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Protein

Zinc finger CCHC domain-containing protein 10

Gene

ZCCHC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 60CCHC-typeAdd BLAST18

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 10
Gene namesi
Name:ZCCHC10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000155329.11
HGNCiHGNC:25954 ZCCHC10
neXtProtiNX_Q8TBK6

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000155329
PharmGKBiPA134876515

Polymorphism and mutation databases

BioMutaiZCCHC10
DMDMi84028163

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509671 – 192Zinc finger CCHC domain-containing protein 10Add BLAST192

Proteomic databases

EPDiQ8TBK6
MaxQBiQ8TBK6
PeptideAtlasiQ8TBK6
PRIDEiQ8TBK6
ProteomicsDBi74024
74025 [Q8TBK6-2]

PTM databases

iPTMnetiQ8TBK6
PhosphoSitePlusiQ8TBK6

Expressioni

Gene expression databases

BgeeiENSG00000155329
CleanExiHS_ZCCHC10
ExpressionAtlasiQ8TBK6 baseline and differential
GenevisibleiQ8TBK6 HS

Organism-specific databases

HPAiHPA038944

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120174, 52 interactors
IntActiQ8TBK6, 62 interactors
MINTiQ8TBK6

Structurei

3D structure databases

ProteinModelPortaliQ8TBK6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi105 – 181Ser-richAdd BLAST77
Compositional biasi187 – 192Poly-Lys6

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri43 – 60CCHC-typeAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00730000111200
HOVERGENiHBG079370
InParanoidiQ8TBK6
OMAiHRIIARR
OrthoDBiEOG091G1CLN
PhylomeDBiQ8TBK6

Family and domain databases

InterProiView protein in InterPro
IPR036875 Znf_CCHC_sf
SUPFAMiSSF57756 SSF57756, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8TBK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE
60 70 80 90 100
FGHWTYECTG KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA
110 120 130 140 150
KKKRSKSVTS SSSSSSDSSA SDSSSESEET STSSSSEDSD TDESSSSSSS
160 170 180 190
SASSTTSSSS SDSDSDSSSS SSSSTSTDSS SDDEPPKKKK KK
Length:192
Mass (Da):20,967
Last modified:June 1, 2002 - v1
Checksum:iE600FD109936B53E
GO
Isoform 2 (identifier: Q8TBK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-36: Missing.

Show »
Length:170
Mass (Da):18,410
Checksum:iF1864E485E59C931
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01371815 – 36Missing in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000101 mRNA Translation: BAA90946.1
BC005211 mRNA Translation: AAH05211.1
BC022443 mRNA Translation: AAH22443.1
CCDSiCCDS4165.1 [Q8TBK6-2]
CCDS75301.1 [Q8TBK6-1]
RefSeqiNP_001287745.1, NM_001300816.2 [Q8TBK6-1]
NP_001287746.1, NM_001300817.2
NP_001287747.1, NM_001300818.2
NP_001287748.1, NM_001300819.2
NP_001287751.1, NM_001300822.2
NP_001295056.1, NM_001308127.1
NP_001295057.1, NM_001308128.1
NP_001295058.1, NM_001308129.1
NP_001295059.1, NM_001308130.1
NP_060135.1, NM_017665.3 [Q8TBK6-2]
UniGeneiHs.29700

Genome annotation databases

EnsembliENST00000324170; ENSP00000324274; ENSG00000155329 [Q8TBK6-2]
ENST00000509437; ENSP00000423276; ENSG00000155329 [Q8TBK6-1]
GeneIDi54819
KEGGihsa:54819
UCSCiuc003kyg.4 human [Q8TBK6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZCH10_HUMAN
AccessioniPrimary (citable) accession number: Q8TBK6
Secondary accession number(s): Q9NXR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2002
Last modified: July 18, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM

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