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UniProtKB - Q8TBB0 (THAP6_HUMAN)

Entry version 144 (10 Feb 2021)
Sequence version 1 (01 Jun 2002)
Previous versions | rss
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Protein

THAP domain-containing protein 6

Gene

THAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1 – 89THAP-typePROSITE-ProRule annotationAdd BLAST89

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q8TBB0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
THAP domain-containing protein 6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:THAP6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23189, THAP6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612535, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q8TBB0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000174796.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000174796

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134873449

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q8TBB0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		THAP6

Domain mapping of disease mutations (DMDM)

More...DMDMi		29839572

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000686471 – 222THAP domain-containing protein 6Add BLAST222

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q8TBB0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q8TBB0

PeptideAtlas

More...PeptideAtlasi		Q8TBB0

PRoteomics IDEntifications database

More...PRIDEi		Q8TBB0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5725
73980 [Q8TBB0-1]
73981 [Q8TBB0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q8TBB0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q8TBB0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174796, Expressed in testis and 203 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q8TBB0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q8TBB0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174796, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127466, 17 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q8TBB0

Protein interaction database and analysis system

More...IntActi		Q8TBB0, 18 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309007

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q8TBB0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q8TBB0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili149 – 194Sequence analysisAdd BLAST46

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi139 – 142HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 89THAP-typePROSITE-ProRule annotationAdd BLAST89

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S349, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162692

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_076186_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q8TBB0

Identification of Orthologs from Complete Genome Data

More...OMAi		RLEAFCW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q8TBB0

TreeFam database of animal gene trees

More...TreeFami		TF335838

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.180, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05485, THAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50950, ZF_THAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBB0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVKCCSAIGC ASRCLPNSKL KGLTFHVFPT DENIKRKWVL AMKRLDVNAA 
        60         70         80         90        100
GIWEPKKGDV LCSRHFKKTD FDRSAPNIKL KPGVIPSIFD SPYHLQGKRE 
       110        120        130        140        150
KLHCRKNFTL KTVPATNYNH HLVGASSCIE EFQSQFIFEH SYSVMDSPKK 
       160        170        180        190        200
LKHKLDHVIG ELEDTKESLR NVLDREKRFQ KSLRKTIREL KDECLISQET 
       210        220 
ANRLDTFCWD CCQESIEQDY IS
Length:222
Mass (Da):25,691
Last modified:June 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4E039592D64C50FB
GO
Isoform 2 (identifier: Q8TBB0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-138: Missing.

Show »
Length:180
Mass (Da):20,828
Checksum:iBC13C7F1223939B2
GO
Isoform 3 (identifier: Q8TBB0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     139-220: EHSYSVMDSP...CCQESIEQDY → KHRKRKQEQEEEQKPRREKC

Show »
Length:160
Mass (Da):18,511
Checksum:i88E72EC61DAEF04F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFK7D6RFK7_HUMAN
THAP domain containing 6, isoform C...
THAP6 hCG_24385
77Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC19D6RC19_HUMAN
THAP domain-containing protein 6
THAP6
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBC3D6RBC3_HUMAN
THAP domain containing 6, isoform C...
THAP6 hCG_24385
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RF27D6RF27_HUMAN
THAP domain-containing protein 6
THAP6
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REL7D6REL7_HUMAN
THAP domain-containing protein 6
THAP6
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REQ5D6REQ5_HUMAN
THAP domain containing 6, isoform C...
THAP6 hCG_24385
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RJG2D6RJG2_HUMAN
THAP domain-containing protein 6
THAP6
32Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03907297 – 138Missing in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_054378139 – 220EHSYS…IEQDY → KHRKRKQEQEEEQKPRREKC in isoform 3. 1 PublicationAdd BLAST82

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK303658 mRNA Translation: BAG64658.1
AK313765 mRNA Translation: BAG36503.1
AL833350 mRNA Translation: CAI46111.1
BX647579 mRNA Translation: CAI46093.1
AC096759 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05731.1
BC022989 mRNA Translation: AAH22989.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3568.1 [Q8TBB0-1]
CCDS82932.1 [Q8TBB0-2]

