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UniProtKB - Q8TBK6 (ZCH10_HUMAN)
Protein
Zinc finger CCHC domain-containing protein 10
Gene
ZCCHC10
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 43 – 60 | CCHC-typeAdd BLAST | 18 |
GO - Molecular functioni
- nucleic acid binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TBK6 |
SignaLinki | Q8TBK6 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger CCHC domain-containing protein 10 |
Gene namesi | Name:ZCCHC10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25954, ZCCHC10 |
neXtProti | NX_Q8TBK6 |
VEuPathDBi | HostDB:ENSG00000155329 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54819 |
OpenTargetsi | ENSG00000155329 |
PharmGKBi | PA134876515 |
Miscellaneous databases
Pharosi | Q8TBK6, Tdark |
Genetic variation databases
BioMutai | ZCCHC10 |
DMDMi | 84028163 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000150967 | 1 – 192 | Zinc finger CCHC domain-containing protein 10Add BLAST | 192 |
Proteomic databases
EPDi | Q8TBK6 |
jPOSTi | Q8TBK6 |
MassIVEi | Q8TBK6 |
MaxQBi | Q8TBK6 |
PeptideAtlasi | Q8TBK6 |
PRIDEi | Q8TBK6 |
ProteomicsDBi | 74024 [Q8TBK6-1] 74025 [Q8TBK6-2] |
PTM databases
iPTMneti | Q8TBK6 |
PhosphoSitePlusi | Q8TBK6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000155329, Expressed in amniotic fluid and 238 other tissues |
ExpressionAtlasi | Q8TBK6, baseline and differential |
Genevisiblei | Q8TBK6, HS |
Organism-specific databases
HPAi | ENSG00000155329, Low tissue specificity |
Interactioni
Binary interactionsi
Q8TBK6
Protein-protein interaction databases
BioGRIDi | 120174, 232 interactors |
IntActi | Q8TBK6, 65 interactors |
MINTi | Q8TBK6 |
STRINGi | 9606.ENSP00000423276 |
Miscellaneous databases
RNActi | Q8TBK6, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 89 – 192 | DisorderedSequence analysisAdd BLAST | 104 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 107 – 180 | Polar residuesSequence analysisAdd BLAST | 74 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 43 – 60 | CCHC-typeAdd BLAST | 18 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3116, Eukaryota |
GeneTreei | ENSGT00730000111200 |
HOGENOMi | CLU_111178_0_0_1 |
InParanoidi | Q8TBK6 |
OMAi | TGHFTYQ |
OrthoDBi | 1638633at2759 |
PhylomeDBi | Q8TBK6 |
Family and domain databases
InterProi | View protein in InterPro IPR039715, ZCCHC10 IPR036875, Znf_CCHC_sf |
PANTHERi | PTHR13491, PTHR13491, 1 hit |
SUPFAMi | SSF57756, SSF57756, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TBK6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATPMHRLIA RRQAFDTELQ PVKTFWILIQ PSIVISEANK QHVRCQKCLE
60 70 80 90 100
FGHWTYECTG KRKYLHRPSR TAELKKALKE KENRLLLQQS IGETNVERKA
110 120 130 140 150
KKKRSKSVTS SSSSSSDSSA SDSSSESEET STSSSSEDSD TDESSSSSSS
160 170 180 190
SASSTTSSSS SDSDSDSSSS SSSSTSTDSS SDDEPPKKKK KK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAM1 | G3XAM1_HUMAN | Zinc finger CCHC domain-containing ... | ZCCHC10 hCG_1639963 | 156 | Annotation score: | ||
B3KVL5 | B3KVL5_HUMAN | Zinc finger CCHC domain-containing ... | ZCCHC10 hCG_1639963 | 186 | Annotation score: | ||
D6R9G7 | D6R9G7_HUMAN | Zinc finger CCHC domain-containing ... | ZCCHC10 | 114 | Annotation score: | ||
D6RHC2 | D6RHC2_HUMAN | Zinc finger CCHC domain-containing ... | ZCCHC10 hCG_1639963 | 92 | Annotation score: | ||
D6RIV3 | D6RIV3_HUMAN | Zinc finger CCHC domain-containing ... | ZCCHC10 | 72 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013718 | 15 – 36 | Missing in isoform 2. 2 PublicationsAdd BLAST | 22 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000101 mRNA Translation: BAA90946.1 BC005211 mRNA Translation: AAH05211.1 BC022443 mRNA Translation: AAH22443.1 |
