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Protein

Probable cationic amino acid transporter

Gene

SLC7A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in arginine transport.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • amino acid transport Source: UniProtKB-KW
  • negative regulation of phosphatase activity Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.3.3.7 the amino acid-polyamine-organocation (apc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cationic amino acid transporter
Alternative name(s):
Solute carrier family 7 member 14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC7A14
Synonyms:KIAA1613
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000013293.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29326 SLC7A14

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615720 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TBB6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei119 – 141HelicalSequence analysisAdd BLAST23
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei216 – 236HelicalSequence analysisAdd BLAST21
Transmembranei251 – 271HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei384 – 404HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei565 – 585HelicalSequence analysisAdd BLAST21
Transmembranei596 – 616HelicalSequence analysisAdd BLAST21
Transmembranei628 – 648HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Retinitis pigmentosa 68 (RP68)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
See also OMIM:615725
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_071050132A → V in RP68. 1 PublicationCorresponds to variant dbSNP:rs587777273EnsemblClinVar.1
Natural variantiVAR_071051209N → S in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs765054383Ensembl.1
Natural variantiVAR_071052323M → I in RP68; uncertain pathological significance. 1 Publication1
Natural variantiVAR_035417330G → R in RP68; affects subcellular location. 1 PublicationCorresponds to variant dbSNP:rs2276717EnsemblClinVar.1
Natural variantiVAR_071053391S → L in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375705180Ensembl.1
Natural variantiVAR_071054464C → F in RP68. 1 PublicationCorresponds to variant dbSNP:rs79668755EnsemblClinVar.1
Natural variantiVAR_071055695R → C in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs181011740Ensembl.1
Natural variantiVAR_071056708F → V in RP68. 1 PublicationCorresponds to variant dbSNP:rs587777272EnsemblClinVar.1

Keywords - Diseasei

Retinitis pigmentosa

Organism-specific databases

DisGeNET

More...
DisGeNETi
57709

MalaCards human disease database

More...
MalaCardsi
SLC7A14
MIMi615725 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000013293

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
791 Retinitis pigmentosa

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142670913

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC7A14

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452968

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003073601 – 771Probable cationic amino acid transporterAdd BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei465PhosphoserineBy similarity1
Modified residuei468PhosphoserineBy similarity1
Modified residuei488PhosphoserineBy similarity1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei757PhosphoserineBy similarity1
Modified residuei769PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TBB6

PeptideAtlas

More...
PeptideAtlasi
Q8TBB6

PRoteomics IDEntifications database

More...
PRIDEi
Q8TBB6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
73987

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TBB6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TBB6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in skin fibroblasts.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000013293 Expressed in 99 organ(s), highest expression level in cerebellar vermis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SLC7A14

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q8TBB6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045929

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121733, 27 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TBB6, 38 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000231706

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q8TBB6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TBB6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1286 Eukaryota
COG0531 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155893

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000250623

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000280

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TBB6

KEGG Orthology (KO)

More...
KOi
K13871

Identification of Orthologs from Complete Genome Data

More...
OMAi
TISRWMV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G05NM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TBB6

TreeFam database of animal gene trees

More...
TreeFami
TF315212

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q8TBB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGFFTSLDP RRVQWGAAWY AMHSRILRTK PVESMLEGTG TTTAHGTKLA
60 70 80 90 100
QVLTTVDLIS LGVGSCVGTG MYVVSGLVAK EMAGPGVIVS FIIAAVASIL
110 120 130 140 150
SGVCYAEFGV RVPKTTGSAY TYSYVTVGEF VAFFIGWNLI LEYLIGTAAG
160 170 180 190 200
ASALSSMFDS LANHTISRWM ADSVGTLNGL GKGEESYPDL LALLIAVIVT
210 220 230 240 250
IIVALGVKNS IGFNNVLNVL NLAVWVFIMI AGLFFINGKY WAEGQFLPHG
260 270 280 290 300
WSGVLQGAAT CFYAFIGFDI IATTGEEAKN PNTSIPYAIT ASLVICLTAY
310 320 330 340 350
VSVSVILTLM VPYYTIDTES PLMEMFVAHG FYAAKFVVAI GSVAGLTVSL
360 370 380 390 400
LGSLFPMPRV IYAMAGDGLL FRFLAHVSSY TETPVVACIV SGFLAALLAL
410 420 430 440 450
LVSLRDLIEM MSIGTLLAYT LVSVCVLLLR YQPESDIDGF VKFLSEEHTK
460 470 480 490 500
KKEGILADCE KEACSPVSEG DEFSGPATNT CGAKNLPSLG DNEMLIGKSD
510 520 530 540 550
KSTYNVNHPN YGTVDMTTGI EADESENIYL IKLKKLIGPH YYTMRIRLGL
560 570 580 590 600
PGKMDRPTAA TGHTVTICVL LLFILMFIFC SFIIFGSDYI SEQSWWAILL
610 620 630 640 650
VVLMVLLIST LVFVILQQPE NPKKLPYMAP CLPFVPAFAM LVNIYLMLKL
660 670 680 690 700
STITWIRFAV WCFVGLLIYF GYGIWNSTLE ISAREEALHQ STYQRYDVDD
710 720 730 740 750
PFSVEEGFSY ATEGESQEDW GGPTEDKGFY YQQMSDAKAN GRTSSKAKSK
760 770
SKHKQNSEAL IANDELDYSP E
Length:771
Mass (Da):84,052
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55F490AE219B3342
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13439 differs from that shown. Reason: Erroneous termination at position 765. Translated as Glu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498K → R in BAG53645 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_071050132A → V in RP68. 1 PublicationCorresponds to variant dbSNP:rs587777273EnsemblClinVar.1
Natural variantiVAR_071051209N → S in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs765054383Ensembl.1
Natural variantiVAR_071052323M → I in RP68; uncertain pathological significance. 1 Publication1
Natural variantiVAR_035417330G → R in RP68; affects subcellular location. 1 PublicationCorresponds to variant dbSNP:rs2276717EnsemblClinVar.1
Natural variantiVAR_071053391S → L in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs375705180Ensembl.1
Natural variantiVAR_071054464C → F in RP68. 1 PublicationCorresponds to variant dbSNP:rs79668755EnsemblClinVar.1
Natural variantiVAR_071055695R → C in RP68; uncertain pathological significance. 1 PublicationCorresponds to variant dbSNP:rs181011740Ensembl.1
Natural variantiVAR_071056708F → V in RP68. 1 PublicationCorresponds to variant dbSNP:rs587777272EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK122655 mRNA Translation: BAG53645.1
AC008041 Genomic DNA No translation available.
BC022968 mRNA Translation: AAH22968.2
AB046833 mRNA Translation: BAB13439.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33892.1

NCBI Reference Sequences

More...
RefSeqi
NP_066000.2, NM_020949.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.596660

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000231706; ENSP00000231706; ENSG00000013293

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57709

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57709

UCSC genome browser

More...
UCSCi
uc003fgz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122655 mRNA Translation: BAG53645.1
AC008041 Genomic DNA No translation available.
BC022968 mRNA Translation: AAH22968.2
AB046833 mRNA Translation: BAB13439.1 Sequence problems.
CCDSiCCDS33892.1
RefSeqiNP_066000.2, NM_020949.2
UniGeneiHs.596660

3D structure databases

ProteinModelPortaliQ8TBB6
SMRiQ8TBB6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121733, 27 interactors
IntActiQ8TBB6, 38 interactors
STRINGi9606.ENSP00000231706

Protein family/group databases

TCDBi2.A.3.3.7 the amino acid-polyamine-organocation (apc) family

PTM databases

iPTMnetiQ8TBB6
PhosphoSitePlusiQ8TBB6

Polymorphism and mutation databases

BioMutaiSLC7A14
DMDMi296452968

Proteomic databases

PaxDbiQ8TBB6
PeptideAtlasiQ8TBB6
PRIDEiQ8TBB6
ProteomicsDBi73987

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57709
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000231706; ENSP00000231706; ENSG00000013293
GeneIDi57709
KEGGihsa:57709
UCSCiuc003fgz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57709
DisGeNETi57709
EuPathDBiHostDB:ENSG00000013293.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC7A14
HGNCiHGNC:29326 SLC7A14
HPAiHPA045929
MalaCardsiSLC7A14
MIMi615720 gene
615725 phenotype
neXtProtiNX_Q8TBB6
OpenTargetsiENSG00000013293
Orphaneti791 Retinitis pigmentosa
PharmGKBiPA142670913

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1286 Eukaryota
COG0531 LUCA
GeneTreeiENSGT00940000155893
HOGENOMiHOG000250623
HOVERGENiHBG000280
InParanoidiQ8TBB6
KOiK13871
OMAiTISRWMV
OrthoDBiEOG091G05NM
PhylomeDBiQ8TBB6
TreeFamiTF315212

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57709

Protein Ontology

More...
PROi
PR:Q8TBB6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000013293 Expressed in 99 organ(s), highest expression level in cerebellar vermis
CleanExiHS_SLC7A14
GenevisibleiQ8TBB6 HS

Family and domain databases

InterProiView protein in InterPro
IPR002293 AA/rel_permease1
IPR029485 CAT_C
PfamiView protein in Pfam
PF13520 AA_permease_2, 1 hit
PF13906 AA_permease_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS7A14_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBB6
Secondary accession number(s): B3KV33, Q9HCF9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: December 5, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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