UniProtKB - Q8TBP5 (F174A_HUMAN)
Protein
Membrane protein FAM174A
Gene
FAM174A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Membrane protein FAM174AAlternative name(s): Hepatitis C virus NS5A-transactivated protein 6 Short name: HCV NS5A-transactivated protein 6 Transmembrane protein 157 |
Gene namesi | Name:FAM174A Synonyms:NS5ATP6, TMEM157 ORF Names:UNQ1912/PRO4371 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24943, FAM174A |
neXtProti | NX_Q8TBP5 |
VEuPathDBi | HostDB:ENSG00000174132.8 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 123 | ExtracellularSequence analysisAdd BLAST | 94 | |
Transmembranei | 124 – 144 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 145 – 190 | CytoplasmicSequence analysisAdd BLAST | 46 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 345757 |
OpenTargetsi | ENSG00000174132 |
PharmGKBi | PA162387296 |
Miscellaneous databases
Pharosi | Q8TBP5, Tdark |
Genetic variation databases
BioMutai | FAM174A |
DMDMi | 74730492 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000263650 | 30 – 190 | Membrane protein FAM174AAdd BLAST | 161 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 83 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q8TBP5 |
jPOSTi | Q8TBP5 |
MassIVEi | Q8TBP5 |
MaxQBi | Q8TBP5 |
PaxDbi | Q8TBP5 |
PeptideAtlasi | Q8TBP5 |
PRIDEi | Q8TBP5 |
ProteomicsDBi | 74036 |
PTM databases
GlyGeni | Q8TBP5, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8TBP5 |
PhosphoSitePlusi | Q8TBP5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174132, Expressed in bronchial epithelial cell and 213 other tissues |
Genevisiblei | Q8TBP5, HS |
Organism-specific databases
HPAi | ENSG00000174132, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8TBP5
Protein-protein interaction databases
BioGRIDi | 131364, 90 interactors |
IntActi | Q8TBP5, 83 interactors |
STRINGi | 9606.ENSP00000307954 |
Miscellaneous databases
RNActi | Q8TBP5, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 41 – 66 | Pro-richAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the FAM174 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4HB, Eukaryota |
GeneTreei | ENSGT00730000111385 |
HOGENOMi | CLU_126641_0_0_1 |
InParanoidi | Q8TBP5 |
OMAi | ASHCCCC |
OrthoDBi | 1515948at2759 |
PhylomeDBi | Q8TBP5 |
TreeFami | TF105425 |
Family and domain databases
InterProi | View protein in InterPro IPR009565, DUF1180 |
PANTHERi | PTHR28607, PTHR28607, 1 hit |
Pfami | View protein in Pfam PF06679, DUF1180, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q8TBP5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKASQCCCCL SHLLASVLLL LLLPELSGPL AVLLQAAEAA PGLGPPDPRP
60 70 80 90 100
RTLPPLPPGP TPAQQPGRGL AEAAGPRGSE GGNGSNPVAG LETDDHGGKA
110 120 130 140 150
GEGSVGGGLA VSPNPGDKPM TQRALTVLMV VSGAVLVYFV VRTVRMRRRN
160 170 180 190
RKTRRYGVLD TNIENMELTP LEQDDEDDDN TLFDANHPRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF529367 mRNA Translation: AAQ09601.1 AY359108 mRNA Translation: AAQ89466.1 AK289539 mRNA Translation: BAF82228.1 AC021086 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49106.1 BC027332 mRNA Translation: AAH27332.1 |
CCDSi | CCDS4090.1 |
RefSeqi | NP_940909.1, NM_198507.2 |
Genome annotation databases
Ensembli | ENST00000312637; ENSP00000307954; ENSG00000174132 |
GeneIDi | 345757 |
KEGGi | hsa:345757 |
UCSCi | uc003knj.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF529367 mRNA Translation: AAQ09601.1 AY359108 mRNA Translation: AAQ89466.1 AK289539 mRNA Translation: BAF82228.1 AC021086 Genomic DNA No translation available. CH471086 Genomic DNA Translation: EAW49106.1 BC027332 mRNA Translation: AAH27332.1 |
CCDSi | CCDS4090.1 |
RefSeqi | NP_940909.1, NM_198507.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131364, 90 interactors |
IntActi | Q8TBP5, 83 interactors |
STRINGi | 9606.ENSP00000307954 |
PTM databases
GlyGeni | Q8TBP5, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q8TBP5 |
PhosphoSitePlusi | Q8TBP5 |
Genetic variation databases
BioMutai | FAM174A |
DMDMi | 74730492 |
Proteomic databases
EPDi | Q8TBP5 |
jPOSTi | Q8TBP5 |
MassIVEi | Q8TBP5 |
MaxQBi | Q8TBP5 |
PaxDbi | Q8TBP5 |
PeptideAtlasi | Q8TBP5 |
PRIDEi | Q8TBP5 |
ProteomicsDBi | 74036 |
Protocols and materials databases
Antibodypediai | 13308, 47 antibodies |
Genome annotation databases
Ensembli | ENST00000312637; ENSP00000307954; ENSG00000174132 |
GeneIDi | 345757 |
KEGGi | hsa:345757 |
UCSCi | uc003knj.2, human |
Organism-specific databases
CTDi | 345757 |
DisGeNETi | 345757 |
GeneCardsi | FAM174A |
HGNCi | HGNC:24943, FAM174A |
HPAi | ENSG00000174132, Low tissue specificity |
neXtProti | NX_Q8TBP5 |
OpenTargetsi | ENSG00000174132 |
PharmGKBi | PA162387296 |
VEuPathDBi | HostDB:ENSG00000174132.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S4HB, Eukaryota |
GeneTreei | ENSGT00730000111385 |
HOGENOMi | CLU_126641_0_0_1 |
InParanoidi | Q8TBP5 |
OMAi | ASHCCCC |
OrthoDBi | 1515948at2759 |
PhylomeDBi | Q8TBP5 |
TreeFami | TF105425 |
Enzyme and pathway databases
PathwayCommonsi | Q8TBP5 |
Miscellaneous databases
BioGRID-ORCSi | 345757, 2 hits in 878 CRISPR screens |
ChiTaRSi | FAM174A, human |
GenomeRNAii | 345757 |
Pharosi | Q8TBP5, Tdark |
PROi | PR:Q8TBP5 |
RNActi | Q8TBP5, protein |
Gene expression databases
Bgeei | ENSG00000174132, Expressed in bronchial epithelial cell and 213 other tissues |
Genevisiblei | Q8TBP5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR009565, DUF1180 |
PANTHERi | PTHR28607, PTHR28607, 1 hit |
Pfami | View protein in Pfam PF06679, DUF1180, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F174A_HUMAN | |
Accessioni | Q8TBP5Primary (citable) accession number: Q8TBP5 Secondary accession number(s): A8K0H4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM