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1 to 15 of 15  Show
  1. 1
    "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Category: Sequences.
    Tissue: Brain.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 12925 other entries.

  2. 2
    "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Category: Sequences.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3633 other entries.

  3. 3
    "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS SER-185 AND GLY-206.
    Category: Sequences.
    Tissue: Brain.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 50446 other entries.

  4. 4
    "Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling."
    Levy D., Kuo A.J., Chang Y., Schaefer U., Kitson C., Cheung P., Espejo A., Zee B.M., Liu C.L., Tangsombatvisit S., Tennen R.I., Kuo A.Y., Tanjing S., Cheung R., Chua K.F., Utz P.J., Shi X., Prinjha R.K.
    Gozani O.
    Nat. Immunol. 12:29-36(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF TYR-285.
    Category: Function, Subcellular Location, Pathology & Biotech.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 3 and mapped to 39 other entries.

  5. 5
    "SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal."
    Binda O., Sevilla A., LeRoy G., Lemischka I.R., Garcia B.A., Richard S.
    Epigenetics 8:177-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Category: Function.
    Source: UniProtKB/Swiss-Prot (reviewed).

    This publication is cited by 2 and mapped to 4 other entries.

  6. 6
    "Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling."
    Chang Y., Levy D., Horton J.R., Peng J., Zhang X., Gozani O., Cheng X.
    Nucleic Acids Res. 39:6380-6389(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Structure.
    Source: PDB:3QXY, PDB:3RC0.

    This publication is mapped to 1 other entry.

  7. 7
    "A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome."
    Blandin G., Marchand S., Charton K., Daniele N., Gicquel E., Boucheteil J.B., Bentaib A., Barrault L., Stockholm D., Bartoli M., Richard I.
    Skelet Muscle 3:3-3(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Source: IntAct:Q8TBK2.

    This publication is mapped to 499 other entries.

  8. 8
    "SETD6 controls the expression of estrogen-responsive genes and proliferation of breast carcinoma cells."
    O'Neill D.J., Williamson S.C., Alkharaif D., Monteiro I.C., Goudreault M., Gaughan L., Robson C.N., Gingras A.C., Binda O.
    Epigenetics 9:942-950(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation.
    Source: GeneRIF:79918.

    This publication is mapped to 3 other entries.

  9. 9
    "SETD6 is a negative regulator of oxidative stress response."
    Chen A., Feldman M., Vershinin Z., Levy D.
    Biochim. Biophys. Acta 1859:420-427(2016) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location, Interaction.
    Annotation: these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin.
    Source: GeneRIF:79918.

    This publication is mapped to 10 other entries.

  10. 10
    "PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/beta-Catenin Pathway."
    Vershinin Z., Feldman M., Chen A., Levy D.
    J. Biol. Chem. 291:6786-6795(2016) [PubMed] [Europe PMC] [Abstract]
    Category: PTM / Processing.
    Annotation: PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway.
    Source: GeneRIF:79918.

    This publication is mapped to 12 other entries.

  11. 11
    "SETD6 regulates NF-kappaB signaling in urothelial cell survival: Implications for bladder cancer."
    Mukherjee N., Cardenas E., Bedolla R., Ghosh R.
    Oncotarget 8:15114-15125(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: High SETD6 expression is associated with bladder cancer.
    Source: GeneRIF:79918.

    This publication is mapped to 5 other entries.

  12. 12
    "SETD6 dominant negative mutation in familial colorectal cancer type X."
    Martin-Morales L., Feldman M., Vershinin Z., Garre P., Caldes T., Levy D.
    Hum. Mol. Genet. 26:4481-4493(2017) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Findings suggest that the identified mutation impairs the normal function of SETD6 which may result in the deregulation of the different pathways in which it is involved contributing to the increased susceptibility to cancer in this FCCTX family.
    Source: GeneRIF:79918.

    This publication is mapped to 3 other entries.

  13. 13
    "Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6."
    Weil L.E., Shmidov Y., Kublanovsky M., Morgenstern D., Feldman M., Bitton R., Levy D.
    J. Mol. Biol. 430:4359-4368(2018) [PubMed] [Europe PMC] [Abstract]
    Annotation: Study demonstrates that SETD6 monomeric dimeric and trimeric forms are stabilized by the methyl donor S-adenosyl-l-methionine. SETD6 has auto-methylation activity at K39 and K179 which serves as the major auto-methylation sites with a moderate auto-methylation activity toward K372. Data support a model by which SETD6 auto-methylation and self-interaction positively regulate its enzymatic activity in vitro.
    Source: GeneRIF:79918.

    This publication is mapped to 3 other entries.

  14. 14
    "Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration."
    Yao R., Wang Y., Han D., Ma Y., Ma M., Zhao Y., Tan J., Lu J., Xu G., Li X.
    Oncol. Rep. 40:3069-3077(2018) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech, PTM / Processing.
    Annotation: WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration.
    Source: GeneRIF:79918.

    This publication is mapped to 5 other entries.

  15. 15
    "The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation."
    Feldman M., Vershinin Z., Goliand I., Elia N., Levy D.
    Proc. Natl. Acad. Sci. U.S.A. 116:1235-1240(2019) [PubMed] [Europe PMC] [Abstract]
    Category: Function, PTM / Processing.
    Annotation: During mitosis SETD6 binds and methylates PLK1.
    Source: GeneRIF:79918.

    This publication is mapped to 9 other entries.

1 to 15 of 15  Show
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