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Protein

Solute carrier family 25 member 40

Gene

SLC25A40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.14.6 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 40
Alternative name(s):
Mitochondrial carrier family protein
Gene namesi
Name:SLC25A40
Synonyms:MCFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000075303.12
HGNCiHGNC:29680 SLC25A40
MIMi610821 gene
neXtProtiNX_Q8TBP6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei103 – 123Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei142 – 162Helical; Name=3Sequence analysisAdd BLAST21
Transmembranei199 – 220Helical; Name=4Sequence analysisAdd BLAST22
Transmembranei239 – 259Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei298 – 318Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55972
OpenTargetsiENSG00000075303
PharmGKBiPA162403655

Polymorphism and mutation databases

BioMutaiSLC25A40
DMDMi74751387

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002918091 – 338Solute carrier family 25 member 40Add BLAST338

Proteomic databases

EPDiQ8TBP6
MaxQBiQ8TBP6
PaxDbiQ8TBP6
PeptideAtlasiQ8TBP6
PRIDEiQ8TBP6
ProteomicsDBi74037

PTM databases

iPTMnetiQ8TBP6
PhosphoSitePlusiQ8TBP6

Expressioni

Gene expression databases

BgeeiENSG00000075303
CleanExiHS_SLC25A40
ExpressionAtlasiQ8TBP6 baseline and differential
GenevisibleiQ8TBP6 HS

Organism-specific databases

HPAiHPA055197

Interactioni

Protein-protein interaction databases

BioGridi121018, 1 interactor
STRINGi9606.ENSP00000344831

Structurei

3D structure databases

ProteinModelPortaliQ8TBP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 131Solcar 1Add BLAST119
Repeati139 – 223Solcar 2Add BLAST85
Repeati233 – 327Solcar 3Add BLAST95

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0761 Eukaryota
ENOG410XQVP LUCA
GeneTreeiENSGT00790000123051
HOGENOMiHOG000214473
HOVERGENiHBG011439
InParanoidiQ8TBP6
KOiK15119
OMAiKWLCEKS
OrthoDBiEOG091G07QQ
PhylomeDBiQ8TBP6
TreeFamiTF314720

Family and domain databases

Gene3Di1.50.40.10, 2 hits
InterProiView protein in InterPro
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 2 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q8TBP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPETRGQEI IKVTPLQQML ASCTGAILTS VIVTPLDVVK IRLQAQNNPL
60 70 80 90 100
PKGKCFVYSN GLMDHLCVCE EGGNKLWYKK PGNFQGTLDA FFKIIRNEGI
110 120 130 140 150
KSLWSGLPPT LVMAVPATVI YFTCYDQLSA LLRSKLGENE TCIPIVAGIV
160 170 180 190 200
ARFGAVTVIS PLELIRTKMQ SKKFSYVELH RFVSKKVSED GWISLWRGWA
210 220 230 240 250
PTVLRDVPFS AMYWYNYEIL KKWLCEKSGL YEPTFMINFT SGALSGSFAA
260 270 280 290 300
VATLPFDVVK TQKQTQLWTY ESHKISMPLH MSTWIIMKNI VAKNGFSGLF
310 320 330
SGLIPRLIKI APACAIMIST YEFGKAFFQK QNVRRQQY
Length:338
Mass (Da):38,125
Last modified:June 1, 2002 - v1
Checksum:i19F3AC921F5A6961
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71E → K in BAD96740 (Ref. 3) Curated1
Sequence conflicti161P → Q in AAF17225 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079372105S → N1 PublicationCorresponds to variant dbSNP:rs200954020Ensembl.1
Natural variantiVAR_032863123T → I. Corresponds to variant dbSNP:rs724665Ensembl.1
Natural variantiVAR_032864186K → Q. Corresponds to variant dbSNP:rs3213633Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125531 mRNA Translation: AAF17225.1
AK223020 mRNA Translation: BAD96740.1
AK290848 mRNA Translation: BAF83537.1
AC003083 Genomic DNA Translation: AAS07443.1
CH236949 Genomic DNA Translation: EAL24171.1
CH471091 Genomic DNA Translation: EAW76933.1
CH471091 Genomic DNA Translation: EAW76935.1
BC027322 mRNA Translation: AAH27322.1
CCDSiCCDS5610.1
RefSeqiNP_061331.2, NM_018843.3
UniGeneiHs.208414

Genome annotation databases

EnsembliENST00000341119; ENSP00000344831; ENSG00000075303
GeneIDi55972
KEGGihsa:55972
UCSCiuc003uje.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS2540_HUMAN
AccessioniPrimary (citable) accession number: Q8TBP6
Secondary accession number(s): A8K483
, D6W5P6, Q53GB1, Q9UHR1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2002
Last modified: June 20, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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