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Protein

N-acylneuraminate-9-phosphatase

Gene

NANP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by vanadate and calcium.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.09 mM for N-acetylneuraminate 9-P1 Publication
  2. KM=19.2 mM for fructose 1,6-P21 Publication
  3. KM=2.7 mM for 6-P-gluconate1 Publication
  4. KM=5.9 mM for N-acetylglucosamine 6-P1 Publication
  1. Vmax=112 µmol/min/mg enzyme with N-acetylneuraminate 9-P as substrate1 Publication
  2. Vmax=6.10 µmol/min/mg enzyme with fructose 1,6-P2 as substrate1 Publication
  3. Vmax=2.79 µmol/min/mg enzyme with 6-P-gluconate as substrate1 Publication
  4. Vmax=2.46 µmol/min/mg enzyme with N-acetylglucosamine 6-P as substrate1 Publication
  5. Vmax=0.149 µmol/min/mg enzyme with sorbitol 6-P as substrate1 Publication
  6. Vmax=0.140 µmol/min/mg enzyme with 3-P glycerate as substrate1 Publication
  7. Vmax=0.095 µmol/min/mg enzyme with P-serine as substrate1 Publication
  8. Vmax=0.094 µmol/min/mg enzyme with glycerol 3-P as substrate1 Publication
  9. Vmax=0.090 µmol/min/mg enzyme with ribulose 5-P as substrate1 Publication
  10. Vmax=0.072 µmol/min/mg enzyme with N-acetylmannosamine 6-P as substrate1 Publication
  11. Vmax=0.063 µmol/min/mg enzyme with arabinose 6-P as substrate1 Publication
  12. Vmax=0.042 µmol/min/mg enzyme with ribose 6-P as substrate1 Publication
  13. Vmax=0.023 µmol/min/mg enzyme with glucosamine 6-P as substrate1 Publication
  14. Vmax=0.019 µmol/min/mg enzyme with phosphoglycolate as substrate1 Publication
  15. Vmax=0.019 µmol/min/mg enzyme with fructose 6-P as substrate1 Publication
  16. Vmax=0.017 µmol/min/mg enzyme with glycerol 2-P as substrate1 Publication
  17. Vmax=0.016 µmol/min/mg enzyme with glucose 6-P as substrate1 Publication
  18. Vmax=0.015 µmol/min/mg enzyme with mannose 6-P as substrate1 Publication
  19. Vmax=0.004 µmol/min/mg enzyme with glucose 1-P as substrate1 Publication
  20. Vmax=0.002 µmol/min/mg enzyme with P-enolpyruvate as substrate1 Publication
  21. Vmax=0.001 µmol/min/mg enzyme with ATP as substrate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: N-acetylneuraminate biosynthesis

This protein is involved in the pathway N-acetylneuraminate biosynthesis, which is part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate biosynthesis and in Amino-sugar metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei164Substrate1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • N-acylneuraminate-9-phosphatase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism
LigandMagnesium

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS10082-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-4085001 Sialic acid metabolism

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q8TBE9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00630

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
N-acylneuraminate-9-phosphatase (EC:3.1.3.29)
Alternative name(s):
Haloacid dehalogenase-like hydrolase domain-containing protein 4
Neu5Ac-9-Pase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NANP
Synonyms:C20orf147, HDHD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000170191.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16140 NANP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610763 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TBE9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
140838

Open Targets

More...
OpenTargetsi
ENSG00000170191

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25689

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2401602

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NANP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30315932

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839381 – 248N-acylneuraminate-9-phosphataseAdd BLAST248

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TBE9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TBE9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TBE9

PeptideAtlas

More...
PeptideAtlasi
Q8TBE9

PRoteomics IDEntifications database

More...
PRIDEi
Q8TBE9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
74002

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
Q8TBE9

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TBE9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TBE9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000170191 Expressed in 179 organ(s), highest expression level in material anatomical entity

CleanEx database of gene expression profiles

More...
CleanExi
HS_NANP

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TBE9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050342

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126729, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TBE9, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302441

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q8TBE9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TBE9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TBE9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q8TBE9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 14Substrate binding3
Regioni131 – 132Substrate binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3085 Eukaryota
COG1011 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000248345

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051895

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TBE9

KEGG Orthology (KO)

More...
KOi
K01097

Identification of Orthologs from Complete Genome Data

More...
OMAi
PQETHDT

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0G6E

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TBE9

TreeFam database of animal gene trees

More...
TreeFami
TF324589

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1000, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011950 HAD-SF_hydro_IA_CTE7
IPR023214 HAD_sf

