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Entry version 154 (07 Apr 2021)
Sequence version 3 (11 Jan 2011)
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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=31 µM for ATP1 Publication
  2. KM=389 µM for GTP1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.149, 2681

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q8TBX8

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1660499, Synthesis of PIPs at the plasma membrane
    R-HSA-6811555, PI5P Regulates TP53 Acetylation
    R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-8847453, Synthesis of PIPs in the nucleus

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaCurated (EC:2.7.1.1491 Publication)
    Alternative name(s):
    Phosphatidylinositol 5-phosphate 4-kinase type II gamma
    Short name:
    PI(5)P 4-kinase type II gamma
    Short name:
    PIP4KII-gamma
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PIP4K2CImported
    Synonyms:PIP5K2C
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:23786, PIP4K2C

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q8TBX8

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    HostDB:ENSG00000166908.17

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69 – 75VMLLPDD → EIFLPNN: Loss of interaction with PIP5K1A. Loss of inhibition of PIP5K1A activity. 1 Publication7

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    79837

    Open Targets

    More...
    OpenTargetsi
    ENSG00000166908

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA162399665

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q8TBX8, Tchem

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL1770034

    Drug and drug target database

    More...
    DrugBanki
    DB12010, Fostamatinib

    DrugCentral

    More...
    DrugCentrali
    Q8TBX8

    Genetic variation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    PIP4K2C

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    317373532

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002857502 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
    Modified residuei26PhosphoserineCombined sources1
    Modified residuei349PhosphoserineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylated, phosphorylation is induced by EGF.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q8TBX8

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q8TBX8

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q8TBX8

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q8TBX8

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q8TBX8

    PeptideAtlas

    More...
    PeptideAtlasi
    Q8TBX8

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q8TBX8

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    74044 [Q8TBX8-1]
    74045 [Q8TBX8-2]
    74046 [Q8TBX8-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q8TBX8

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q8TBX8

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000166908, Expressed in vagina and 241 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q8TBX8, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q8TBX8, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000166908, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with PIP5K1A; the interaction inhibits PIP5K1A kinase activity.

    1 Publication

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Q8TBX8
    With#Exp.IntAct
    itself2EBI-1383637,EBI-1383637

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    122928, 55 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q8TBX8, 25 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000347032

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q8TBX8

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q8TBX8, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1421
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q8TBX8

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q8TBX8

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni69 – 75Required for interaction with PIP5K1A1 Publication7

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0229, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000156890

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_004312_7_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q8TBX8

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    SEWDGDC

    Database of Orthologous Groups

    More...
    OrthoDBi
    1562683at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q8TBX8

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF354315

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.800.10, 1 hit
    3.30.810.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR23086, PTHR23086, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01504, PIP5K, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00330, PIPKc, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51455, PIPK, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
    60 70 80 90 100
    FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
    110 120 130 140 150
    KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV
    160 170 180 190 200
    IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM
    210 220 230 240 250
    LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
    260 270 280 290 300
    KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA
    310 320 330 340 350
    PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
    360 370 380 390 400
    IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI
    410 420
    STVHPEQYAK RFLDFITNIF A
    Length:421
    Mass (Da):47,300
    Last modified:January 11, 2011 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65D1CBCF0826D476
    GO
    Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         124-171: Missing.

    Show »
    Length:373
    Mass (Da):41,922
    Checksum:i45948B5F37090624
    GO
    Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-100: Missing.

    Show »
    Length:403
    Mass (Da):45,053
    Checksum:iA3980DE66031431E
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    H0YIJ6H0YIJ6_HUMAN
    Phosphatidylinositol 5-phosphate 4-...
    PIP4K2C
    134Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VNT5F8VNT5_HUMAN
    Phosphatidylinositol 5-phosphate 4-...
    PIP4K2C
    160Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VU68F8VU68_HUMAN
    Phosphatidylinositol 5-phosphate 4-...
    PIP4K2C
    171Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    F8VVB2F8VVB2_HUMAN
    Phosphatidylinositol 5-phosphate 4-...
    PIP4K2C
    50Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB15223 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03204984V → A. Corresponds to variant dbSNP:rs17550713Ensembl.1
    Natural variantiVAR_032050241K → R1 PublicationCorresponds to variant dbSNP:rs17852569Ensembl.1
    Natural variantiVAR_032051300A → G. Corresponds to variant dbSNP:rs2277319Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04336983 – 100Missing in isoform 3. 1 PublicationAdd BLAST18
    Alternative sequenceiVSP_042929124 – 171Missing in isoform 2. 1 PublicationAdd BLAST48

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AK025708 mRNA Translation: BAB15223.1 Different initiation.
    AK297243 mRNA Translation: BAG59723.1
    AK302254 mRNA Translation: BAG63606.1
    AK315588 mRNA Translation: BAG37960.1
    AC022506 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97031.1
    BC028596 mRNA Translation: AAH28596.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS53808.1 [Q8TBX8-2]
    CCDS55839.1 [Q8TBX8-3]
    CCDS8946.1 [Q8TBX8-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001139730.1, NM_001146258.1 [Q8TBX8-1]
    NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
    NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
    NP_079055.3, NM_024779.4 [Q8TBX8-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
    ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
    ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
    ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    79837

