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UniProtKB - Q8TBB5 (KLDC4_HUMAN)

Entry version 143 (07 Apr 2021)
Sequence version 1 (01 Jun 2002)
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Protein

Kelch domain-containing protein 4

Gene

KLHDC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TBB5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kelch domain-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLHDC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25272, KLHDC4

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TBB5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000104731.13

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		54758

Open Targets

More...OpenTargetsi		ENSG00000104731

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134914472

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TBB5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KLHDC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		74730447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002289981 – 520Kelch domain-containing protein 4Add BLAST520

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei413PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q8TBB5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q8TBB5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TBB5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q8TBB5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TBB5

PeptideAtlas

More...PeptideAtlasi		Q8TBB5

PRoteomics IDEntifications database

More...PRIDEi		Q8TBB5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		73984 [Q8TBB5-1]
73985 [Q8TBB5-2]
73986 [Q8TBB5-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TBB5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TBB5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000104731, Expressed in sural nerve and 169 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TBB5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TBB5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000104731, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120134, 19 interactors

Protein interaction database and analysis system

More...IntActi		Q8TBB5, 13 interactors

Molecular INTeraction database

More...MINTi		Q8TBB5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000270583

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TBB5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TBB5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati77 – 129Kelch 1Add BLAST53
Repeati133 – 187Kelch 2Add BLAST55
Repeati188 – 241Kelch 3Add BLAST54
Repeati243 – 289Kelch 4Add BLAST47
Repeati308 – 361Kelch 5Add BLAST54
Repeati443 – 494Kelch 6Add BLAST52

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1230, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008722_3_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TBB5

Identification of Orthologs from Complete Genome Data

More...OMAi		KQYIILF

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TBB5

TreeFam database of animal gene trees

More...TreeFami		TF323290

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.120.10.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR011498, Kelch_2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07646, Kelch_2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF117281, SSF117281, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBB5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKR 
        60         70         80         90        100
TQTVELPCPP PSPRLNASLS VHPEKDELIL FGGEYFNGQK TFLYNELYVY 
       110        120        130        140        150
NTRKDTWTKV DIPSPPPRRC AHQAVVVPQG GGQLWVFGGE FASPNGEQFY 
       160        170        180        190        200
HYKDLWVLHL ATKTWEQVKS TGGPSGRSGH RMVAWKRQLI LFGGFHESTR 
       210        220        230        240        250
DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMSVTP QGGIVVYGGY 
       260        270        280        290        300
SKQRVKKDVD KGTRHSDMFL LKPEDGREDK WVWTRMNPSG VKPTPRSGFS 
       310        320        330        340        350
VAMAPNHQTL FFGGVCDEEE EESLSGEFFN DLYFYDATRN RWFEGQLKGP 
       360        370        380        390        400
KSEKKKRRRG RKEEPEGGSR PACGGAGTQG PVQLVKEVVA EDGTVVTIKQ 
       410        420        430        440        450
VLTAPGSAGQ PRSEDEDSLE EAGSPAPGPC PRSNAMLAVK HGVLYVYGGM 
       460        470        480        490        500
FEAGDRQVTL SDLHCLDLHR MEAWKALVEM DPETQEWLEE TDSEEDSEEV 
       510        520
EGAEGGVDDE DSGEESGAED
Length:520
Mass (Da):57,892
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DD22CB9FEBD5A72
GO
Isoform 2 (identifier: Q8TBB5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     34-90: Missing.

Show »
Length:463
Mass (Da):51,547
Checksum:iF603F987FD8C9357
GO
Isoform 3 (identifier: Q8TBB5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-200: Missing.

Show »
Length:489
Mass (Da):54,496
Checksum:iF579B9C0AA4A1D16
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BQH3H3BQH3_HUMAN
Kelch domain-containing protein 4
KLHDC4
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BV82H3BV82_HUMAN
Kelch domain-containing protein 4
KLHDC4
173Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q86VH3Q86VH3_HUMAN
HCG1980662
KLHDC4 hCG_1980662
291Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQ90H3BQ90_HUMAN
Kelch domain-containing protein 4
KLHDC4
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP99H3BP99_HUMAN
Kelch domain-containing protein 4
KLHDC4
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQL0H3BQL0_HUMAN
Kelch domain-containing protein 4
KLHDC4
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTB1H3BTB1_HUMAN
Kelch domain-containing protein 4
KLHDC4
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BUX8H3BUX8_HUMAN
Kelch domain-containing protein 4
KLHDC4
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9UF94Q9UF94_HUMAN
Kelch domain containing 4, isoform ...
KLHDC4 DKFZp434G0522, hCG_20391
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03398656L → V. Corresponds to variant dbSNP:rs2303772Ensembl.1
Natural variantiVAR_050054102T → I1 PublicationCorresponds to variant dbSNP:rs2303771Ensembl.1
Natural variantiVAR_061340130G → V. Corresponds to variant dbSNP:rs34779002Ensembl.1
Natural variantiVAR_033987155L → V. Corresponds to variant dbSNP:rs3751727Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01772834 – 90Missing in isoform 2. 1 PublicationAdd BLAST57
Alternative sequenceiVSP_017729170 – 200Missing in isoform 3. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
CH471114 Genomic DNA Translation: EAW95377.1
CH471114 Genomic DNA Translation: EAW95378.1
CH471114 Genomic DNA Translation: EAW95379.1
CH471114 Genomic DNA Translation: EAW95381.1
CH471114 Genomic DNA Translation: EAW95382.1
CH471114 Genomic DNA Translation: EAW95383.1
BC001044 mRNA Translation: AAH01044.1
BC011680 mRNA Translation: AAH11680.1
BC022969 mRNA Translation: AAH22969.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10963.1 [Q8TBB5-1]
CCDS54050.1 [Q8TBB5-2]
CCDS54051.1 [Q8TBB5-3]