NCBI Reference Sequences

More...RefSeqi		NP_001304720.1, NM_001317791.1 [Q8TBB0-2]
NP_653322.1, NM_144721.5 [Q8TBB0-1]
XP_005262831.1, XM_005262774.3 [Q8TBB0-3]
XP_011529968.1, XM_011531666.2 [Q8TBB0-1]
XP_011529969.1, XM_011531667.2 [Q8TBB0-1]
XP_016863289.1, XM_017007800.1 [Q8TBB0-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1]
ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2]
ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3]
ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		152815

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:152815

UCSC genome browser

More...UCSCi		uc003him.4, human [Q8TBB0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303658 mRNA Translation: BAG64658.1
AK313765 mRNA Translation: BAG36503.1
AL833350 mRNA Translation: CAI46111.1
BX647579 mRNA Translation: CAI46093.1
AC096759 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05731.1
BC022989 mRNA Translation: AAH22989.1
CCDSiCCDS3568.1 [Q8TBB0-1]
CCDS82932.1 [Q8TBB0-2]
RefSeqiNP_001304720.1, NM_001317791.1 [Q8TBB0-2]
NP_653322.1, NM_144721.5 [Q8TBB0-1]
XP_005262831.1, XM_005262774.3 [Q8TBB0-3]
XP_011529968.1, XM_011531666.2 [Q8TBB0-1]
XP_011529969.1, XM_011531667.2 [Q8TBB0-1]
XP_016863289.1, XM_017007800.1 [Q8TBB0-2]

3D structure databases

SMRiQ8TBB0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127466, 17 interactors
ELMiQ8TBB0
IntActiQ8TBB0, 18 interactors
STRINGi9606.ENSP00000309007

PTM databases

iPTMnetiQ8TBB0
PhosphoSitePlusiQ8TBB0

Genetic variation databases

BioMutaiTHAP6
DMDMi29839572

Proteomic databases

MassIVEiQ8TBB0
PaxDbiQ8TBB0
PeptideAtlasiQ8TBB0
PRIDEiQ8TBB0
ProteomicsDBi5725
73980 [Q8TBB0-1]
73981 [Q8TBB0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24670, 224 antibodies

The DNASU plasmid repository

More...DNASUi		152815

Genome annotation databases

EnsembliENST00000311638; ENSP00000309007; ENSG00000174796 [Q8TBB0-1]
ENST00000380837; ENSP00000370217; ENSG00000174796 [Q8TBB0-2]
ENST00000507556; ENSP00000427651; ENSG00000174796 [Q8TBB0-3]
ENST00000514480; ENSP00000423720; ENSG00000174796 [Q8TBB0-1]
GeneIDi152815
KEGGihsa:152815
UCSCiuc003him.4, human [Q8TBB0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		152815

GeneCards: human genes, protein and diseases

More...GeneCardsi		THAP6
HGNCiHGNC:23189, THAP6
HPAiENSG00000174796, Low tissue specificity
MIMi612535, gene
neXtProtiNX_Q8TBB0
OpenTargetsiENSG00000174796
PharmGKBiPA134873449
VEuPathDBiHostDB:ENSG00000174796.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S349, Eukaryota
GeneTreeiENSGT00940000162692
HOGENOMiCLU_076186_3_0_1
InParanoidiQ8TBB0
OMAiRLEAFCW
PhylomeDBiQ8TBB0
TreeFamiTF335838

Enzyme and pathway databases

PathwayCommonsiQ8TBB0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		152815, 6 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		THAP6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		THAP6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		152815
PharosiQ8TBB0, Tdark

Protein Ontology

More...PROi		PR:Q8TBB0
RNActiQ8TBB0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000174796, Expressed in testis and 203 other tissues
ExpressionAtlasiQ8TBB0, baseline and differential
GenevisibleiQ8TBB0, HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR006612, THAP_Znf
IPR038441, THAP_Znf_sf
PfamiView protein in Pfam
PF05485, THAP, 1 hit
SMARTiView protein in SMART
SM00692, DM3, 1 hit
SM00980, THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950, ZF_THAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHAP6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBB0
Secondary accession number(s): B4E146, Q5HYJ7, Q5JPC6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: June 1, 2002
Last modified: February 10, 2021
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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