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Protein

Fez family zinc finger protein 2

Gene

FEZF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 440C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 2
Alternative name(s):
Forebrain embryonic zinc finger-like protein 2
Zinc finger protein 312
Zinc finger protein Fez-like
Gene namesi
Name:FEZF2
Synonyms:FEZL, ZNF312
ORF Names:FKSG36
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000153266.12
HGNCiHGNC:13506 FEZF2
MIMi607414 gene
neXtProtiNX_Q8TBJ5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55079
OpenTargetsiENSG00000153266
PharmGKBiPA162388420

Polymorphism and mutation databases

BioMutaiFEZF2
DMDMi152032462

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951191 – 459Fez family zinc finger protein 2Add BLAST459

Proteomic databases

PaxDbiQ8TBJ5
PeptideAtlasiQ8TBJ5
PRIDEiQ8TBJ5
ProteomicsDBi74020
74021 [Q8TBJ5-2]

PTM databases

iPTMnetiQ8TBJ5
PhosphoSitePlusiQ8TBJ5

Expressioni

Gene expression databases

BgeeiENSG00000153266 Expressed in 50 organ(s), highest expression level in cerebral cortex
CleanExiHS_FEZF2
ExpressionAtlasiQ8TBJ5 baseline and differential
GenevisibleiQ8TBJ5 HS

Interactioni

Protein-protein interaction databases

BioGridi120394, 1 interactor
STRINGi9606.ENSP00000283268

Structurei

3D structure databases

ProteinModelPortaliQ8TBJ5
SMRiQ8TBJ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi27 – 42Engrailed homology 1 repressorBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 125Gly-richAdd BLAST24

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri277 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri361 – 383C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri389 – 411C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri417 – 440C2H2-type 6PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000013052
HOVERGENiHBG098441
InParanoidiQ8TBJ5
OMAiKPQVIHQ
OrthoDBiEOG091G0ISJ
PhylomeDBiQ8TBJ5
TreeFamiTF316780

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q8TBJ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP
60 70 80 90 100
GALEADGSQG KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSELWKSSLR
110 120 130 140 150
AGGGGGGGGG GGGGGGGAPV CGASGLCKTN CGVCCKAELG LAPSALPAGR
160 170 180 190 200
VIKPQVINQA VGLPASGSLY YFNYLDSTAY PPSELLSGHL FPSGLLNAQA
210 220 230 240 250
PAALAAHPKL FLLENAKLAG LAADKFPHPA PYPHKERLPA PLEQVLKENS
260 270 280 290 300
ALTAERGGVK GHSKLPGGSA DGKPKNFTCE VCGKVFNAHY NLTRHMPVHT
310 320 330 340 350
GARPFVCKVC GKGFRQASTL CRHKIIHTQE KPHKCNQCGK AFNRSSTLNT
360 370 380 390 400
HIRIHAGYKP FVCEFCGKGF HQKGNYKNHK LTHSGEKQYK CTICNKAFHQ
410 420 430 440 450
VYNLTFHMHT HNDKKPFTCA TCGKGFCRNF DLKKHVRKLH DSVGPAAPSA

KDLTRTVQS
Length:459
Mass (Da):48,811
Last modified:July 10, 2007 - v2
Checksum:iF1C9A512C7F0FEAF
GO
Isoform 2 (identifier: Q8TBJ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     296-304: MPVHTGARP → LRQRVLQKL
     305-459: Missing.

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):31,326
Checksum:i7ED24FA0AEDB2E13
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → L in BAA91464 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033213164P → T1 PublicationCorresponds to variant dbSNP:rs17852031Ensembl.1
Natural variantiVAR_065740188G → D in a patient with amyotrophic lateral sclerosis. 1 PublicationCorresponds to variant dbSNP:rs199850439Ensembl.1
Natural variantiVAR_033214250S → W1 PublicationCorresponds to variant dbSNP:rs17852032Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026734296 – 304MPVHTGARP → LRQRVLQKL in isoform 2. 1 Publication9
Alternative sequenceiVSP_026735305 – 459Missing in isoform 2. 1 PublicationAdd BLAST155

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA Translation: AAG50287.1
AK001004 mRNA Translation: BAA91464.1
AK290464 mRNA Translation: BAF83153.1
CH471055 Genomic DNA Translation: EAW65404.1
BC022464 mRNA Translation: AAH22464.1
CCDSiCCDS2897.1 [Q8TBJ5-1]
RefSeqiNP_060478.3, NM_018008.3 [Q8TBJ5-1]
UniGeneiHs.241523

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266 [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266 [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266 [Q8TBJ5-1]
GeneIDi55079
KEGGihsa:55079
UCSCiuc003dlh.3 human [Q8TBJ5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF332890 mRNA Translation: AAG50287.1
AK001004 mRNA Translation: BAA91464.1
AK290464 mRNA Translation: BAF83153.1
CH471055 Genomic DNA Translation: EAW65404.1
BC022464 mRNA Translation: AAH22464.1
CCDSiCCDS2897.1 [Q8TBJ5-1]
RefSeqiNP_060478.3, NM_018008.3 [Q8TBJ5-1]
UniGeneiHs.241523

3D structure databases

ProteinModelPortaliQ8TBJ5
SMRiQ8TBJ5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120394, 1 interactor
STRINGi9606.ENSP00000283268

PTM databases

iPTMnetiQ8TBJ5
PhosphoSitePlusiQ8TBJ5

Polymorphism and mutation databases

BioMutaiFEZF2
DMDMi152032462

Proteomic databases

PaxDbiQ8TBJ5
PeptideAtlasiQ8TBJ5
PRIDEiQ8TBJ5
ProteomicsDBi74020
74021 [Q8TBJ5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283268; ENSP00000283268; ENSG00000153266 [Q8TBJ5-1]
ENST00000475839; ENSP00000418804; ENSG00000153266 [Q8TBJ5-1]
ENST00000486811; ENSP00000418589; ENSG00000153266 [Q8TBJ5-1]
GeneIDi55079
KEGGihsa:55079
UCSCiuc003dlh.3 human [Q8TBJ5-1]

Organism-specific databases

CTDi55079
DisGeNETi55079
EuPathDBiHostDB:ENSG00000153266.12
GeneCardsiFEZF2
HGNCiHGNC:13506 FEZF2
MIMi607414 gene
neXtProtiNX_Q8TBJ5
OpenTargetsiENSG00000153266
PharmGKBiPA162388420
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00740000115096
HOGENOMiHOG000013052
HOVERGENiHBG098441
InParanoidiQ8TBJ5
OMAiKPQVIHQ
OrthoDBiEOG091G0ISJ
PhylomeDBiQ8TBJ5
TreeFamiTF316780

Miscellaneous databases

GenomeRNAii55079
PROiPR:Q8TBJ5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153266 Expressed in 50 organ(s), highest expression level in cerebral cortex
CleanExiHS_FEZF2
ExpressionAtlasiQ8TBJ5 baseline and differential
GenevisibleiQ8TBJ5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 6 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 6 hits
PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFEZF2_HUMAN
AccessioniPrimary (citable) accession number: Q8TBJ5
Secondary accession number(s): A8K349, Q9BZ91, Q9NWB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 10, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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