UniProtKB - Q8TBC4 (UBA3_HUMAN)
NEDD8-activating enzyme E1 catalytic subunit
UBA3
Functioni
Miscellaneous
Catalytic activityi
- ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.1 Publication EC:6.2.1.64
Activity regulationi
: protein neddylation Pathwayi
This protein is involved in the pathway protein neddylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein neddylation and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 211 | Determines specificity for NEDD8 | 1 | |
Active sitei | 237 | Glycyl thioester intermediate | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 100 – 124 | ATP1 PublicationAdd BLAST | 25 | |
Nucleotide bindingi | 148 – 171 | ATP1 PublicationAdd BLAST | 24 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- identical protein binding Source: IntAct
- NEDD8 activating enzyme activity Source: MGI
- nuclear receptor binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
GO - Biological processi
- cellular protein modification process Source: ProtInc
- endomitotic cell cycle Source: Ensembl
- negative regulation of transcription, DNA-templated Source: Ensembl
- post-translational protein modification Source: Reactome
- protein modification by small protein conjugation Source: GO_Central
- protein neddylation Source: UniProtKB
- proteolysis Source: ProtInc
- regulation of cell cycle Source: Ensembl
Keywordsi
Molecular function | Ligase |
Biological process | Cell cycle, Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS07200-MONOMER |
BRENDAi | 2.3.2.B5, 2681 6.2.1.B9, 2681 |
PathwayCommonsi | Q8TBC4 |
Reactomei | R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q8TBC4 |
UniPathwayi | UPA00885 |
Protein family/group databases
MoonDBi | Q8TBC4, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: NEDD8-activating enzyme E1 catalytic subunit (EC:6.2.1.641 Publication)Alternative name(s): NEDD8-activating enzyme E1C Ubiquitin-activating enzyme E1C Ubiquitin-like modifier-activating enzyme 3 Short name: Ubiquitin-activating enzyme 3 |
Gene namesi | Name:UBA3 Synonyms:UBE1C |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12470, UBA3 |
MIMi | 603172, gene |
neXtProti | NX_Q8TBC4 |
VEuPathDBi | HostDB:ENSG00000144744.16 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: LIFEdb
Other locations
- cytoplasm Source: GO_Central
- protein-containing complex Source: UniProtKB
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 65 | F → G: Reduces affinity for UBE2M. 1 Publication | 1 | |
Mutagenesisi | 148 | I → A: No effect on NEDD8 adenylation. 1 Publication | 1 | |
Mutagenesisi | 160 – 161 | HI → AA: Reduces affinity for UBE2M. 1 Publication | 2 | |
Mutagenesisi | 167 | D → A: Abolishes NEDD8 adenylation. 1 Publication | 1 | |
Mutagenesisi | 192 | P → A: Reduces affinity for UBE2M; when associated with A-195 and A-197. 1 Publication | 1 | |
Mutagenesisi | 195 | I → A: Reduces affinity for UBE2M; when associated with A-192 and A-197. 1 Publication | 1 | |
Mutagenesisi | 197 | P → A: Reduces affinity for UBE2M; when associated with A-192 and A-195. 1 Publication | 1 | |
Mutagenesisi | 211 | R → Q: Abolishes specificity for NEDD8. 1 Publication | 1 | |
Mutagenesisi | 214 | L → A: Reduces affinity for UBE2M; when associated with A-217. 1 Publication | 1 | |
Mutagenesisi | 217 | M → A: Reduces affinity for UBE2M; when associated with A-214. 1 Publication | 1 | |
Mutagenesisi | 227 – 228 | LY → DD: Strongly reduces NEDD8 adenylation. 1 Publication | 2 | |
Mutagenesisi | 237 | C → S: Abolishes thioester intermediate formation. 1 Publication | 1 | |
Mutagenesisi | 238 | T → A: No effect on NEDD8 adenylation; impairs thioester intermediate formation. 1 Publication | 1 | |
Mutagenesisi | 310 | I → A: No effect on NEDD8 adenylation or thioester intermediate formation; impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 331 | I → A: Reduces affinity for UBE2M. 1 Publication | 1 | |
Mutagenesisi | 352 – 357 | YTYTFE → ATATA: Abolishes NEDD8 adenylation. 1 Publication | 6 | |
Mutagenesisi | 368 | S → P: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 369 | Q → P: No effect on NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 370 | L → P: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 412 | T → A: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 415 | L → A: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 418 | V → A: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 421 | I → A: Impairs NEDD8 transfer to UBE2M. 1 Publication | 1 | |
Mutagenesisi | 424 | R → A: No effect on NEDD8 transfer to UBE2M. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 9039 |
OpenTargetsi | ENSG00000144744 |
PharmGKBi | PA162407622 |
Miscellaneous databases
Pharosi | Q8TBC4, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2016430 |
Genetic variation databases
BioMutai | UBA3 |
DMDMi | 83305811 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000194941 | 2 – 463 | NEDD8-activating enzyme E1 catalytic subunitAdd BLAST | 462 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q8TBC4 |
jPOSTi | Q8TBC4 |
MassIVEi | Q8TBC4 |
MaxQBi | Q8TBC4 |
PaxDbi | Q8TBC4 |
PeptideAtlasi | Q8TBC4 |
PRIDEi | Q8TBC4 |
ProteomicsDBi | 73991 [Q8TBC4-1] 73992 [Q8TBC4-2] |
PTM databases
iPTMneti | Q8TBC4 |
MetOSitei | Q8TBC4 |
PhosphoSitePlusi | Q8TBC4 |
SwissPalmi | Q8TBC4 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000144744, Expressed in substantia nigra and 248 other tissues |
ExpressionAtlasi | Q8TBC4, baseline and differential |
Genevisiblei | Q8TBC4, HS |
Organism-specific databases
HPAi | ENSG00000144744, Low tissue specificity |
Interactioni
Subunit structurei
Heterodimer of UBA3 and NAE1.
Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand (By similarity).
Interacts with TBATA (By similarity).
By similarityBinary interactionsi
Hide detailsQ8TBC4
GO - Molecular functioni
- identical protein binding Source: IntAct
- nuclear receptor binding Source: Ensembl
- protein heterodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 114503, 55 interactors |
CORUMi | Q8TBC4 |
IntActi | Q8TBC4, 22 interactors |
MINTi | Q8TBC4 |
STRINGi | 9606.ENSP00000354340 |
Chemistry databases
BindingDBi | Q8TBC4 |
Miscellaneous databases
RNActi | Q8TBC4, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q8TBC4 |
SMRi | Q8TBC4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q8TBC4 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 53 – 70 | Interaction with UBE2M N-terminusAdd BLAST | 18 | |
Regioni | 157 – 161 | Interaction with UBE2M N-terminus | 5 | |
Regioni | 192 – 217 | Interaction with UBE2M N-terminusAdd BLAST | 26 | |
Regioni | 227 – 229 | Interaction with NEDD8 | 3 | |
Regioni | 242 – 248 | Interaction with NAE11 Publication | 7 | |
Regioni | 292 – 295 | Interaction with NAE11 Publication | 4 | |
Regioni | 331 – 338 | Interaction with UBE2M N-terminus | 8 | |
Regioni | 352 – 357 | Interaction with NEDD8 | 6 | |
Regioni | 368 – 463 | Interaction with UBE2M core domainAdd BLAST | 96 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2015, Eukaryota |
GeneTreei | ENSGT00550000074831 |
HOGENOMi | CLU_013325_13_1_1 |
InParanoidi | Q8TBC4 |
OMAi | YYMQFKI |
OrthoDBi | 686413at2759 |
PhylomeDBi | Q8TBC4 |
TreeFami | TF300499 |
Family and domain databases
DisProti | DP02306 |
Gene3Di | 1.10.10.520, 1 hit |
