THAP6

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 89	THAP-typePROSITE-ProRule annotationAdd BLAST		89

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: THAP domain-containing protein 6
Gene namesⁱ	Name:THAP6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000174796.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23189 THAP6
MIMⁱ	612535 gene
neXtProtⁱ	NX_Q8TBB0

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000174796
PharmGKBⁱ	PA134873449

Polymorphism and mutation databases

BioMutaⁱ	THAP6
DMDMⁱ	29839572

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068647	1 – 222	THAP domain-containing protein 6Add BLAST		222

Proteomic databases

PaxDbⁱ	Q8TBB0
PeptideAtlas More...PeptideAtlasⁱ	Q8TBB0
PRIDEⁱ	Q8TBB0
ProteomicsDBⁱ	73980 73981 [Q8TBB0-2]

PTM databases

iPTMnetⁱ	Q8TBB0
PhosphoSitePlusⁱ	Q8TBB0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000174796 Expressed in 190 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_THAP6
ExpressionAtlasⁱ	Q8TBB0 baseline and differential
Genevisibleⁱ	Q8TBB0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA035767

HPAⁱ

HPA035767

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
KRTAP10-7	P60409	3	EBI-3925505,EBI-10172290
PICK1	Q9NRD5	4	EBI-3925505,EBI-79165

Protein-protein interaction databases

BioGridⁱ	127466, 2 interactors
ELMⁱ	Q8TBB0
IntActⁱ	Q8TBB0, 18 interactors
STRINGⁱ	9606.ENSP00000309007

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q8TBB0
SMRⁱ	Q8TBB0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	149 – 194	Sequence analysisAdd BLAST		46

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	139 – 142	HCFC1-binding motif (HBM)By similarity		4

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 89	THAP-typePROSITE-ProRule annotationAdd BLAST		89

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IVN3 Eukaryota ENOG410YUA1 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063390
HOGENOMⁱ	HOG000294215
HOVERGENⁱ	HBG055966
InParanoidⁱ	Q8TBB0
OMAⁱ	RLEAFCW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BYK
PhylomeDBⁱ	Q8TBB0
TreeFamⁱ	TF335838

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q8TBB0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA 
        60         70         80         90        100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE 
       110        120        130        140        150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFEH SYSVMDSPKK 
       160        170        180        190        200
LKHKLDHVIG ELEDTKESLR NVLDREKRFQ KSLRKTIREL KDECLISQET 
       210        220 
ANRLDTFCWD CCQESIEQDY IS

Length:222

Mass (Da):25,691

Last modified:June 1, 2002 - v1

Checksum:ⁱ4E039592D64C50FB

GO

Isoform 2 (identifier: Q8TBB0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
97-138: Missing.

« Hide

        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA 
        60         70         80         90        100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQEHSY 
       110        120        130        140        150
SVMDSPKKLK HKLDHVIGEL EDTKESLRNV LDREKRFQKS LRKTIRELKD 
       160        170        180
ECLISQETAN RLDTFCWDCC QESIEQDYIS

Show »

Length:180

Mass (Da):20,828

Checksum:ⁱBC13C7F1223939B2

GO

Isoform 3 (identifier: Q8TBB0-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
139-220: EHSYSVMDSP...CCQESIEQDY → KHRKRKQEQEEEQKPRREKC

« Hide

        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA 
        60         70         80         90        100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE 
       110        120        130        140        150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFKH RKRKQEQEEE 
       160
QKPRREKCIS

Note: No experimental confirmation available.

Show »

Length:160

Mass (Da):18,511

Checksum:ⁱ88E72EC61DAEF04F

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RC19	D6RC19_HUMAN	THAP domain-containing protein 6 THAP domain-containing protein 6	THAP6	80	Annotation score:
D6RBC3	D6RBC3_HUMAN	THAP domain containing 6, isoform C... THAP domain containing 6, isoform CRA_e (THAP domain-containing protein 6)	THAP6 hCG_24385	119	Annotation score:
D6RFK7	D6RFK7_HUMAN	THAP domain containing 6, isoform C... THAP domain containing 6, isoform CRA_a (THAP domain-containing protein 6)	THAP6 hCG_24385	77	Annotation score:
D6REL7	D6REL7_HUMAN	THAP domain-containing protein 6 THAP domain-containing protein 6	THAP6	111	Annotation score:
D6REQ5	D6REQ5_HUMAN	THAP domain containing 6, isoform C... THAP domain containing 6, isoform CRA_d (THAP domain-containing protein 6)	THAP6 hCG_24385	89	Annotation score:
D6RF27	D6RF27_HUMAN	THAP domain-containing protein 6 THAP domain-containing protein 6	THAP6	98	Annotation score:
D6RJG2	D6RJG2_HUMAN	THAP domain-containing protein 6 THAP domain-containing protein 6	THAP6	32	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_039072	97 – 138	Missing in isoform 2. 1 PublicationAdd BLAST		42
Alternative sequenceⁱVSP_054378	139 – 220	EHSYS…IEQDY → KHRKRKQEQEEEQKPRREKC in isoform 3. 1 PublicationAdd BLAST		82

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK303658 mRNA Translation: BAG64658.1 AK313765 mRNA Translation: BAG36503.1 AL833350 mRNA Translation: CAI46111.1 BX647579 mRNA Translation: CAI46093.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05731.1 BC022989 mRNA Translation: AAH22989.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3568.1 [Q8TBB0-1] CCDS82932.1 [Q8TBB0-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001304720.1, NM_001317791.1 [Q8TBB0-2] NP_653322.1, NM_144721.5 [Q8TBB0-1] XP_005262831.1, XM_005262774.3 [Q8TBB0-3] XP_011529968.1, XM_011531666.2 [Q8TBB0-1] XP_011529969.1, XM_011531667.2 [Q8TBB0-1] XP_016863289.1, XM_017007800.1 [Q8TBB0-2]
UniGeneⁱ	Hs.479971

Genome annotation databases

Ensemblⁱ	ENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1] ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2] ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3] ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1]
GeneIDⁱ	152815
KEGGⁱ	hsa:152815
UCSC genome browser More...UCSCⁱ	uc003him.4 human [Q8TBB0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Protein	Similar proteins		Species	Score	Length	Source
Q8TBB0	THAP domain containing 6, isoform CRA_b		HUMAN		222	UniRef100_Q8TBB0
THAP6 isoform 1 (Fragment)		PONAB		80
THAP6 isoform 1 (Fragment)		PANTR		80
THAP domain-containing protein 6 (Fragment)		HUMAN		80
UPI000387DD32		HUMAN		181
Q8TBB0-3	THAP domain containing 6, isoform CRA_e		HUMAN		119	UniRef100_D6RBC3
THAP domain containing 6		PANTR		160
THAP domain containing 6		GORGO		160
THAP6 isoform 6		PONAB		150
THAP6 isoform 9		PONAB		109
+1

Protein	Similar proteins		Species	Score	Length	Source
Q8TBB0	THAP domain containing 6, isoform CRA_b		HUMAN		222	UniRef90_Q8TBB0
THAP6 isoform 1 (Fragment)		PONAB		80
THAP6 isoform 1 (Fragment)		PANTR		80
Uncharacterized protein		FELCA		223
THAP domain containing 6		HORSE		222
+64
Q8TBB0-2	Uncharacterized protein		FELCA		181	UniRef90_Q8TBB0-2
THAP domain-containing protein 6 isoform X3		PHYCD		181
THAP domain containing 6		PANTR		180
THAP domain containing 6		BOVIN		180
THAP domain-containing protein 6 isoform X3		BALAS		180
+29
Q8TBB0-3	THAP domain containing 6, isoform CRA_e		HUMAN		119	UniRef90_D6RBC3
THAP domain containing 6		PANTR		160
THAP domain containing 6		GORGO		160
THAP6 isoform 6		PONAB		150
Uncharacterized protein		CALJA		160
+12

