UniProtKB - Q8TBB0 (THAP6_HUMAN)
Protein
THAP domain-containing protein 6
Gene
THAP6
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 89 | THAP-typePROSITE-ProRule annotationAdd BLAST | 89 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q8TBB0 |
Names & Taxonomyi
Protein namesi | Recommended name: THAP domain-containing protein 6 |
Gene namesi | Name:THAP6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23189, THAP6 |
MIMi | 612535, gene |
neXtProti | NX_Q8TBB0 |
VEuPathDBi | HostDB:ENSG00000174796.12 |
Subcellular locationi
Cytoskeleton
- microtubule cytoskeleton Source: LIFEdb
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000174796 |
PharmGKBi | PA134873449 |
Miscellaneous databases
Pharosi | Q8TBB0, Tdark |
Genetic variation databases
BioMutai | THAP6 |
DMDMi | 29839572 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068647 | 1 – 222 | THAP domain-containing protein 6Add BLAST | 222 |
Proteomic databases
MassIVEi | Q8TBB0 |
PaxDbi | Q8TBB0 |
PeptideAtlasi | Q8TBB0 |
PRIDEi | Q8TBB0 |
ProteomicsDBi | 5725 73980 [Q8TBB0-1] 73981 [Q8TBB0-2] |
PTM databases
iPTMneti | Q8TBB0 |
PhosphoSitePlusi | Q8TBB0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174796, Expressed in testis and 203 other tissues |
ExpressionAtlasi | Q8TBB0, baseline and differential |
Genevisiblei | Q8TBB0, HS |
Organism-specific databases
HPAi | ENSG00000174796, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ8TBB0
Protein-protein interaction databases
BioGRIDi | 127466, 17 interactors |
ELMi | Q8TBB0 |
IntActi | Q8TBB0, 18 interactors |
STRINGi | 9606.ENSP00000309007 |
Miscellaneous databases
RNActi | Q8TBB0, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 149 – 194 | Sequence analysisAdd BLAST | 46 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 139 – 142 | HCFC1-binding motif (HBM)By similarity | 4 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 89 | THAP-typePROSITE-ProRule annotationAdd BLAST | 89 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502S349, Eukaryota |
GeneTreei | ENSGT00940000162692 |
HOGENOMi | CLU_076186_3_0_1 |
InParanoidi | Q8TBB0 |
OMAi | RLEAFCW |
PhylomeDBi | Q8TBB0 |
TreeFami | TF335838 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8TBB0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA
60 70 80 90 100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE
110 120 130 140 150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFEH SYSVMDSPKK
160 170 180 190 200
LKHKLDHVIG ELEDTKESLR NVLDREKRFQ KSLRKTIREL KDECLISQET
210 220
ANRLDTFCWD CCQESIEQDY IS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RFK7 | D6RFK7_HUMAN | THAP domain containing 6, isoform C... | THAP6 hCG_24385 | 77 | Annotation score: | ||
D6RC19 | D6RC19_HUMAN | THAP domain-containing protein 6 | THAP6 | 80 | Annotation score: | ||
D6RBC3 | D6RBC3_HUMAN | THAP domain containing 6, isoform C... | THAP6 hCG_24385 | 119 | Annotation score: | ||
D6RF27 | D6RF27_HUMAN | THAP domain-containing protein 6 | THAP6 | 98 | Annotation score: | ||
D6REL7 | D6REL7_HUMAN | THAP domain-containing protein 6 | THAP6 | 111 | Annotation score: | ||
D6REQ5 | D6REQ5_HUMAN | THAP domain containing 6, isoform C... | THAP6 hCG_24385 | 89 | Annotation score: | ||
D6RJG2 | D6RJG2_HUMAN | THAP domain-containing protein 6 | THAP6 | 32 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039072 | 97 – 138 | Missing in isoform 2. 1 PublicationAdd BLAST | 42 | |