NCBI Reference Sequences

More...RefSeqi		NP_001171783.1, NM_001184854.1 [Q8TBB5-2]
NP_001171785.1, NM_001184856.1 [Q8TBB5-3]
NP_060036.2, NM_017566.3 [Q8TBB5-1]
XP_005256051.1, XM_005255994.3 [Q8TBB5-1]
XP_016878833.1, XM_017023344.1 [Q8TBB5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000270583; ENSP00000270583; ENSG00000104731 [Q8TBB5-1]
ENST00000347925; ENSP00000325717; ENSG00000104731 [Q8TBB5-3]
ENST00000353170; ENSP00000262530; ENSG00000104731 [Q8TBB5-2]
ENST00000567298; ENSP00000457570; ENSG00000104731 [Q8TBB5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		54758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:54758

UCSC genome browser

More...UCSCi		uc002fki.4, human [Q8TBB5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471114 Genomic DNA Translation: EAW95377.1
CH471114 Genomic DNA Translation: EAW95378.1
CH471114 Genomic DNA Translation: EAW95379.1
CH471114 Genomic DNA Translation: EAW95381.1
CH471114 Genomic DNA Translation: EAW95382.1
CH471114 Genomic DNA Translation: EAW95383.1
BC001044 mRNA Translation: AAH01044.1
BC011680 mRNA Translation: AAH11680.1
BC022969 mRNA Translation: AAH22969.1
CCDSiCCDS10963.1 [Q8TBB5-1]
CCDS54050.1 [Q8TBB5-2]
CCDS54051.1 [Q8TBB5-3]
RefSeqiNP_001171783.1, NM_001184854.1 [Q8TBB5-2]
NP_001171785.1, NM_001184856.1 [Q8TBB5-3]
NP_060036.2, NM_017566.3 [Q8TBB5-1]
XP_005256051.1, XM_005255994.3 [Q8TBB5-1]
XP_016878833.1, XM_017023344.1 [Q8TBB5-1]

3D structure databases

SMRiQ8TBB5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120134, 19 interactors
IntActiQ8TBB5, 13 interactors
MINTiQ8TBB5
STRINGi9606.ENSP00000270583

PTM databases

iPTMnetiQ8TBB5
PhosphoSitePlusiQ8TBB5

Genetic variation databases

BioMutaiKLHDC4
DMDMi74730447

Proteomic databases

EPDiQ8TBB5
jPOSTiQ8TBB5
MassIVEiQ8TBB5
MaxQBiQ8TBB5
PaxDbiQ8TBB5
PeptideAtlasiQ8TBB5
PRIDEiQ8TBB5
ProteomicsDBi73984 [Q8TBB5-1]
73985 [Q8TBB5-2]
73986 [Q8TBB5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30690, 157 antibodies

Genome annotation databases

EnsembliENST00000270583; ENSP00000270583; ENSG00000104731 [Q8TBB5-1]
ENST00000347925; ENSP00000325717; ENSG00000104731 [Q8TBB5-3]
ENST00000353170; ENSP00000262530; ENSG00000104731 [Q8TBB5-2]
ENST00000567298; ENSP00000457570; ENSG00000104731 [Q8TBB5-1]
GeneIDi54758
KEGGihsa:54758
UCSCiuc002fki.4, human [Q8TBB5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		54758
DisGeNETi54758

GeneCards: human genes, protein and diseases

More...GeneCardsi		KLHDC4
HGNCiHGNC:25272, KLHDC4
HPAiENSG00000104731, Low tissue specificity
neXtProtiNX_Q8TBB5
OpenTargetsiENSG00000104731
PharmGKBiPA134914472
VEuPathDBiHostDB:ENSG00000104731.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1230, Eukaryota
GeneTreeiENSGT00390000003374
HOGENOMiCLU_008722_3_1_1
InParanoidiQ8TBB5
OMAiKQYIILF
PhylomeDBiQ8TBB5
TreeFamiTF323290

Enzyme and pathway databases

PathwayCommonsiQ8TBB5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		54758, 7 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KLHDC4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		54758
PharosiQ8TBB5, Tdark

Protein Ontology

More...PROi		PR:Q8TBB5
RNActiQ8TBB5, protein

Gene expression databases

BgeeiENSG00000104731, Expressed in sural nerve and 169 other tissues
ExpressionAtlasiQ8TBB5, baseline and differential
GenevisibleiQ8TBB5, HS

Family and domain databases

Gene3Di2.120.10.80, 1 hit
InterProiView protein in InterPro
IPR015915, Kelch-typ_b-propeller
IPR011498, Kelch_2
PfamiView protein in Pfam
PF07646, Kelch_2, 2 hits
SUPFAMiSSF117281, SSF117281, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKLDC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBB5
Secondary accession number(s): D3DUN3
, D3DUN4, D3DUN5, Q96F29, Q9BVN3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: June 1, 2002
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
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