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Protein

Zinc finger CCHC-type and RNA-binding motif-containing protein 1

Gene

ZCRB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri105 – 122CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

  • mRNA splicing, via spliceosome Source: GO_Central
  • RNA splicing Source: HGNC

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
Alternative name(s):
U11/U12 small nuclear ribonucleoprotein 31 kDa protein
Short name:
U11/U12 snRNP 31 kDa protein
Short name:
U11/U12-31K
Gene namesi
Name:ZCRB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139168.7
HGNCiHGNC:29620 ZCRB1
MIMi610750 gene
neXtProtiNX_Q8TBF4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000139168
PharmGKBiPA143485674

Polymorphism and mutation databases

BioMutaiZCRB1
DMDMi158931154

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002523731 – 217Zinc finger CCHC-type and RNA-binding motif-containing protein 1Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineCombined sources1
Modified residuei210PhosphoserineCombined sources1
Modified residuei216PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8TBF4
MaxQBiQ8TBF4
PaxDbiQ8TBF4
PeptideAtlasiQ8TBF4
PRIDEiQ8TBF4
ProteomicsDBi74010

PTM databases

iPTMnetiQ8TBF4
PhosphoSitePlusiQ8TBF4

Expressioni

Inductioni

Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius.1 Publication

Gene expression databases

BgeeiENSG00000139168 Expressed in 207 organ(s), highest expression level in oocyte
CleanExiHS_ZCRB1
ExpressionAtlasiQ8TBF4 baseline and differential
GenevisibleiQ8TBF4 HS

Interactioni

Subunit structurei

Component of the U11/U12 snRNPs that are part of the U12-type spliceosome.1 Publication

Protein-protein interaction databases

BioGridi124524, 71 interactors
CORUMiQ8TBF4
IntActiQ8TBF4, 1 interactor
STRINGi9606.ENSP00000266529

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ8TBF4
SMRiQ8TBF4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8TBF4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 88RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 141Poly-Lys10

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri105 – 122CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IQXP Eukaryota
ENOG4111IY7 LUCA
GeneTreeiENSGT00730000111061
HOGENOMiHOG000007632
HOVERGENiHBG107480
InParanoidiQ8TBF4
KOiK13154
OMAiAHNCARA
OrthoDBiEOG091G0NFT
PhylomeDBiQ8TBF4
TreeFamiTF106263

Family and domain databases

CDDicd12393 RRM_ZCRB1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034219 ZCRB1_RRM
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50158 ZF_CCHC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q8TBF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGGLAPSKS TVYVSNLPFS LTNNDLYRIF SKYGKVVKVT IMKDKDTRKS
60 70 80 90 100
KGVAFILFLD KDSAQNCTRA INNKQLFGRV IKASIAIDNG RAAEFIRRRN
110 120 130 140 150
YFDKSKCYEC GESGHLSYAC PKNMLGEREP PKKKEKKKKK KAPEPEEEIE
160 170 180 190 200
EVEESEDEGE DPALDSLSQA IAFQQAKIEE EQKKWKPSSG VPSTSDDSRR
210
PRIKKSTYFS DEEELSD
Length:217
Mass (Da):24,592
Last modified:October 2, 2007 - v2
Checksum:iCC0C2BB6D2E42444
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1V1G3V1V1_HUMAN
Zinc finger CCHC-type and RNA bindi...
ZCRB1 hCG_1818570
176Annotation score:
F8VXY6F8VXY6_HUMAN
Zinc finger CCHC-type and RNA-bindi...
ZCRB1
133Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027845131P → Q1 PublicationCorresponds to variant dbSNP:rs17852093Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062361 mRNA Translation: BAB56132.1
CH471111 Genomic DNA Translation: EAW57842.1
BC010177 mRNA Translation: AAH10177.1
BC022543 mRNA Translation: AAH22543.1
BK005200 mRNA Translation: DAA05498.1
CCDSiCCDS8740.1
RefSeqiNP_149105.3, NM_033114.3
UniGeneiHs.496279

Genome annotation databases

EnsembliENST00000266529; ENSP00000266529; ENSG00000139168
GeneIDi85437
KEGGihsa:85437
UCSCiuc001rmz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB062361 mRNA Translation: BAB56132.1
CH471111 Genomic DNA Translation: EAW57842.1
BC010177 mRNA Translation: AAH10177.1
BC022543 mRNA Translation: AAH22543.1
BK005200 mRNA Translation: DAA05498.1
CCDSiCCDS8740.1
RefSeqiNP_149105.3, NM_033114.3
UniGeneiHs.496279

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E5HNMR-A1-87[»]
ProteinModelPortaliQ8TBF4
SMRiQ8TBF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124524, 71 interactors
CORUMiQ8TBF4
IntActiQ8TBF4, 1 interactor
STRINGi9606.ENSP00000266529

PTM databases

iPTMnetiQ8TBF4
PhosphoSitePlusiQ8TBF4

Polymorphism and mutation databases

BioMutaiZCRB1
DMDMi158931154

Proteomic databases

EPDiQ8TBF4
MaxQBiQ8TBF4
PaxDbiQ8TBF4
PeptideAtlasiQ8TBF4
PRIDEiQ8TBF4
ProteomicsDBi74010

Protocols and materials databases

DNASUi85437
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266529; ENSP00000266529; ENSG00000139168
GeneIDi85437
KEGGihsa:85437
UCSCiuc001rmz.4 human

Organism-specific databases

CTDi85437
EuPathDBiHostDB:ENSG00000139168.7
GeneCardsiZCRB1
HGNCiHGNC:29620 ZCRB1
MIMi610750 gene
neXtProtiNX_Q8TBF4
OpenTargetsiENSG00000139168
PharmGKBiPA143485674
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQXP Eukaryota
ENOG4111IY7 LUCA
GeneTreeiENSGT00730000111061
HOGENOMiHOG000007632
HOVERGENiHBG107480
InParanoidiQ8TBF4
KOiK13154
OMAiAHNCARA
OrthoDBiEOG091G0NFT
PhylomeDBiQ8TBF4
TreeFamiTF106263

Enzyme and pathway databases

ReactomeiR-HSA-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

ChiTaRSiZCRB1 human
EvolutionaryTraceiQ8TBF4
GenomeRNAii85437
PROiPR:Q8TBF4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139168 Expressed in 207 organ(s), highest expression level in oocyte
CleanExiHS_ZCRB1
ExpressionAtlasiQ8TBF4 baseline and differential
GenevisibleiQ8TBF4 HS

Family and domain databases

CDDicd12393 RRM_ZCRB1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR003954 RRM_dom_euk
IPR034219 ZCRB1_RRM
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00098 zf-CCHC, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00361 RRM_1, 1 hit
SM00343 ZnF_C2HC, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiZCRB1_HUMAN
AccessioniPrimary (citable) accession number: Q8TBF4
Secondary accession number(s): Q6PJX0, Q96TA6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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