Alternative sequenceiVSP_054378 | 139 – 220 | EHSYS…IEQDY → KHRKRKQEQEEEQKPRREKC in isoform 3. 1 PublicationAdd BLAST | 82 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303658 mRNA Translation: BAG64658.1 AK313765 mRNA Translation: BAG36503.1 AL833350 mRNA Translation: CAI46111.1 BX647579 mRNA Translation: CAI46093.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05731.1 BC022989 mRNA Translation: AAH22989.1 |
CCDSi | CCDS3568.1 [Q8TBB0-1] CCDS82932.1 [Q8TBB0-2] |
RefSeqi | NP_001304720.1, NM_001317791.1 [Q8TBB0-2] NP_653322.1, NM_144721.5 [Q8TBB0-1] XP_005262831.1, XM_005262774.3 [Q8TBB0-3] XP_011529968.1, XM_011531666.2 [Q8TBB0-1] XP_011529969.1, XM_011531667.2 [Q8TBB0-1] XP_016863289.1, XM_017007800.1 [Q8TBB0-2] |
Genome annotation databases
Ensembli | ENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1] ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2] ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3] ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1] |
GeneIDi | 152815 |
KEGGi | hsa:152815 |
UCSCi | uc003him.4, human [Q8TBB0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK303658 mRNA Translation: BAG64658.1 AK313765 mRNA Translation: BAG36503.1 AL833350 mRNA Translation: CAI46111.1 BX647579 mRNA Translation: CAI46093.1 AC096759 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05731.1 BC022989 mRNA Translation: AAH22989.1 |
CCDSi | CCDS3568.1 [Q8TBB0-1] CCDS82932.1 [Q8TBB0-2] |
RefSeqi | NP_001304720.1, NM_001317791.1 [Q8TBB0-2] NP_653322.1, NM_144721.5 [Q8TBB0-1] XP_005262831.1, XM_005262774.3 [Q8TBB0-3] XP_011529968.1, XM_011531666.2 [Q8TBB0-1] XP_011529969.1, XM_011531667.2 [Q8TBB0-1] XP_016863289.1, XM_017007800.1 [Q8TBB0-2] |
3D structure databases
SMRi | Q8TBB0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127466, 17 interactors |
ELMi | Q8TBB0 |
IntActi | Q8TBB0, 18 interactors |
STRINGi | 9606.ENSP00000309007 |
PTM databases
iPTMneti | Q8TBB0 |
PhosphoSitePlusi | Q8TBB0 |
Genetic variation databases
BioMutai | THAP6 |
DMDMi | 29839572 |
Proteomic databases
MassIVEi | Q8TBB0 |
PaxDbi | Q8TBB0 |
PeptideAtlasi | Q8TBB0 |
PRIDEi | Q8TBB0 |
ProteomicsDBi | 5725 73980 [Q8TBB0-1] 73981 [Q8TBB0-2] |
Protocols and materials databases
Antibodypediai | 24670, 224 antibodies |
DNASUi | 152815 |
Genome annotation databases
Ensembli | ENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1] ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2] ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3] ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1] |
GeneIDi | 152815 |
KEGGi | hsa:152815 |
UCSCi | uc003him.4, human [Q8TBB0-1] |
Organism-specific databases
CTDi | 152815 |
GeneCardsi | THAP6 |
HGNCi | HGNC:23189, THAP6 |
HPAi | ENSG00000174796, Low tissue specificity |
MIMi | 612535, gene |
neXtProti | NX_Q8TBB0 |
OpenTargetsi | ENSG00000174796 |
PharmGKBi | PA134873449 |
VEuPathDBi | HostDB:ENSG00000174796.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S349, Eukaryota |
GeneTreei | ENSGT00940000162692 |
HOGENOMi | CLU_076186_3_0_1 |
InParanoidi | Q8TBB0 |
OMAi | RLEAFCW |
PhylomeDBi | Q8TBB0 |
TreeFami | TF335838 |
Enzyme and pathway databases
PathwayCommonsi | Q8TBB0 |
Miscellaneous databases
BioGRID-ORCSi | 152815, 6 hits in 894 CRISPR screens |
ChiTaRSi | THAP6, human |
GeneWikii | THAP6 |
GenomeRNAii | 152815 |
Pharosi | Q8TBB0, Tdark |
PROi | PR:Q8TBB0 |
RNActi | Q8TBB0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000174796, Expressed in testis and 203 other tissues |
ExpressionAtlasi | Q8TBB0, baseline and differential |
Genevisiblei | Q8TBB0, HS |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THAP6_HUMAN | |
Accessioni | Q8TBB0Primary (citable) accession number: Q8TBB0 Secondary accession number(s): B4E146, Q5HYJ7, Q5JPC6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM