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Entry version 161 (07 Oct 2020)
Sequence version 3 (18 May 2010)
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Protein

Golgin subfamily A member 5

Gene

GOLGA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q8TBA6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811438, Intra-Golgi traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgin subfamily A member 5
Alternative name(s):
Cell proliferation-inducing gene 31 protein
Golgin-84
Protein Ret-II
RET-fused gene 5 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GOLGA5
Synonyms:RETII, RFG5
ORF Names:PIG31
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000066455.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4428, GOLGA5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606918, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q8TBA6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 698CytoplasmicSequence analysisAdd BLAST697
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei699 – 719Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini720 – 731LumenalSequence analysisAdd BLAST12

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei497 – 498Breakpoint for translocation to form RET-GOLGA5 oncogene2

Organism-specific databases

DisGeNET

More...
DisGeNETi
9950

MalaCards human disease database

More...
MalaCardsi
GOLGA5

Open Targets

More...
OpenTargetsi
ENSG00000066455

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
146, Differentiated thyroid carcinoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28809

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q8TBA6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GOLGA5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439337

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001900612 – 731Golgin subfamily A member 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei89Dimethylated arginineBy similarity1
Modified residuei116PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q8TBA6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q8TBA6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q8TBA6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q8TBA6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q8TBA6

PeptideAtlas

More...
PeptideAtlasi
Q8TBA6

PRoteomics IDEntifications database

More...
PRIDEi
Q8TBA6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
73978 [Q8TBA6-1]
73979 [Q8TBA6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q8TBA6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q8TBA6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000066455, Expressed in secondary oocyte and 233 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q8TBA6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q8TBA6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000066455, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1.

Interacts with isoform CASP of CUX1.

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115275, 104 interactors

Protein interaction database and analysis system

More...
IntActi
Q8TBA6, 46 interactors

Molecular INTeraction database

More...
MINTi
Q8TBA6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000163416

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q8TBA6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q8TBA6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili216 – 632Sequence analysisAdd BLAST417

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4677, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018470

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q8TBA6

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQMQSEY

Database of Orthologous Groups

More...
OrthoDBi
1325011at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q8TBA6

TreeFam database of animal gene trees

More...
TreeFami
TF319468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019177, Golgin_subfamily_A_member_5

The PANTHER Classification System

More...
PANTHERi
PTHR13815, PTHR13815, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09787, Golgin_A5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWFVDLAGK AEDLLNRVDQ GAATALSRKD NASNIYSKNT DYTELHQQNT
60 70 80 90 100
DLIYQTGPKS TYISSAADNI RNQKATILAG TANVKVGSRT PVEASHPVEN
110 120 130 140 150
ASVPRPSSHF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEI RKEKGKTPVF
160 170 180 190 200
QSSQTSSVSS VNPSVTTIKT IEENSFGSQT HEAASNSDSS HEGQEESSKE
210 220 230 240 250
NVSSNAACPD HTPTPNDDGK SHELSNLRLE NQLLRNEVQS LNQEMASLLQ
260 270 280 290 300
RSKETQEELN KARARVEKWN ADHSKSDRMT RGLRAQVDDL TEAVAAKDSQ
310 320 330 340 350
LAVLKVRLQE ADQLLSTRTE ALEALQSEKS RIMQDQSEGN SLQNQALQTF
360 370 380 390 400
QERLHEADAT LKREQESYKQ MQSEFAARLN KVEMERQNLA EAITLAERKY
410 420 430 440 450
SDEKKRVDEL QQQVKLYKLN LESSKQELID YKQKATRILQ SKEKLINSLK
460 470 480 490 500
EGSGFEGLDS STASSMELEE LRHEKEMQRE EIQKLMGQIH QLRSELQDME
510 520 530 540 550
AQQVNEAESA REQLQDLHDQ IAGQKASKQE LETELERLKQ EFHYIEEDLY
560 570 580 590 600
RTKNTLQSRI KDRDEEIQKL RNQLTNKTLS NSSQSELENR LHQLTETLIQ
610 620 630 640 650
KQTMLESLST EKNSLVFQLE RLEQQMNSAS GSSSNGSSIN MSGIDNGEGT
660 670 680 690 700
RLRNVPVLFN DTETNLAGMY GKVRKAASSI DQFSIRLGIF LRRYPIARVF
710 720 730
VIIYMALLHL WVMIVLLTYT PEMHHDQPYG K
Length:731
Mass (Da):83,024
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i650B5D46096A2DDE
GO
Isoform 2 (identifier: Q8TBA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     684-691: SIRLGIFL → RLCFTSGS
     692-731: Missing.

Show »
Length:691
Mass (Da):78,108
Checksum:iB5E3CED3DE0F96CC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK03H0YK03_HUMAN
Golgin subfamily A member 5
GOLGA5
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA33787 differs from that shown. Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350F → L in AAD09753 (PubMed:9915833).Curated1
Sequence conflicti350F → L in AAV85456 (Ref. 2) Curated1
Sequence conflicti350F → L in EAW81502 (Ref. 4) Curated1
Sequence conflicti350F → L in AAH23021 (PubMed:15489334).Curated1
Sequence conflicti350F → L in CAA33787 (PubMed:2734021).Curated1
Sequence conflicti350F → L in CAB36967 (PubMed:9443391).Curated1
Sequence conflicti584 – 585QS → PV in CAB36967 (PubMed:9443391).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05585967A → G1 PublicationCorresponds to variant dbSNP:rs17128572Ensembl.1
Natural variantiVAR_055860486M → V. Corresponds to variant dbSNP:rs34139657Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_007731684 – 691SIRLGIFL → RLCFTSGS in isoform 2. 1 Publication8
Alternative sequenceiVSP_007732692 – 731Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF085199 mRNA Translation: AAD09753.1
AY644768 mRNA Translation: AAV85456.1
AL132987 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81502.1
BC023021 mRNA Translation: AAH23021.1
X15786 mRNA Translation: CAA33787.1 Sequence problems.
AJ132949 mRNA Translation: CAB36967.1
BX248744 mRNA Translation: CAD66551.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9905.1 [Q8TBA6-1]

Protein sequence database of the Protein Information Resource

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PIRi
I38153

NCBI Reference Sequences

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RefSeqi
NP_005104.3, NM_005113.3 [Q8TBA6-1]
XP_011535722.1, XM_011537420.2 [Q8TBA6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000163416; ENSP00000163416; ENSG00000066455 [Q8TBA6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9950

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9950

UCSC genome browser

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UCSCi
uc001yaz.3, human [Q8TBA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085199 mRNA Translation: AAD09753.1
AY644768 mRNA Translation: AAV85456.1
AL132987 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81502.1
BC023021 mRNA Translation: AAH23021.1
X15786 mRNA Translation: CAA33787.1 Sequence problems.
AJ132949 mRNA Translation: CAB36967.1
BX248744 mRNA Translation: CAD66551.1
CCDSiCCDS9905.1 [Q8TBA6-1]
PIRiI38153
RefSeqiNP_005104.3, NM_005113.3 [Q8TBA6-1]
XP_011535722.1, XM_011537420.2 [Q8TBA6-2]

3D structure databases

SMRiQ8TBA6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115275, 104 interactors
IntActiQ8TBA6, 46 interactors
MINTiQ8TBA6
STRINGi9606.ENSP00000163416

PTM databases

iPTMnetiQ8TBA6
PhosphoSitePlusiQ8TBA6

Polymorphism and mutation databases

BioMutaiGOLGA5
DMDMi296439337

Proteomic databases

EPDiQ8TBA6
jPOSTiQ8TBA6
MassIVEiQ8TBA6
MaxQBiQ8TBA6
PaxDbiQ8TBA6
PeptideAtlasiQ8TBA6
PRIDEiQ8TBA6
ProteomicsDBi73978 [Q8TBA6-1]
73979 [Q8TBA6-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
Q8TBA6, 1 sequenced antibody

Antibodypedia a portal for validated antibodies

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Antibodypediai
15, 255 antibodies

Genome annotation databases

EnsembliENST00000163416; ENSP00000163416; ENSG00000066455 [Q8TBA6-1]
GeneIDi9950
KEGGihsa:9950
UCSCiuc001yaz.3, human [Q8TBA6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9950
DisGeNETi9950
EuPathDBiHostDB:ENSG00000066455.12

GeneCards: human genes, protein and diseases

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GeneCardsi
GOLGA5
HGNCiHGNC:4428, GOLGA5
HPAiENSG00000066455, Low tissue specificity
MalaCardsiGOLGA5
MIMi606918, gene
neXtProtiNX_Q8TBA6
OpenTargetsiENSG00000066455
Orphaneti146, Differentiated thyroid carcinoma
PharmGKBiPA28809

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4677, Eukaryota
GeneTreeiENSGT00390000018470
HOGENOMiCLU_022484_0_0_1
InParanoidiQ8TBA6
OMAiRQMQSEY
OrthoDBi1325011at2759
PhylomeDBiQ8TBA6
TreeFamiTF319468

Enzyme and pathway databases

PathwayCommonsiQ8TBA6
ReactomeiR-HSA-6811438, Intra-Golgi traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9950, 2 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GOLGA5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GOLGA5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9950
PharosiQ8TBA6, Tbio

Protein Ontology

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PROi
PR:Q8TBA6
RNActiQ8TBA6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000066455, Expressed in secondary oocyte and 233 other tissues
ExpressionAtlasiQ8TBA6, baseline and differential
GenevisibleiQ8TBA6, HS

Family and domain databases

InterProiView protein in InterPro
IPR019177, Golgin_subfamily_A_member_5
PANTHERiPTHR13815, PTHR13815, 1 hit
PfamiView protein in Pfam
PF09787, Golgin_A5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGOGA5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8TBA6
Secondary accession number(s): C9JRU1
, O95287, Q03962, Q2TS49, Q9UQQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: October 7, 2020
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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