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Protein

Protein kish-A

Gene

TMEM167A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the early part of the secretory pathway.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kish-A
Alternative name(s):
Transmembrane protein 167
Transmembrane protein 167A
Gene namesi
Name:TMEM167A
Synonyms:TMEM167
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000174695.9
HGNCiHGNC:28330 TMEM167A
neXtProtiNX_Q8TBQ9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 53ExtracellularSequence analysisAdd BLAST27
Transmembranei54 – 71HelicalSequence analysisAdd BLAST18
Topological domaini72CytoplasmicSequence analysis1

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174695
PharmGKBiPA162405909

Polymorphism and mutation databases

BioMutaiTMEM167A
DMDMi74730497

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000024776827 – 72Protein kish-AAdd BLAST46

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8TBQ9
MaxQBiQ8TBQ9
PaxDbiQ8TBQ9
PeptideAtlasiQ8TBQ9
PRIDEiQ8TBQ9
ProteomicsDBi74039
TopDownProteomicsiQ8TBQ9

PTM databases

iPTMnetiQ8TBQ9
PhosphoSitePlusiQ8TBQ9

Expressioni

Gene expression databases

BgeeiENSG00000174695 Expressed in 208 organ(s), highest expression level in substantia nigra
CleanExiHS_TMEM167A
GenevisibleiQ8TBQ9 HS

Interactioni

Protein-protein interaction databases

BioGridi127490, 1 interactor
IntActiQ8TBQ9, 1 interactor
STRINGi9606.ENSP00000424707

Structurei

3D structure databases

ProteinModelPortaliQ8TBQ9
SMRiQ8TBQ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KISH family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3808 Eukaryota
ENOG4112243 LUCA
GeneTreeiENSGT00860000133824
HOGENOMiHOG000231410
HOVERGENiHBG080265
InParanoidiQ8TBQ9
OMAiFSILFMQ
OrthoDBiEOG091G15C1
PhylomeDBiQ8TBQ9
TreeFamiTF300138

Family and domain databases

InterProiView protein in InterPro
IPR009653 Ksh1
PANTHERiPTHR13229 PTHR13229, 1 hit
PfamiView protein in Pfam
PF06842 DUF1242, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8TBQ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAIFNFQSL LTVILLLICT CAYIRSLAPS LLDRNKTGLL GIFWKCARIG
60 70
ERKSPYVAVC CIVMAFSILF IQ
Length:72
Mass (Da):8,060
Last modified:June 1, 2002 - v1
Checksum:i1A346F4BE4FD8C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026285 mRNA Translation: AAH26285.1
BC028585 mRNA Translation: AAH28585.1
BC107575 mRNA Translation: AAI07576.1
CCDSiCCDS34198.1
RefSeqiNP_777569.1, NM_174909.4
UniGeneiHs.355606

Genome annotation databases

EnsembliENST00000502346; ENSP00000424707; ENSG00000174695
GeneIDi153339
KEGGihsa:153339
UCSCiuc003khx.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026285 mRNA Translation: AAH26285.1
BC028585 mRNA Translation: AAH28585.1
BC107575 mRNA Translation: AAI07576.1
CCDSiCCDS34198.1
RefSeqiNP_777569.1, NM_174909.4
UniGeneiHs.355606

3D structure databases

ProteinModelPortaliQ8TBQ9
SMRiQ8TBQ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127490, 1 interactor
IntActiQ8TBQ9, 1 interactor
STRINGi9606.ENSP00000424707

PTM databases

iPTMnetiQ8TBQ9
PhosphoSitePlusiQ8TBQ9

Polymorphism and mutation databases

BioMutaiTMEM167A
DMDMi74730497

Proteomic databases

EPDiQ8TBQ9
MaxQBiQ8TBQ9
PaxDbiQ8TBQ9
PeptideAtlasiQ8TBQ9
PRIDEiQ8TBQ9
ProteomicsDBi74039
TopDownProteomicsiQ8TBQ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000502346; ENSP00000424707; ENSG00000174695
GeneIDi153339
KEGGihsa:153339
UCSCiuc003khx.5 human

Organism-specific databases

CTDi153339
EuPathDBiHostDB:ENSG00000174695.9
GeneCardsiTMEM167A
HGNCiHGNC:28330 TMEM167A
neXtProtiNX_Q8TBQ9
OpenTargetsiENSG00000174695
PharmGKBiPA162405909
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3808 Eukaryota
ENOG4112243 LUCA
GeneTreeiENSGT00860000133824
HOGENOMiHOG000231410
HOVERGENiHBG080265
InParanoidiQ8TBQ9
OMAiFSILFMQ
OrthoDBiEOG091G15C1
PhylomeDBiQ8TBQ9
TreeFamiTF300138

Miscellaneous databases

ChiTaRSiTMEM167A human
GenomeRNAii153339
PROiPR:Q8TBQ9

Gene expression databases

BgeeiENSG00000174695 Expressed in 208 organ(s), highest expression level in substantia nigra
CleanExiHS_TMEM167A
GenevisibleiQ8TBQ9 HS

Family and domain databases

InterProiView protein in InterPro
IPR009653 Ksh1
PANTHERiPTHR13229 PTHR13229, 1 hit
PfamiView protein in Pfam
PF06842 DUF1242, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKISHA_HUMAN
AccessioniPrimary (citable) accession number: Q8TBQ9
Secondary accession number(s): Q0P692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: June 1, 2002
Last modified: September 12, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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