 Feb 2020)
Sequence version 2 (03 Apr 2007)
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Protein

WD repeat-containing protein 20

Gene

WDR20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12 (PubMed:20147737, PubMed:27373336). Anchors at the base of the ubiquitin-contacting loop of USP12 and remotely modulates the catalytic center of the enzyme (PubMed:27373336).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689880 Ub-specific processing proteases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q8TBZ3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 20
Alternative name(s):
Protein DMR
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19667 WDR20

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617741 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TBZ3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi262F → A: Impaired binding to USP12. 1 Publication1
Mutagenesisi306W → A: Impaired binding to USP12. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
91833

Open Targets

More...
OpenTargetsi
ENSG00000140153

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134936678

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TBZ3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
143811476

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000513662 – 569WD repeat-containing protein 20Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei434PhosphoserineCombined sources1
Modified residuei465PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TBZ3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TBZ3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TBZ3

PeptideAtlas

More...
PeptideAtlasi
Q8TBZ3

PRoteomics IDEntifications database

More...
PRIDEi
Q8TBZ3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
18529
30372
32621
39351
74057 [Q8TBZ3-1]
74058 [Q8TBZ3-2]
74059 [Q8TBZ3-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TBZ3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TBZ3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000140153 Expressed in secondary oocyte and 189 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8TBZ3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TBZ3 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with USP12 (PubMed:20147737, PubMed:27373336).

Component of the USP12/WDR20/WDR48 deubiquitinating complex (PubMed:20147737, PubMed:27373336).

Interacts with USP46 (PubMed:20147737).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124884, 49 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q8TBZ3

Protein interaction database and analysis system

More...
IntActi
Q8TBZ3, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000406084

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TBZ3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TBZ3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati94 – 138WD 1Add BLAST45
Repeati139 – 210WD 2Add BLAST72
Repeati211 – 252WD 3Add BLAST42
Repeati253 – 331WD 4Add BLAST79
Repeati332 – 426WD 5Add BLAST95
Repeati427 – 523WD 6Add BLAST97
Repeati524 – 559WD 7Add BLAST36

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007686

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_120535_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TBZ3

Database of Orthologous Groups

More...
OrthoDBi
907634at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TBZ3

TreeFam database of animal gene trees

More...
TreeFami
TF314961

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 8 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBZ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATEGGGKEM NEIKTQFTTR EGLYKLLPHS EYSRPNRVPF NSQGSNPVRV
60 70 80 90 100
SFVNLNDQSG NGDRLCFNVG RELYFYIYKG VRKAADLSKP IDKRIYKGTQ
110 120 130 140 150
PTCHDFNHLT ATAESVSLLV GFSAGQVQLI DPIKKETSKL FNEERLIDKS
160 170 180 190 200
RVTCVKWVPG SESLFLVAHS SGNMYLYNVE HTCGTTAPHY QLLKQGESFA
210 220 230 240 250
VHTCKSKSTR NPLLKWTVGE GALNEFAFSP DGKFLACVSQ DGFLRVFNFD
260 270 280 290 300
SVELHGTMKS YFGGLLCVCW SPDGKYIVTG GEDDLVTVWS FVDCRVIARG
310 320 330 340 350
HGHKSWVSVV AFDPYTTSVE EGDPMEFSGS DEDFQDLLHF GRDRANSTQS
360 370 380 390 400
RLSKRNSTDS RPVSVTYRFG SVGQDTQLCL WDLTEDILFP HQPLSRARTH
410 420 430 440 450
TNVMNATSPP AGSNGNSVTT PGNSVPPPLP RSNSLPHSAV SNAGSKSSVM
460 470 480 490 500
DGAIASGVSK FATLSLHDRK ERHHEKDHKR NHSMGHISSK SSDKLNLVTK
510 520 530 540 550
TKTDPAKTLG TPLCPRMEDV PLLEPLICKK IAHERLTVLI FLEDCIVTAC
560
QEGFICTWGR PGKVVSFNP
Length:569
Mass (Da):62,893
Last modified:April 3, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5779A68D94C34CAF
GO
Isoform 2 (identifier: Q8TBZ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Show »
Length:581
Mass (Da):63,848
Checksum:iBBCBE3C8CBEF8F75
GO
Isoform 3 (identifier: Q8TBZ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-195: RLIDKSRVTC...TAPHYQLLKQ → NSCQHLWKVD...RMQGVLQDQN
     196-569: Missing.

Show »
Length:195
Mass (Da):22,205
Checksum:iF21E71C2C629E6CB
GO
Isoform 4 (identifier: Q8TBZ3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.
     84-144: Missing.

Show »
Length:499
Mass (Da):55,348
Checksum:iA8E7A7927C37544A
GO
Isoform 5 (identifier: Q8TBZ3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.