CCDSi | CCDS4165.1 [Q8TBK6-2] CCDS75301.1 [Q8TBK6-1] |
RefSeqi | NP_001287745.1, NM_001300816.2 [Q8TBK6-1] NP_001287746.1, NM_001300817.2 NP_001287747.1, NM_001300818.2 NP_001287748.1, NM_001300819.2 NP_001287751.1, NM_001300822.2 NP_001295056.1, NM_001308127.1 NP_001295057.1, NM_001308128.1 NP_001295058.1, NM_001308129.1 NP_001295059.1, NM_001308130.1 NP_060135.1, NM_017665.3 [Q8TBK6-2] |
Genome annotation databases
Ensembli | ENST00000324170; ENSP00000324274; ENSG00000155329 [Q8TBK6-2] ENST00000509437; ENSP00000423276; ENSG00000155329 |
GeneIDi | 54819 |
KEGGi | hsa:54819 |
MANE-Selecti | ENST00000509437.6; ENSP00000423276.1; NM_001300816.3; NP_001287745.1 |
UCSCi | uc003kyg.4, human [Q8TBK6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000101 mRNA Translation: BAA90946.1 BC005211 mRNA Translation: AAH05211.1 BC022443 mRNA Translation: AAH22443.1 |
CCDSi | CCDS4165.1 [Q8TBK6-2] CCDS75301.1 [Q8TBK6-1] |
RefSeqi | NP_001287745.1, NM_001300816.2 [Q8TBK6-1] NP_001287746.1, NM_001300817.2 NP_001287747.1, NM_001300818.2 NP_001287748.1, NM_001300819.2 NP_001287751.1, NM_001300822.2 NP_001295056.1, NM_001308127.1 NP_001295057.1, NM_001308128.1 NP_001295058.1, NM_001308129.1 NP_001295059.1, NM_001308130.1 NP_060135.1, NM_017665.3 [Q8TBK6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120174, 232 interactors |
IntActi | Q8TBK6, 65 interactors |
MINTi | Q8TBK6 |
STRINGi | 9606.ENSP00000423276 |
PTM databases
iPTMneti | Q8TBK6 |
PhosphoSitePlusi | Q8TBK6 |
Genetic variation databases
BioMutai | ZCCHC10 |
DMDMi | 84028163 |
Proteomic databases
EPDi | Q8TBK6 |
jPOSTi | Q8TBK6 |
MassIVEi | Q8TBK6 |
MaxQBi | Q8TBK6 |
PeptideAtlasi | Q8TBK6 |
PRIDEi | Q8TBK6 |
ProteomicsDBi | 74024 [Q8TBK6-1] 74025 [Q8TBK6-2] |
Protocols and materials databases
Antibodypediai | 26217, 30 antibodies from 11 providers |
DNASUi | 54819 |
Genome annotation databases
Ensembli | ENST00000324170; ENSP00000324274; ENSG00000155329 [Q8TBK6-2] ENST00000509437; ENSP00000423276; ENSG00000155329 |
GeneIDi | 54819 |
KEGGi | hsa:54819 |
MANE-Selecti | ENST00000509437.6; ENSP00000423276.1; NM_001300816.3; NP_001287745.1 |
UCSCi | uc003kyg.4, human [Q8TBK6-1] |
Organism-specific databases
CTDi | 54819 |
DisGeNETi | 54819 |
GeneCardsi | ZCCHC10 |
HGNCi | HGNC:25954, ZCCHC10 |
HPAi | ENSG00000155329, Low tissue specificity |
neXtProti | NX_Q8TBK6 |
OpenTargetsi | ENSG00000155329 |
PharmGKBi | PA134876515 |
VEuPathDBi | HostDB:ENSG00000155329 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3116, Eukaryota |
GeneTreei | ENSGT00730000111200 |
HOGENOMi | CLU_111178_0_0_1 |
InParanoidi | Q8TBK6 |
OMAi | TGHFTYQ |
OrthoDBi | 1638633at2759 |
PhylomeDBi | Q8TBK6 |
Enzyme and pathway databases
PathwayCommonsi | Q8TBK6 |
SignaLinki | Q8TBK6 |
Miscellaneous databases
BioGRID-ORCSi | 54819, 10 hits in 1044 CRISPR screens |
ChiTaRSi | ZCCHC10, human |
GenomeRNAii | 54819 |
Pharosi | Q8TBK6, Tdark |
PROi | PR:Q8TBK6 |
RNActi | Q8TBK6, protein |
Gene expression databases
Bgeei | ENSG00000155329, Expressed in amniotic fluid and 238 other tissues |
ExpressionAtlasi | Q8TBK6, baseline and differential |
Genevisiblei | Q8TBK6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR039715, ZCCHC10 IPR036875, Znf_CCHC_sf |
PANTHERi | PTHR13491, PTHR13491, 1 hit |
SUPFAMi | SSF57756, SSF57756, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ZCH10_HUMAN | |
Accessioni | Q8TBK6Primary (citable) accession number: Q8TBK6 Secondary accession number(s): Q9NXR4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2005 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 23, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM