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Protein

Synaptoporin

Gene

SYNPR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intrinsic membrane protein of small synaptic vesicles. Probable vesicular channel protein (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptoporin
Gene namesi
Name:SYNPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000163630.10
HGNCiHGNC:16507 SYNPR
neXtProtiNX_Q8TBG9

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 81VesicularSequence analysisAdd BLAST56
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 114CytoplasmicSequence analysisAdd BLAST12
Transmembranei115 – 135HelicalSequence analysisAdd BLAST21
Topological domaini136 – 177VesicularSequence analysisAdd BLAST42
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 265CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi132204
OpenTargetsiENSG00000163630
PharmGKBiPA38154

Polymorphism and mutation databases

BioMutaiSYNPR
DMDMi48474879

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001791571 – 265SynaptoporinAdd BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei212PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8TBG9
PeptideAtlasiQ8TBG9
PRIDEiQ8TBG9
ProteomicsDBi74016

PTM databases

iPTMnetiQ8TBG9
PhosphoSitePlusiQ8TBG9

Expressioni

Gene expression databases

BgeeiENSG00000163630 Expressed in 94 organ(s), highest expression level in caudate nucleus
CleanExiHS_SYNPR
ExpressionAtlasiQ8TBG9 baseline and differential
GenevisibleiQ8TBG9 HS

Organism-specific databases

HPAiHPA051368
HPA061671

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FATE1Q969F03EBI-10273251,EBI-743099

Protein-protein interaction databases

BioGridi126311, 2 interactors
IntActiQ8TBG9, 11 interactors
STRINGi9606.ENSP00000418994

Structurei

3D structure databases

ProteinModelPortaliQ8TBG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 202MARVELPROSITE-ProRule annotationAdd BLAST202
Repeati210 – 21415
Repeati222 – 22625
Repeati227 – 23135
Repeati232 – 23645
Repeati238 – 24255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni210 – 2425 X approximate repeatsAdd BLAST33

Sequence similaritiesi

Belongs to the synaptophysin/synaptobrevin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDYC Eukaryota
ENOG4111J4N LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ8TBG9
OMAiCEGKRRE
OrthoDBiEOG091G0ZEI
PhylomeDBiQ8TBG9
TreeFamiTF315804

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
PS00604 SYNAPTOP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBG9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR
60 70 80 90 100
LHQVTFEVPT CEGKERQKLA LIGDSSSSAE FFVTVAVFAF LYSLAATVVY
110 120 130 140 150
IFFQNKYREN NRGPLIDFIV TVVFSFLWLV GSSAWAKGLS DVKVATDPKE
160 170 180 190 200
VLLLMSACKQ PSNKCMAIHS PVMSSLNTSV VFGFLNFILW AGNIWFVFKE
210 220 230 240 250
TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSSGYSQ QASLGPTSDE
260
FGQQPTGPTS FTNQI
Length:265
Mass (Da):29,166
Last modified:June 1, 2002 - v1
Checksum:i2A9DEC870A70F947
GO
Isoform 2 (identifier: Q8TBG9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MCMVIFAP → MDPVSQLASAGTFRVLKEPLAFLRALEL

Note: No experimental confirmation available.
Show »
Length:285
Mass (Da):31,329
Checksum:i3F251FBBAA1B5B04
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0A2C9J0A2_HUMAN
Synaptoporin
SYNPR
202Annotation score:
C9J976C9J976_HUMAN
Synaptoporin
SYNPR
201Annotation score:
F8WF23F8WF23_HUMAN
Synaptoporin
SYNPR
75Annotation score:
F8WDF9F8WDF9_HUMAN
Synaptoporin
SYNPR
55Annotation score:
B3KVD8B3KVD8_HUMAN
cDNA FLJ16439 fis, clone BRAMY20461...
SYNPR
276Annotation score:
F8WE43F8WE43_HUMAN
Synaptoporin
SYNPR
34Annotation score:
F8WDB8F8WDB8_HUMAN
Synaptoporin
SYNPR
51Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0461991 – 8MCMVIFAP → MDPVSQLASAGTFRVLKEPL AFLRALEL in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411860 mRNA Translation: AAN03681.2
AK312465 mRNA Translation: BAG35372.1
AL834457 mRNA Translation: CAD39117.1
CR936762 mRNA No translation available.
AC099056 Genomic DNA No translation available.
AC099545 Genomic DNA No translation available.
AC104436 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65413.1
CH471055 Genomic DNA Translation: EAW65414.1
BC022518 mRNA Translation: AAH22518.1
CCDSiCCDS46859.1 [Q8TBG9-2]
CCDS46860.1 [Q8TBG9-1]
RefSeqiNP_001123475.1, NM_001130003.1 [Q8TBG9-2]
NP_653243.1, NM_144642.4 [Q8TBG9-1]
UniGeneiHs.648668

