UniProtKB - Q8TBX0 (Q8TBX0_HUMAN)
Protein
Pyrroline-5-carboxylate reductase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
: L-proline biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde.ARBA annotationProteins known to be involved in this subpathway in this organism are:
- Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (P5CR2), Pyrroline-5-carboxylate reductase (PIG45), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR3), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1), Pyrroline-5-carboxylate reductase 2 (PYCR2), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCR3), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase 3 (PYCR3), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCRL), Pyrroline-5-carboxylate reductase (PYCR2), Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase, Pyrroline-5-carboxylate reductase (PYCR1), Pyrroline-5-carboxylate reductase (PYCR1)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-proline from L-glutamate 5-semialdehyde, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- pyrroline-5-carboxylate reductase activity Source: UniProtKB-EC
GO - Biological processi
- L-proline biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Biological process | Amino-acid biosynthesis, Proline biosynthesisARBA annotation |
Ligand | NADPARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
Names & Taxonomyi
Protein namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 120 | P5CR_dimerInterPro annotationAdd BLAST | 105 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 146 – 171 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the pyrroline-5-carboxylate reductase family.ARBA annotation
Family and domain databases
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF14748, P5CR_dimer, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q8TBX0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEQLLSSVGF CTEVEEDLID AVTGLSGSGP AYAFTALDAL ADGGVKMGLP
60 70 80 90 100
RRLAVRLGAQ ALLGAAKMLL HSEQHPGQLK DNVSSPGGAT IHALHVLESG
110 120 130 140 150
GFRSLLINAV EASCIRTREL QSMADQEQVS PAAIKKTILD KVKLDSPAGT
160 170
ALSPSGHTKL LPRSLAPAGK D
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC022244 mRNA Translation: AAH22244.1 |
RefSeqi | NP_008838.2, NM_006907.3 NP_722546.1, NM_153824.2 |
Genome annotation databases
GeneIDi | 5831 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC022244 mRNA Translation: AAH22244.1 |
RefSeqi | NP_008838.2, NM_006907.3 NP_722546.1, NM_153824.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q8TBX0 |
Genome annotation databases
GeneIDi | 5831 |
Organism-specific databases
CTDi | 5831 |
Enzyme and pathway databases
UniPathwayi | UPA00098;UER00361 |
Miscellaneous databases
BioGRID-ORCSi | 5831, 14 hits in 843 CRISPR screens |
GenomeRNAii | 5831 |
Family and domain databases
InterProi | View protein in InterPro IPR008927, 6-PGluconate_DH-like_C_sf IPR029036, P5CR_dimer IPR000304, Pyrroline-COOH_reductase |
Pfami | View protein in Pfam PF14748, P5CR_dimer, 1 hit |
SUPFAMi | SSF48179, SSF48179, 1 hit |
PROSITEi | View protein in PROSITE PS00521, P5CR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q8TBX0_HUMAN | |
Accessioni | Q8TBX0Primary (citable) accession number: Q8TBX0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2002 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 95 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |