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UniProtKB - Q8TBX8 (PI42C_HUMAN)

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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • phosphatidylinositol biosynthetic process Source: Reactome
  • positive regulation of autophagosome assembly Source: ParkinsonsUK-UCL
  • regulation of autophagy Source: ParkinsonsUK-UCL
  • regulation of phosphatidylinositol 3-kinase signaling Source: Reactome
View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.149 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847453 Synthesis of PIPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:PIP4K2C
Synonyms:PIP5K2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166908.17
HGNCiHGNC:23786 PIP4K2C
neXtProtiNX_Q8TBX8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79837
OpenTargetsiENSG00000166908
PharmGKBiPA162399665

Chemistry databases

ChEMBLiCHEMBL1770034
GuidetoPHARMACOLOGYi2163

Polymorphism and mutation databases

BioMutaiPIP4K2C
DMDMi317373532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002857502 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TBX8
MaxQBiQ8TBX8
PaxDbiQ8TBX8
PeptideAtlasiQ8TBX8
PRIDEiQ8TBX8
ProteomicsDBi74044
74045 [Q8TBX8-2]
74046 [Q8TBX8-3]

PTM databases

iPTMnetiQ8TBX8
PhosphoSitePlusiQ8TBX8

Expressioni

Gene expression databases

BgeeiENSG00000166908
CleanExiHS_PIP4K2C
ExpressionAtlasiQ8TBX8 baseline and differential
GenevisibleiQ8TBX8 HS

Organism-specific databases

HPAiHPA028658
HPA058551

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1383637,EBI-1383637

GO - Molecular functioni

  • identical protein binding Source: IntAct
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi122928, 43 interactors
IntActiQ8TBX8, 3 interactors
STRINGi9606.ENSP00000347032

Chemistry databases

BindingDBiQ8TBX8

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 62Combined sources17
Helixi73 – 77Combined sources5
Beta strandi79 – 85Combined sources7
Beta strandi87 – 89Combined sources3
Beta strandi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Helixi105 – 113Combined sources9
Turni114 – 116Combined sources3
Helixi119 – 127Combined sources9
Beta strandi147 – 153Combined sources7
Helixi156 – 175Combined sources20
Beta strandi180 – 182Combined sources3
Beta strandi185 – 190Combined sources6
Beta strandi193 – 195Combined sources3
Beta strandi199 – 204Combined sources6
Beta strandi209 – 211Combined sources3
Helixi260 – 275Combined sources16
Helixi405 – 415Combined sources11

3D structure databases

ProteinModelPortaliQ8TBX8
SMRiQ8TBX8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TBX8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiQ8TBX8
KOiK00920
OMAiCGLTGPP
OrthoDBiEOG091G0857
PhylomeDBiQ8TBX8
TreeFamiTF354315

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV 
        60         70         80         90        100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF 
       110        120        130        140        150
KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV 
       160        170        180        190        200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM 
       210        220        230        240        250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ 
       260        270        280        290        300
KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA 
       310        320        330        340        350
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF 
       360        370        380        390        400
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI 
       410        420 
STVHPEQYAK RFLDFITNIF A
Length:421
Mass (Da):47,300
Last modified:January 11, 2011 - v3
Checksum:i65D1CBCF0826D476
GO
Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-171: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):41,922
Checksum:i45948B5F37090624
GO
Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-100: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,053
Checksum:iA3980DE66031431E
GO

Sequence cautioni

The sequence BAB15223 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03204984V → A. Corresponds to variant dbSNP:rs17550713Ensembl.1
Natural variantiVAR_032050241K → R1 PublicationCorresponds to variant dbSNP:rs17852569Ensembl.1
Natural variantiVAR_032051300A → G. Corresponds to variant dbSNP:rs2277319Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04336983 – 100Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042929124 – 171Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA Translation: BAB15223.1 Different initiation.
AK297243 mRNA Translation: BAG59723.1
AK302254 mRNA Translation: BAG63606.1
AK315588 mRNA Translation: BAG37960.1
AC022506 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97031.1
BC028596 mRNA Translation: AAH28596.1
CCDSiCCDS53808.1 [Q8TBX8-2]
CCDS55839.1 [Q8TBX8-3]
CCDS8946.1 [Q8TBX8-1]
RefSeqiNP_001139730.1, NM_001146258.1 [Q8TBX8-1]
NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
NP_079055.3, NM_024779.4 [Q8TBX8-1]
UniGeneiHs.745011

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]
GeneIDi79837
KEGGihsa:79837
UCSCiuc001sot.4 human [Q8TBX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPI42C_HUMAN
AccessioniPrimary (citable) accession number: Q8TBX8
Secondary accession number(s): B2RDL3
, B4DM11, B4DY44, Q9H6N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 11, 2011
Last modified: July 18, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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