InterProi | View protein in InterPro IPR014929, E2-binding IPR000594, ThiF_NAD_FAD-bd IPR023318, Ub_act_enz_dom_a_sf IPR030468, Uba3 IPR035985, Ubiquitin-activating_enz IPR033127, UBQ-activ_enz_E1_Cys_AS |
PANTHERi | PTHR10953:SF6, PTHR10953:SF6, 1 hit |
Pfami | View protein in Pfam PF08825, E2_bind, 1 hit PF00899, ThiF, 1 hit |
SMARTi | View protein in SMART SM01181, E2_bind, 1 hit |
SUPFAMi | SSF69572, SSF69572, 1 hit |
PROSITEi | View protein in PROSITE PS00865, UBIQUITIN_ACTIVAT_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADGEEPEKK RRRIEELLAE KMAVDGGCGD TGDWEGRWNH VKKFLERSGP
60 70 80 90 100
FTHPDFEPST ESLQFLLDTC KVLVIGAGGL GCELLKNLAL SGFRQIHVID
110 120 130 140 150
MDTIDVSNLN RQFLFRPKDI GRPKAEVAAE FLNDRVPNCN VVPHFNKIQD
160 170 180 190 200
FNDTFYRQFH IIVCGLDSII ARRWINGMLI SLLNYEDGVL DPSSIVPLID
210 220 230 240 250
GGTEGFKGNA RVILPGMTAC IECTLELYPP QVNFPMCTIA SMPRLPEHCI
260 270 280 290 300
EYVRMLQWPK EQPFGEGVPL DGDDPEHIQW IFQKSLERAS QYNIRGVTYR
310 320 330 340 350
LTQGVVKRII PAVASTNAVI AAVCATEVFK IATSAYIPLN NYLVFNDVDG
360 370 380 390 400
LYTYTFEAER KENCPACSQL PQNIQFSPSA KLQEVLDYLT NSASLQMKSP
410 420 430 440 450
AITATLEGKN RTLYLQSVTS IEERTRPNLS KTLKELGLVD GQELAVADVT
460
TPQTVLFKLH FTS
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W8D4 | F8W8D4_HUMAN | NEDD8-activating enzyme E1 catalyti... | UBA3 | 422 | Annotation score: | ||
F8WF86 | F8WF86_HUMAN | NEDD8-activating enzyme E1 catalyti... | UBA3 | 129 | Annotation score: | ||
F8WAT6 | F8WAT6_HUMAN | NEDD8-activating enzyme E1 catalyti... | UBA3 | 64 | Annotation score: | ||
A0A0D9SF81 | A0A0D9SF81_HUMAN | NEDD8-activating enzyme E1 catalyti... | UBA3 | 41 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 146 | N → Y in CAB55996 (PubMed:11230166).Curated | 1 | |
Sequence conflicti | 271 | D → G in CAB55996 (PubMed:11230166).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023945 | 9 | K → R2 PublicationsCorresponds to variant dbSNP:rs17852113Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041127 | 8 – 21 | Missing in isoform 2. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117566 mRNA Translation: CAB55996.2 AK002159 mRNA Translation: BAG51021.1 AK289392 mRNA Translation: BAF82081.1 AC092060 Genomic DNA No translation available. AC109587 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65470.1 BC022853 mRNA Translation: AAH22853.1 AF046024 mRNA Translation: AAC27648.1 Different initiation. AB012190 mRNA Translation: BAA33144.1 |
CCDSi | CCDS2909.1 [Q8TBC4-1] CCDS2910.1 [Q8TBC4-2] |
PIRi | T17306 |
RefSeqi | NP_003959.3, NM_003968.3 [Q8TBC4-1] NP_937838.1, NM_198195.1 [Q8TBC4-2] |
Genome annotation databases
Ensembli | ENST00000349511; ENSP00000340041; ENSG00000144744 [Q8TBC4-2] ENST00000361055; ENSP00000354340; ENSG00000144744 [Q8TBC4-1] |
GeneIDi | 9039 |
KEGGi | hsa:9039 |
UCSCi | uc003dno.4, human [Q8TBC4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117566 mRNA Translation: CAB55996.2 AK002159 mRNA Translation: BAG51021.1 AK289392 mRNA Translation: BAF82081.1 AC092060 Genomic DNA No translation available. AC109587 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65470.1 BC022853 mRNA Translation: AAH22853.1 AF046024 mRNA Translation: AAC27648.1 Different initiation. AB012190 mRNA Translation: BAA33144.1 |
CCDSi | CCDS2909.1 [Q8TBC4-1] CCDS2910.1 [Q8TBC4-2] |
PIRi | T17306 |
RefSeqi | NP_003959.3, NM_003968.3 [Q8TBC4-1] NP_937838.1, NM_198195.1 [Q8TBC4-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1R4M | X-ray | 3.00 | B/D/F/H | 33-463 | [»] | |
1R4N | X-ray | 3.60 | B/D/F/H | 33-463 | [»] | |
1TT5 | X-ray | 2.60 | B/D | 33-463 | [»] | |
1Y8X | X-ray | 2.40 | B | 368-463 | [»] | |