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:79837

    UCSC genome browser

    More...
    UCSCi
    uc001sot.4, human [Q8TBX8-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AK025708 mRNA Translation: BAB15223.1 Different initiation.
    AK297243 mRNA Translation: BAG59723.1
    AK302254 mRNA Translation: BAG63606.1
    AK315588 mRNA Translation: BAG37960.1
    AC022506 Genomic DNA No translation available.
    CH471054 Genomic DNA Translation: EAW97031.1
    BC028596 mRNA Translation: AAH28596.1
    CCDSiCCDS53808.1 [Q8TBX8-2]
    CCDS55839.1 [Q8TBX8-3]
    CCDS8946.1 [Q8TBX8-1]
    RefSeqiNP_001139730.1, NM_001146258.1 [Q8TBX8-1]
    NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
    NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
    NP_079055.3, NM_024779.4 [Q8TBX8-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2GK9X-ray2.80A/B/C/D32-421[»]
    SMRiQ8TBX8
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi122928, 55 interactors
    IntActiQ8TBX8, 25 interactors
    STRINGi9606.ENSP00000347032

    Chemistry databases

    BindingDBiQ8TBX8
    ChEMBLiCHEMBL1770034
    DrugBankiDB12010, Fostamatinib
    DrugCentraliQ8TBX8

    PTM databases

    iPTMnetiQ8TBX8
    PhosphoSitePlusiQ8TBX8

    Genetic variation databases

    BioMutaiPIP4K2C
    DMDMi317373532

    Proteomic databases

    EPDiQ8TBX8
    jPOSTiQ8TBX8
    MassIVEiQ8TBX8
    MaxQBiQ8TBX8
    PaxDbiQ8TBX8
    PeptideAtlasiQ8TBX8
    PRIDEiQ8TBX8
    ProteomicsDBi74044 [Q8TBX8-1]
    74045 [Q8TBX8-2]
    74046 [Q8TBX8-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    28802, 106 antibodies

    The DNASU plasmid repository

    More...
    DNASUi
    79837

    Genome annotation databases

    EnsembliENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
    ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
    ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
    ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]
    GeneIDi79837
    KEGGihsa:79837
    UCSCiuc001sot.4, human [Q8TBX8-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    79837
    DisGeNETi79837

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    PIP4K2C
    HGNCiHGNC:23786, PIP4K2C
    HPAiENSG00000166908, Low tissue specificity
    neXtProtiNX_Q8TBX8
    OpenTargetsiENSG00000166908
    PharmGKBiPA162399665
    VEuPathDBiHostDB:ENSG00000166908.17

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0229, Eukaryota
    GeneTreeiENSGT00940000156890
    HOGENOMiCLU_004312_7_0_1
    InParanoidiQ8TBX8
    OMAiSEWDGDC
    OrthoDBi1562683at2759
    PhylomeDBiQ8TBX8
    TreeFamiTF354315

    Enzyme and pathway databases

    BRENDAi2.7.1.149, 2681
    PathwayCommonsiQ8TBX8
    ReactomeiR-HSA-1660499, Synthesis of PIPs at the plasma membrane
    R-HSA-6811555, PI5P Regulates TP53 Acetylation
    R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
    R-HSA-8847453, Synthesis of PIPs in the nucleus

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    79837, 13 hits in 997 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    PIP4K2C, human
    EvolutionaryTraceiQ8TBX8

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    79837
    PharosiQ8TBX8, Tchem

    Protein Ontology

    More...
    PROi
    PR:Q8TBX8
    RNActiQ8TBX8, protein

    Gene expression databases

    BgeeiENSG00000166908, Expressed in vagina and 241 other tissues
    ExpressionAtlasiQ8TBX8, baseline and differential
    GenevisibleiQ8TBX8, HS

    Family and domain databases

    Gene3Di3.30.800.10, 1 hit
    3.30.810.10, 2 hits
    InterProiView protein in InterPro
    IPR023610, PInositol-4-P-5-kinase
    IPR027483, PInositol-4-P-5-kinase_C
    IPR002498, PInositol-4-P-5-kinase_core
    IPR027484, PInositol-4-P-5-kinase_N
    PANTHERiPTHR23086, PTHR23086, 1 hit
    PfamiView protein in Pfam
    PF01504, PIP5K, 1 hit
    SMARTiView protein in SMART
    SM00330, PIPKc, 1 hit
    PROSITEiView protein in PROSITE
    PS51455, PIPK, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI42C_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBX8
    Secondary accession number(s): B2RDL3
    , B4DM11, B4DY44, Q9H6N2
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: January 11, 2011
    Last modified: April 7, 2021
    This is version 154 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with genetic variants
      List of human entries with genetic variants
    3. Human variants curated from literature reports
      Index of human variants curated from literature reports
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
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