Show »
Length:508
Mass (Da):56,208
Checksum:i88D69FEEBB379AE0
GO
Isoform 6 (identifier: Q8TBZ3-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-144: Missing.
     565-569: VSFNP → GSLSSPSQASSPGGTVV

Show »
Length:520
Mass (Da):57,163
Checksum:i3052279BDE983E1D
GO
Isoform 7 (identifier: Q8TBZ3-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-144: E → ENSCQHLWKVDWNEERQNEGSKTSEEALVTVQ

Show »
Length:600
Mass (Da):66,521
Checksum:iCD7F36221219CDEA
GO
Isoform 8 (identifier: Q8TBZ3-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     84-569: AADLSKPIDK...RPGKVVSFNP → TIP

Show »
Length:86
Mass (Da):9,820
Checksum:i9C7D52794DEBA5E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A088AWN2A0A088AWN2_HUMAN
WD repeat-containing protein 20
WDR20
612Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5V2G3V5V2_HUMAN
WD repeat-containing protein 20
WDR20
23Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNU0H0YNU0_HUMAN
WD repeat-containing protein 20
WDR20
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK31H0YK31_HUMAN
WD repeat-containing protein 20
WDR20
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKE8H0YKE8_HUMAN
WD repeat-containing protein 20
WDR20
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL56014 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195Q → H in AAL56014 (Ref. 5) Curated1
Sequence conflicti299R → K in AAL56014 (Ref. 5) Curated1
Sequence conflicti337L → P in BAG60080 (PubMed:14702039).Curated1
Sequence conflicti353S → P in BAG60080 (PubMed:14702039).Curated1
Sequence conflicti474H → L in CAB63713 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031580159P → H1 PublicationCorresponds to variant dbSNP:rs17852545Ensembl.1
Natural variantiVAR_053425444G → C. Corresponds to variant dbSNP:rs12888595Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0452251 – 9Missing in isoform 4. 1 Publication9
Alternative sequenceiVSP_04706484 – 569AADLS…VSFNP → TIP in isoform 8. CuratedAdd BLAST486
Alternative sequenceiVSP_04522684 – 144Missing in isoform 4, isoform 5 and isoform 6. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_047065144E → ENSCQHLWKVDWNEERQNEG SKTSEEALVTVQ in isoform 7. 1 Publication1
Alternative sequenceiVSP_043412145 – 195RLIDK…QLLKQ → NSCQHLWKVDWNEERQNEGS KTSEEALVTVQPAEHFCRQE DRMQGVLQDQN in isoform 3. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_043413196 – 569Missing in isoform 3. 1 PublicationAdd BLAST374
Alternative sequenceiVSP_024387565 – 569VSFNP → GSLSSPSQASSPGGTVV in isoform 2 and isoform 6. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX248274 mRNA Translation: CAD62602.1
AK297727 mRNA Translation: BAG60080.1
AL133223 Genomic DNA No translation available.
AL359402 Genomic DNA No translation available.
BC028387 mRNA Translation: AAH28387.1
BC030654 mRNA Translation: AAH30654.1
AF327354 mRNA Translation: AAL56014.1 Different initiation.
AL133558 mRNA Translation: CAB63713.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS55942.1 [Q8TBZ3-8]
CCDS55943.1 [Q8TBZ3-7]
CCDS55944.1 [Q8TBZ3-3]
CCDS55945.1 [Q8TBZ3-6]
CCDS9968.1 [Q8TBZ3-2]
CCDS9969.1 [Q8TBZ3-1]
CCDS9970.1 [Q8TBZ3-5]

Protein sequence database of the Protein Information Resource

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PIRi
T43440

NCBI Reference Sequences

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RefSeqi
NP_001229343.1, NM_001242414.1 [Q8TBZ3-8]
NP_001229344.1, NM_001242415.1 [Q8TBZ3-3]
NP_001229345.1, NM_001242416.1 [Q8TBZ3-6]
NP_001229346.1, NM_001242417.1 [Q8TBZ3-7]
NP_001229347.1, NM_001242418.1
NP_653175.2, NM_144574.3 [Q8TBZ3-1]
NP_851808.1, NM_181291.2 [Q8TBZ3-2]
NP_851825.1, NM_181308.2 [Q8TBZ3-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299135; ENSP00000299135; ENSG00000140153 [Q8TBZ3-8]
ENST00000322340; ENSP00000314209; ENSG00000140153 [Q8TBZ3-3]
ENST00000335263; ENSP00000335434; ENSG00000140153 [Q8TBZ3-2]
ENST00000342702; ENSP00000341037; ENSG00000140153 [Q8TBZ3-1]
ENST00000454394; ENSP00000406084; ENSG00000140153 [Q8TBZ3-7]
ENST00000555879; ENSP00000452470; ENSG00000140153 [Q8TBZ3-8]
ENST00000556511; ENSP00000451633; ENSG00000140153 [Q8TBZ3-5]
ENST00000556807; ENSP00000450636; ENSG00000140153 [Q8TBZ3-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91833

