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UniProtKB - Q8TBX8 (PI42C_HUMAN)

Entry version 147 (11 Dec 2019)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

Gene

PIP4K2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play an important role in the production of Phosphatidylinositol bisphosphate (PIP2), in the endoplasmic reticulum.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.149 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847453 Synthesis of PIPs in the nucleus

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC:2.7.1.149)
Alternative name(s):
Phosphatidylinositol 5-phosphate 4-kinase type II gamma
Short name:
PI(5)P 4-kinase type II gamma
Short name:
PIP4KII-gamma
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP4K2C
Synonyms:PIP5K2C
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000166908.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:23786 PIP4K2C

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TBX8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79837

Open Targets

More...OpenTargetsi		ENSG00000166908

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162399665

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TBX8 Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1770034

Drug and drug target database

More...DrugBanki		DB12010 Fostamatinib

DrugCentral

More...DrugCentrali		Q8TBX8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PIP4K2C

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373532

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002857502 – 421Phosphatidylinositol 5-phosphate 4-kinase type-2 gammaAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei26PhosphoserineCombined sources1
Modified residuei349PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TBX8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TBX8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TBX8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TBX8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TBX8

PeptideAtlas

More...PeptideAtlasi		Q8TBX8

PRoteomics IDEntifications database

More...PRIDEi		Q8TBX8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		74044 [Q8TBX8-1]
74045 [Q8TBX8-2]
74046 [Q8TBX8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TBX8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TBX8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166908 Expressed in 229 organ(s), highest expression level in vagina

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TBX8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TBX8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA028658
HPA058551

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-1383637,EBI-1383637

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122928, 48 interactors

Protein interaction database and analysis system

More...IntActi		Q8TBX8, 24 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000347032

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q8TBX8

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TBX8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TBX8

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q8TBX8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 420PIPKPROSITE-ProRule annotationAdd BLAST378

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0229 Eukaryota
COG5253 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156890

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000007832

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TBX8

KEGG Orthology (KO)

More...KOi		K00920

Identification of Orthologs from Complete Genome Data

More...OMAi		SEWDGDC

Database of Orthologous Groups

More...OrthoDBi		1562683at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TBX8

TreeFam database of animal gene trees

More...TreeFami		TF354315

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.800.10, 1 hit
3.30.810.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N

The PANTHER Classification System

More...PANTHERi		PTHR23086 PTHR23086, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01504 PIP5K, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00330 PIPKc, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51455 PIPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBX8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSSVPPAT VSAATAGPGP GFGFASKTKK KHFVQQKVKV FRAADPLVGV 
        60         70         80         90        100
FLWGVAHSIN ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF 
       110        120        130        140        150
KEYCPQVFRN LRDRFGIDDQ DYLVSLTRNP PSESEGSDGR FLISYDRTLV 
       160        170        180        190        200
IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT LLPQFLGMYR VSVDNEDSYM 
       210        220        230        240        250
LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL KDMDFLNKNQ 
       260        270        280        290        300
KVYIGEEEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEA 
       310        320        330        340        350
PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF 
       360        370        380        390        400
IDVYAIRSAE GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI 
       410        420 
STVHPEQYAK RFLDFITNIF A
Length:421
Mass (Da):47,300
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65D1CBCF0826D476
GO
Isoform 2 (identifier: Q8TBX8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-171: Missing.

Show »
Length:373
Mass (Da):41,922
Checksum:i45948B5F37090624
GO
Isoform 3 (identifier: Q8TBX8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-100: Missing.

Show »
Length:403
Mass (Da):45,053
Checksum:iA3980DE66031431E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YIJ6H0YIJ6_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VU68F8VU68_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNT5F8VNT5_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VVB2F8VVB2_HUMAN
Phosphatidylinositol 5-phosphate 4-...
PIP4K2C
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15223 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03204984V → A. Corresponds to variant dbSNP:rs17550713Ensembl.1
Natural variantiVAR_032050241K → R1 PublicationCorresponds to variant dbSNP:rs17852569Ensembl.1
Natural variantiVAR_032051300A → G. Corresponds to variant dbSNP:rs2277319Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04336983 – 100Missing in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_042929124 – 171Missing in isoform 2. 1 PublicationAdd BLAST48

