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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.149 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847453 Synthesis of PIPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
Gene namesi
Name:PIP4K2C
Synonyms:PIP5K2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166908.17
HGNCiHGNC:23786 PIP4K2C
neXtProtiNX_Q8TBX8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi79837
OpenTargetsiENSG00000166908
PharmGKBiPA162399665

Chemistry databases

ChEMBLiCHEMBL1770034

Polymorphism and mutation databases

BioMutaiPIP4K2C
DMDMi317373532

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002857502 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8TBX8
MaxQBiQ8TBX8
PaxDbiQ8TBX8
PeptideAtlasiQ8TBX8
PRIDEiQ8TBX8
ProteomicsDBi74044
74045 [Q8TBX8-2]
74046 [Q8TBX8-3]

PTM databases

iPTMnetiQ8TBX8
PhosphoSitePlusiQ8TBX8

Expressioni

Gene expression databases

BgeeiENSG00000166908 Expressed in 229 organ(s), highest expression level in vagina
CleanExiHS_PIP4K2C
ExpressionAtlasiQ8TBX8 baseline and differential
GenevisibleiQ8TBX8 HS

Organism-specific databases

HPAiHPA028658
HPA058551

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1383637,EBI-1383637

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122928, 43 interactors
IntActiQ8TBX8, 4 interactors
STRINGi9606.ENSP00000347032

Chemistry databases

BindingDBiQ8TBX8

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TBX8
SMRiQ8TBX8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TBX8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiQ8TBX8
KOiK00920
OMAiCGLTGPP
OrthoDBiEOG091G0857
PhylomeDBiQ8TBX8
TreeFamiTF354315

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV
60 70 80 90 100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF
110 120 130 140 150
KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV
160 170 180 190 200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM
210 220 230 240 250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ
260 270 280 290 300
KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA
310 320 330 340 350
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF
360 370 380 390 400
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI
410 420
STVHPEQYAK RFLDFITNIF A
Length:421
Mass (Da):47,300
Last modified:January 11, 2011 - v3
Checksum:i65D1CBCF0826D476
GO
Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-171: Missing.

Note: No experimental confirmation available.
Show »
Length:373
Mass (Da):41,922
Checksum:i45948B5F37090624
GO
Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-100: Missing.

Note: No experimental confirmation available.
Show »
Length:403
Mass (Da):45,053
Checksum:iA3980DE66031431E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU68F8VU68_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
171Annotation score:
H0YIJ6H0YIJ6_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
134Annotation score:
F8VNT5F8VNT5_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
160Annotation score:
F8VVB2F8VVB2_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
50Annotation score:

Sequence cautioni

The sequence BAB15223 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03204984V → A. Corresponds to variant dbSNP:rs17550713Ensembl.1
Natural variantiVAR_032050241K → R1 PublicationCorresponds to variant dbSNP:rs17852569Ensembl.1
Natural variantiVAR_032051300A → G. Corresponds to variant dbSNP:rs2277319Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04336983 – 100Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042929124 – 171Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA Translation: BAB15223.1 Different initiation.
AK297243 mRNA Translation: BAG59723.1
AK302254 mRNA Translation: BAG63606.1
AK315588 mRNA Translation: BAG37960.1
AC022506 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97031.1
BC028596 mRNA Translation: AAH28596.1
CCDSiCCDS53808.1 [Q8TBX8-2]
CCDS55839.1 [Q8TBX8-3]
CCDS8946.1 [Q8TBX8-1]
RefSeqiNP_001139730.1, NM_001146258.1 [Q8TBX8-1]
NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
NP_079055.3, NM_024779.4 [Q8TBX8-1]
UniGeneiHs.745011

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]
GeneIDi79837
KEGGihsa:79837
UCSCiuc001sot.4 human [Q8TBX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA Translation: BAB15223.1 Different initiation.
AK297243 mRNA Translation: BAG59723.1
AK302254 mRNA Translation: BAG63606.1
AK315588 mRNA Translation: BAG37960.1
AC022506 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97031.1
BC028596 mRNA Translation: AAH28596.1
CCDSiCCDS53808.1 [Q8TBX8-2]
CCDS55839.1 [Q8TBX8-3]
CCDS8946.1 [Q8TBX8-1]
RefSeqiNP_001139730.1, NM_001146258.1 [Q8TBX8-1]
NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
NP_079055.3, NM_024779.4 [Q8TBX8-1]
UniGeneiHs.745011

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GK9X-ray2.80A/B/C/D32-421[»]
ProteinModelPortaliQ8TBX8
SMRiQ8TBX8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122928, 43 interactors
IntActiQ8TBX8, 4 interactors
STRINGi9606.ENSP00000347032

Chemistry databases

BindingDBiQ8TBX8
ChEMBLiCHEMBL1770034

PTM databases

iPTMnetiQ8TBX8
PhosphoSitePlusiQ8TBX8

Polymorphism and mutation databases

BioMutaiPIP4K2C
DMDMi317373532

Proteomic databases

EPDiQ8TBX8
MaxQBiQ8TBX8
PaxDbiQ8TBX8
PeptideAtlasiQ8TBX8
PRIDEiQ8TBX8
ProteomicsDBi74044
74045 [Q8TBX8-2]
74046 [Q8TBX8-3]

Protocols and materials databases

DNASUi79837
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]
GeneIDi79837
KEGGihsa:79837
UCSCiuc001sot.4 human [Q8TBX8-1]

Organism-specific databases

CTDi79837
DisGeNETi79837
EuPathDBiHostDB:ENSG00000166908.17
GeneCardsiPIP4K2C
H-InvDBiHIX0201836
HGNCiHGNC:23786 PIP4K2C
HPAiHPA028658
HPA058551
neXtProtiNX_Q8TBX8
OpenTargetsiENSG00000166908
PharmGKBiPA162399665
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00760000119184
HOGENOMiHOG000007832
HOVERGENiHBG000072
InParanoidiQ8TBX8
KOiK00920
OMAiCGLTGPP
OrthoDBiEOG091G0857
PhylomeDBiQ8TBX8
TreeFamiTF354315

Enzyme and pathway databases

BRENDAi2.7.1.149 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847453 Synthesis of PIPs in the nucleus

Miscellaneous databases

ChiTaRSiPIP4K2C human
EvolutionaryTraceiQ8TBX8
GenomeRNAii79837
PROiPR:Q8TBX8

Gene expression databases

BgeeiENSG00000166908 Expressed in 229 organ(s), highest expression level in vagina
CleanExiHS_PIP4K2C
ExpressionAtlasiQ8TBX8 baseline and differential
GenevisibleiQ8TBX8 HS

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPI42C_HUMAN
AccessioniPrimary (citable) accession number: Q8TBX8
Secondary accession number(s): B2RDL3
, B4DM11, B4DY44, Q9H6N2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 11, 2011
Last modified: September 12, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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