Protein	Similar proteins		Species	Score	Length	Source
Q8TBB0	THAP domain containing 6, isoform CRA_b		HUMAN		222	UniRef50_Q8TBB0
THAP6 isoform 1 (Fragment)		PONAB		80
THAP6 isoform 1 (Fragment)		PANTR		80
Uncharacterized protein		FELCA		223
Uncharacterized protein		CHLSB		222
+119
Q8TBB0-2	Uncharacterized protein		FELCA		181	UniRef50_Q8TBB0-2
THAP domain-containing protein 6 isoform X3		PHYCD		181
THAP domain containing 6		GORGO		180
Uncharacterized protein		RHIRO		180
Uncharacterized protein		RHIBE		180
+54
Q8TBB0-3	Isoform 2 of THAP domain-containing protein 6		HUMAN		180	UniRef50_Q8TBB0-2
Uncharacterized protein		FELCA		181
THAP domain-containing protein 6 isoform X3		PHYCD		181
THAP domain containing 6		GORGO		180
Uncharacterized protein		RHIRO		180
+54

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK303658 mRNA Translation: BAG64658.1 AK313765 mRNA Translation: BAG36503.1 AL833350 mRNA Translation: CAI46111.1 BX647579 mRNA Translation: CAI46093.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05731.1 BC022989 mRNA Translation: AAH22989.1
CCDSⁱ	CCDS3568.1 [Q8TBB0-1] CCDS82932.1 [Q8TBB0-2]
RefSeqⁱ	NP_001304720.1, NM_001317791.1 [Q8TBB0-2] NP_653322.1, NM_144721.5 [Q8TBB0-1] XP_005262831.1, XM_005262774.3 [Q8TBB0-3] XP_011529968.1, XM_011531666.2 [Q8TBB0-1] XP_011529969.1, XM_011531667.2 [Q8TBB0-1] XP_016863289.1, XM_017007800.1 [Q8TBB0-2]
UniGeneⁱ	Hs.479971

3D structure databases

ProteinModelPortalⁱ	Q8TBB0
SMRⁱ	Q8TBB0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127466, 2 interactors
ELMⁱ	Q8TBB0
IntActⁱ	Q8TBB0, 18 interactors
STRINGⁱ	9606.ENSP00000309007

PTM databases

iPTMnetⁱ	Q8TBB0
PhosphoSitePlusⁱ	Q8TBB0

Polymorphism and mutation databases

BioMutaⁱ	THAP6
DMDMⁱ	29839572

Proteomic databases

PaxDbⁱ	Q8TBB0
PeptideAtlasⁱ	Q8TBB0
PRIDEⁱ	Q8TBB0
ProteomicsDBⁱ	73980 73981 [Q8TBB0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	152815
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1] ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2] ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3] ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1]
GeneIDⁱ	152815
KEGGⁱ	hsa:152815
UCSCⁱ	uc003him.4 human [Q8TBB0-1]

Organism-specific databases

CTDⁱ	152815
EuPathDBⁱ	HostDB:ENSG00000174796.12
GeneCardsⁱ	THAP6
HGNCⁱ	HGNC:23189 THAP6
HPAⁱ	HPA035767
MIMⁱ	612535 gene
neXtProtⁱ	NX_Q8TBB0
OpenTargetsⁱ	ENSG00000174796
PharmGKBⁱ	PA134873449
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVN3 Eukaryota ENOG410YUA1 LUCA
GeneTreeⁱ	ENSGT00530000063390
HOGENOMⁱ	HOG000294215
HOVERGENⁱ	HBG055966
InParanoidⁱ	Q8TBB0
OMAⁱ	RLEAFCW
OrthoDBⁱ	EOG091G0BYK
PhylomeDBⁱ	Q8TBB0
TreeFamⁱ	TF335838

Miscellaneous databases

ChiTaRSⁱ	THAP6 human
GeneWikiⁱ	THAP6
GenomeRNAiⁱ	152815
Protein Ontology More...PROⁱ	PR:Q8TBB0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000174796 Expressed in 190 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_THAP6
ExpressionAtlasⁱ	Q8TBB0 baseline and differential
Genevisibleⁱ	Q8TBB0 HS

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THAP6_HUMAN
Accessionⁱ	Q8TBB0Primary (citable) accession number: Q8TBB0 Secondary accession number(s): B4E146, Q5HYJ7, Q5JPC6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
	Last sequence update:	June 1, 2002
	Last modified:	November 7, 2018
	This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q8TBB0 (THAP6_HUMAN)

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THAP domain-containing protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