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Protein

Golgin subfamily A member 5

Gene

GOLGA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.2 Publications

GO - Molecular functioni

  • protein homodimerization activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

  • Golgi organization Source: UniProtKB
  • Golgi vesicle transport Source: UniProtKB
  • retrograde transport, vesicle recycling within Golgi Source: GO_Central

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 5
Alternative name(s):
Cell proliferation-inducing gene 31 protein
Golgin-84
Protein Ret-II
RET-fused gene 5 protein
Gene namesi
Name:GOLGA5
Synonyms:RETII, RFG5
ORF Names:PIG31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000066455.12
HGNCiHGNC:4428 GOLGA5
MIMi606918 gene
neXtProtiNX_Q8TBA6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 698CytoplasmicSequence analysisAdd BLAST697
Transmembranei699 – 719Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini720 – 731LumenalSequence analysisAdd BLAST12

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei497 – 498Breakpoint for translocation to form RET-GOLGA5 oncogene2

Organism-specific databases

DisGeNETi9950
MalaCardsiGOLGA5
OpenTargetsiENSG00000066455
Orphaneti146 Differentiated thyroid carcinoma
PharmGKBiPA28809

Polymorphism and mutation databases

DMDMi296439337

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001900612 – 731Golgin subfamily A member 5Add BLAST730

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei89Dimethylated arginine; alternateBy similarity1
Modified residuei89Omega-N-methylated arginine; alternateBy similarity1
Modified residuei116PhosphoserineCombined sources1

Post-translational modificationi

Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase.1 Publication

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ8TBA6
MaxQBiQ8TBA6
PaxDbiQ8TBA6
PeptideAtlasiQ8TBA6
PRIDEiQ8TBA6
ProteomicsDBi73978
73979 [Q8TBA6-2]

PTM databases

iPTMnetiQ8TBA6
PhosphoSitePlusiQ8TBA6

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in seminiferous tubules and Leydig cells in testis, and detected at much lower levels in the other tissues tested. Expression is very low or not detectable in spermatozoa.1 Publication

Gene expression databases

BgeeiENSG00000066455 Expressed in 221 organ(s), highest expression level in secondary oocyte
CleanExiHS_GOLGA5
ExpressionAtlasiQ8TBA6 baseline and differential
GenevisibleiQ8TBA6 HS

Organism-specific databases

HPAiHPA000992
HPA063876

Interactioni

Subunit structurei

Homodimer. Interacts with RAB1A that has been activated by GTP-binding, and possibly also with OCRL1. Interacts with isoform CASP of CUX1.3 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115275, 92 interactors
IntActiQ8TBA6, 14 interactors
STRINGi9606.ENSP00000163416

Structurei

3D structure databases

ProteinModelPortaliQ8TBA6
SMRiQ8TBA6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili216 – 632Sequence analysisAdd BLAST417

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4677 Eukaryota
ENOG410XR4F LUCA
GeneTreeiENSGT00390000018470
HOGENOMiHOG000273871
HOVERGENiHBG051755
InParanoidiQ8TBA6
OMAiEPTGRVE
OrthoDBiEOG091G0HP5
PhylomeDBiQ8TBA6
TreeFamiTF319468

Family and domain databases

InterProiView protein in InterPro
IPR019177 Golgin_subfamily_A_member_5
PANTHERiPTHR13815 PTHR13815, 1 hit
PfamiView protein in Pfam
PF09787 Golgin_A5, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q8TBA6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSWFVDLAGK AEDLLNRVDQ GAATALSRKD NASNIYSKNT DYTELHQQNT
60 70 80 90 100
DLIYQTGPKS TYISSAADNI RNQKATILAG TANVKVGSRT PVEASHPVEN
110 120 130 140 150
ASVPRPSSHF VRRKKSEPDD ELLFDFLNSS QKEPTGRVEI RKEKGKTPVF
160 170 180 190 200
QSSQTSSVSS VNPSVTTIKT IEENSFGSQT HEAASNSDSS HEGQEESSKE
210 220 230 240 250
NVSSNAACPD HTPTPNDDGK SHELSNLRLE NQLLRNEVQS LNQEMASLLQ
260 270 280 290 300
RSKETQEELN KARARVEKWN ADHSKSDRMT RGLRAQVDDL TEAVAAKDSQ
310 320 330 340 350
LAVLKVRLQE ADQLLSTRTE ALEALQSEKS RIMQDQSEGN SLQNQALQTF
360 370 380 390 400
QERLHEADAT LKREQESYKQ MQSEFAARLN KVEMERQNLA EAITLAERKY
410 420 430 440 450
SDEKKRVDEL QQQVKLYKLN LESSKQELID YKQKATRILQ SKEKLINSLK
460 470 480 490 500
EGSGFEGLDS STASSMELEE LRHEKEMQRE EIQKLMGQIH QLRSELQDME
510 520 530 540 550
AQQVNEAESA REQLQDLHDQ IAGQKASKQE LETELERLKQ EFHYIEEDLY
560 570 580 590 600
RTKNTLQSRI KDRDEEIQKL RNQLTNKTLS NSSQSELENR LHQLTETLIQ
610 620 630 640 650
KQTMLESLST EKNSLVFQLE RLEQQMNSAS GSSSNGSSIN MSGIDNGEGT
660 670 680 690 700
RLRNVPVLFN DTETNLAGMY GKVRKAASSI DQFSIRLGIF LRRYPIARVF
710 720 730
VIIYMALLHL WVMIVLLTYT PEMHHDQPYG K
Length:731
Mass (Da):83,024
Last modified:May 18, 2010 - v3
Checksum:i650B5D46096A2DDE
GO
Isoform 2 (identifier: Q8TBA6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     684-691: SIRLGIFL → RLCFTSGS
     692-731: Missing.