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK025708 mRNA Translation: BAB15223.1 Different initiation.
AK297243 mRNA Translation: BAG59723.1
AK302254 mRNA Translation: BAG63606.1
AK315588 mRNA Translation: BAG37960.1
AC022506 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97031.1
BC028596 mRNA Translation: AAH28596.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS53808.1 [Q8TBX8-2]
CCDS55839.1 [Q8TBX8-3]
CCDS8946.1 [Q8TBX8-1]

NCBI Reference Sequences

More...RefSeqi		NP_001139730.1, NM_001146258.1 [Q8TBX8-1]
NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
NP_079055.3, NM_024779.4 [Q8TBX8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79837

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79837

UCSC genome browser

More...UCSCi		uc001sot.4 human [Q8TBX8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025708 mRNA Translation: BAB15223.1 Different initiation.
AK297243 mRNA Translation: BAG59723.1
AK302254 mRNA Translation: BAG63606.1
AK315588 mRNA Translation: BAG37960.1
AC022506 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW97031.1
BC028596 mRNA Translation: AAH28596.1
CCDSiCCDS53808.1 [Q8TBX8-2]
CCDS55839.1 [Q8TBX8-3]
CCDS8946.1 [Q8TBX8-1]
RefSeqiNP_001139730.1, NM_001146258.1 [Q8TBX8-1]
NP_001139731.1, NM_001146259.1 [Q8TBX8-3]
NP_001139732.1, NM_001146260.1 [Q8TBX8-2]
NP_079055.3, NM_024779.4 [Q8TBX8-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GK9X-ray2.80A/B/C/D32-421[»]
SMRiQ8TBX8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi122928, 48 interactors
IntActiQ8TBX8, 24 interactors
STRINGi9606.ENSP00000347032

Chemistry databases

BindingDBiQ8TBX8
ChEMBLiCHEMBL1770034
DrugBankiDB12010 Fostamatinib
DrugCentraliQ8TBX8

PTM databases

iPTMnetiQ8TBX8
PhosphoSitePlusiQ8TBX8

Polymorphism and mutation databases

BioMutaiPIP4K2C
DMDMi317373532

Proteomic databases

EPDiQ8TBX8
jPOSTiQ8TBX8
MassIVEiQ8TBX8
MaxQBiQ8TBX8
PaxDbiQ8TBX8
PeptideAtlasiQ8TBX8
PRIDEiQ8TBX8
ProteomicsDBi74044 [Q8TBX8-1]
74045 [Q8TBX8-2]
74046 [Q8TBX8-3]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		79837

Genome annotation databases

EnsembliENST00000354947; ENSP00000347032; ENSG00000166908 [Q8TBX8-1]
ENST00000422156; ENSP00000412035; ENSG00000166908 [Q8TBX8-2]
ENST00000540759; ENSP00000439878; ENSG00000166908 [Q8TBX8-1]
ENST00000550465; ENSP00000447390; ENSG00000166908 [Q8TBX8-3]
GeneIDi79837
KEGGihsa:79837
UCSCiuc001sot.4 human [Q8TBX8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79837
DisGeNETi79837
EuPathDBiHostDB:ENSG00000166908.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		PIP4K2C
HGNCiHGNC:23786 PIP4K2C
HPAiHPA028658
HPA058551
neXtProtiNX_Q8TBX8
OpenTargetsiENSG00000166908
PharmGKBiPA162399665

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG5253 LUCA
GeneTreeiENSGT00940000156890
HOGENOMiHOG000007832
InParanoidiQ8TBX8
KOiK00920
OMAiSEWDGDC
OrthoDBi1562683at2759
PhylomeDBiQ8TBX8
TreeFamiTF354315

Enzyme and pathway databases

BRENDAi2.7.1.149 2681
ReactomeiR-HSA-1660499 Synthesis of PIPs at the plasma membrane
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8847453 Synthesis of PIPs in the nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PIP4K2C human
EvolutionaryTraceiQ8TBX8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79837
PharosiQ8TBX8 Tchem

Protein Ontology

More...PROi		PR:Q8TBX8
RNActiQ8TBX8 protein

Gene expression databases

BgeeiENSG00000166908 Expressed in 229 organ(s), highest expression level in vagina
ExpressionAtlasiQ8TBX8 baseline and differential
GenevisibleiQ8TBX8 HS

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504 PIP5K, 1 hit
SMARTiView protein in SMART
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI42C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBX8
Secondary accession number(s): B2RDL3
, B4DM11, B4DY44, Q9H6N2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: January 11, 2011
Last modified: December 11, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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