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00413 HADHALOGNASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02253 CTE7, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TBE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSRVRAVF FDLDNTLIDT AGASRRGMLE VIKLLQSKYH YKEEAEIICD
60 70 80 90 100
KVQVKLSKEC FHPYNTCITD LRTSHWEEAI QETKGGAANR KLAEECYFLW
110 120 130 140 150
KSTRLQHMTL AEDVKAMLTE LRKEVRLLLL TNGDRQTQRE KIEACACQSY
160 170 180 190 200
FDAVVVGGEQ REEKPAPSIF YYCCNLLGVQ PGDCVMVGDT LETDIQGGLN
210 220 230 240
AGLKATVWIN KNGIVPLKSS PVPHYMVSSV LELPALLQSI DCKVSMST
Length:248
Mass (Da):27,813
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i360E6D7AB965294B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85055 differs from that shown. It seems to be derived from genomic DNA and not from cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti32 – 55IKLLQ…KVQVK → TSPPMALLWAGSVRPAPSCT LTSP in BAB85055 (PubMed:14702039).CuratedAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055472 mRNA Translation: BAG51524.1
AK074335 mRNA Translation: BAB85055.1 Sequence problems.
AL031673 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10081.1
BC022552 mRNA Translation: AAH22552.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13173.1

NCBI Reference Sequences

More...
RefSeqi
NP_689880.1, NM_152667.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.143137
Hs.606268

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000304788; ENSP00000302441; ENSG00000170191

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140838

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:140838

UCSC genome browser

More...
UCSCi
uc002wuy.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055472 mRNA Translation: BAG51524.1
AK074335 mRNA Translation: BAB85055.1 Sequence problems.
AL031673 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10081.1
BC022552 mRNA Translation: AAH22552.1
CCDSiCCDS13173.1
RefSeqiNP_689880.1, NM_152667.2
UniGeneiHs.143137
Hs.606268

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2W4MX-ray2.60A1-248[»]
4KNVX-ray1.99A/B7-242[»]
4KNWX-ray2.70A/B/C2-248[»]
ProteinModelPortaliQ8TBE9
SMRiQ8TBE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126729, 10 interactors
IntActiQ8TBE9, 7 interactors
STRINGi9606.ENSP00000302441

Chemistry databases

BindingDBiQ8TBE9
ChEMBLiCHEMBL2401602

PTM databases

DEPODiQ8TBE9
iPTMnetiQ8TBE9
PhosphoSitePlusiQ8TBE9

Polymorphism and mutation databases

BioMutaiNANP
DMDMi30315932

Proteomic databases

EPDiQ8TBE9
MaxQBiQ8TBE9
PaxDbiQ8TBE9
PeptideAtlasiQ8TBE9
PRIDEiQ8TBE9
ProteomicsDBi74002

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
140838
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304788; ENSP00000302441; ENSG00000170191
GeneIDi140838
KEGGihsa:140838
UCSCiuc002wuy.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140838
DisGeNETi140838
EuPathDBiHostDB:ENSG00000170191.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NANP
HGNCiHGNC:16140 NANP
HPAiHPA050342
MIMi610763 gene
neXtProtiNX_Q8TBE9
OpenTargetsiENSG00000170191
PharmGKBiPA25689

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3085 Eukaryota
COG1011 LUCA
GeneTreeiENSGT00390000003094
HOGENOMiHOG000248345
HOVERGENiHBG051895
InParanoidiQ8TBE9
KOiK01097
OMAiPQETHDT
OrthoDBiEOG091G0G6E
PhylomeDBiQ8TBE9
TreeFamiTF324589

Enzyme and pathway databases

UniPathwayi
UPA00630

BioCyciMetaCyc:HS10082-MONOMER
ReactomeiR-HSA-4085001 Sialic acid metabolism
SABIO-RKiQ8TBE9

Miscellaneous databases

EvolutionaryTraceiQ8TBE9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
140838

Protein Ontology

More...
PROi
PR:Q8TBE9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000170191 Expressed in 179 organ(s), highest expression level in material anatomical entity
CleanExiHS_NANP
GenevisibleiQ8TBE9 HS

Family and domain databases

Gene3Di3.40.50.1000, 1 hit
InterProiView protein in InterPro
IPR036412 HAD-like_sf
IPR006439 HAD-SF_hydro_IA
IPR011950 HAD-SF_hydro_IA_CTE7
IPR023214 HAD_sf
PRINTSiPR00413 HADHALOGNASE
SUPFAMiSSF56784 SSF56784, 1 hit
TIGRFAMsiTIGR02253 CTE7, 1 hit
TIGR01549 HAD-SF-IA-v1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNANP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBE9
Secondary accession number(s): B3KP12
, Q5JYN8, Q8TE97, Q9Y3N0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: June 1, 2002
Last modified: December 5, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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