1YOV | X-ray | 2.60 | B/D | 22-463 | [»] | |
2LQ7 | NMR | - | A | 369-463 | [»] | |
2NVU | X-ray | 2.80 | B | 33-463 | [»] | |
3DBH | X-ray | 2.85 | B/D/F/H | 33-463 | [»] | |
3DBL | X-ray | 2.90 | B/D/F/H | 33-463 | [»] | |
3DBR | X-ray | 3.05 | B/D/F/H | 33-463 | [»] | |
3FN1 | X-ray | 2.50 | A | 368-463 | [»] | |
3GZN | X-ray | 3.00 | B/D | 1-463 | [»] | |
5JJM | X-ray | 2.15 | G/H/I/J | 62-69 | [»] | |
BMRBi | Q8TBC4 | |||||
SMRi | Q8TBC4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114503, 55 interactors |
CORUMi | Q8TBC4 |
IntActi | Q8TBC4, 22 interactors |
MINTi | Q8TBC4 |
STRINGi | 9606.ENSP00000354340 |
Chemistry databases
BindingDBi | Q8TBC4 |
ChEMBLi | CHEMBL2016430 |
Protein family/group databases
MoonDBi | Q8TBC4, Predicted |
PTM databases
iPTMneti | Q8TBC4 |
MetOSitei | Q8TBC4 |
PhosphoSitePlusi | Q8TBC4 |
SwissPalmi | Q8TBC4 |
Genetic variation databases
BioMutai | UBA3 |
DMDMi | 83305811 |
Proteomic databases
EPDi | Q8TBC4 |
jPOSTi | Q8TBC4 |
MassIVEi | Q8TBC4 |
MaxQBi | Q8TBC4 |
PaxDbi | Q8TBC4 |
PeptideAtlasi | Q8TBC4 |
PRIDEi | Q8TBC4 |
ProteomicsDBi | 73991 [Q8TBC4-1] 73992 [Q8TBC4-2] |
Protocols and materials databases
Antibodypediai | 31863, 172 antibodies |
DNASUi | 9039 |
Genome annotation databases
Ensembli | ENST00000349511; ENSP00000340041; ENSG00000144744 [Q8TBC4-2] ENST00000361055; ENSP00000354340; ENSG00000144744 [Q8TBC4-1] |
GeneIDi | 9039 |
KEGGi | hsa:9039 |
UCSCi | uc003dno.4, human [Q8TBC4-1] |
Organism-specific databases
CTDi | 9039 |
DisGeNETi | 9039 |
GeneCardsi | UBA3 |
HGNCi | HGNC:12470, UBA3 |
HPAi | ENSG00000144744, Low tissue specificity |
MIMi | 603172, gene |
neXtProti | NX_Q8TBC4 |
OpenTargetsi | ENSG00000144744 |
PharmGKBi | PA162407622 |
VEuPathDBi | HostDB:ENSG00000144744.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2015, Eukaryota |
GeneTreei | ENSGT00550000074831 |
HOGENOMi | CLU_013325_13_1_1 |
InParanoidi | Q8TBC4 |
OMAi | YYMQFKI |
OrthoDBi | 686413at2759 |
PhylomeDBi | Q8TBC4 |
TreeFami | TF300499 |
Enzyme and pathway databases
UniPathwayi | UPA00885 |
BioCyci | MetaCyc:HS07200-MONOMER |
BRENDAi | 2.3.2.B5, 2681 6.2.1.B9, 2681 |
PathwayCommonsi | Q8TBC4 |
Reactomei | R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-8951664, Neddylation R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q8TBC4 |
Miscellaneous databases
BioGRID-ORCSi | 9039, 557 hits in 1014 CRISPR screens |
ChiTaRSi | UBA3, human |
EvolutionaryTracei | Q8TBC4 |
GeneWikii | UBE1C |
GenomeRNAii | 9039 |
Pharosi | Q8TBC4, Tbio |
PROi | PR:Q8TBC4 |
RNActi | Q8TBC4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000144744, Expressed in substantia nigra and 248 other tissues |
ExpressionAtlasi | Q8TBC4, baseline and differential |
Genevisiblei | Q8TBC4, HS |
Family and domain databases
DisProti | DP02306 |
Gene3Di | 1.10.10.520, 1 hit |
InterProi | View protein in InterPro IPR014929, E2-binding IPR000594, ThiF_NAD_FAD-bd IPR023318, Ub_act_enz_dom_a_sf IPR030468, Uba3 IPR035985, Ubiquitin-activating_enz IPR033127, UBQ-activ_enz_E1_Cys_AS |
PANTHERi | PTHR10953:SF6, PTHR10953:SF6, 1 hit |
Pfami | View protein in Pfam PF08825, E2_bind, 1 hit PF00899, ThiF, 1 hit |
SMARTi | View protein in SMART SM01181, E2_bind, 1 hit |
SUPFAMi | SSF69572, SSF69572, 1 hit |
PROSITEi | View protein in PROSITE PS00865, UBIQUITIN_ACTIVAT_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBA3_HUMAN | |
Accessioni | Q8TBC4Primary (citable) accession number: Q8TBC4 Secondary accession number(s): A6NLB5 Q9NTU3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | December 6, 2005 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families