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91833

UCSC genome browser

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UCSCi
uc001ykz.4 human [Q8TBZ3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX248274 mRNA Translation: CAD62602.1
AK297727 mRNA Translation: BAG60080.1
AL133223 Genomic DNA No translation available.
AL359402 Genomic DNA No translation available.
BC028387 mRNA Translation: AAH28387.1
BC030654 mRNA Translation: AAH30654.1
AF327354 mRNA Translation: AAL56014.1 Different initiation.
AL133558 mRNA Translation: CAB63713.1
CCDSiCCDS55942.1 [Q8TBZ3-8]
CCDS55943.1 [Q8TBZ3-7]
CCDS55944.1 [Q8TBZ3-3]
CCDS55945.1 [Q8TBZ3-6]
CCDS9968.1 [Q8TBZ3-2]
CCDS9969.1 [Q8TBZ3-1]
CCDS9970.1 [Q8TBZ3-5]
PIRiT43440
RefSeqiNP_001229343.1, NM_001242414.1 [Q8TBZ3-8]
NP_001229344.1, NM_001242415.1 [Q8TBZ3-3]
NP_001229345.1, NM_001242416.1 [Q8TBZ3-6]
NP_001229346.1, NM_001242417.1 [Q8TBZ3-7]
NP_001229347.1, NM_001242418.1
NP_653175.2, NM_144574.3 [Q8TBZ3-1]
NP_851808.1, NM_181291.2 [Q8TBZ3-2]
NP_851825.1, NM_181308.2 [Q8TBZ3-5]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5K19X-ray2.60A/B/C1-569[»]
5K1CX-ray3.00C1-569[»]
6JLQX-ray3.10C279-318[»]
SMRiQ8TBZ3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124884, 49 interactors
CORUMiQ8TBZ3
IntActiQ8TBZ3, 38 interactors
STRINGi9606.ENSP00000406084

PTM databases

iPTMnetiQ8TBZ3
PhosphoSitePlusiQ8TBZ3

Polymorphism and mutation databases

BioMutaiWDR20
DMDMi143811476

Proteomic databases

jPOSTiQ8TBZ3
MassIVEiQ8TBZ3
MaxQBiQ8TBZ3
PeptideAtlasiQ8TBZ3
PRIDEiQ8TBZ3
ProteomicsDBi18529
30372
32621
39351
74057 [Q8TBZ3-1]
74058 [Q8TBZ3-2]
74059 [Q8TBZ3-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
91833

Genome annotation databases

EnsembliENST00000299135; ENSP00000299135; ENSG00000140153 [Q8TBZ3-8]
ENST00000322340; ENSP00000314209; ENSG00000140153 [Q8TBZ3-3]
ENST00000335263; ENSP00000335434; ENSG00000140153 [Q8TBZ3-2]
ENST00000342702; ENSP00000341037; ENSG00000140153 [Q8TBZ3-1]
ENST00000454394; ENSP00000406084; ENSG00000140153 [Q8TBZ3-7]
ENST00000555879; ENSP00000452470; ENSG00000140153 [Q8TBZ3-8]
ENST00000556511; ENSP00000451633; ENSG00000140153 [Q8TBZ3-5]
ENST00000556807; ENSP00000450636; ENSG00000140153 [Q8TBZ3-6]
GeneIDi91833
KEGGihsa:91833
UCSCiuc001ykz.4 human [Q8TBZ3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
91833
DisGeNETi91833

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR20
HGNCiHGNC:19667 WDR20
MIMi617741 gene
neXtProtiNX_Q8TBZ3
OpenTargetsiENSG00000140153
PharmGKBiPA134936678

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000007686
HOGENOMiCLU_120535_0_0_1
InParanoidiQ8TBZ3
OrthoDBi907634at2759
PhylomeDBiQ8TBZ3
TreeFamiTF314961

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases
SignaLinkiQ8TBZ3

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
WDR20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
91833
PharosiQ8TBZ3 Tbio

Protein Ontology

More...
PROi
PR:Q8TBZ3
RNActiQ8TBZ3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000140153 Expressed in secondary oocyte and 189 other tissues
ExpressionAtlasiQ8TBZ3 baseline and differential
GenevisibleiQ8TBZ3 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 4 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBZ3
Secondary accession number(s): B4DN18
, E7EUY8, F8W9S4, G3V2F8, G3V5R0, H0YJJ1, Q86TU2, Q8NCN7, Q8WXX2, Q9UF86
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: April 3, 2007
Last modified: February 26, 2020
This is version 157 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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