Genome annotation databases

EnsembliENST00000295894; ENSP00000295894; ENSG00000163630 [Q8TBG9-1]
ENST00000478300; ENSP00000418994; ENSG00000163630 [Q8TBG9-2]
GeneIDi132204
KEGGihsa:132204
UCSCiuc003dlp.4 human [Q8TBG9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF411860 mRNA Translation: AAN03681.2
AK312465 mRNA Translation: BAG35372.1
AL834457 mRNA Translation: CAD39117.1
CR936762 mRNA No translation available.
AC099056 Genomic DNA No translation available.
AC099545 Genomic DNA No translation available.
AC104436 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65413.1
CH471055 Genomic DNA Translation: EAW65414.1
BC022518 mRNA Translation: AAH22518.1
CCDSiCCDS46859.1 [Q8TBG9-2]
CCDS46860.1 [Q8TBG9-1]
RefSeqiNP_001123475.1, NM_001130003.1 [Q8TBG9-2]
NP_653243.1, NM_144642.4 [Q8TBG9-1]
UniGeneiHs.648668

3D structure databases

ProteinModelPortaliQ8TBG9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126311, 2 interactors
IntActiQ8TBG9, 11 interactors
STRINGi9606.ENSP00000418994

PTM databases

iPTMnetiQ8TBG9
PhosphoSitePlusiQ8TBG9

Polymorphism and mutation databases

BioMutaiSYNPR
DMDMi48474879

Proteomic databases

PaxDbiQ8TBG9
PeptideAtlasiQ8TBG9
PRIDEiQ8TBG9
ProteomicsDBi74016

Protocols and materials databases

DNASUi132204
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295894; ENSP00000295894; ENSG00000163630 [Q8TBG9-1]
ENST00000478300; ENSP00000418994; ENSG00000163630 [Q8TBG9-2]
GeneIDi132204
KEGGihsa:132204
UCSCiuc003dlp.4 human [Q8TBG9-1]

Organism-specific databases

CTDi132204
DisGeNETi132204
EuPathDBiHostDB:ENSG00000163630.10
GeneCardsiSYNPR
HGNCiHGNC:16507 SYNPR
HPAiHPA051368
HPA061671
neXtProtiNX_Q8TBG9
OpenTargetsiENSG00000163630
PharmGKBiPA38154
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IDYC Eukaryota
ENOG4111J4N LUCA
GeneTreeiENSGT00390000010039
HOGENOMiHOG000252913
HOVERGENiHBG006681
InParanoidiQ8TBG9
OMAiCEGKRRE
OrthoDBiEOG091G0ZEI
PhylomeDBiQ8TBG9
TreeFamiTF315804

Miscellaneous databases

ChiTaRSiSYNPR human
GeneWikiiSYNPR
GenomeRNAii132204
PROiPR:Q8TBG9

Gene expression databases

BgeeiENSG00000163630 Expressed in 94 organ(s), highest expression level in caudate nucleus
CleanExiHS_SYNPR
ExpressionAtlasiQ8TBG9 baseline and differential
GenevisibleiQ8TBG9 HS

Family and domain databases

InterProiView protein in InterPro
IPR008253 Marvel
IPR001285 Synaptophysin/porin
PANTHERiPTHR10306 PTHR10306, 1 hit
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR00220 SYNAPTOPHYSN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit
PS00604 SYNAPTOP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYNPR_HUMAN
AccessioniPrimary (citable) accession number: Q8TBG9
Secondary accession number(s): B2R675, G5E9W4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: June 1, 2002
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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