Note: No experimental confirmation available.
Show »
Length:691
Mass (Da):78,108
Checksum:iB5E3CED3DE0F96CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK03H0YK03_HUMAN
Golgin subfamily A member 5
GOLGA5
117Annotation score:

Sequence cautioni

The sequence CAA33787 differs from that shown. Chimeric cDNA. A chimeric cDNA originating from chromosomes 14 and 10.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti350F → L in AAD09753 (PubMed:9915833).Curated1
Sequence conflicti350F → L in AAV85456 (Ref. 2) Curated1
Sequence conflicti350F → L in EAW81502 (Ref. 4) Curated1
Sequence conflicti350F → L in AAH23021 (PubMed:15489334).Curated1
Sequence conflicti350F → L in CAA33787 (PubMed:2734021).Curated1
Sequence conflicti350F → L in CAB36967 (PubMed:9443391).Curated1
Sequence conflicti584 – 585QS → PV in CAB36967 (PubMed:9443391).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05585967A → G1 PublicationCorresponds to variant dbSNP:rs17128572Ensembl.1
Natural variantiVAR_055860486M → V. Corresponds to variant dbSNP:rs34139657Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007731684 – 691SIRLGIFL → RLCFTSGS in isoform 2. 1 Publication8
Alternative sequenceiVSP_007732692 – 731Missing in isoform 2. 1 PublicationAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085199 mRNA Translation: AAD09753.1
AY644768 mRNA Translation: AAV85456.1
AL132987 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81502.1
BC023021 mRNA Translation: AAH23021.1
X15786 mRNA Translation: CAA33787.1 Sequence problems.
AJ132949 mRNA Translation: CAB36967.1
BX248744 mRNA Translation: CAD66551.1
CCDSiCCDS9905.1 [Q8TBA6-1]
PIRiI38153
RefSeqiNP_005104.3, NM_005113.3
XP_011535722.1, XM_011537420.2 [Q8TBA6-2]
UniGeneiHs.104320

Genome annotation databases

EnsembliENST00000163416; ENSP00000163416; ENSG00000066455 [Q8TBA6-1]
GeneIDi9950
KEGGihsa:9950
UCSCiuc001yaz.3 human [Q8TBA6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF085199 mRNA Translation: AAD09753.1
AY644768 mRNA Translation: AAV85456.1
AL132987 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81502.1
BC023021 mRNA Translation: AAH23021.1
X15786 mRNA Translation: CAA33787.1 Sequence problems.
AJ132949 mRNA Translation: CAB36967.1
BX248744 mRNA Translation: CAD66551.1
CCDSiCCDS9905.1 [Q8TBA6-1]
PIRiI38153
RefSeqiNP_005104.3, NM_005113.3
XP_011535722.1, XM_011537420.2 [Q8TBA6-2]
UniGeneiHs.104320

3D structure databases

ProteinModelPortaliQ8TBA6
SMRiQ8TBA6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115275, 92 interactors
IntActiQ8TBA6, 14 interactors
STRINGi9606.ENSP00000163416

PTM databases

iPTMnetiQ8TBA6
PhosphoSitePlusiQ8TBA6

Polymorphism and mutation databases

DMDMi296439337

Proteomic databases

EPDiQ8TBA6
MaxQBiQ8TBA6
PaxDbiQ8TBA6
PeptideAtlasiQ8TBA6
PRIDEiQ8TBA6
ProteomicsDBi73978
73979 [Q8TBA6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000163416; ENSP00000163416; ENSG00000066455 [Q8TBA6-1]
GeneIDi9950
KEGGihsa:9950
UCSCiuc001yaz.3 human [Q8TBA6-1]

Organism-specific databases

CTDi9950
DisGeNETi9950
EuPathDBiHostDB:ENSG00000066455.12
GeneCardsiGOLGA5
H-InvDBiHIX0011907
HGNCiHGNC:4428 GOLGA5
HPAiHPA000992
HPA063876
MalaCardsiGOLGA5
MIMi606918 gene
neXtProtiNX_Q8TBA6
OpenTargetsiENSG00000066455
Orphaneti146 Differentiated thyroid carcinoma
PharmGKBiPA28809
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4677 Eukaryota
ENOG410XR4F LUCA
GeneTreeiENSGT00390000018470
HOGENOMiHOG000273871
HOVERGENiHBG051755
InParanoidiQ8TBA6
OMAiEPTGRVE
OrthoDBiEOG091G0HP5
PhylomeDBiQ8TBA6
TreeFamiTF319468

Enzyme and pathway databases

ReactomeiR-HSA-6811438 Intra-Golgi traffic

Miscellaneous databases

ChiTaRSiGOLGA5 human
GeneWikiiGOLGA5
GenomeRNAii9950
PROiPR:Q8TBA6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000066455 Expressed in 221 organ(s), highest expression level in secondary oocyte
CleanExiHS_GOLGA5
ExpressionAtlasiQ8TBA6 baseline and differential
GenevisibleiQ8TBA6 HS

Family and domain databases

InterProiView protein in InterPro
IPR019177 Golgin_subfamily_A_member_5
PANTHERiPTHR13815 PTHR13815, 1 hit
PfamiView protein in Pfam
PF09787 Golgin_A5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA5_HUMAN
AccessioniPrimary (citable) accession number: Q8TBA6
Secondary accession number(s): C9JRU1
, O95287, Q03962, Q2TS49, Q9UQQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 147 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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